JP7723666B2 - 環式化合物およびその使用方法 - Google Patents

環式化合物およびその使用方法

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Publication number
JP7723666B2
JP7723666B2 JP2022539348A JP2022539348A JP7723666B2 JP 7723666 B2 JP7723666 B2 JP 7723666B2 JP 2022539348 A JP2022539348 A JP 2022539348A JP 2022539348 A JP2022539348 A JP 2022539348A JP 7723666 B2 JP7723666 B2 JP 7723666B2
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triazol
methyl
cancer
compound
protein
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Japanese (ja)
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JP2023509886A (ja
JP2023509886A5 (enExample
Inventor
シュル フェン，
モーガン ローレンツ，
ゴラン クリロフ，
アンドリュー プラチェック，
ジェ ニエ，
リニー トルゾス，
マイケル トルゾス，
ハイフェン タン，
エイチ． レイチェル ラギアコス，
Original Assignee
シュレーディンガー， インコーポレイテッド
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Publication of JP2023509886A publication Critical patent/JP2023509886A/ja
Priority to JP2023212834A priority Critical patent/JP2024023699A/ja
Publication of JP2023509886A5 publication Critical patent/JP2023509886A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2022539348A 2019-12-27 2020-12-24 環式化合物およびその使用方法 Active JP7723666B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023212834A JP2024023699A (ja) 2019-12-27 2023-12-18 環式化合物およびその使用方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962954262P 2019-12-27 2019-12-27
US62/954,262 2019-12-27
US202063040582P 2020-06-18 2020-06-18
US63/040,582 2020-06-18
US202063119521P 2020-11-30 2020-11-30
US63/119,521 2020-11-30
PCT/US2020/066999 WO2021134004A1 (en) 2019-12-27 2020-12-24 Cyclic compounds and methods of using same

Related Child Applications (1)

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JP2023212834A Division JP2024023699A (ja) 2019-12-27 2023-12-18 環式化合物およびその使用方法

Publications (3)

Publication Number Publication Date
JP2023509886A JP2023509886A (ja) 2023-03-10
JP2023509886A5 JP2023509886A5 (enExample) 2023-12-26
JP7723666B2 true JP7723666B2 (ja) 2025-08-14

Family

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Family Applications (2)

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JP2022539348A Active JP7723666B2 (ja) 2019-12-27 2020-12-24 環式化合物およびその使用方法
JP2023212834A Pending JP2024023699A (ja) 2019-12-27 2023-12-18 環式化合物およびその使用方法

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Country Status (14)

Country Link
US (1) US20240018157A1 (enExample)
EP (1) EP4081526A1 (enExample)
JP (2) JP7723666B2 (enExample)
KR (1) KR20220123023A (enExample)
CN (1) CN114945571B (enExample)
AU (1) AU2020413333A1 (enExample)
BR (1) BR112022012684A2 (enExample)
CA (1) CA3161339A1 (enExample)
CL (1) CL2022001741A1 (enExample)
IL (1) IL294214B2 (enExample)
MX (1) MX2022007171A (enExample)
PH (1) PH12022551523A1 (enExample)
TW (1) TWI878423B (enExample)
WO (1) WO2021134004A1 (enExample)

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CN117120442A (zh) * 2021-01-26 2023-11-24 薛定谔公司 用于治疗癌症、自身免疫性病症和炎性病症的三环化合物
EP4284804A1 (en) 2021-01-26 2023-12-06 Schrödinger, Inc. Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
WO2023051759A1 (zh) * 2021-09-30 2023-04-06 上海拓界生物医药科技有限公司 三环化合物及其制备方法
EP4444340A4 (en) * 2021-12-10 2025-12-24 Rarefied Biosciences Inc METHODS OF TREATING DISEASES USING MALT1 INHIBITORS
KR20240144146A (ko) 2022-02-02 2024-10-02 오노 야꾸힝 고교 가부시키가이샤 Malt1 저해약을 유효 성분으로서 포함하는 암 치료제
JP2025524002A (ja) * 2022-07-22 2025-07-25 シュレーディンガー， インコーポレイテッド 環式化合物及びそれを使用する方法
EP4638458A1 (en) * 2022-12-23 2025-10-29 Janssen Pharmaceutica NV Malt1 inhibitors
CN117624189B (zh) * 2023-11-24 2025-11-11 上海馨远医药科技有限公司 一种6-氧杂-3-氮杂双环[3.1.1]庚烷盐酸盐的制备方法
WO2026003045A1 (en) * 2024-06-26 2026-01-02 Janssen Pharmaceutica Nv Synthesis of a malt1 inhibitor
WO2026050766A1 (en) * 2024-09-02 2026-03-05 Blueprint Medicines Corporation Intermediate salts for synthesis of a cdk2 inhibitor
WO2026064683A1 (en) * 2024-09-20 2026-03-26 Kodiak Sciences Inc. Targeted drug polymer conjugates
CN119285519B (zh) * 2024-10-11 2025-04-18 无锡科华生物科技有限公司 一种5,5’-二甲基吡咯烷-3-醇的制备方法

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WO2018226150A1 (en) 2017-06-05 2018-12-13 Medivir Aktiebolag Pyrazolopyrimidine as malt-1 inhibitors

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CA3161339A1 (en) 2021-07-01
PH12022551523A1 (en) 2024-01-29
CN114945571B (zh) 2025-02-25
JP2023509886A (ja) 2023-03-10
KR20220123023A (ko) 2022-09-05
BR112022012684A2 (pt) 2023-03-07
CL2022001741A1 (es) 2023-01-27
CN114945571A (zh) 2022-08-26
AU2020413333A1 (en) 2022-06-16
TW202136270A (zh) 2021-10-01
IL294214A (en) 2022-08-01
IL294214B2 (en) 2026-04-01
TWI878423B (zh) 2025-04-01
US20240018157A1 (en) 2024-01-18
WO2021134004A1 (en) 2021-07-01
EP4081526A1 (en) 2022-11-02
IL294214B1 (en) 2025-12-01
JP2024023699A (ja) 2024-02-21
MX2022007171A (es) 2022-08-22

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