KR20180096592A - 호흡기 세포융합 바이러스 백신 - Google Patents
호흡기 세포융합 바이러스 백신 Download PDFInfo
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- KR20180096592A KR20180096592A KR1020187014339A KR20187014339A KR20180096592A KR 20180096592 A KR20180096592 A KR 20180096592A KR 1020187014339 A KR1020187014339 A KR 1020187014339A KR 20187014339 A KR20187014339 A KR 20187014339A KR 20180096592 A KR20180096592 A KR 20180096592A
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- rsv
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- antigenic polypeptide
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- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2015024668A2 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Respiratory syncytial virus (rsv) vaccine |
| DK3134131T3 (en) | 2014-04-23 | 2022-02-07 | Modernatx Inc | Nucleic acid vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| WO2017015463A2 (en) | 2015-07-21 | 2017-01-26 | Modernatx, Inc. | Infectious disease vaccines |
| US12150980B2 (en) | 2015-07-30 | 2024-11-26 | Modernatx, Inc. | Concatemeric peptide epitope RNAs |
| US11564893B2 (en) | 2015-08-17 | 2023-01-31 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| EP3718565B1 (en) | 2015-10-22 | 2022-04-27 | ModernaTX, Inc. | Respiratory virus vaccines |
| CA3002922A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| MA46080A (fr) | 2015-10-22 | 2019-07-10 | Modernatx Inc | Vaccins à base d'acide nucléique contre le virus varicelle-zona (vzv) |
| MA45209A (fr) | 2015-10-22 | 2019-04-17 | Modernatx Inc | Vaccins contre les maladies sexuellement transmissibles |
| EP3364950A4 (en) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | VACCINES AGAINST TROPICAL DISEASES |
| JP7080172B2 (ja) | 2015-12-10 | 2022-06-03 | モデルナティエックス インコーポレイテッド | 治療薬の送達のための組成物及び方法 |
| US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
| EP4477662A3 (en) * | 2016-05-04 | 2025-03-19 | CureVac SE | Nucleic acid molecules and uses thereof |
| WO2017201340A2 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding relaxin |
| US12128113B2 (en) | 2016-05-18 | 2024-10-29 | Modernatx, Inc. | Polynucleotides encoding JAGGED1 for the treatment of Alagille syndrome |
| ES2928475T3 (es) | 2016-09-14 | 2022-11-18 | Modernatx Inc | Composiciones de ARN de alta pureza y métodos para su preparación |
| WO2018075980A1 (en) | 2016-10-21 | 2018-04-26 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| EP3538146A4 (en) | 2016-11-11 | 2020-07-15 | ModernaTX, Inc. | INFLUENZA VACCINE |
| MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | VERY POWERFUL IMMUNOGENIC COMPOSITIONS |
| WO2018170260A1 (en) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| US11576961B2 (en) | 2017-03-15 | 2023-02-14 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| US20200030432A1 (en) | 2017-03-17 | 2020-01-30 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| US11905525B2 (en) | 2017-04-05 | 2024-02-20 | Modernatx, Inc. | Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| MA49913A (fr) | 2017-08-18 | 2021-05-05 | Modernatx Inc | Variants d'arn polymérase |
| US11912982B2 (en) | 2017-08-18 | 2024-02-27 | Modernatx, Inc. | Methods for HPLC analysis |
| EP3668977A4 (en) | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | HPLC ANALYTICAL PROCESSES |
| JP7275111B2 (ja) | 2017-08-31 | 2023-05-17 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子の生成方法 |
| MA50253A (fr) | 2017-09-14 | 2020-07-22 | Modernatx Inc | Vaccins à arn contre le virus zika |
| EP3746090A4 (en) * | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | RSV RNA Vaccines |
| CA3092497A1 (en) | 2018-03-19 | 2019-09-26 | Crispr Therapeutics Ag | Novel rna-programmable endonuclease systems and uses thereof |
| US11576960B2 (en) | 2018-03-30 | 2023-02-14 | Georgia State University Research Foundation, Inc. | Respiratory syncytial virus (RSV) vaccines |
| EP4227319B1 (en) | 2018-04-17 | 2025-11-26 | CureVac SE | Novel rsv rna molecules and compositions for vaccination |
| JP2021533162A (ja) * | 2018-08-07 | 2021-12-02 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | プロセス及びワクチン |
| US12383508B2 (en) | 2018-09-19 | 2025-08-12 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| JP7526168B2 (ja) | 2018-09-19 | 2024-07-31 | モデルナティエックス インコーポレイテッド | Peg脂質及びそれらの使用 |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| KR102725189B1 (ko) * | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| JP7564102B2 (ja) | 2018-11-28 | 2024-10-08 | クリスパー セラピューティクス アクチェンゲゼルシャフト | LNPでの使用に最適化された、CAS9をコードするmRNA |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| MA55037A (fr) | 2019-02-20 | 2021-12-29 | Modernatx Inc | Variants d'arn polymérase pour le coiffage co-transcriptionnel |
| US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
| CN114025793A (zh) * | 2019-02-28 | 2022-02-08 | 诺瓦瓦克斯股份有限公司 | 用于预防由rsv感染引起的疾病或障碍的方法 |
| CN113874502A (zh) | 2019-03-11 | 2021-12-31 | 摩登纳特斯有限公司 | 补料分批体外转录方法 |
| MA55297A (fr) | 2019-03-12 | 2022-01-19 | Bayer Healthcare Llc | Nouveaux systèmes d'endonucléase à arn programmable haute fidélité et leurs utilisations |
| MA55321A (fr) | 2019-03-15 | 2022-01-19 | Modernatx Inc | Vaccins à base d'arn contre le vih |
| CN114269373A (zh) * | 2019-04-02 | 2022-04-01 | 赛诺菲 | 抗原性多聚呼吸道合胞病毒多肽 |
| CN115778904B (zh) * | 2019-10-29 | 2025-03-28 | 珠海丽凡达生物技术有限公司 | 一种用于体外转染和体内递送mRNA的制剂 |
| IL295148A (en) * | 2020-01-30 | 2022-09-01 | Modernatx Inc | Respiratory virus immunizing compositions |
| CN118490818A (zh) | 2020-04-22 | 2024-08-16 | 生物技术欧洲股份公司 | 冠状病毒疫苗 |
| CA3170740A1 (en) | 2020-05-29 | 2021-12-02 | Curevac Ag | Nucleic acid based combination vaccines |
| JP2023533721A (ja) | 2020-07-02 | 2023-08-04 | ライフ テクノロジーズ コーポレーション | トリヌクレオチドキャップ類似体、それらの調製、及び使用 |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| CN111973563B (zh) * | 2020-09-02 | 2022-06-28 | 崔海港 | 一种鼠李糖脂冻干粉制剂及其制备方法和应用 |
| TW202233232A (zh) * | 2020-11-06 | 2022-09-01 | 法商賽諾菲公司 | 遞送mRNA疫苗的脂質奈米顆粒 |
| US12329811B2 (en) | 2021-01-11 | 2025-06-17 | Modernatx, Inc. | Seasonal RNA influenza virus vaccines |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| EP4101928A1 (en) | 2021-06-11 | 2022-12-14 | Bayer AG | Type v rna programmable endonuclease systems |
| BR112023023768A2 (pt) | 2021-06-11 | 2024-02-27 | Bayer Ag | Sistemas de endonucleases programáveis por rna tipo v |
| WO2023031394A1 (en) | 2021-09-03 | 2023-03-09 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| EP4144841A1 (en) | 2021-09-07 | 2023-03-08 | Bayer AG | Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| EP4453191A1 (en) | 2021-12-23 | 2024-10-30 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
| WO2023144330A1 (en) | 2022-01-28 | 2023-08-03 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| CN119212720A (zh) | 2022-05-25 | 2024-12-27 | 库瑞瓦格欧洲股份公司 | 编码大肠杆菌FimH抗原性多肽的基于核酸的疫苗 |
| CA3258733A1 (en) | 2022-06-10 | 2023-12-14 | Bayer Aktiengesellschaft | NEW SMALL PROGRAMMABLE TYPE V RNA ENDONUCLEASE SYSTEMS |
| WO2024002985A1 (en) | 2022-06-26 | 2024-01-04 | BioNTech SE | Coronavirus vaccine |
| CN120153078A (zh) * | 2022-10-27 | 2025-06-13 | 辉瑞大药厂 | 编码rsv-f的rna分子及含所述rna分子的疫苗 |
| DE202023106198U1 (de) | 2022-10-28 | 2024-03-21 | CureVac SE | Impfstoff auf Nukleinsäurebasis |
| CN120752335A (zh) | 2022-12-13 | 2025-10-03 | 拜耳公司 | 工程化v型rna可编程核酸内切酶及其用途 |
| US12239701B2 (en) | 2023-02-03 | 2025-03-04 | Vernagen, LLC | Respiratory syncytial virus mRNA vaccine |
| CN116286672B (zh) * | 2023-02-07 | 2025-01-28 | 金宇保灵生物药品有限公司 | 一种口蹄疫病毒及其应用 |
| WO2024179559A1 (en) * | 2023-03-02 | 2024-09-06 | Suzhou Abogen Biosciences Co., Ltd. | Nucleic acid vaccines for respiratory syncytial virus (rsv) |
| AU2024233180A1 (en) | 2023-03-08 | 2025-09-25 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024194153A1 (en) * | 2023-03-17 | 2024-09-26 | Glaxosmithkline Biologicals Sa | Rsv-f-encoding nucleic acids |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| WO2024260359A1 (zh) * | 2023-06-20 | 2024-12-26 | 石药集团巨石生物制药有限公司 | 一种抵抗呼吸道合胞病毒的mRNA疫苗及其制备方法 |
| WO2024259624A1 (en) * | 2023-06-21 | 2024-12-26 | Shenzhen Genius Biotech Service Co. Ltd | A modified rsv f protein, a nanoparticle, a composition and a vaccine against respiratory syncytial virus infection |
| CN119490569A (zh) * | 2023-08-16 | 2025-02-21 | 深圳瑞吉生物科技有限公司 | 呼吸道合胞病毒抗原性多肽、核酸、疫苗及其应用 |
| CN117487823B (zh) * | 2023-09-28 | 2024-10-29 | 怡道生物科技(苏州)有限公司 | 呼吸道合胞体病毒mRNA疫苗及其制备方法和应用 |
| WO2025076291A1 (en) | 2023-10-06 | 2025-04-10 | Bluerock Therapeutics Lp | Engineered type v rna programmable endonucleases and their uses |
| CN120022355A (zh) * | 2023-11-22 | 2025-05-23 | 长春百克生物科技股份公司 | 一种mRNA疫苗及其应用 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| US6998115B2 (en) | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US7708915B2 (en) | 2004-05-06 | 2010-05-04 | Castor Trevor P | Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein |
| ES2356934T3 (es) | 2001-06-05 | 2011-04-14 | Curevac Gmbh | ARNm ESTABILIZADO CON UN CONTENIDO DE G/C AUMENTADO QUE CODIFICA PARA UN ANTÍGENO VIRAL. |
| EP1412065A2 (en) | 2001-07-27 | 2004-04-28 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| WO2003028657A2 (en) | 2001-10-03 | 2003-04-10 | The Johns Hopkins University | Compositions for oral gene therapy and methods of using same |
| WO2003092665A2 (en) | 2002-05-02 | 2003-11-13 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| EP1713514B1 (en) | 2004-01-28 | 2021-11-24 | Johns Hopkins University | Drugs and gene carrier particles that rapidly move through mucous barriers |
| CA2563533C (en) | 2004-04-15 | 2013-10-01 | Shmuel A. Ben-Sasson | Compositions capable of facilitating penetration across a biological barrier |
| CA2590098C (en) | 2004-12-10 | 2015-03-31 | Justin Hanes | Functionalized poly (ether-anhydride) block copolymers |
| MX2007012157A (es) | 2005-04-01 | 2008-03-14 | Intezyne Technologies Llc | Micelas polimericas para suministro de farmacos. |
| WO2006110776A2 (en) | 2005-04-12 | 2006-10-19 | Nektar Therapeutics Al, Corporation | Polyethylene glycol cojugates of antimicrobial agents |
| WO2006138572A2 (en) | 2005-06-16 | 2006-12-28 | Nektar Therapeutics Al, Corporation | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| CN103030801B (zh) | 2006-02-21 | 2015-07-22 | 尼克塔治疗公司 | 嵌段可降解聚合物及由其制备的轭合物 |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| DE602007012559D1 (de) | 2006-09-08 | 2011-03-31 | Univ Johns Hopkins | H die schleimhaut |
| AU2007339280B2 (en) | 2006-12-21 | 2013-12-05 | Stryker Corporation | Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents |
| JP5410434B2 (ja) | 2007-09-28 | 2014-02-05 | バインド セラピューティックス インコーポレイテッド | ナノ粒子を用いた癌細胞の標的化 |
| WO2010005725A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences, Inc. | Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same |
| DK2774608T3 (da) | 2008-06-16 | 2020-01-13 | Pfizer | Lægemiddelladede polymere nanopartikler og fremgangsmåder til fremstilling og anvendelse deraf |
| HUE035770T2 (en) | 2008-06-16 | 2018-05-28 | Pfizer | Process for the preparation of diblock copolymers functionalized with targeting material for use in the preparation of therapeutic nanoparticles |
| US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
| WO2010030763A2 (en) | 2008-09-10 | 2010-03-18 | Bind Biosciences, Inc. | High throughput fabrication of nanoparticles |
| EP3757090B1 (en) * | 2008-11-10 | 2024-06-12 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
| EA201100765A1 (ru) | 2008-12-15 | 2012-04-30 | Бинд Биосаиэнсис | Наночастицы длительной циркуляции для замедленного высвобождения терапевтических средств |
| CA2751342C (en) * | 2009-01-29 | 2019-05-07 | Alnylam Pharmaceuticals, Inc. | Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid |
| JP5622254B2 (ja) | 2009-03-31 | 2014-11-12 | 国立大学法人東京大学 | 二本鎖リボ核酸ポリイオンコンプレックス |
| US8287910B2 (en) | 2009-04-30 | 2012-10-16 | Intezyne Technologies, Inc. | Polymeric micelles for polynucleotide encapsulation |
| EP2496700B1 (en) | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| EP2512459A4 (en) | 2009-12-15 | 2013-08-07 | THERAPEUTIC POLYMERIC NANOPARTICLES COMPRISING EPOTHILONE AND METHODS OF MAKING AND USING SAME | |
| US9295649B2 (en) | 2009-12-15 | 2016-03-29 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers |
| WO2011084518A2 (en) | 2009-12-15 | 2011-07-14 | Bind Biosciences, Inc. | Therapeutic polymeric nanoparticles comprising corticosteroids and methods of making and using same |
| US20130101609A1 (en) | 2010-01-24 | 2013-04-25 | Novartis Ag | Irradiated biodegradable polymer microparticles |
| US8207290B2 (en) | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
| US20110262491A1 (en) | 2010-04-12 | 2011-10-27 | Selecta Biosciences, Inc. | Emulsions and methods of making nanocarriers |
| JP2013531634A (ja) | 2010-05-24 | 2013-08-08 | メルク・シャープ・エンド・ドーム・コーポレイション | オリゴヌクレオチド送達のための新規なアミノアルコールカチオン性脂質 |
| US20130196948A1 (en) | 2010-06-25 | 2013-08-01 | Massachusetts Insitute Of Technology | Polymers for biomaterials and therapeutics |
| FI4005592T3 (fi) * | 2010-07-06 | 2023-01-13 | Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille | |
| PL2591114T3 (pl) * | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| AU2011276234B2 (en) * | 2010-07-06 | 2016-02-25 | Glaxosmithkline Biologicals S.A. | Liposomes with lipids having an advantageous pKa- value for RNA delivery |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| EA201390600A1 (ru) | 2010-10-22 | 2013-09-30 | Байнд Терапьютикс, Инк. | Терапевтические наночастицы с сополимерами с большим молекулярным весом |
| CA2816977C (en) | 2010-11-05 | 2019-10-29 | The Johns Hopkins University | Compositions and methods relating to reduced mucoadhesion |
| WO2012099805A2 (en) | 2011-01-19 | 2012-07-26 | Ocean Nanotech, Llc | Nanoparticle based immunological stimulation |
| US20140066363A1 (en) | 2011-02-07 | 2014-03-06 | Arun K. Bhunia | Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide |
| AU2012237260A1 (en) | 2011-03-31 | 2013-11-14 | Ingell Technologies Holding B.V. | Biodegradable compositions suitable for controlled release |
| CA2831471C (en) | 2011-03-31 | 2020-02-25 | Ingell Technologies Holding B.V. | Biodegradable compositions suitable for controlled release |
| US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| WO2012166923A2 (en) | 2011-05-31 | 2012-12-06 | Bind Biosciences | Drug loaded polymeric nanoparticles and methods of making and using same |
| CN103764121A (zh) * | 2011-07-06 | 2014-04-30 | 诺华股份有限公司 | 用于递送rna分子的具有有用n:p比的脂质体 |
| AU2012280904B2 (en) * | 2011-07-06 | 2017-02-23 | Glaxosmithkline Biologicals S.A. | Cationic oil-in-water emulsions |
| CN103732211B (zh) | 2011-07-21 | 2017-03-01 | 禾大国际股份公开有限公司 | 支化的聚醚‑聚酰胺嵌段共聚物及其制造与使用方法 |
| PH12014500214A1 (en) | 2011-08-26 | 2019-03-22 | Arrowhead Res Corporation | Poly (vinyl ester) polymers for in vivo nucleic acid delivery |
| WO2013033438A2 (en) | 2011-08-31 | 2013-03-07 | Mallinckrodt Llc | Nanoparticle peg modification with h-phosphonates |
| EP2747761A1 (en) | 2011-09-22 | 2014-07-02 | Bind Therapeutics, Inc. | Methods of treating cancers with therapeutic nanoparticles |
| WO2013072929A2 (en) | 2011-09-23 | 2013-05-23 | Indian Institute Of Technology | Nanop article based cosmetic composition |
| WO2013059496A1 (en) | 2011-10-18 | 2013-04-25 | Dicerna Pharmaceuticals, Inc. | Amine cationic lipids and uses thereof |
| EP4074694A1 (en) | 2011-10-27 | 2022-10-19 | Massachusetts Institute Of Technology | Amino acid-, peptide- an polypeptide-lipids, isomers, compositions, an uses thereof |
| WO2013078199A2 (en) | 2011-11-23 | 2013-05-30 | Children's Medical Center Corporation | Methods for enhanced in vivo delivery of synthetic, modified rnas |
| DE12858350T1 (de) | 2011-12-16 | 2021-10-07 | Modernatx, Inc. | Modifizierte mrna zusammensetzungen |
| CA2863632C (en) | 2012-01-19 | 2017-07-11 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| CA3069030C (en) | 2012-02-03 | 2021-11-16 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| WO2013120052A1 (en) | 2012-02-10 | 2013-08-15 | E. I. Du Pont De Nemours And Company | Preparation, purification and use of high-x diblock copolymers |
| HK1206601A1 (en) * | 2012-04-02 | 2016-01-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| JP6561378B2 (ja) * | 2012-06-08 | 2019-08-21 | トランスレイト バイオ, インコーポレイテッド | 非肺標的細胞へのmRNAの経肺送達 |
| ES2968649T3 (es) * | 2012-12-07 | 2024-05-13 | Translate Bio Inc | Nanopartículas lipídicas para la administración de ARNm en los pulmones |
| WO2014160463A1 (en) * | 2013-03-13 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prefusion rsv f proteins and their use |
| US9738689B2 (en) * | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| RS62565B1 (sr) * | 2013-03-14 | 2021-12-31 | Translate Bio Inc | Metode i kompozicije za isporuku antitela kodiranih od strane irnk |
| US10077439B2 (en) | 2013-03-15 | 2018-09-18 | Modernatx, Inc. | Removal of DNA fragments in mRNA production process |
| EP2971033B8 (en) | 2013-03-15 | 2019-07-10 | ModernaTX, Inc. | Manufacturing methods for production of rna transcripts |
| US20160032273A1 (en) | 2013-03-15 | 2016-02-04 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
| EP2983804A4 (en) | 2013-03-15 | 2017-03-01 | Moderna Therapeutics, Inc. | Ion exchange purification of mrna |
| US11377470B2 (en) | 2013-03-15 | 2022-07-05 | Modernatx, Inc. | Ribonucleic acid purification |
| WO2014144711A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Analysis of mrna heterogeneity and stability |
| HUE071526T2 (hu) * | 2013-03-15 | 2025-09-28 | Translate Bio Inc | Nukleinsavak bejuttatásának szinergista fokozása kevert kiszerelésekkel |
| TW201534578A (zh) * | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| EP3024483B1 (en) * | 2013-07-25 | 2020-01-15 | Calder Biosciences Inc. | Conformationally stabilized rsv pre-fusion f proteins |
| WO2015024668A2 (en) * | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Respiratory syncytial virus (rsv) vaccine |
| MX2016005239A (es) | 2013-10-22 | 2016-08-12 | Shire Human Genetic Therapies | Tratamiento con acido ribonucleico mensajero para la fenilcetonuria. |
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2016
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- 2016-10-21 SG SG10201914006UA patent/SG10201914006UA/en unknown
- 2016-10-21 MX MX2018004917A patent/MX2018004917A/es unknown
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- 2016-10-21 SG SG11201803363YA patent/SG11201803363YA/en unknown
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- 2016-10-21 EA EA201891000A patent/EA201891000A1/ru unknown
- 2016-10-21 MA MA046317A patent/MA46317A/fr unknown
- 2016-10-21 CN CN201680075062.6A patent/CN108472354A/zh active Pending
- 2016-10-21 US US15/767,613 patent/US20180271970A1/en not_active Abandoned
- 2016-10-21 EP EP16858402.7A patent/EP3365008A4/en active Pending
- 2016-10-21 PE PE2018000599A patent/PE20181530A1/es unknown
- 2016-10-21 WO PCT/US2016/058321 patent/WO2017070622A1/en not_active Ceased
- 2016-10-21 JP JP2018541089A patent/JP7687767B2/ja active Active
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2018
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Also Published As
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| MA46317A (fr) | 2019-08-07 |
| TN2018000154A1 (en) | 2019-10-04 |
| US20230390379A1 (en) | 2023-12-07 |
| CL2018001053A1 (es) | 2018-10-19 |
| JP2025041835A (ja) | 2025-03-26 |
| JP2019501208A (ja) | 2019-01-17 |
| JP2023015151A (ja) | 2023-01-31 |
| US20180271970A1 (en) | 2018-09-27 |
| SG11201803363YA (en) | 2018-05-30 |
| IL258831A (en) | 2018-06-28 |
| BR112018008102A2 (pt) | 2018-11-06 |
| SG10201914006UA (en) | 2020-03-30 |
| EA201891000A1 (ru) | 2018-12-28 |
| JP7687767B2 (ja) | 2025-06-03 |
| CN108472354A (zh) | 2018-08-31 |
| PH12018500856A1 (en) | 2018-10-29 |
| WO2017070622A1 (en) | 2017-04-27 |
| MX2018004917A (es) | 2019-04-01 |
| EP3365008A4 (en) | 2019-08-07 |
| TW201729836A (zh) | 2017-09-01 |
| AU2016341311A1 (en) | 2018-06-07 |
| CO2018005229A2 (es) | 2018-11-30 |
| CA3002820A1 (en) | 2017-04-27 |
| EP3365008A1 (en) | 2018-08-29 |
| AU2016341311B2 (en) | 2023-11-16 |
| PE20181530A1 (es) | 2018-09-26 |
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