KR20150127720A - 안드로겐 수용체 하향 조절제 및 그의 용도 - Google Patents

안드로겐 수용체 하향 조절제 및 그의 용도 Download PDF

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KR20150127720A
KR20150127720A KR1020157029073A KR20157029073A KR20150127720A KR 20150127720 A KR20150127720 A KR 20150127720A KR 1020157029073 A KR1020157029073 A KR 1020157029073A KR 20157029073 A KR20157029073 A KR 20157029073A KR 20150127720 A KR20150127720 A KR 20150127720A
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compound
pharmaceutically acceptable
acceptable salt
formula
mmol
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Korean (ko)
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빈센트 씨오 엔제이에이알
랄지 케이 게디야
푸라닉 푸루솟타마차르
아비지트 고드볼레
앤드류 크웨지르-애플
타다스 바새티스
Original Assignee
유니버시티 오브 매릴랜드, 발티모어
유니버시티 오브 매릴랜드 이스턴 쇼
토마스 제퍼슨 유니버시티
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Publication of KR20150127720A publication Critical patent/KR20150127720A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
KR1020157029073A 2013-03-14 2014-03-14 안드로겐 수용체 하향 조절제 및 그의 용도 Withdrawn KR20150127720A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361782383P 2013-03-14 2013-03-14
US61/782,383 2013-03-14
PCT/US2014/029667 WO2014153215A1 (en) 2013-03-14 2014-03-14 Androgen receptor down-regulating agents and uses thereof

Publications (1)

Publication Number Publication Date
KR20150127720A true KR20150127720A (ko) 2015-11-17

Family

ID=51583862

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157029073A Withdrawn KR20150127720A (ko) 2013-03-14 2014-03-14 안드로겐 수용체 하향 조절제 및 그의 용도

Country Status (13)

Country Link
US (2) US9884067B2 (enExample)
EP (2) EP2968370A4 (enExample)
JP (1) JP2016514165A (enExample)
KR (1) KR20150127720A (enExample)
CN (1) CN105682662A (enExample)
AU (1) AU2014236135A1 (enExample)
BR (1) BR112015023098A2 (enExample)
CA (1) CA2904170A1 (enExample)
IL (1) IL240820A0 (enExample)
MX (1) MX2015012274A (enExample)
RU (1) RU2015137617A (enExample)
SG (1) SG11201507093WA (enExample)
WO (1) WO2014153215A1 (enExample)

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US20100048914A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
CN105682662A (zh) * 2013-03-14 2016-06-15 马里兰大学巴尔的摩校区 雄激素受体减量调节剂及其用途
CA3151555A1 (en) 2013-04-04 2014-10-09 University Of Maryland, Baltimore Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
BR112016002970A2 (pt) * 2013-08-12 2017-09-12 Tokai Pharmaceuticals Inc biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio
EP3200801B1 (en) 2014-10-02 2024-04-24 University of Maryland, Baltimore Methods of treating pancreatic cancer
CN105713063A (zh) * 2014-12-02 2016-06-29 重庆安格龙翔医药科技有限公司 一种阿比特龙乙酸酯的制备方法
WO2017066697A1 (en) 2015-10-14 2017-04-20 Dou Qingping Treatments and diagnostics for cancers
WO2017140183A1 (zh) * 2016-02-19 2017-08-24 深圳市塔吉瑞生物医药有限公司 一种取代的甾体类化合物及其应用
CN107365343A (zh) * 2016-05-12 2017-11-21 四川海思科制药有限公司 一种苯并咪唑雄甾衍生物及其制备方法和医药用途
EP3474848A4 (en) * 2016-06-22 2020-04-15 University of Maryland, Baltimore PROCESS FOR PRODUCING NEW GALETERONE ANALOGS AND USES THEREOF
WO2019023651A2 (en) 2017-07-28 2019-01-31 Massachusetts Institute Of Technology MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR
CN107857790A (zh) * 2017-12-14 2018-03-30 中国药科大学 一种新型甾体类雄激素受体抑制剂、制备方法及其医药用途
US12245355B2 (en) 2021-02-19 2025-03-04 Mevion Medical Systems, Inc. Gantry for a particle therapy system
CN116444599A (zh) * 2022-01-07 2023-07-18 中国科学院上海药物研究所 甾体类化合物及制备方法和用途

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