CN114945571B - 环状化合物及其使用方法 - Google Patents

环状化合物及其使用方法 Download PDF

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Publication number
CN114945571B
CN114945571B CN202080092668.7A CN202080092668A CN114945571B CN 114945571 B CN114945571 B CN 114945571B CN 202080092668 A CN202080092668 A CN 202080092668A CN 114945571 B CN114945571 B CN 114945571B
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compound
methyl
cancer
triazol
cyano
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Chinese (zh)
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CN114945571A (zh
Inventor
冯书路
摩根·劳伦斯
戈兰·克里洛夫
安德鲁·普莱泽克
聂喆
林尼·特佐斯
迈克尔·特佐斯
唐海峰
H·雷切尔·拉吉亚科斯
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Schrodinger & Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
CN202080092668.7A 2019-12-27 2020-12-24 环状化合物及其使用方法 Active CN114945571B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962954262P 2019-12-27 2019-12-27
US62/954,262 2019-12-27
US202063040582P 2020-06-18 2020-06-18
US63/040,582 2020-06-18
US202063119521P 2020-11-30 2020-11-30
US63/119,521 2020-11-30
PCT/US2020/066999 WO2021134004A1 (en) 2019-12-27 2020-12-24 Cyclic compounds and methods of using same

Publications (2)

Publication Number Publication Date
CN114945571A CN114945571A (zh) 2022-08-26
CN114945571B true CN114945571B (zh) 2025-02-25

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US (1) US20240018157A1 (enExample)
EP (1) EP4081526A1 (enExample)
JP (2) JP7723666B2 (enExample)
KR (1) KR20220123023A (enExample)
CN (1) CN114945571B (enExample)
AU (1) AU2020413333A1 (enExample)
BR (1) BR112022012684A2 (enExample)
CA (1) CA3161339A1 (enExample)
CL (1) CL2022001741A1 (enExample)
IL (1) IL294214B2 (enExample)
MX (1) MX2022007171A (enExample)
PH (1) PH12022551523A1 (enExample)
TW (1) TWI878423B (enExample)
WO (1) WO2021134004A1 (enExample)

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CN117120442A (zh) * 2021-01-26 2023-11-24 薛定谔公司 用于治疗癌症、自身免疫性病症和炎性病症的三环化合物
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WO2023051759A1 (zh) * 2021-09-30 2023-04-06 上海拓界生物医药科技有限公司 三环化合物及其制备方法
EP4444340A4 (en) * 2021-12-10 2025-12-24 Rarefied Biosciences Inc METHODS OF TREATING DISEASES USING MALT1 INHIBITORS
KR20240144146A (ko) 2022-02-02 2024-10-02 오노 야꾸힝 고교 가부시키가이샤 Malt1 저해약을 유효 성분으로서 포함하는 암 치료제
JP2025524002A (ja) * 2022-07-22 2025-07-25 シュレーディンガー， インコーポレイテッド 環式化合物及びそれを使用する方法
EP4638458A1 (en) * 2022-12-23 2025-10-29 Janssen Pharmaceutica NV Malt1 inhibitors
CN117624189B (zh) * 2023-11-24 2025-11-11 上海馨远医药科技有限公司 一种6-氧杂-3-氮杂双环[3.1.1]庚烷盐酸盐的制备方法
WO2026003045A1 (en) * 2024-06-26 2026-01-02 Janssen Pharmaceutica Nv Synthesis of a malt1 inhibitor
WO2026050766A1 (en) * 2024-09-02 2026-03-05 Blueprint Medicines Corporation Intermediate salts for synthesis of a cdk2 inhibitor
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CN119285519B (zh) * 2024-10-11 2025-04-18 无锡科华生物科技有限公司 一种5,5’-二甲基吡咯烷-3-醇的制备方法

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CA3161339A1 (en) 2021-07-01
PH12022551523A1 (en) 2024-01-29
JP2023509886A (ja) 2023-03-10
KR20220123023A (ko) 2022-09-05
BR112022012684A2 (pt) 2023-03-07
CL2022001741A1 (es) 2023-01-27
CN114945571A (zh) 2022-08-26
AU2020413333A1 (en) 2022-06-16
TW202136270A (zh) 2021-10-01
IL294214A (en) 2022-08-01
IL294214B2 (en) 2026-04-01
JP7723666B2 (ja) 2025-08-14
TWI878423B (zh) 2025-04-01
US20240018157A1 (en) 2024-01-18
WO2021134004A1 (en) 2021-07-01
EP4081526A1 (en) 2022-11-02
IL294214B1 (en) 2025-12-01
JP2024023699A (ja) 2024-02-21
MX2022007171A (es) 2022-08-22

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