MA46317A - Vaccin contre le virus respiratoire syncytial - Google Patents

Vaccin contre le virus respiratoire syncytial

Info

Publication number
MA46317A
MA46317A MA046317A MA46317A MA46317A MA 46317 A MA46317 A MA 46317A MA 046317 A MA046317 A MA 046317A MA 46317 A MA46317 A MA 46317A MA 46317 A MA46317 A MA 46317A
Authority
MA
Morocco
Prior art keywords
respiratory syncytial
syncytial virus
virus vaccine
vaccine
respiratory
Prior art date
Application number
MA046317A
Other languages
English (en)
Inventor
Kapil Bahl
Andrew J Bett
Giuseppe Ciaramella
Amy Espeseth
Dai Wang
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA46317A publication Critical patent/MA46317A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
MA046317A 2015-10-22 2016-10-21 Vaccin contre le virus respiratoire syncytial MA46317A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562245208P 2015-10-22 2015-10-22
US201562245031P 2015-10-22 2015-10-22
US201562247563P 2015-10-28 2015-10-28
US201562248250P 2015-10-29 2015-10-29

Publications (1)

Publication Number Publication Date
MA46317A true MA46317A (fr) 2019-08-07

Family

ID=58558153

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046317A MA46317A (fr) 2015-10-22 2016-10-21 Vaccin contre le virus respiratoire syncytial

Country Status (20)

Country Link
US (2) US20180271970A1 (fr)
EP (1) EP3365008A4 (fr)
JP (2) JP2019501208A (fr)
KR (1) KR20180096592A (fr)
CN (1) CN108472354A (fr)
AU (1) AU2016341311B2 (fr)
BR (1) BR112018008102A2 (fr)
CA (1) CA3002820A1 (fr)
CL (1) CL2018001053A1 (fr)
CO (1) CO2018005229A2 (fr)
EA (1) EA201891000A1 (fr)
IL (1) IL258831A (fr)
MA (1) MA46317A (fr)
MX (1) MX2018004917A (fr)
PE (1) PE20181530A1 (fr)
PH (1) PH12018500856A1 (fr)
SG (2) SG10201914006UA (fr)
TN (1) TN2018000154A1 (fr)
TW (1) TW201729836A (fr)
WO (1) WO2017070622A1 (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
SI3134131T1 (sl) 2014-04-23 2022-04-29 Modernatx, Inc. Cepiva na osnovi nukleinskih kislin
WO2017015463A2 (fr) 2015-07-21 2017-01-26 Modernatx, Inc. Vaccins contre une maladie infectieuse
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
WO2017031232A1 (fr) 2015-08-17 2017-02-23 Modernatx, Inc. Procédés de préparation de particules et compositions associées
WO2017070624A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins contre des maladies tropicales
MD3718565T2 (ro) 2015-10-22 2022-09-30 Modernatx Inc Vaccinuri împotriva virusului respirator
JP6925688B2 (ja) 2015-10-22 2021-08-25 モデルナティーエックス, インコーポレイテッド 水痘帯状疱疹ウイルス(vzv)のための核酸ワクチン
WO2017070616A2 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins contre les maladies sexuellement transmissibles
JP6921833B2 (ja) 2015-10-22 2021-08-18 モデルナティーエックス, インコーポレイテッド ヒトサイトメガロウイルスワクチン
MD3386484T2 (ro) 2015-12-10 2022-11-30 Modernatx Inc Compoziții și metode de livrare a unor agenți terapeutici
US10465190B1 (en) 2015-12-23 2019-11-05 Modernatx, Inc. In vitro transcription methods and constructs
EP3452493A1 (fr) * 2016-05-04 2019-03-13 CureVac AG Molécules d'acide nucléique et leurs utilisations
EP3458034A4 (fr) 2016-05-18 2020-01-01 ModernaTX, Inc. Polynucléotides codant la relaxine
CA3036831A1 (fr) 2016-09-14 2018-03-22 Modernatx, Inc. Compositions d'arn de haute purete et procedes pour leur preparation
WO2018075980A1 (fr) 2016-10-21 2018-04-26 Modernatx, Inc. Vaccin contre le cytomégalovirus humain
US10925958B2 (en) 2016-11-11 2021-02-23 Modernatx, Inc. Influenza vaccine
WO2018107088A2 (fr) 2016-12-08 2018-06-14 Modernatx, Inc. Vaccins à acide nucléique contre des virus respiratoires
US11384352B2 (en) 2016-12-13 2022-07-12 Modernatx, Inc. RNA affinity purification
WO2018151816A1 (fr) 2017-02-16 2018-08-23 Modernatx, Inc. Compositions immunogènes très puissantes
US11752206B2 (en) 2017-03-15 2023-09-12 Modernatx, Inc. Herpes simplex virus vaccine
US11464848B2 (en) 2017-03-15 2022-10-11 Modernatx, Inc. Respiratory syncytial virus vaccine
WO2018170245A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin à large spectre contre le virus de la grippe
US11045540B2 (en) 2017-03-15 2021-06-29 Modernatx, Inc. Varicella zoster virus (VZV) vaccine
EP3595676A4 (fr) 2017-03-17 2021-05-05 Modernatx, Inc. Vaccins à base d'arn contre des maladies zoonotiques
EP3607074A4 (fr) 2017-04-05 2021-07-07 Modernatx, Inc. Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée
WO2018232357A1 (fr) 2017-06-15 2018-12-20 Modernatx, Inc. Formulations d'arn
CN111212905A (zh) 2017-08-18 2020-05-29 摩登纳特斯有限公司 Rna聚合酶变体
WO2019036685A1 (fr) 2017-08-18 2019-02-21 Modernatx, Inc. Procédés pour analyse par clhp
US11866696B2 (en) 2017-08-18 2024-01-09 Modernatx, Inc. Analytical HPLC methods
WO2019046809A1 (fr) 2017-08-31 2019-03-07 Modernatx, Inc. Procédés de fabrication de nanoparticules lipidiques
EP3681514A4 (fr) 2017-09-14 2021-07-14 ModernaTX, Inc. Vaccins à arn contre le virus zika
MA54676A (fr) 2018-01-29 2021-11-17 Modernatx Inc Vaccins à base d'arn contre le vrs
EP3775174A4 (fr) * 2018-03-30 2022-07-06 Georgia State University Research Foundation, Inc. Vaccins contre le virus respiratoire syncytial (vrs)
EP4227319A1 (fr) 2018-04-17 2023-08-16 CureVac SE Nouvelles molécules d'arn rsv et compositions pour vaccination
BR112021000965A2 (pt) * 2018-08-07 2021-04-27 Glaxosmithkline Biologicals S.A. processos e vacinas
WO2020061457A1 (fr) * 2018-09-20 2020-03-26 Modernatx, Inc. Préparation de nanoparticules lipidiques et leurs méthodes d'administration
KR20200050264A (ko) * 2018-11-01 2020-05-11 에스케이바이오사이언스(주) 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물
US11351242B1 (en) 2019-02-12 2022-06-07 Modernatx, Inc. HMPV/hPIV3 mRNA vaccine composition
US11851694B1 (en) 2019-02-20 2023-12-26 Modernatx, Inc. High fidelity in vitro transcription
JP2022521094A (ja) 2019-02-20 2022-04-05 モデルナティエックス インコーポレイテッド 共転写キャッピング用rnaポリメラーゼバリアント
EP3937963A2 (fr) 2019-03-12 2022-01-19 CRISPR Therapeutics AG Nouveaux systèmes d'endonucléase à arn programmable haute fidélité et leurs utilisations
CN110638759A (zh) * 2019-10-29 2020-01-03 珠海丽凡达生物技术有限公司 一种用于体外转染和体内递送mRNA的制剂
EP4096683A4 (fr) * 2020-01-30 2024-04-10 Modernatx Inc Compositions d'immunisation contre le virus respiratoire
WO2021213924A1 (fr) 2020-04-22 2021-10-28 BioNTech SE Vaccin contre un coronavirus
IL298084A (en) 2020-05-29 2023-01-01 CureVac SE Nucleic acid-based combination vaccines
EP4175967A2 (fr) 2020-07-02 2023-05-10 Life Technologies Corporation Analogues de coiffe trinucléotidique, préparation et utilisations de ceux-ci
US11406703B2 (en) 2020-08-25 2022-08-09 Modernatx, Inc. Human cytomegalovirus vaccine
CN111973563B (zh) * 2020-09-02 2022-06-28 崔海港 一种鼠李糖脂冻干粉制剂及其制备方法和应用
US11771652B2 (en) * 2020-11-06 2023-10-03 Sanofi Lipid nanoparticles for delivering mRNA vaccines
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
EP4101928A1 (fr) 2021-06-11 2022-12-14 Bayer AG Systèmes d'endonucléase programmables à arn de type v
AU2022290382A1 (en) 2021-06-11 2023-11-23 Bayer Aktiengesellschaft Type v rna programmable endonuclease systems
IL309505A (en) 2021-09-03 2024-02-01 CureVac SE Lipid nanoparticles for nucleic acid delivery
EP4144841A1 (fr) 2021-09-07 2023-03-08 Bayer AG Nouveaux systèmes d'endonucléase programmables à petit arn à spécificité pam améliorée et leurs utilisations
WO2023073228A1 (fr) 2021-10-29 2023-05-04 CureVac SE Arn circulaire amélioré pour exprimer des protéines thérapeutiques
WO2023118068A1 (fr) 2021-12-23 2023-06-29 Bayer Aktiengesellschaft Nouveaux petits systèmes programmables d'endonucléases à arn de type v
WO2023144330A1 (fr) 2022-01-28 2023-08-03 CureVac SE Inhibiteurs de facteurs de transcription codés par un acide nucleique
WO2023227608A1 (fr) 2022-05-25 2023-11-30 Glaxosmithkline Biologicals Sa Vaccin à base d'acide nucléique codant pour un polypeptide antigénique fimh d'escherichia coli
WO2023237587A1 (fr) 2022-06-10 2023-12-14 Bayer Aktiengesellschaft Nouveaux petits systèmes programmables d'endonucléases à arn de type v
WO2024002985A1 (fr) 2022-06-26 2024-01-04 BioNTech SE Vaccin contre le coronavirus
US20240156949A1 (en) 2022-10-28 2024-05-16 Glaxosmithkline Biologicals Sa Nucleic Acid Based Vaccine
CN117487823A (zh) * 2023-09-28 2024-02-02 怡道生物科技(苏州)有限公司 呼吸道合胞体病毒mRNA疫苗及其制备方法和应用

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7708915B2 (en) 2004-05-06 2010-05-04 Castor Trevor P Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
ES2356934T3 (es) 2001-06-05 2011-04-14 Curevac Gmbh ARNm ESTABILIZADO CON UN CONTENIDO DE G/C AUMENTADO QUE CODIFICA PARA UN ANTÍGENO VIRAL.
AU2002319668A1 (en) 2001-07-27 2003-02-17 President And Fellows Of Harvard College Laminar mixing apparatus and methods
WO2003028657A2 (fr) 2001-10-03 2003-04-10 The Johns Hopkins University Compositions pour therapie genique orale et procedes d'utilisation associes
AU2003217531A1 (en) 2002-05-02 2003-11-17 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
NZ570709A (en) * 2003-06-13 2010-04-30 Univ Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
EP1713514B1 (fr) 2004-01-28 2021-11-24 Johns Hopkins University Medicaments et particules de transport de genes se depla ant rapidement a travers les barrieres muqueuses
CA2563533C (fr) 2004-04-15 2013-10-01 Shmuel A. Ben-Sasson Compositions capables de faciliter la penetration a travers une barriere biologique
EP1856179B1 (fr) 2004-12-10 2013-05-15 Kala Pharmaceuticals, Inc. Copolymeres sequences de poly(ether-anhydride) fonctionnalises
NZ562064A (en) 2005-04-01 2011-03-31 Intezyne Technologies Inc Polymeric micelles for drug delivery
US8273339B2 (en) 2005-04-12 2012-09-25 Nektar Therapeutics Polymer-based compositions and conjugates of antimicrobial agents
RS53968B1 (en) 2005-06-16 2015-08-31 Nektar Therapeutics CONJUGATES WHICH HAVE A COUPLING WHICH MAY BE DEGRADED AND POLYMER REAGENTS USED FOR THE PREPARATION OF SUCH CONJUGATES
CN101420984B (zh) 2006-02-21 2013-01-02 尼克塔治疗公司 嵌段可降解聚合物及由其制备的轭合物
JP5630998B2 (ja) 2006-05-15 2014-11-26 マサチューセッツ インスティテュート オブ テクノロジー 機能的粒子のためのポリマー
WO2008030557A2 (fr) 2006-09-08 2008-03-13 Johns Hopkins University Compositions et méthodes destinées à améliorer le transport à travers le mucus
US20100184659A1 (en) 2006-12-21 2010-07-22 Warren Jaworowicz Sustained-Release Formulations Comprising Crystals, Macromolecular Gels, and Particulate Suspensions of Biologic Agents
HUE035101T2 (hu) 2007-09-28 2018-05-02 Pfizer Ráksejtek célzása nanorészecskék alkalmazásával
JP2011525180A (ja) 2008-06-16 2011-09-15 バインド バイオサイエンシズ インコーポレイテッド 治療的標的化ナノ粒子の製作に用いるためのジブロックコポリマーで官能化された標的薬の製造方法
EP2309991B1 (fr) 2008-06-16 2019-03-06 Pfizer Inc Nanoparticules polymères thérapeutiques comprenant des alcaloïdes vinca et procédés de fabrication et d utilisation associés
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
KR20170127069A (ko) 2008-06-16 2017-11-20 화이자 인코포레이티드 약물 부하된 중합체성 나노입자, 및 이의 제조 및 사용 방법
WO2010030763A2 (fr) 2008-09-10 2010-03-18 Bind Biosciences, Inc. Fabrication de nanoparticles à rendement élevé
NO2355851T3 (fr) * 2008-11-10 2018-09-01
ES2776126T3 (es) 2008-12-15 2020-07-29 Pfizer Nanopartículas de circulación prolongada para la liberación sostenida de agentes terapéuticos
AU2010208035B2 (en) * 2009-01-29 2016-06-23 Arbutus Biopharma Corporation Improved lipid formulation for the delivery of nucleic acids
JP5622254B2 (ja) 2009-03-31 2014-11-12 国立大学法人東京大学 二本鎖リボ核酸ポリイオンコンプレックス
WO2010127159A2 (fr) 2009-04-30 2010-11-04 Intezyne Technologies, Incorporated Micelles polymères pour l'encapsulation de polynucléotides
RU2573409C2 (ru) 2009-11-04 2016-01-20 Дзе Юниверсити Оф Бритиш Коламбиа Содержащие нуклеиновые кислоты липидные частицы и относящиеся к ним способы
JP5965844B2 (ja) 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
JP6175237B2 (ja) 2009-12-15 2017-08-02 ファイザー・インク コルチコステロイドを含む治療用ポリマーナノ粒およびそれを製造かつ使用する方法
EP2512459A4 (fr) 2009-12-15 2013-08-07 Nanoparticules polymères thérapeutiques comportant de l'épothilone et leurs procédés de fabrication et d'utilisation
WO2012082165A1 (fr) 2010-01-24 2012-06-21 Novartis Ag Microparticules de polymère biodégradable irradiées
WO2011119262A1 (fr) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Procédés et systèmes de production de nanoparticules
US20110262491A1 (en) 2010-04-12 2011-10-27 Selecta Biosciences, Inc. Emulsions and methods of making nanocarriers
WO2011149733A2 (fr) 2010-05-24 2011-12-01 Merck Sharp & Dohme Corp. Nouveaux lipides cationiques alcools aminés pour l'administration d'oligonucléotides
WO2011163483A2 (fr) 2010-06-25 2011-12-29 Massachusetts Institute Of Technology Polymères pour des biomatériaux et des agents thérapeutiques
EP2590626B1 (fr) * 2010-07-06 2015-10-28 GlaxoSmithKline Biologicals SA Liposomes à lipides ayant une valeur de pka avantageuse pour la délivrance d'arn
CN106421773A (zh) * 2010-07-06 2017-02-22 诺华股份有限公司 自我复制rna分子的病毒样递送颗粒
CA3169291A1 (fr) * 2010-07-06 2012-01-12 Glaxosmithkline Biologicals Sa Immunisation de grands mammiferes a l'aide de faibles doses d'arn
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
WO2012054923A2 (fr) 2010-10-22 2012-04-26 Bind Biosciences, Inc. Nanoparticules thérapeutiques contenant des copolymères de masse moléculaire élevée
US20120121718A1 (en) 2010-11-05 2012-05-17 The Johns Hopkins University Compositions and methods relating to reduced mucoadhesion
US20120189700A1 (en) 2011-01-19 2012-07-26 Zoraida Aguilar Nanoparticle Based Immunological Stimulation
WO2012109121A1 (fr) 2011-02-07 2012-08-16 Purdue Research Foundation Nanoparticules glucidiques pour une efficacité prolongée d'un peptide antimicrobien
DK2691079T3 (da) 2011-03-31 2020-09-28 Ingell Tech Holding B V Bionedbrydelige sammensætninger, der er egnet til kontrolleret udløsning
US9795679B2 (en) 2011-03-31 2017-10-24 Ingell Technologies Holding B.V. Biodegradable compositions suitable for controlled release
US8691750B2 (en) 2011-05-17 2014-04-08 Axolabs Gmbh Lipids and compositions for intracellular delivery of biologically active compounds
US20140308363A1 (en) 2011-05-31 2014-10-16 Bind Therapeutics, Inc. Drug loaded polymeric nanoparticles and methods of making and using same
WO2013006837A1 (fr) * 2011-07-06 2013-01-10 Novartis Ag Emulsions huile dans eau cationiques
JP2014520806A (ja) * 2011-07-06 2014-08-25 ノバルティス アーゲー Rna分子の送達のための有用なn:p比を有するリポソーム
CN103732211B (zh) 2011-07-21 2017-03-01 禾大国际股份公开有限公司 支化的聚醚‑聚酰胺嵌段共聚物及其制造与使用方法
JP2014531476A (ja) 2011-08-26 2014-11-27 アローヘッド リサーチ コーポレイション インビボ核酸送達のためのポリ(ビニルエステル)ポリマー
US8889657B2 (en) 2011-08-31 2014-11-18 Mallinckrodt Llc Nanoparticle PEG modification with H-phosphonates
WO2013044219A1 (fr) 2011-09-22 2013-03-28 Bind Biosciences Méthodes de traitement de cancers au moyen de nanoparticules thérapeutiques
WO2013072929A2 (fr) 2011-09-23 2013-05-23 Indian Institute Of Technology Composition cosmétique à base d'articles nanoparticulaires
AU2012325997C1 (en) 2011-10-18 2018-07-05 Dicerna Pharmaceuticals, Inc. Amine cationic lipids and uses thereof
CN107522664B (zh) 2011-10-27 2021-03-16 麻省理工学院 能够形成药物包封微球的在n末端上官能化的氨基酸衍生物
WO2013078199A2 (fr) 2011-11-23 2013-05-30 Children's Medical Center Corporation Méthodes pour une administration in vivo améliorée d'arn synthétiques modifiés
US20130156849A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
US9415020B2 (en) 2012-01-19 2016-08-16 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
CA2863203C (fr) 2012-02-03 2020-03-24 Rutgers, The State Of University Of New Jersey Biomateriaux polymeres derives de monomeres phenoliques et leurs utilisations a des fins medicales
EP2812383A1 (fr) 2012-02-10 2014-12-17 E. I. Du Pont de Nemours and Company Préparation, purification et utilisation de copolymères à deux blocs à élevé
WO2013151667A1 (fr) * 2012-04-02 2013-10-10 modeRNA Therapeutics Polynucléotides modifiés
EA201492055A1 (ru) * 2012-06-08 2015-11-30 Шир Хьюман Дженетик Терапис, Инк. ИНГАЛЯЦИОННАЯ ДОСТАВКА мРНК В НЕЛЕГОЧНЫЕ КЛЕТКИ-МИШЕНИ
WO2014089486A1 (fr) * 2012-12-07 2014-06-12 Shire Human Genetic Therapies, Inc. Nanoparticules lipidiques pour administration de marn
US9738689B2 (en) * 2013-03-13 2017-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Prefusion RSV F proteins and their use
MX2015013065A (es) * 2013-03-13 2016-06-06 Us Health Proteinas f de rsv de prefusion y su uso.
HUE055044T2 (hu) * 2013-03-14 2021-10-28 Translate Bio Inc MRNS-kódolt ellenanyagok bejuttatására szolgáló eljárások és készítmények
WO2014144767A1 (fr) 2013-03-15 2014-09-18 Moderna Therapeutics, Inc. Purification d'arnm par échange d'ions
HUE039189T2 (hu) * 2013-03-15 2018-12-28 Translate Bio Inc Nukleinsavak bejuttatásának szinergista fokozása kevert kiszerelésekkel
US10138507B2 (en) 2013-03-15 2018-11-27 Modernatx, Inc. Manufacturing methods for production of RNA transcripts
EP2971161B1 (fr) 2013-03-15 2018-12-26 ModernaTX, Inc. Purification d'acide ribonucléique
US20160017313A1 (en) 2013-03-15 2016-01-21 Moderna Therapeutics, Inc. Analysis of mrna heterogeneity and stability
WO2014152030A1 (fr) 2013-03-15 2014-09-25 Moderna Therapeutics, Inc. Elimination de fragments d'adn dans des procédés de production d'arnm
WO2014144039A1 (fr) 2013-03-15 2014-09-18 Moderna Therapeutics, Inc. Caractérisation de molécules d'arnm
TW201534578A (zh) * 2013-07-08 2015-09-16 Daiichi Sankyo Co Ltd 新穎脂質
JP6685903B2 (ja) * 2013-07-25 2020-04-22 アバター・メディカル・エルエルシー 立体構造的に安定化されたrsv融合前fタンパク質
BR112016003361A2 (pt) * 2013-08-21 2017-11-21 Curevac Ag vacina do vírus sincicial respiratório (rsv)

Also Published As

Publication number Publication date
CN108472354A (zh) 2018-08-31
PE20181530A1 (es) 2018-09-26
EP3365008A4 (fr) 2019-08-07
BR112018008102A2 (pt) 2018-11-06
AU2016341311B2 (en) 2023-11-16
AU2016341311A1 (en) 2018-06-07
KR20180096592A (ko) 2018-08-29
WO2017070622A1 (fr) 2017-04-27
SG10201914006UA (en) 2020-03-30
SG11201803363YA (en) 2018-05-30
US20180271970A1 (en) 2018-09-27
TN2018000154A1 (en) 2019-10-04
IL258831A (en) 2018-06-28
PH12018500856A1 (en) 2018-10-29
MX2018004917A (es) 2019-04-01
JP2019501208A (ja) 2019-01-17
EA201891000A1 (ru) 2018-12-28
TW201729836A (zh) 2017-09-01
CA3002820A1 (fr) 2017-04-27
CL2018001053A1 (es) 2018-10-19
US20230390379A1 (en) 2023-12-07
JP2023015151A (ja) 2023-01-31
CO2018005229A2 (es) 2018-11-30
EP3365008A1 (fr) 2018-08-29

Similar Documents

Publication Publication Date Title
MA47787A (fr) Vaccin contre le virus respiratoire syncytial
MA46317A (fr) Vaccin contre le virus respiratoire syncytial
MA52645A (fr) Vaccins contre le virus respiratoire
MA46766A (fr) Vaccin antigrippal
HK1256169A1 (zh) 傳染病疫苗
PL3393510T3 (pl) Szczepionka przeciwko wirusowi zika
MA46316A (fr) Vaccin contre le cytomégalovirus humain
MA43762A (fr) Vaccin contre le rsv
ZA201700165B (en) Influenza virus vaccines and uses thereof
SG11201510746WA (en) Respiratory syncytial virus (rsv) vaccine
IL240504A0 (en) Combined vaccine for respiratory syncytial virus and influenza
SG11201610443WA (en) Influenza virus vaccines and uses thereof
HK1254344A1 (zh) 抗原匹配的流感疫苗
SG11201701256RA (en) Vaccine compositions against dengue virus diseases
HK1246659A1 (zh) 口蹄疫疫苗
HK1246781A1 (zh) 呼吸道合胞病毒抑制劑
HK1223644A1 (zh) 呼吸道合胞病毒半活疫苗
EP3240568A4 (fr) Vaccins antigrippal recombinés contre le virus de la grippe et le virus respiratoire syncytial
GB201506041D0 (en) Avian vaccine
HK1223643A1 (zh) 呼吸道合胞病毒半活疫苗
LT3383428T (lt) Respiracinio sincitinio viruso vakcina
IL249705B (en) Influenza virus vaccines and their uses
IL249704A0 (en) Influenza virus vaccines and their uses