KR20130138240A - 마이크로에멀젼을 포함하는 나노캡슐 - Google Patents
마이크로에멀젼을 포함하는 나노캡슐 Download PDFInfo
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- KR20130138240A KR20130138240A KR1020137009962A KR20137009962A KR20130138240A KR 20130138240 A KR20130138240 A KR 20130138240A KR 1020137009962 A KR1020137009962 A KR 1020137009962A KR 20137009962 A KR20137009962 A KR 20137009962A KR 20130138240 A KR20130138240 A KR 20130138240A
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Abstract
마이크로에멀젼을 포함하는 폴리머 나노캡슐에 기초한 전달 시스템 및 약제학적, 화장품 및/또는 식이성 조성물의 제조에 있어서 이들의 용도.
Description
본 발명은 유중수(w/o)의 마이크로에멀젼을 포함하고 수성 상에 용해된 적어도 하나의 친수성 활성 성분을 포함하는 폴리머 나노캡슐에 기초한 약제학적, 화장품 및/또는 식이성 활성 성분을 위한 신규의 전달 시스템에 관한 것이다.
고형 지질 나노입자(SLN; solid lipid nanoparticle)는 에멀젼, 리포좀, 미셀, 마이크로입자 및/또는 폴리머 나노입자와 같은 활성 성분의 전달을 위한 다른 미립자 시스템의 대안이 된다. SLN은 에멀젼 중의 액체 지질을 고형 지질로 교체하는 것에 의해 생성되는데, 이는 SLN이 체온뿐 아니라 실온에서도 고형인 것을 의미한다.
전달 시스템으로서 SLN의 이용은 생리적으로 허용 가능한 지질의 사용, 제제에서 유기 용매 사용의 방지 가능성, 그리고 피부, 경구 또는 정맥내를 포함하는 광범위한 투여 경로를 허용한다. 양호한 생체이용률뿐 아니라, 이들의 주된 장점은 다음과 같다:
1. 화학적 분해로부터 활성 성분의 보호. SLN의 지질 매트릭스는 토코페롤,레티놀 및 코엔자임 Q10과 같이 가수분해 및/또는 산화로부터 불안정한 활성 성분을 보호할 수 있다[Gohla, S. et al . J. Microencapsul . 18: 149-158 (2001); Schafer-Korting, M. et al . Adv . Drug Del . Rev. 59: 427-443 (2007)].
2. 지질 입자의 조성물에 기초하여, 활성 성분 방출의 조절과, 이에 따른 지속적 방출 프로파일 달성의 가능성을 제공한다 [Mehnert, W. et al . Eur . J. Pharm. Biopharm . 45: 149-155 (1998)].
3. 폐색 효과로 인한 피부의 탈수 조절[Muller, R.H. et al . J. Cosm . Sci . 52: 313-323 (2001)].
4. 이의 성분에 따라, 자외선 방사 필터로서 작용할 수 있다 [Muller, R.H. et al. Int. J. Cosm. Sci. 23: 233-243 (2001)].
새로운 세대의 고형 지질 나노입자는 나노 구조의 지질 담체(NLC; nanostructured lipid carriers)이다. 이들 시스템은 SLN과 같은 장점을 갖고, 또한 낮은 적재 용량 및 저장중 활성 성분 축출과 같은, SLN과 관련된 몇 가지 가능한 문제점을 최소화 또는 방지한다. SLN에서의 지질 상의 적어도 부분적인 결정 상태와 대조적으로, NLC는 덜 조직적인 고형 지질 매트릭스를 보여준다. NLC의 경우, 매트릭스 내에 고형 및 액체 화합물 양자가 존재하여, 더 큰 해체로 더 많은 수의 구멍의 존재에 수반되는 활성 성분의 캡슐화 능력의 증가를 유도한다. NLC의 제조를 위해서는, 입체 구조가 매우 다른 지질 분자가 함께, 액체 지질 또는 오일을 갖는 고형 지질의 혼합물과 혼합된다 [Muller, R. H. et al . Adv . Drug Deliv . Rev . 54 (Suppl. 1): S131-S155 (2002)].
SLN 및 NLC는 크기가 50 내지 1000 ㎚이고 계면활성제 또는 친수성 폴리머에 의해 수성 현탁액 내에서 안정화된 상태로 유지된다. NLC 및 SLN은 피부를 통한 활성 성분의 방출에 매우 적합한 비히클이다. 활성 성분의 더욱 양호한 표피 침투는, 이들이 용액 또는 에멀젼의 형태로 피부에 적용될 때 보다 SLN 또는 NLC로 도입될 때 달성된다.
SLN은 보다 통상적으로 사용하는 경우인 지질 친화성 약물을 용해시킬 수 있는 고형 지질 핵을 갖는다. 그러나, 지질 입자 내 펩티드 도입 가능성은 위장관 기구 내에서 단백질 효소 분해로부터 활성 성분의 보호를 이룰 수 있다. 그러나, 지질 매트릭스의 소수성으로 인해 펩티드 및 단백질의 제형을 위한 매트릭스 재료로서 지질의 사용에 대한 참고문헌은 얼마 없으며, 이는 친수성 단백질 보다 지질 친화성 활성 성분의 도입을 보다 적절하게 만든다. SLN 내에 인슐린과 같은 친수성 활성 성분을 도입하기 위한 에멀젼의 사용은 개시되어 있다 [Gallarate, M. et al . J. Microencapsul . 26: 394-402 (2009)]. Gallarate 등의 문헌에서, SLN의 제조 방법은 유기 용매의 사용을 시사하는데, 이들 잔사의 저류 가능성으로 인해 문제가 되는 요소이다. Gasco 등은 두 가지 다른 방법에 의해 고형 지질 나노입자 내에 티모펜틴 펜타펩티드를 도입한다: 헥사데실포스페이트와의 지질 친화성 이온-쌍의 형성, 또는 내부의 수성 상에 펩티드를 용해시키는 w/o/w 다중 에멀젼의 형성에 의한 것 [Gasco, M.R. et al . Int . J. Pharm . 132: 259-261 (1996)]; 후자의 방법은 또한 SLN 내에 LHRH로부터 유래된 폴리펩티드를 도입하기 위해 동일한 저자에 의해 사용된다 [Gasco, M.R. et al . Int . J. Pharm . 105: R1-R3 (1994)]. Zhou 등은 유화제로서 PLGA(락트산과 글리콜산의 코폴리머)를 사용하여 다른 단백질을 SLN으로 도입시키는 데 있어서 하중 용량 및 캡슐화 효율을 증가시킨 것을 개시한다 [Zhou, W. et al . Colloids and Surfaces , B: Biointerfaces , 67: 199-204 (2008)].
SLN 또는 NLC 내의 친수성 화합물의 캡슐화는, 시스템 내에서 활성 성분이 보다 가용성인 매질로, 즉, 지질 나노입자가 현탁액 중에 있는 수성 시스템으로 확산되는 것과 같은 다른 문제를 제시한다.
비록 SLN 및 NLC가 도입된 활성 성분의 화학적 안정성을 증진시킬 수 있다하더라도, 이러한 안정화는 완전하지 않다. 놀랍게도, 본 발명자들은 SLN 또는 NLC가 폴리머 코팅되었을 때 SLN 또는 NLC로 도입되는 화장품 및/또는 약제학적 활성 성분의 분해에 대한 안정성이 더욱 크다는 것을 발견하였다 [스페인 특허 출원 ES P2010-30431].
SLN 및 NLC의 제조 공정은 스페인 특허 출원 ES P2010-30431에서 발명자에 의해 기술된 전달 시스템과 마찬가지로, 캡슐화될 활성 성분이 매트릭스 내 지질의 융점 온도로 노출되는 것을 시사하는데, 이는 50 ℃ 위로 매우 높을 수 있으며, 대부분의 경우 혼합물을 약 80-90 ℃로 가열하는 것이 보통이다. 많은 생물학적 화합물 및 합성 펩티드와 같은 합성 유래의 화합물처럼 열에 불안정한 활성 성분의 경우, 이는 고형 지질에 기초하는 전달 시스템의 사용을 저해한다. 친수성 화합물은 안정한 마이크로에멀젼의 형태로 지질 전달 시스템에 도입될 수 있으며, 이는 활성 성분을 안정화할 뿐 아니라 이의 생체이용률을 촉진시킨다.
마이크로에멀젼은 광학적 등방체이고 열역학적으로 안정한 용액인 물, 오일 및 양친매성 물질의 시스템으로 정의된다. 마이크로에멀젼은 자발적으로 형성된다. 그러나, 보통의 에멀젼은 그 형성에 에너지를 필요로 하고 열역학적으로 불안정하다 [Eastoe, J. Microemulsions , in " Colloid Science : principles , methods and applications", Chapter 5. Ed. T. Cosgrove, John Wiley & Sons, Ltd (2005)].
본 발명은 선행기술에 기재된 시스템에 의해 제시된 문제를 해결하는, 친수성 활성 성분의 마이크로에멀젼을 포함하는 폴리머 나노캡슐에 기초한 전달 시스템을 제안한다. 나노캡슐 내에서 고형 지질의 액체 지질에 의한 교체는 열에 불안정한 활성 성분이 SLN 및 NLC의 제조에 사용되는 많은 지질의 높은 융점에 노출되는 것을 방지한다.
본 발명의 전달 시스템은 열에 불안정한 친수성 활성 성분의 제조 공정 중 분해를 방지하는 것을 허용한다. 또한, 본 발명의 전달 시스템은 도입되는 활성 성분의 보다 큰 안정화를 가능하게 하고, 나노캡슐의 수성 현탁액에서 친수성 활성 성분의 확산을 방지하고, 높은 표피 침투 능력을 갖는다.
본 발명은 위에 언급된 문제에 대한 해법을 제공한다. 제 1 태양에서, 본 발명은 액체 지질 또는 오일 중 물의 마이크로에멀젼(w/o)을 포함하고 내부 수성 상에 용해된 적어도 하나의 친수성 활성 성분을 포함하는 폴리머 코팅된 나노캡슐의 신규 전달 시스템과 관련된다.
본 발명의 나노캡슐은 액체 지질 또는 오일의 매트릭스 및 폴리머 코팅을포함한다. 적어도 하나의 친수성 활성 성분의 w/o 마이크로에멀젼은 지질 매트릭스로 도입된다. 나노캡슐의 코팅은 이의 외부를 구성하고 내부 매트릭스의 완전하고 연속적인 코팅을 제공한다. 액체 지질과 오일이라는 용어는 본 발명에서 구분 없이 사용된다.
본 발명의 나노캡슐은 그 내부로 도입된 친수성 활성 성분을 포함한다. 본 발명의 나노캡슐로 도입되는 친수성 활성 성분은, 무엇보다도 화장품, 약제학적 및/또는 식이성 활성 성분 및/또는 보조제일 수 있으며 이들만으로 제한되지 않는다.
본 발명의 나노캡슐의 폴리머 코팅은 나노캡슐의 외부 장벽을 구성하며; 이들 성분의 캡슐화를 가능하게 하고 활성 성분을 위한 보호를 제공한다. 이는 조성물의 다른 가능한 성분과의 상호작용에 의한, 가수분해에 의한, 그리고/또는 산소 및/또는 광의 존재에 기인하는 산화에 의한 화학적 분해에 대하여 이들의 안정성을 증가시킨다. 또한, 펩티드와 같은 친수성 활성 성분의 경우, SLN 또는 NLC의 수성 분산액에서 종종 일어나는 바와 같은, 외부 수성 상으로의 확산에 의한 활성 성분의 손실을 방지한다. 마이크로에멀젼, 리포좀, SLN 및 NLC와 관련하여, 본 발명의 나노캡슐로 도입된 활성 성분의 보다 큰 경피 침투 역시 달성된다.
본 발명의 나노캡슐의 제조방법은 2 단계를 포함한다: a) 액체 지질 또는 오일 중 친수성 활성 성분의 수성 용액의 w/o 마이크로에멀젼의 제조, 및 b) 폴리머 코팅에 의한 마이크로에멀젼의 캡슐화.
친수성 활성 성분의 마이크로캡슐의 제조를 위해서는, 액체 지질 또는 오일, 활성 성분, 계면활성제, 보조계면활성제 및/또는 다른 부형제의 혼합물이 교반에 의해 물과 함께 마이크로에멀젼화된다. 이어서, 마이크로에멀젼은 폴리머 코팅된다.
고압에서의 균질화와 같은 균질화 방법은 보다 작은 입자가 얻어지는 것과, 보다 적은 양의 계면활성제의 사용을 가능하게 만든다.
특정 실시 형태에서, 내부 마이크로에멀젼의 액적 크기는 0.1 내지 80 ㎚, 바람직하게는 1 내지 50 ㎚, 보다 바람직하게는 10 내지 20 ㎚ 범위이다.
다른 특정 실시 형태에 의하면, 본 발명의 나노캡슐의 제조에 있어서, 폴리머 코팅은 선행기술에서의 통상적인 과정에 따라 만들어질 수 있다: 물리적-화학적 공정(단순 코아세르베이션, 복합 코아세르베이션, 가교 중 pH 변화를 수반하는 단순 또는 복합 코아세르베이션, 용매의 증발) 및 화학적 공정(계면 축중합). 바람직하게는, 본 발명의 나노캡슐의 제조에 사용되는 공정은 코아세르베이션이다.
캡슐화가 코아세르베이션에 의해 수행될 때, 수성 상에 용해된 친수성 활성 성분을 포함하는 마이크로에멀젼은 적어도 하나의 코팅 폴리머를 포함하고 임의로 다른 활성 성분, 유화제, 폴리머 및/또는 다른 부형제를 포함할 수 있는 분산액 또는 외부 수성 용액 중에 분산된다. 이 공정은 코아세르베이션제의 용액(단순 코아세르베이션) 또는 다른 폴리머의 용액(복합 코아세르베이션)을 앞서의 w/o/w 혼합물로 교반 하에 붓는다면 단 한 단계로 수행될 수 있다.
다른 특정 실시 형태에 의하면, 본 발명의 나노캡슐의 폴리머 코팅의 형성에 있어서 가교제가 사용된다. 가교제는, 이들만으로 제한되지 않는 예를 들어 알데하이드, 글루타르알데하이드, 포름알데하이드, 트랜스글루타미나제, 메틸렌비스아크릴아마이드의 유도체, N,N-메틸렌비스아크릴아마이드, N,N-(1,2-디하이드록시에틸렌)비스아크릴아마이드, 에틸렌 글리콜 디메타크릴레이트의 유도체, 에틸렌 글리콜 디아크릴레이트, 디에틸렌 글리콜 디아크릴레이트, 테트라에틸렌 글리콜 디아크릴레이트, 에틸렌 글리콜 디메타크릴레이트, 디에틸렌 글리콜 디메타크릴레이트, 트리에틸렌 글리콜 디메타크릴레이트, 소디움 트리폴리포스페이트, N-하이드록시숙신아마이드 에스테르 및/또는 이미도에스테르에 의해 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 복합 코아세르베이션은 일단 코아세르베이트가 형성되면 가교 형성 전에 pH를 올리는 것에 의해 수행될 수 있다. 즉, 캡슐이 가교되는 pH는 코아세르베이션의 pH 보다 높으며, 이는 보다 작은 캡슐이 얻어지는 것을 가능하게 만든다 [스페인 특허 출원 ES P2010-30432].
본 발명의 나노캡슐은 여과, 원심분리, 스프레이-건조 및/또는 동결건조와같은 통상적인 기술에 의해 수집될 수 있다.
또 다른 특정 실시 형태에서, 본 발명의 나노캡슐의 크기는 10 내지 5000 ㎚, 바람직하게는 20 내지 2000 ㎚, 더욱 바람직하게는 50 내지 1000 ㎚ 사이에서 변화한다.
본 발명의 나노캡슐로의 활성 성분의 도입 백분율은 정량적이다.
또 다른 특정 실시 형태에서, 본 발명의 나노캡슐의 액체 지질은 4 ℃ 아래의 융점을 갖고 액체 또는 반-액체일 수 있다. 액체 지질은 대두유, 해바라기씨유, 옥수수유, 올리브유, 야자유, 면실유, 평지유, 낙화생유, 코코넛유, 피마자유, 아마인유, 보라지유, 달맞이꽃유와 같은 식물성 오일; 어유 및 해조류 오일과 같은 수산 오일; 광유, 액체 파라핀 및 바세린과 같은 석유로부터 유래된 오일; 단쇄 지방산 알코올; 중쇄 지방족 분지 지방산 알코올; 이소프로필 미리스테이트, 이소프로필 팔미테이트 및 이소프로필 스테아레이트 및 디부틸 아디페이트와 같은 단쇄 알코올과의 지방산 에스테르; 카프릭 및 카프릴릭 트리글리세라이드(INCI; 카프릭/카프릴릭 트리글리세라이드) 및 Miglyol® 시리즈의 다른 오일과 같은 중쇄 트리글리세라이드(MCT); C12-C16 옥타노에이트; 디옥틸 에테르와 같은 지방산 알코올 에테르 및/또는 이들의 혼합물에 의해 구성되는 그룹으로부터 제한 없이 선택된다. 어떤 지질친화성 활성 성분은 실온에서 액체 지질 매트릭스로서 작용할 수도 있으며, 베타-카로틴, 비타민 E 및 레티놀 및/또는 이들의 혼합물을 예로 들 수 있으며 이들만으로 제한되지 않는다.
또 다른 특정 실시 형태에서, 계면활성제는 비이온성 계면활성제, 양쪽성 계면활성제, 음이온성 계면활성제, 양이온성 계면활성제 및/또는 이들의 혼합물에 의해 구성되는 그룹으로부터 선택된다. 비이온성 계면활성제 및/또는 양쪽성 계면활성제는 레시틴, 6 내지 24 탄소원자를 갖는 알킬 그룹의 알킬 글리코사이드, 6 내지 24 탄소원자를 갖는 알킬 그룹의 알킬말토사이드, 6 내지 24 탄소원자를 갖는 알킬 그룹과 5 내지 30 에틸렌 옥사이드 유닛을 갖는 에톡실화된 알킬페놀, 6 내지 24 탄소원자를 갖는 알킬 그룹의 알킬페놀 폴리옥시에틸렌 에테르, 8 내지 24 탄소원자를 갖는 알킬 그룹의 포화 및 불포화된 지방산 알코올, 폴록사머, 폴리소르베이트, 당과의 지방산 에스테르, 소르비탄 에스테르, 폴리에틸렌 글리콜 지방산 에스테르, 피마자유, 지방산 알코올 및 폴리옥시에틸렌 에테르, 지방산 알칸올아마이드, 아민 옥사이드, 6 내지 24 탄소원자를 갖는 알킬 그룹의 알킬 베타인, 아실 아미도 베타인, 6 내지 24 탄소원자를 갖는 알킬 그룹의 알킬설포베타인, 글리신 유도체, 디기토닌, 이눌린 라우릴 카바메이트 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다. 더욱 바람직하게는, 비이온성 계면활성제 및/또는 양쪽성 계면활성제는 옥틸 글루코사이드, 데실 글루코사이드, 라우릴 글루코사이드, 옥틸 프럭토사이드, 도데실 말토사이드, 데실 말토사이드, 노녹시놀-9, 폴리에틸렌 글리콜 p-(1,1,3,3-테트라메틸부틸)페닐 에테르, 팔미틸 알코올, 올레일 알코올, 폴록사머 188, 폴록사머 407, 폴리소르베이트 20, 폴리소르베이트 60, 폴리소르베이트 80, 메틸 글루코스 디올레이트, 소르비탄 모노스테아레이트 또는 스판 60, 소르비탄 모노라우레이트 또는 스판 20, 소르비탄 모노팔미테이트 또는 스판 20, 소르비탄 올리베이트, 폴리에틸렌 글리콜 40 스테아레이트, 폴리에틸렌 글리콜 50 스테아레이트, 폴리에틸렌 글리콜 100 스테아레이트, 폴리옥시에틸렌 스테아릴 에테르, 폴리옥시에틸렌 라우릴 에테르, 코카마이드 모노에탄올아민, 코카마이드 디에탄올아민, 코카마이드 트리에탄올아민, 라우라마이드 디에탄올아민, 라우라마이드 모노에탄올아민, 코카마이도프로필아민 옥사이드, 데실 베타인, 도데실 베타인, 테트라데실 베타인, 코코일 베타인, 코카마이도프로필 베타인, 코카마이도프로필 하이드록시설타인, N-2-코코일 아마이도에틸 하이드록시에틸글리시네이트 및 N-2-코코일 아마이도에틸 하이드록시에틸 카복시글리시네이트 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다. 음이온성 계면활성제는 알킬벤젠 설포네이트, 알킬나프탈렌 설포네이트, 에톡실화된 지방산 알코올 설포네이트, 지방족 설포네이트, 하이드록시 알칸 설포네이트, 알킬 글리세릴 설포네이트 에테르, 퍼플루오로옥탄 설포네이트와 같은 설포네이트; 알킬 설포숙시네이트, 알킬 설포아세테이트; 소디움 및 암모늄 라우릴 셀페이트, 에톡실화된 알킬 셀페이트와 같은 알킬 설페이트; 지방산 에스테르 설페이트; 에톡실화된 지방산 알코올 설페이트; 알킬 에테르 설페이트; 아실 이소시아네이트; 펜타플루오로옥타노에이트; 카복실레이트; 에톡실화된 알킬페놀; 에탄올 암모늄 염; 디에탄올암모늄, 메틸암모늄, 디메틸암모늄, 트리메틸암모늄; 알킬 타우레이트, 아실 또는 지방산; 알킬 도는 아실 사르코시네이트; 포스페이트 에스테르, 알킬 포스페이트, 폴리옥시에틸렌 라우릴 에테르 포스페이트와 같은 포스페이트; 글루타메이트; 스테아레이트; 글리코콜산 및 소디움 글리코콜레이트, 타우로콜산 및 소디움 타우로콜레이트, 타우로데속시콜레이트와 같은 담즙산 및 이들의 염 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다. 양이온성 계면활성제는 세틸 트리메틸 암모늄 브로마이드, 라우릴 트리메틸 암모늄 클로라이드, 벤질 디메틸 헥사데실 암모늄 클로라이드, 디스테아릴 디메틸 암모늄 클로라이드, 디라우릴 디메틸 암모늄 클로라이드, 디미리스틸 디메틸 암모늄 클로라이드, 세틸피리디늄 클로라이드, 벤잘코늄 클로라이드, 벤제토늄 클로라이드, 메틸 벤제토늄 클로라이드과 같은 4급 암모늄염 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다.
또 다른 특정 실시 형태에서, 보조계면활성제는 프로판올, 이소프로판올, 부탄올 및 헥산올과 같은 저분자량 알코올 및 글리콜; 옥타노산 및 부티르산과 같은 장쇄 지방산; 포스포릭산 모노에스테르; 벤질 알코올; 소디움 콜레이트, 소디움 글리콜레이트, 소디움 타우로콜레이트, 소디움 타우로데속시콜레이트와 같은 담즙산염 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다.
또 다른 특정 실시 형태에서, 응집방지제는 소디움 시트레이트, 소디움 피로포스페이트, 소디움 소르베이트, 양쪽성 계면활성제, 양이온성 계면활성제 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다.
또 다른 특정 실시 형태에서, 증점제는 메틸 셀룰로스, 하이드록시에틸 셀룰로스, 하이드록시프로필 셀룰로스 및 소디움 카복시메틸 세룰로스와 같은 셀룰로스 에테르 및 에스테르; 폴리비닐 알코올, 폴리비닐피롤리돈 및 폴리비닐 아세테이트와 같은 폴리비닐 유도체; 알기네이트; 폴리아크릴레이트; 잔탄; 펙틴 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다.
또 다른 특정 실시 형태에서, 본 발명의 나노캡슐의 폴리머 코팅의 폴리머는 단백질, 다당류, 폴리에스테르, 폴리아크릴레이트, 폴리시아노아크릴레이트, 코폴리머 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다. 바람직하게는, 나노캡슐의 코팅의 폴리머는 젤라틴, 알부민, 대두 단백질, 완두콩 단백질, 잠두 단백질, 감자 단백질, 밀 단백질, 유청 단백질, β-락토글로불린, 카제이네이트, 밀 전분, 옥수수 전분, 제인, 알기네이트, 카라기난, 펙틴, 아라비노갈락탄, 아라비아검, 잔탄검, 메스키트검, 트라가칸타검, 갈락토만난, 구아검, 캐럽시드검, 키토산, 한천, 폴리(L-리진), 덱스트란 설페이트 소디움, 카복시메틸 갈락토만난, 카복시메틸 셀룰로스, 메틸 셀룰로스, 에틸 셀룰로스, 하이드록시프로필메틸 셀룰로스(HPMC), 셀룰로스 니트레이트, 셀룰로스 아세테이트 부티레이트, 셀룰로스 아세테이트 프탈레이트, 셀룰로스 하이드록시프로필 메틸 프탈레이트, 셀룰로스 하이드록시프로필 메틸 아세테이트 숙시네이트, 폴리비닐 아세테이트 프탈레이트, 폴리(ε-카프로락톤), 폴리(p-디옥사논), 폴리(δ-발레로락톤), 폴리(β-하이드록시부티레이트), 폴리(β-하이드록시부티레이트) 및 β-하이드록시발레레이트 코폴리머, 폴리(β-하이드록시프로피오네이트), 메틸아크릴산 코폴리머(Eudragit® L 및 S), 디메틸아미노에틸 메타크릴레이트 코폴리머(Eudragit® E), 트리메틸암모늄 에틸 메타크릴레이트 코폴리머(Eudragit® RL 및 RS), 락트산 및 글리콜산 폴리머 및 코폴리머, 락트산 및 글리콜산 폴리머 및 코폴리머 및 폴리에틸렌 글리콜 및 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
본 발명의 나노캡슐의 폴리머 코팅에 사용되는 폴리머의 특성에 따라, 그 특이성을 증가시키는 것이 가능하다. 양의 전하를 갖는 폴리머 코팅을 제공하는 폴리머는 본 발명의 나노캡슐과 머리카락 또는 섬유 재료 사이의 결합을 더 강하게 한다. 임의로, 본 발명의 나노캡슐의 코팅의 폴리머는 양이온 폴리머일 수 있다. 양이온 폴리머는 천연 또는 합성 폴리머일 수 있으며, Amerchol에 의해 Polymer JR 400™이라는 이름으로 입수할 수 있는 4급화된 하이드록시에틸 셀룰로스와 같은 셀룰로스의 양이온 유도체; 양이온 전분; 디알릴 암모늄 및 아크릴아마이드염 코폴리머; Luviquat™(BASF)과 같은 4급화된 비닐피롤리돈/비닐이미다졸 폴리머; 폴리글리콜과 아민의 축합 산물; 폴리쿼터늄 폴리머 및 코폴리머; 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-16, 폴리쿼터늄-10 Merquats로 불리우는 폴리머; 폴리쿼터늄-4 코폴리머; 디코코일에틸하이드록시에틸암모늄, 셀룰로스 골격 및 4급 암모늄 그룹과의 그래프트 코폴리머; 라우르디모늄 하이드록시프로필 가수분해된 콜라겐(Grunau의 Lamequat™)과 같은 4급화된 콜라겐 폴리펩티드; 4급화된 밀 폴리펩티드; 폴리에틸렌이민; 아마이도메티콘 또는 쿼터늄-22 실리콘과 같은 양이온 실리콘 폴리머; 아디프산 및 디메틸아미노 하이드록시프로필 디에틸렌트리아민 코폴리머(Sandoz의 Cartaretin™); 디메틸디알릴암모늄 클로라이드와의 아크릴산 코폴리머(Chemviron의 Merquat™ 550); 키토산 및 이의 유도체와 같은 양이온 키틴 유도체; 비스디알킬아민과 디브로모부탄과 같은 양이온 디할로겐 알킬렌의 축합 산물; 비스-디메틸아미노-1,3-프로판; 구아-하이드록시프로필트리모늄, Jaguar™ CBS, Jaguar™ C-17, Jaguar™ C-16(Celanese에서 시판)과 같은 양이온 구아검의 유도체; Miranol의 Mirapol™ A-15, Mirapol™ AD-1, Mirapol™ AZ-1과 같은 4급 암모늄염 폴리머; 아자로스와 같은 천연 유도체의 4급화된 다당류 폴리머; 젤라틴, 아라비아검으로부터 선택되는 양이온 단백질; 폴리아마이드, 폴리시아노아크릴레이트, 폴리락타이드, 폴리글리콜라이드, 폴리아닐린, 폴리피롤, 폴리비닐피롤리돈, 아미노 실리콘 폴리머 및 코폴리머, 폴리스티렌, 폴리비닐 알코올, 폴리스티렌 및 말레인산 무수물 코폴리머, 메틸 비닐 에테르, 에폭시 수지 및 스티렌 및 메틸 메타크릴레이트 코폴리머로 구성되는 그룹으로부터의 양이온 폴리머; 디메틸아미노 메타크릴레이트, 양이온 폴리아크릴레이트 및 Rohm의 Eudragit™ RL 30 D와 같은 폴리메타크릴레이트; 폴리에틸렌 글리콜 유도체로 임의로 치환된 폴리아민 유도체; 양이온인 pH 조건 하에서의 폴리아미노산; 폴리에틸렌이민; 친수성 우레탄 폴리머 및 폴리비닐피롤리돈(PVP)의 4급화된 유도체, 그리고 이들 양이온 그룹의 임의의 혼합물을 예로 들 수 있으며, 이들만으로 제한되지 않는다.
임의로, 본 발명의 나노캡슐의 코팅 폴리머는 가소성 첨가제를 포함할 수 있다. 가소성 첨가제는 트리에틸 시트레이트, 트리부틸 시트레이트, 아세틸 트리부틸 시트레이트 및 아세틸 트리에틸 시트레이트와 같은 시트르산 알킬 에스테르, 부틸 프탈레이트 및 디에틸 프탈레이트와 같은 프탈레이트, 글리세린, 소르비톨, 말티톨, 프로필렌 글리콜, 폴리에틸렌 글리콜, 글루코스, 사카로스, 라놀린, 팔미트산, 올레인산, 스테아린산, 스테아린산 또는 팔미트산과 같은 지방산 금속염, 스테아린산 나트륨, 스테아린산 칼륨, 프로필렌 글리콜 모노스테아레이트, 모노아세틸 글리세린 및 글리세릴 트리아세테이트 또는 트리아세틴과 같은 아세틸화된 모노글리세라이드, 글리세릴 레시틴, 글리세릴 모노스테아레이트, 디부틸 세바세이트 또는 디에틸 세바세이트와 같은 알킬 세바세이트, 알킬 푸마레이트, 알킬 숙시네이트, 중쇄 트리글리세라이드(MCT), 피마자유, 경화된 식물유, 왁스 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다.
임의로, 예를 들어 탈크, 콜로이드성 이산화규소, 글리세린, 폴리에틸렌 글리콜, 글리세린 모노스테아레이트 및/또는 스테아레이트 금속염과 같은 유동화제와 같이, 캡슐화 공정을 개선 또는 용이하게 하는 폴리머의 다른 기술적 첨가제가 첨가될 수 있다.
본 발명에서, 친수성이라는 용어는 20 ℃에서 물 100 ㎖ 당 1 g 보다 큰 용해도로 물에 가용성인 물질을 의미한다. 본 발명에서, 친수성과 수용성이라는 용어는 구분 없이 사용된다.
친수성 화장품, 약제학적 및/또는 식이성 활성 성분 및/또는 보조제의 본질은 합성 또는 천연일 수 있거나, 생물기술적 과정으로부터, 또는 합성 과정과 생물기술적 과정의 조합으로부터 나올 수 있다. 바람직하게는, 본 발명의 나노캡슐의 친수성 활성 성분은 열에 불안정하다. 본 발명에서, 열에 불안정한 성분은 80 ℃의 온도에서 2 시간 동안 처리된 후 0.5%와 동등하거나 이보다 큰 분해를 나타내는 것으로 이해된다.
특정 실시 형태에서, 친수성 화장품, 약제학적 및/또는 식이성 활성 성분은 아미노산, 펩티드, 단백질, 가수분해된 단백질, 효소, 호르몬, 비타민, 미네랄 염, 당, 뉴클레오티드, 핵산, 생물학적 및 생물기술적 기원의 추출물 및 분자, 백신, 합성 또는 부분 합성 친수성 분자 및/또는 이들의 혼합물로 구성되는 그룹으로부터 제한 없이 선택된다.
특정 실시 형태에서, 아미노산, 이들의 염 및/또는 유도체뿐 아니라 이들을 포함하는 상업용 혼합물은, 이들만으로 제한되지 않는 예를 들어 세린, 프롤린, 알라닌, 글루타메이트, 알기닌, 글리신, 메티오닌, 시트룰린, 소디움 메틸글리신 디아세테이트(BASF에서 시판하는 TRILON® M), 시스테인을 포함하는 아미노산 유도체, 특히 N-아세틸 시스테인, 에르고티오네인 또는 S-카복시메틸시스테인, 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 펩티드 또는 이들을 포함하는 상업용 혼합물은, 이들만으로 제한되지 않는 예를 들면 무엇보다도, GHK [INCI: 트리펩티드-1], 아세틸-글루타밀-메티오닐-알라닐-이소류신, 아세틸-알기닐-페닐글리실-페닐글리신, Bodyfensine™ [INCI: 아세틸 디펩티드-3 아미노헥사노에이트], Relistase™ [INCI: 아세틸알기닐트립토필 디페닐글리신], 아세틸-알기닐-페닐글리실-발릴-글리신, 아세틸-알기닐-페닐글리실-발릴-페닐글리신, 디아미노프로피오닐-알라닐-아스파라기닐-히스티딘, 아세틸-알기닐-아스파라기닐-히스티딜-시트룰린-아마이드, Aldenine® [INCI: 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-1], Decorinyl® [INCI: 트리펩티드-10 시트룰린], Serilesine® [INCI: 헥사펩티드-10], 펩티드 AC29 [INCI: 아세틸 트리펩티드-30 시트룰린], Vilastene™ [INCI: 리진 HCI, 레시틴, 트리펩티드-10 시트룰린], dGlyage™ [INCI: 리진 HCI, 레시틴, 트리펩티드-9 시트룰린], Eyeseryl® [INCI: 아세틸 테트라펩티드-5], Preventhelia® [INCI: 디아미노프로피오닐 트리펩티드-33], Argireline® [INCI: 아세틸 헥사펩티드-8], SNAP-7 [INCI: 아세틸 헵타펩티드-4], SNAP-8 [INCI: 아세틸 옥타펩티드-3], Leuphasyl® [INCI: 펜타펩티드-18], Trylagen® [INCI: 슈도알테로모나스 발효 추출물, 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-10 시트룰린, 트리펩티드-1], Inylin™ [INCI: 아세틸 헥사펩티드-30], Melatime™ [INCI: 아세틸 트리펩티드-40], Thermostressine™ [INCI: 아세틸 테트라펩티드-22] 또는 Liporeductyl® [INCI: 카페인, 부처브룸(Ruscus Aculeatus) 뿌리 추출물, TEA-하이드로요오다이드, 카르니틴, 아이비(Hedera Helix) 추출물, 에스신, 트리펩티드-1](Lipotec에서 시판), Matrixyl® [INCI: 팔미토일 펜타펩티드-4], Matrixyl® 3000 [INCI: 팔미토일 테트라펩티드-7, 팔미토일 올리고펩티드], Dermaxyl® [INCI: 팔미토일 올리고펩티드], Calmosensine™ [INCI: 아세틸 디펩티드-1], Biopeptide CL™ [INCI: 글리세릴 폴리메타크릴레이트, 프로필렌글리콜, 팔미토일 올리고펩티드] 또는 Biopeptide EL™ [INCI: 팔미토일 올리고펩티드](Sederma에서 시판), 슈도디펩티드, IP 2000 [INCI: 덱스트란, 트리플루오로아세틸 트리펩티드-2](IEB 및 Atrium에서 시판), Pepha®-Timp [INCI: 인간 올리고펩티드-20], ECM-Protect® [INCI: 물(Aqua), 덱스트란, 트리펩티드-2] 또는 Melanostatine®-5 [INCI: 덱스트란, 노나펩티드-1](Atrium Innovations에서 시판), Timp-Peptide [INCI 제안: 아세틸 헥사펩티드], Bronzing S.F. [INCI 제안: 부티릴 펜타펩티드], BONT-L-Peptide [INCI: 팔미토일 헥사펩티드-19] 또는 ECM Moduline [INCI 제안: 팔미토일트리펩티드](Infinitec Activos에서 시판), IP2000 [INCI: 덱스트란, 트리플루오로아세틸 트리펩티드-2](Institut Europeen de Biologie Cellulaire에서 시판), Syn®-Coll [INCI: 팔미토일 트리펩티드-5](Pentapharm에서 시판), Neutrazen™ [INCI :물, 부틸렌 글리콜, 덱스트란, 팔미토일 트리펩티드-8], ChroNOIine™ [INCI: 카프로일 테트라펩티드-3] 또는 Thymulen-4 [INCI: 아세틸 테트라펩티드-2](Atrium Innovations/Unipex Group에서 시판), Meliprene® [INCI: 덱스트란, 아세틸 헵타펩티드-1] 또는 Melitane® [INCI: 아세틸 헥사펩티드-1](Institut Europeen de Biologie Cellulaire/Unipex Group에서 시판), Skinasensyl™ [INCI: 아세틸 테트라펩티드-15](Laboratoires Serobiologiques/Cognis에서 시판), Vialox® [INCI: 펜타펩티드-3], Syn®-Ake® [INCI: 디펩티드 디아미노부티로일 벤질아마이드 디아세테이트], Syn®-Coll [INCI: 팔미토일 트리펩티드-5], Syniorage™ [INCI: 아세틸 테트라펩티드-11], Dermican™ [INCI: 아세틸 테트라펩티드-9](Laboratoires Serobiologiques/Cognis에서 시판), Kollaren® [INCI: 트리펩티드-1, 덱스트란](Institut Europeen de Biologie Cellulaire에서 시판), Collaxyl® IS [INCI: 헥사펩티드-9], Laminixyl IS™ [INCI: 헵타펩티드], Quintescine™ IS [INCI: 디펩티드-4], UCPeptide™ V [INCI: 펜타펩티드] 또는 AT Peptide™ IS [INCI: 트리펩티드-3](Vincience/ISP에서 시판), 글루타치온, 카르노신 및/또는 이들의 혼합물과 같은 화장품 용의 펩티드; 및 글루카곤, 류프롤라이드, 고세렐린, 트립토렐린, 부세렐린, 나파렐린, 데슬로렐린, 히스트렐린, 아보렐린, 아바렐릭스, 세트로렐릭스, 가니렐릭스, 데가렐릭스, 데스모프레신, 소마토스타틴 및 옥트레오타이드, 바프레오타이드 및 란레오타이드와 같은 소마토스타틴의 유사체와 같은 약제학적 용도의 펩티드로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 단백질, 가수분해된 단백질, 효소 및 호르몬뿐 아니라 이들을 포함하는 상업용 혼합물은, 이들만으로 제한되지 않는 예를 들어, Elhibin® [INCI: 글리신 소야(대두) 단백질], Preregen® [INCI: 글리신 소야(대두) 단백질, 산화 환원 효소] 또는 Regu®-Age [INCI: 가수분해된 쌀겨 단백질, 글리신 소야(대두) 단백질, 산화 환원 효소](Pentapharm/DSM에서 시판), 카데린, 인테그린, 셀렉틴, 히알루론산 수용체, 면역글로불린, 섬유아세포 성장 인자, 결합 조직 성장 인자, 혈소판-유도된 성장 인자, 혈관 내피 성장 인자, 표피 성장 인자, 인슐린-유사 성장 인자, 케라틴세포 성장 인자, 집락-자극 성장 인자, 형질전환 성장 인자-베타, 종양 괴사 인자-알파, 인터페론, 인터류킨, 기질 금속단백질분해효소, 수용체 단백질 타이로신 포스파타제, 가수분해된 밀 단백질, 가수분해된 대두 단백질 또는 가수분해된 유청 단백질과 같은 가수분해된 식물성 단백질, Lipotec의 Lipeptide [INCI: 가수분해된 식물성 단백질], Collalift® [INCI: 가수분해된 맥아 추출물](Coletica/Engelhard에서 시판), Colhibin [INCI: 가수분해된 쌀 단백질](Pentapharm에서 시판), Cytokinol® LS [INCI: 가수분해된 카제인, 가수분해된 효모 단백질, 리진 HCL](Laboratoires Serobiologiques/Cognis에서 시판), Liftline® [INCI: 가수분해된 밀 단백질] 또는 Ridulisse C® [가수분해된 대두 단백질](Silab에서 시판), 카탈라제, 수퍼옥사이드 디스뮤타제, 락토퍼옥시다제, 글루타치온 퍼옥시다제, 락토단백질, 카제인, 락토퍼옥시다제, 라이소자임, 글리코시다제, 피부 각질 카이모트립신 효소 또는 SCCE, 트립신, 카이모트립신, 수틸라인, 파파인 또는 브로멜라인과 같은 단백질분해효소, 포톨리아제 또는 T4 엔도뉴클레아제 V와 같은 DNA 수복 효소, 리파제, 황체형성 호르몬(LH), 난포-자극 호르몬(FSH), 성장 호르몬, 인슐린 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서 비타민은, 이들만으로 제한되지 않는 예를 들어, 비타민 C, 비타민 B1, 비타민 B2, 비타민 B3, 비타민 B5, 비타민 B6, 비타민 B7, 비타민 B9, 비타민 B12, 카르니틴과 같은 수용성 비타민 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 생물학적 또는 생물기술적 기원의 화학적으로 변형될 수 있는 추출물뿐 아니라 이들을 포함하는 상업용 혼합물은, 이들만으로 제한되지 않는 예를 들어, 식물 추출물, 수산 추출물, 세포 추출물 및 미생물에 의해 생산되는 추출물로 구성되는 그룹으로부터 선택된다.
식물 추출물은 수용성 식물 추출물, 이들만으로 제한되지 않는 예를 들면무엇보다도, 캐모마일, 아이비, 레몬, 인삼, 산딸기, 로스트 아마란스(Roast amaranth), 지황, 치자, 당근, 오랜지, 복숭아, 파인애플, 용담, 히비스커스 꽃, 호두나무 잎, 호박, 작약, 퀴노아, 볼도, 러프 바인드위드(rough bindweed), 샐비아, 석류, 오레가노, 생강, 마죠람, 크랜베리, 포도, 토마토, 녹차, 홍차, 알로에 베라(Aloe Barbadensis), 사포라 자포니카(Saphora japonica), 파파야, 파인애플, 호박, 고구마, 시호(Bupleurum Chinensis), 세크로피아 오브투시폴리아(Cecropia Obtusifolia), 맨드라미(Celosia Cristata), 병풀(Centella Asiatica), 명아주(Chenopodium Quinoa), 감국(Chrysanthellum Indicum), 광귤(Citrus Aurantium Amara), 커피나무(Coffea Arabica), 콜레우스(Coleus Forskohlii), 코미포라 뮈라(Commiphora Myrrha), 크리쓰뭄 마리티뭄(Crithmum Maritimum), 유게니아 카리오필루스(Eugenia Caryophyllus), 은행나무(Ginkgo Biloba), 아이비(Hedera Helix; ivy), 로젤(Hibiscus Sabdariffa), 일렉스 파라구아리엔시스(Ilex Paraguariensis), 라미나리아 디기타타(Laminaria Digitata), 넬룸비움 스페시오숨(Nelumbium Speciosum), 파울리니아 쿠파나(Paullinia Cupana), 볼도(Peumus Boldus), 필라칸타 피브로사(Phyllacantha Fibrosa), 꿀풀(Prunella Vulgaris), 아몬드(Prunus Amygdalus Dulcis), 루스쿠스(Ruscus Aculeatus)(부처브룸 추출물), 삼부쿠스 니그라(Sambucus Nigra), 스피룰리나(Spirulina Platensis Algae), 운카리아 토멘토사(Uncaria Tomentosa), 마편초(Verbena Officinalis), 선인장(Opuntia ficus indica), 백버들(Salix alba), 루피너스 종(Lupinus spp .), 호밀(Secale cereale), 투실라고 파르파라(Tussilago farfara), 서양톱풀(Achillea millefolium), 아라디락타 인디카(Aradirachta indica), 아스무나 자포니카(Asmuna japonica), 아우토카르푸스 인시수스(Autocarpus incisus), 비덴스 필로사(Bidens pilosa), 브로우소네티아 파피리페라(Broussonetia papyrifera), 클로렐라 불가리스(Chlorella vulgaris), 승마(Cimicifuga racemosa), 엠블리카 오피시날리스(Emblica officinalis), 감초(Glycyrrhiza glabra), 감초(Glycyrrhiza uralensis), 일렉스 푸르푸레아(Ilex purpurea), 리구스티쿰 루시둠(Ligusticum lucidum), 리구스티쿰 발리치이(Ligusticum wallichii), 미트라카르푸스 스카버(Mitracarpus scaber), 모린다 시트리폴리아(Morinda citrifolia), 뽕나무(Morus alba), 산뽕나무(Morus bombycis), 나린지 크레눌라타(Naringi crenulata), 자두(Prunus domesticus), 개별꽃(Pseudostellariae radix), 소리쟁이(Rumex crispus), 루멕스 오씨덴탈리스(Rumex occidentalis), 무환자나무(Sapindus mukurossi), 삭시프라기아 사르멘토사(Saxifragia sarmentosa), 스쿠텔라리아 갈레리쿨라테(Scutellaria Galericulate), 돌나물(Sedum sarmentosum Bunge), 스텔라리아 메디카(Stellaria medica), 밀(Triticum Vulgare), 우바 우르시(Uva ursi), 휘타니아 솜니페라(Whitania somnifera), 아리스톨로퀴아 클레마티스(Aristoloquia clematis), 로사 모스카타(Rosa moschata), 자주루드베키아(Echinacea angustifolia), 컴프리(Symphytum officinale), 쇠뜨기(Equisetum arvense), 망종화(Hypericum perforatum), 미모사 테뉘플로라(Mimosa tenuiflora), 아보카도(Persea gratissima), 피지움(Prunus africanum), 토르멘틸라 에렉테아(Tormentilla erectea), 감자(Solanum tuberosum), 로즈마리(Rosmarinus officinalis), 바씨니움 앙구스티폴리움(Vaccinium angustifolium), 마크로키스티스 피리페라 알가(Macrocystis pyrifera algae), 파디나 파보니카(Padina pavonica), 말피기아 푸니시톨리아(Malpighia punicitolia), 아티초크(Cynara scolymus), 면화(Gossypium herbaceum), 기장(Panicum miliaceum), 모루스 니그라(Morus nigra), 참깨(Sesamum indicum), 글리신 소야(Glycine soja), 밀(Triticum vulgare), 콩(Glycine Max(soy)), 맥아, 아마, 붉은 토끼풀, 카콘-토(kakkon-to), 백색 루핀, 헤이즐넛, 옥수수, 너도밤나무 슛(beech tree shoots), 붉은 토끼풀(Trifolium pratense(red clover)), 뉴질랜드 삼(Phormium tenax(뉴질랜드 아마)), 시나모뭄 제일라니쿰(Cinnamommum zeylanicum), 라미나리아 사카리나(Laminaria saccharina), 스피라에아 울마리아(Spiraea ulmaria), 쐐기풀 뿌리(Nettle Root), 피게움 아프리카눔(Pygeum africanum), 귀리(Avena Sativa), 아니카(Arnica Montana), 싱코나 숙시루브라(Cinchona succirubra), 정향나무(Eugenia caryophyllata), 홉(Humulus lupulus), 망종화(Hypericum perforatum), 페퍼민트(Mentha piperita), 로즈마리(Rosmarinus officinalis), 티무스 불가리쿠스(Thymus vulgaricus)의 수용성 추출물, 실리붐(Silybum) 속의 식물 추출물, 콩과 식물 종자의 추출물, 포르피라(Porphyra) 속의 적색 조류 추출물, Phytovityl C® [INCI: 물, 옥수수 추출물](Solabia에서 시판), Micromerol™ [INCI: 피루스 말루스(Pyrus Malus) 추출물] 또는 헤더 추출물 [INCI: 칼루나(Calluna Vulgaris) 추출물](Coletica/Engelhard/BASF에서 시판), Proteasyl® TP LS8657 [INCI: 완두(Pisum Sativum) 추출물](Laboratoires Serobiologiques/Cognis에서 시판), Radicaptol [INCI: 프로필렌 글리콜, 물, 파씨플로라 인카르나타(Passiflora Incarnata) 꽃 추출물, 서양까치밥나무(Ribes Nigrum)(블랙커런트) 잎 추출물, 비티스 비니페라(Vitis Vinifera, 포도) 잎 추출물](Solabia에서 시판) 또는 ViaPure™ Boswellia [INCI: 올리바눔(Boswellia Serrata) 추출물](Soliance에서 시판), EquiStat [INCI: 피루스 말루스(Pyrus Malus) 과일 추출물, 글리신 소야 종자 추출물](Coletica/Engelhard에서 시판), Litchiderm™ [INCI: 릿치 차이넨시스(Litchi Chinensis) 과피 추출물] 또는 Arganyl™ [INCI: 아르가니아 스피노사(Argania Spinosa) 잎 추출물](Laboratories Serobiologiques/Cognis에서 시판), Dakaline [INCI: 아몬드(Prunus amygdalus dulcis), 아노게이수스 레이오카르푸스(Anogeissus leiocarpus) 목피 추출물](Soliance에서 시판), Actimp 1.9.3® [INCI: 가수분해된 루핀 단백질](Expanscience Laboratorios에서 시판), Pronalen® Refirming HSC [INCI: 밀(Triticum vulgare), 밀크티슬(Silybum Marianum), 대두 글리신, 쇠뜨기(Equisetum Arvense), 성모초(Alchemilla Vulgaris), 알팔파(Medicago Sativa), 라파누스 사티부스(Raphanus Sativus)] 또는 Polyplant® Refirming [INCI: 콘플라워(Coneflower), 아시아 병풀(Asiatic Centella), 푸쿠스(Fucus), 호로파(Fenugreek)](Provital에서 시판), Lanablue® [INCI: 소르비톨, 해조류 추출물](Atrium Innovations에서 시판), Firmiderm® LS9120 [INCI: 터미날리아 캐타파(Terminalia Catappa) 잎 추출물, 삼부쿠스 네그라(Sambucus Negra) 꽃 추출물, PVP, 탄닌산](Laboratoires Serobiologiques/Cognis에서 시판)로 구성되는 그룹으로부터 선택된다.
세포 추출물 및 미생물에 의해서 생산되는 추출물, 또는 이들을 포함하는 상업용 혼합물은 미생물에 의해 생산되는 수용성 추출물 및 수용성 세포 추출물, 이들만으로 제한되지 않는 예를 들면 무엇보다도, Antarcticine® [INCI: 슈도알테로모나스 발효 추출물] 및 Trylagen® [INCI: 슈도알테로모나스 발효 추출물, 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-10 시트룰린, 트리펩티드-1](Lipotec에서 시판), 효모 추출물, 사카로마이세스 세레비시아에(Saccharomyces cerivisiae) 추출물 및 락토바실루스 불가리쿠스(Lactobacillus Bulgaricus)에 의한 우유 발효 산물로 구성되는 그룹으로부터 선택된다.
본 발명의 전달 시스템에 포함되는 친수성 활성 성분의 함량은 0.00001 내지 50 중량%, 바람직하게는 0.0001 내지 40 중량%, 더욱 바람직하게는 0.001 내지 30 중량% 범위이다.
또 다른 특정 실시 형태에서, 본 발명의 나노캡슐은 다른 화장품 및/또는 식이성 활성 성분 및/또는 임의의 천연, 소수성, 친수성 및 양친매성 보조제를 포함하며, 이들은 지질 매트릭스 중 현탁액 또는 용액 중, 또는 마이크로에멀젼의 수성 상 중 나노캡슐 내부에서 발견될 수 있다. 특히, 화장품 및/또는 식이성 활성 성분 및/또는 보조제는, 이들만으로 제한되지 않는 예를 들어, 계면활성제, 습윤제 또는 수분을 보유하는 물질, 보습제 또는 유연제, 치유 자극제, 보조 치유제, 재상피화 자극제, 보조 재상피화제, 피부 또는 표피 거대분자 합성제, 고화 및/또는 재치밀화 및/또는 재구성 약제, 사이토카인 성장 인자, 모세혈관 순환 및/또는 미소순환에 작용하는 약제, 항-당화제, 유리 라디칼 청소제 및/또는 항-환경 오염 약제, 반응성 카보닐종 청소제, 5α-리덕타제-저해제, 리질- 및/또는 프롤릴 하이드록실라제 저해제, 디펜신 합성-자극제, 항균제 및/또는 정균제 및/또는 항미생물제 및/또는 살균제 및/또는 살진균제 및/또는 정진균제 및/또는 미생물-억제제, 항바이러스제, 항기생충제, 항히스타민제, NO-합성 저해제, 박리제 또는 각질용해제 및/또는 각질제거제, 여드름방지제, 항-건선제, 항-비듬제, 항염증제 및/또는 진통제, 마취제, 항-주름 및/또는 항-노화제, 화장품 및/또는 흡착성 및/또는 체취 마스킹 탈취제, 발한억제제, 방향 물질 및/또는 방향 오일 및/또는 분리된 방향성 화합물, 항-산화제, 혈관 투과성 억제제, 가수분해성 표피 효소, 미백 또는 피부 탈색제, 땀-분해 효소 저해제, 자외선 차단제, 케라틴세포 분화 자극 또는 조절제, 항-소양제, 멜라닌 합성 자극 또는 저해제, 프로색소침착제, 셀프-태닝제, 멜라닌세포 증식 자극제, 액체 추진제, 비타민, 아미노산, 단백질, 생물폴리머, 겔화 폴리머, 피부 이완제, 눈 아래 주머니 감소 또는 치료 가능 약제, 민감성 피부 케어 및/또는 치료용 약제, 수렴제, 피지 생산 조절제, 튼살 억제제, 지질용해제 또는 지질용해 자극제, 정맥강화제, 항-셀룰라이트제, 진정제, 세포 대사에 작용하는 약제, 피부-표피 연결부 개선제, 모발 성장 유도 또는 모발-손실 지연제, 체모 성장 저해 또는 지연제, 열 쇼크 단백질 합성 자극제, 근육 이완제, 근육 수축 억제제, 아세틸콜린 수용체 군집 억제제, 항콜린효능제, 엘라스타제 저해제, 기질 금속단백질가수분해효소 저해제, 킬레이트제, 식물 추출물, 에센셜 오일, 수산 추출물, 미네랄 염, 세포 추출물, 유화제, 지질 및 각질층 성분(세라마이드, 지방산 등) 합성 자극제, 생물-발효 공정으로부터 얻은 약제 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다. 이들 활성 성분 및/또는 화장품 및/또는 식이성 보조제의 본질은 합성이거나 식물 추출물과 같이 천연이거나, 또는 생물기술 공정으로부터 또는 합성 공정과 생물기술 공정의 혼합으로부터 올 수 있다. 추가적인 예는 CTFA International Cosmetic Ingredient Dictionary & Handbook , 12 th Edition (2008)에서 발견될 수 있다. 본 발명에서, 생물기술 공정은 유기체에서, 또는 이의 일부에서 활성 성분, 또는 이의 일부를 생산하는 임의의 공정으로 이해된다.
특정 실시 형태에서, 습윤제 또는 수분을 보유하는 물질, 보습제 또는 유연제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 글리세린, 에틸헥실글리세린, 카프릴릴 글리콜, 펜틸렌 글리콜, 부틸렌 글리콜, 프로필렌 글리콜 및 이들의 유도체, 트리에틸렌 글리콜, 폴리에틸렌 글리콜, 글리세레쓰-26, 소르베쓰-30과 같은 폴리올 및 폴리에테르; 판테놀; 피로글루탐산 및 이의 염 및 유도체; 세린, 프롤린, 알라닌, 글루타메이트 또는 알기닌과 같은 아미노산; 엑토인 및 이의 유도체; N-(2-하이드록시에틸)아세타마이드; N-라우로일-피롤리돈 카복실산; N-라우로일-L-리진; N-알파-벤조일-L-알기닌; 요소; 크레아틴; 락트산, 글리콜산, 말산, 시트르산 또는 살리실산과 같은 α- 및 β-하이드록시산 및 이들의 염; 폴리글리세릴 아크릴레이트; 당 및 다당류, 예를 들어 글루코스, 사카라이드 아이소머레이트, 소르비톨, 펜타에리쓰리톨, 이노시톨, 자일리톨, 트레할로스 및 이의 유도체, 소디움 글루쿠로네이트, 카라게네이트(Chondrus crispus) 또는 키토산; 글리코사미노글리칸, 예를 들어 히알루론산 및 이의 유도체; 임의의 형태의 알로에 베라; 꿀; 가용성 콜라겐; 레시틴 및 포스파티딜콜린; 세라마이드; 콜레스테롤 및 이의 에스테르; 토코페롤 및 토코페릴 아세테이트 또는 토코페릴 리놀레이트와 같은 이의 에스테르; 세테아릴 알코올, 스테아릴 알코올, 세틸 알코올, 올레일 알코올, 이소세틸 알코올 또는 옥타데칸-2-올과 같은 장쇄 알코올; 라우릴 락테이트, 미리스틸 락테이트 또는 C12-C15 알킬 벤조에이트와 같은 장쇄 알코올 에스테르; 스테아린산, 이소스테아린산 또는 팔미트산과 같은 지방산; 다불포화 지방산(PUFAs); 소르비탄 디스테아레이트와 같은 소르비탄; 글리세릴 모노리시놀레이트, 글리세릴 모노스테아레이트, 글리세릴 스테아레이트 시트레이트 또는 카프릴릭 및 카프릭산 트리글리세라이드와 같은 글리세라이드; 사카로스 팔미테이트 또는 사카로스 올레이트와 같은 사카로스 에스테르; 디카프릴레이트 및 디카프레이트와 같은 부틸렌 글리콜 에스테르; 이소프로필 이소스테아레이트, 이소부틸 팔미테이트, 이소세틸 스테아레이트, 이소프로필 라우레이트, 헥실 라우레이트, 데실 올레이트, 세틸 팔미테이트, 디-n-부틸 세바세이트, 이소프로필 미리스테이트, 이소프로필 팔미테이트, 이소프로필 스테아레이트, 부틸 스테아레이트, 부틸 미리스테이트, 이소프로필 리놀에이트, 2-에틸헥실 팔미테이트, 2-에틸헥실 코코에이트, 데실 올레이트, 미리스틸 미리스테이트와 같은 지방산 에스테르; 스쿠알렌; 밍크 오일; 라놀린 및 이의 유도체; 아세틸화된 라놀린 알코올; 사이클로메티콘, 디메티콘 또는 디메틸폴리실록산 과 같은 실리콘 유도체; Antarcticine® [INCI: 슈도알테로모나스 발효 추출물] 또는 아세틸-글루타밀-메티오닐-알라닐-이소류신, 아세틸-알기닐-페닐글리실-페닐글리신 또는 아세틸-알기닐-6-아미노헥사노일-알라닌(Lipotec에서 시판), 페트롤라툼; 광유; 미네랄 및 합성 왁스; 밀랍(cera alba); 파라핀; 또는 칸델라 왁스(Euphorbia cerifera), 카르나우바 왁스(Copernicia cerifera), 시어 버터(Butirospermum parkii), 코코아 버터(Theobroma cacao), 피마자유(Ricinus communis), 해바라기씨유(Helianthus annuus), 올리브유(Olea europaea), 코코넛 오일(Cocos nucifera), 야자유(Elaeis guineensis), 밀배아유(Triticum vulgare), 아몬드 오일(Prunus amygdalus dulces), 사향 장미 오일(Rosa moschata), 대두 콩 오일(Glycine soja), 포도씨유(Vitis vinifera), 칼렌둘라 오일(Calendula officinalis), 호호바 오일(Simmonsis chinensis), 망고 오일(Mangifera indica), 아보카도 오일(Persea gratissima)과 같은 식물 기원의 왁스 및 오일 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
마찬가지로, 또 다른 실시 형태에서, 치유 자극제, 보조 치유제, 재상피화 자극제, 보조 재상피화제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 아리스톨로퀴아 클레마티스(Aristoloquia clematis), 병풀(Centella asiatica), 사향 장미(Rosa moschata), 에키나세아 앙구스티폴리아(Echinacea angustifolia), 컴프리(Symphytum officinale), 쇠뜨기(Equisetum arvense), 망종화(Hypericum perforatum), 미모사 테뉘플로라(Mimosa tenuiflora), 아보카도(Persea gratisima), 프루누스 아프리카눔(Prunus africanum), 토르멘틸라 에렉테아(Tormentilla erectea), 알로에 베라(Aloe vera) 추출물, Polyplant® Epithelizing [INCI: 금잔화(Calendula Officinalis), 망종화(Hypericum Perforatum), 카모밀라 레쿠티타(Chamomilla Recutita), 로즈마리(Rosmarinus Officinalis)](Provital에서 시판), Cytokinol® LS 9028 [INCI: 가수분해된 카제인, 가수분해된 효모 단백질, 리진 HCI](Laboratories Serobiologiques/Cognis에서 시판) 또는 Deliner® [INCI: 제아 메이(옥수수) 핵 추출물](Coletica/Engelhard/BASF에서 시판), 알란토인, 카데린, 인테그린, 셀렉틴, 히알루론산 수용체, 면역글로불린, 섬유아세포 성장 인자, 결합 조직 성장 인자, 혈소판-유도된 성장 인자, 혈관 내피 성장 인자, 표피 성장 인자, 인슐린-유사 성장 인자, 케라틴세포 성장 인자, 집락-자극 인자, 형질전환 성장 인자 베타, 종양 괴사 인자 알파, 인터페론, 인터류킨, 기질 금속단백질가수분해효소, 수용체 단백질 타이로신 포스파타제, Antarcticine® [INCI: 슈도알테로모나스 발효 추출물], Decorinyl® [INCI: 트리펩티드-10 시트룰린], Trylagen® [INCI: 슈도알테로모나스 발효 추출물, 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-10 시트룰린, 트리펩티드-1], Bodyfensine™ [INCI: 아세틸 디펩티드-3 아미노헥사노에이트](Lipotec에서 시판)로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 피부 또는 표피 거대분자 합성 자극제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 콜라겐 합성 자극제, 엘라스틴 합성 자극제, 데코린 합성 자극제, 라미닌 합성 자극제, 샤프론 합성 자극제, 시르투인 합성 자극제, 히알루론산 합성 자극제, 아쿠아포린 합성 자극제, 피브로넥틴 합성 자극제, 콜라겐 분해 억제제, 엘라스틴 분해 억제제, 류코사이트 엘라스타제 또는 카텝신 G와 같은 세린 프로테아제 저해제, 섬유아세포 증식 자극제, 지방세포 증식 자극제, 지방세포 분화 자극제, 혈관형성 자극제, 글리코사미노글리칸 합성 자극제, DNA 수복제 및/또는 DNA 보호제, 이들만으로 제한되지 않는 예를 들어, 병풀(Centella asiatica), 사카로마이세스 세레비시아에(Saccharomyces cerevisiae), 감자(Solanum tuberosum), 로즈마리(Rosmarinus officinalis), 바씨니움 앙구스티폴리움(Vaccinium angustifolium), 해조류 마크로시스티스 피리페라(Macrocystis pyrifera), 파디나 파보니카(Padina pavonica) 추출물, 식물 대두, 맥아, 아마, 세이지, 붉은 토끼풀, 카콘-토, 백색 루핀 추출물, 헤이즐넛 추출물, 옥수수 추출물, 효모 추출물, 너도밤나무 슛 추출물, 콩과 종자 추출물, 무엇보다도 지베렐린, 오옥신 또는 사이토키닌과 같은 식물 호르몬 추출물, 또는 동물성 플랑크톤 살리나 추출물, 락토바실루스 불가리쿠스(Lactobacillus Bulgaricus)에 의한 우유 발효 산물, 아시아티코사이드 및 이의 유도체, 비타민 C 및 이의 유도체, 신남산 및 이의 유도체, Matrixyl® [INCI: 팔미토일 펜타펩티드-3], Matrixyl® 3000 [INCI: 팔미토일 테트라펩티드-3, 팔미토일 올리고펩티드] 또는 Biopeptide CL™ [INCI: 글리세릴 폴리메타크릴레이트, 프로필렌 글리콜, 팔미토일 올리고펩티드](Sederma에서 시판), Antarcticine® [INCI: 슈도알테로모나스 발효 추출물], Decorinyl® [INCI: 트리펩티드-10 시트룰린], Serilesine® [INCI: 헥사펩티드-10], 리펩티드 [INCI: 가수분해된 식물 단백질], Aldenine® [INCI: 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-1], 펩티드 AC29 [INCI: 아세틸 트리펩티드-30 시트룰린](Lipotec에서 시판), Drieline® PF [INCI: 효모 베타글루칸](Alban Muller에서 시판), Phytovityl C® [INCI: 물, 제아 메이스 추출물](Solabia에서 시판), Collalift® [INCI: 가수분해된 맥아 추출물](Coletica/Engelhard에서 시판), Phytocohesine® PSP [INCI 제안: 소디움 베타-시토스테롤 설페이트](Seporga에서 시판), 무엇보다도 칼슘과 같은 미네랄, 레티노이드 및 이의 유도체, 이소플라보노이드, 카로티노이드, 특히 리코펜, 슈도디펩티드, 레티노이드 및 무엇보다도 레티놀 또는 레티닐 팔미테이트와 같은 이의 유도체, 또는 헤파리노이드로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 엘라스틴 분해 억제제는, 이들만으로 제한되지 않는예를 들면 무엇보다도, Elhibin® [INCI: 글리신 소야(대두) 단백질], Preregen® [INCI: 글리신 소야(대두) 단백질, 산화환원효소] 또는 Regu®-Age [INCI: 가수분해된 쌀겨 단백질, 글리신 소야(대두) 단백질, 산화환원효소](Pentapharm/DSM에서 시판), Juvenesce [INCI: 에톡시디글리콜 및 카프릴릭 트리글리세라이드, 레티놀, 우르솔산, 피토나디온, 일로마스타트], Micromerol™ [INCI: 피루스 말루스(Pyrus Malus) 추출물], 헤더 추출물 [INCI: 칼루나(Calluna Vulgaris) 추출물], Extracellium® [INCI: 가수분해된 감자 단백질] 또는 Flavagrum™ PEG [INCI: PEG-6 이소스테아레이트, 헤스페레틴 라우레이트](Coletica/Engelhard/BASF에서 시판), Proteasyl® TP LS8657 [INCI: 완두(Pisum Sativum) 추출물](Laboratoires Serobiologiques/Cognis에서 시판), Relistase™ [INCI: 아세틸알기닐트립토필 디페닐글리신](Lipotec에서 시판), 세피리프트 DPHP [INCI: 디팔미토일 하이드록시프롤린](SEPPIC에서 시판), Vitaderm® [INCI: 알코올, 물, 글리세린, 가수분해된 쌀 단백질, 일렉스 아퀴폴리움(Ilex Aquifolium) 추출물, 소디움 우르솔레이트, 소디움 올레아놀레이트](Rahn에서 시판), Gatuline® Age Defense 2 [INCI: 페르시아 호두(Juglans Regia, Walnut) 종자 추출물](Gattefosse에서 시판), IP 2000 [INCI: 덱스트란, 트리플루오로아세틸 트리펩티드-2](IEB 및 Atrium에서 시판), 라디캅톨 [INCI: 프로필렌 글리콜, 물, 파씨플로라 인카르나타(Passiflora Incarnata) 꽃 추출물, 서양까치밥나무(Ribes Nigrum, 블랙커런트) 잎 추출물, 비티스 비니페라(Vitis Vinifera, 포도) 잎 추출물](Solabia에서 시판) 또는 ViaPure™ Boswellia [INCI: 올리바눔(Boswellia Serrata) 추출물](Soliance에서 시판)로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 기질 금속단백질가수분해효소-저해제는, 이들만으로제한되지 않는 예를 들면 무엇보다도, 우르솔산, 게니스테인, 쿠에르세틴, 카로티노이드, 리코펜과 같은 이소플라본, 대두 추출물, 크랜베리 추출물, 로즈마리 추출물, 붉은 토끼풀(Trifolium pretense , 레드 클로버) 추출물, 뉴질랜드 삼(Phormium tenax, 뉴질랜드 아마) 추출물, 카콘-토 추출물, 세이지 추출물, 레티놀 및 이의 유도체, 레티노산 및 이의 유도체, 무엇보다도 디오스게닌, 헤코게닌, 스밀라게닌, 살사포게닌, 티고게닌, 야모게닌 및 유카게닌과 같은 사포게닌, Collalift® [INCI: 가수분해된 맥아 추출물], Juvenesce [INCI: 에톡시디글리콜 및 카프릴릭 트리글리세라이드, 레티놀, 우르솔산, 피토나디온, 일로마스타트] 또는 EquiStat [INCI: 피루스 말루스(Pyrus Malus) 과실 추출물, 글리신 소야 종자 추출물](Coletica/Engelhard에서 시판), Pepha®-Timp [INCI: 인간 올리고펩티드-20], Regu-Age [INCI: 가수분해된 쌀겨 단백질, 글리신 소야 단백질, 산화환원효소] 또는 콜히빈 [INCI: 가수분해된 쌀 단백질](Pentapharm에서 시판), 리펩티드 [INCI: 가수분해된 식물 단백질], 펩티드 AC29 [INCI: 아세틸 트리펩티드-30 시트룰린], 아세틸-알기닐-아스파라기닐-히스티틸-시트룰린-아미다(Lipotec에서 시판), Litchiderm™ [INCI: 릿치 차이넨시스(Litchi Chinensis) 과피 추출물] 또는 Arganyl™ [INCI: 아르가니아 스피노사(Argania Spinosa) 잎 추출물](Laboratories Serobiologiques/Cognis에서 시판), MDI Complex® [INCI: 글리코사미노글리칸] 또는 ECM-Protect® [INCI: 물(Aqua), 덱스트란, 트리펩티드-2](Atrium Innovations에서 시판), 다칼린 [INCI: 아몬드(Prunus amygdalus dulcis), 아노게이수스 레이오카르푸스(Anogeissus leiocarpus) 목피 추출물](Soliance에서 시판), 호메오스타틴 [INCI: 엔테로모르파 콤프레싸(Enteromorpha compressa,) 캐살피니아 스피노사(Caesalpinia Spinosa)](Provital에서 시판), Timp-펩티드 [INCI 제안: 아세틸 헥사펩티드] 또는 ECM 모듈린 [INCI 제안: 팔미토일트리펩티드](Infinitec Activos에서 시판), IP2000 [INCI: 덱스트란, 트리플루오로아세틸 트리펩티드-2](Institut Europeen de Biologie Cellulaire에서 시판), Actimp 1.9.3® [INCI: 가수분해된 루핀 단백질](Expanscience Laboratories에서 시판), Vitaderm® [INCI: 알코올, 물(Aqua), 글리세린, 가수분해된 쌀 단백질, 일렉스 아퀴폴리움(Ilex Aquifolium) 추출물, 소디움 우르솔레이트, 소디움 올레아놀레이트](Rahn에서 시판), 아다팔렌, 테트라사이클린 및 이의 유도체, 예를 들어 미노사이클린, 롤리테트라사이클린, 클로르테트라사이클린, 메타사이클린, 옥시테트라사이클린, 독시사이클린, 데메클로사이클린 및 이들의 염, 바티마스타트 [BB94; [4-(N-하이드록시아미노)-2R-이소부틸-3S-(티오펜-2-일티오메틸)숙시닐]-L-페닐알라닌-N-메틸아마이드], 마리마스타트 [BB2516; [2S-[N4(R*),2R*,3S]]-N4[2,2-디메틸-1-[메틸아미노카보닐]프로필]-N1,2-디하이드록시-3-(2-메틸프로필)부탄디아마이드]로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 고화 및/또는 재치밀화 및/또는 재구성 약제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 말피기아 푸니시톨리아(Malpighia punicitolia), 아티초크(Cynara scolymus), 면화(Gossypium herbaceum), 알로에(Aloe Barbadensis), 기장(Panicum miliaceum), 모루스 니그라(Morus nigra), 참깨(Sesamum indicum), 글리신 소야(Glycine soja), 밀(Triticum vulgare) 추출물, Pronalen® Refirming HSC [INCI: 밀(Triticum vulgare), 밀크티슬(Silybum Marianum), 대두 글리신, 쇠뜨기(Equisetum Arvense), 성모초(Alchemilla Vulgaris), 알팔파(Medicago Sativa), 라파누스 사티부스(Raphanus Sativus)] 또는 Polyplant® Refirming [INCI: 루드비키아(Coneflower), 아시아 병풀(Asiatic Centella), 푸쿠스(Fucus), 호로파(Fenugreek)](Provital에서 시판), Lanablue® [INCI: 소르비톨, 해조류 추출물](Atrium Innovations에서 시판), Pepha®-Nutrix [INCI: 천연 영양 인자](Pentapharm에서 시판), 또는 이소플라본을 포함하는 식물 추출물, Biopeptide EL™ [INCI: 팔미토일 올리고펩티드], Biopeptide CL™ [INCI: 팔미토일 올리고펩티드], Vexel® [INCI: 물(Aqua), 프로필렌 글리콜, 레시틴, 카페인, 팔미토일 카르니틴], Matrixyl® [INCI: 팔미토일 펜타펩티드-3], Matrixyl® 3000 [INCI: 팔미토일 테트라펩티드-3, 팔미토일 올리고펩티드] 또는 Bio-Bustyl™ [INCI: 글리세릴 폴리메타크릴레이트, 라넬라 대두 단백질 발효물, 물(Aqua), 프로필렌 글리콜, 글리세린, PEG-8, 팔미토일 올리고펩티드](Sederma에서 시판), Dermosaccharides® HC [INCI: 글리세린, 물(Aqua), 글리코사미노글리칸, 글리코겐], Aglycal® [INCI: 만니톨, 사이클로덱스트린, 글리코겐, 아라토스타필로스 우바 우르시 잎 추출물], Cytokinol® LS [INCI: 가수분해된 카제인, 가수분해된 효모 단백질, 리진 HCI] 또는 Firmiderm® LS9120 [INCI: 터미날리아 캐타파(Terminalia Catappa) 잎 추출물, 삼부쿠스 네그라(Sambucus Negra) 꽃 추출물, PVP, 탄닌산](Laboratoires Serobiologiques/Cognis에서 시판), Liftline® [INCI: 가수분해된 밀 단백질], Raffermine® [INCI: 가수분해된 대두 분말] 또는 Ridulisse C® [가수분해된 대두 단백질](Silab에서 시판), Serilesine® [INCI: 헥사펩티드-10], Decorinyl™ [INCI: 트리펩티드-10 시트룰린], Trylagen® [INCI: 슈도알테로모나스 발효 추출물, 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-10 시트룰린, 트리펩티드-1](Lipotec에서 시판), Ursolisome® [INCI: 레시틴, 우르솔산, 아텔로콜라겐, 잔탄검, 콘드로이틴 황산나트륨] 또는 Collalift® [INCI: 가수분해된 맥아 추출물](Coletica/Engelhard에서 시판), Syn®-Coll [INCI: 팔미토일 트리펩티드-5](Pentapharm에서 시판), Hydriame® [INCI: 물(Aqua), 글리코사미노글리칸, 균핵 검](Atrium Innovations에서 시판) 또는 IP2000 [INCI: 덱스트란, 트리플루오로아세틸 트리펩티드-2](Institut Europeen de Biologie Cellulaire에서 시판)으로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 항-당화제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 바씨니움 앙구스티폴리움(Vaccinium angustifolium) 추출물, 에르고티오네인 및 이의 유도체, 리진, Aldenine® [INCI: 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-1], Vilastene™ [INCI: 리진 HCI, 레시틴, 트리펩티드-10 시트룰린], dGlyage™ [INCI: 리진 HCI, 레시틴, 트리펩티드-9 시트룰린] 또는 Eyeseryl® [INCI: 아세틸 테트라펩티드-5](Lipotec에서 시판), 하이드록시스틸벤 및 이의 유도체, 레스베라트롤 또는 3,3’,5,5’-테트라하이드록시스틸벤으로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 유리 라디칼 청소제 및/또는 항-환경 오염 약제 및/또는 반응성 카보닐종 청소제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 차 추출물, 올리브 잎 추출물, 로즈마리(Rosmarinus officinalis) 추출물 또는 부레옥잠(Eichhornia crassipes) 추출물, 벤조피렌, 비타민 C 및 이의 유도체, 비타민 E 및 이의 유도체, 특히 토코페릴 아세테이트, 아스코빌 글리코사이드, 페놀 및 폴리페놀, 특히 탄닌, 탄닌산 및 엘라직산, 갈로카테콜, 안토시안, 클로로겐산, 스틸벤, 인돌, 시스테인-함유 아미노산 및 유도체, 특히 N-아세틸시스테인, 에르고티오네인, S-카복시메틸시스테인, 킬레이트제, 특히 EDTA 또는 에틸렌디아민, 카로티노이드, 바이오플라보노이드, 유비퀴논, 이데베논, 카탈라제, 수퍼옥사이드 디스뮤타제, 락토퍼옥시다제, 글루타치온 퍼옥시다제, 글루타치온, 벤질리덴 캄포, 피돌레이트, 리그난, 멜라토닌, 오리자놀, 카르노신 및 이의 유도체, GHK [INCI: 트리펩티드-1] 및 이의 염 및/또는 유도체, Aldenine® [INCI: 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-1], Preventhelia® [INCI: 디아미노프로피오닐 트리펩티드-33], 디아미노프로피오닐-알라닐-아스파라기닐-히스티딘 또는 리포크로만-6 [INCI: 디메틸메톡시 크로마놀](Lipotec에서 시판)으로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 5α-리덕타제 저해제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 신나모뭄 제일라니쿰(Cinnamommum zeylanicum), 라미나리아 사카리나(Laminaria saccharina), 스피라에아 울마리아(Spiraea ulmaria), 쐐기풀 뿌리, 피게움 아프리카눔(Pygeum africanum), 귀리(Avena Sativa), 세레노아 레펜스(Serenoa repens) 추출물, 식물 아니카(Arnica Montana), 싱코나 숙시루브라(Cinchona succirubra), 정향나무(Eugenia caryophyllata), 홉(Humulus lupulus), 망종화(Hypericum perforatum), 페퍼민트(Mentha piperita), 로즈마리(Rosmarinus officinalis), 살비아 오피시날리스(Salvia officinalis), 티무스 불가리쿠스(Thymus vulgaricus) 추출물, 실리붐(Silybum) 속의 식물 추출물, 사포게닌을 포함하는 식물의 추출물 및 특히 디오스코레아(Dioscorea) 속의 식물 추출물, 피토스테롤, 레티노이드 및 특히 레티놀, 황 및 이의 유도체, 아연 염 및 특히 락테이트, 글루코네이트, 피돌레이트, 카복실레이트, 살리실레이트 또는 징크 시스테에이트, 셀리늄 클로라이드, 비타민 B6, 피리독신, 카프릴로일 글리신, 사르코신, 파나스테라이드, 두타스테라이드, 이존스테라이드, 투로스테라이드 및 이의 염으로 구성되는 그룹으로부터 선택된다.
마찬가지로, 또 다른 특정 실시 형태에서, 리질- 및/또는 프롤릴-하이드록실라제-저해제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 2,4-디아미노피리미딘 3-옥사이드 또는 2,4-디아미노-6-피페리디노피리미딘 3-옥사이드로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 디펜신 합성-자극제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 가수분해된 알로에 베라(Aloe Vera) 또는 추출물, 로스트 아마란쓰(Roast amaranth), 지황(Rehmannias radix), 아니카, 치자나무, 당근, 오렌지, 복숭아, 파인애플, 민트, 용담, 히비스커스 꽃, 호두나무 잎, 호리병박 열매, 작약, 퀴노아, 볼도, 러프 바인드위드, 해바라기, 엘더베리, 해조류, 가수분해된 옥수수, 가수분해된 대두, 가수분해된 쌀, 발린 및 이의 이성체 및 유도체, 칼슘 및 이의 염, α-MSH 및 α-MSH의 아미노산 서열에 포함되는 단편, 비타민 A 및 이의 유도체 및 전구체, 비타민 D3 및 이의 유도체, 자스몬산, 푸마르산, 말산, 시트르산, 아스코르빈산, 락트산, 아세트산, 아디프산, 타르타르산, 신남산, 글루탐산, 숙신산, 이눌린, 알킬 글루코사이드, 폴리-D-글루탐산, 글리신, L-메티오닌, L-알라닌, L-시트룰린, 락토프로테인, 카제인, 락토퍼옥시다제, 리소자임, 폴리페놀, 알킬 글루코사이드, 락토바실루스(Lactobacillus) 추출물, 푸소박테리아 추출물 또는 비-광합성 및 비-결실 사상균 및 Bodyfensine™ [INCI: 아세틸 디펩티드-3 아미노헥사노에이트](Lipotec에서 시판)로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 항균 및/또는 정균제 및/또는 항미생물 및/또는 살균제 및/또는 살진균제 및/또는 정진균제 및/또는 미생물-억제제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 마크로라이드, 피라노사이드, 칼슘 채널 차단제, 이들만으로 제한되지 않는 예를 들어, 신나리진 및 딜티아젬; 호르몬, 이들만으로 제한되지 않는 예를 들어, 에스트릴, 이의 유사체 또는 티록신 및/또는 이의 염, 카프릴릴 글리콜, 이미다졸리디닐 우레아, 메틸 4-하이드록시벤조에이트 [INCI: 메틸파라벤], 에틸 4-하이드록시벤조에이트 [INCI: 에틸파라벤], 프로필 4-하이드록시벤조에이트 [INCI: 프로필파라벤], 부틸 4-하이드록시벤조에이트 [INCI: 부틸파라벤], 이소부틸 4-하이드록시벤조에이트 [INCI: 이소부틸파라벤], 1,3-비스(하이드록시메틸)-5,5-디메틸이미다졸리딘-2,4-디온 [INCI: DMDM 하이단토인], 벤질 4-하이드록시벤조에이트 [INCI: 벤질파라벤], 벤질알콜, 데하이드로아세트산, 벤조산, 소르빈산, 살리실산, 포름산, 프로피온산, 2-브로모-2-니트로프로판-1,3-디올, 3-p-클로로페녹시-1,2-프로판디올 [INCI: 클로르페네신], 디클로로벤질 알코올, 요오도프로피닐 부틸카바메이트, 벤잘코니움 클로라이드, 냄새-흡수성 살진균제, 예를 들어 징크 리시놀레이트, 사이클로덱스트린, 벤제토니움 클로라이드, 클로르헥시딘, 에탄올, 프로판올, 1,3-부탄디올, 1,2-프로필렌 글리콜, 운데실렌산, 데하이드로아세트산, N-메틸모르폴린 아세토니트릴(MMA), 이소프로판올, 메탄올, 1,2-헥산디올, 1,2-옥탄디올, 펜틸렌 글리콜, 글리세린 라우레이트, 글리세린 카프릴레이트, 글리세린 카프레이트, 벤질 퍼옥사이드, 클로르헥시딘 글루코네이트, 트리클로산 및 이의 유도체, 페녹시에탄올, 테르피넨-4-올, α-테르피네올, 레조르시놀, 스티에마이신, 에리스로마이신, 네오마이신, 클린다마이신 및 이의 에스테르, 테트라사이클린, 메트로니다졸, 아젤라산, 톨나프테이트, 니스타틴, 클로트리마졸, 케토코나졸, 징크 피리티오네이트 또는 트리티오네이트, 징크 옥사이드 및 징크 운데실레네이트와 같은 아연 유도체, 피록톤 올라민, 이소티아졸리논, 셀레늄 설퍼, 벤질 헤미포르말, 붕산, 붕산나트륨, 6,6-디보로모-4,4-디클로로-2,2'-메틸렌디페놀 [INCI: 브로모클로로펜], 5-브로모-5-니트로-1,3-디옥산, 토실클로라마이드 소디움 [INCI: 클로라민 T], 클로로아세타마이드, p-클로로-m-크레졸, 2-벤질-4-클로로페놀 [INCI: 클로로펜], 디메틸 옥사졸리딘, 도데실 디메틸-2-페녹시에틸 암모늄 브로마이드 [INCI: 도미펜 브로마이드], 7-에틸 비사이클로옥사졸리딘, 헥세티딘, 글루타르알데하이드, N-(4-클로로페닐)-N-[4-클로로-3-(트리플루오로메틸)페닐]-우레아 [INCI: 클로플루카르반], 2-하이드록시-4-이소프로필-2,4,6-사이클로헵타트리엔-1-온 [INCI: 히노키티올], 이소프로필메틸페놀, 수은 염, 알루미늄 염, 니신, 페녹시이소프로판올, o-페닐페놀, 3-헵틸-2-[(3-헵틸-4-메틸-3H-트리아졸-2-일리덴)메틸]-4-메틸티아졸 요오다이드 [INCI: 쿼터니움-73], 염화은, 요오드화나트륨, 티몰, 운데실렌산, 디에틸렌트리아민펜타아세트산, 에틸렌디아민테트라아세트산 및 에틸렌디아민테트라아세테이트, 락토퍼옥시다제, 글루코스 옥시다제, 락토페린, 알킬아릴 설포네이트, 할로겐화된 페놀, 페놀 수은 아세테이트 및/또는 이의 혼합물, 벤자미딘, 이소티아졸린, 프탈아마이드 유도체, 피리딘 유도체, 구아니딘, 퀴놀린, 1,2-디브로모-2,4-디시아노부탄, 아이오다인-2-프로필부틸 카바메이트, 요오드, 테임드 아이오다인, 퍼옥소 화합물, 4-클로로-3,5-디메틸페놀, 2,2'-메틸렌-비스(6-브로모-4-클로로페놀), 3-메틸-4-(1-메틸에틸)페놀, 3-(4-클로로페녹시)-1,2-프로판디올, 3,4,4'-트리클로로카바닐리드(TTC), 트리아민 에센스, 유게놀, 파네솔, 글리세린 모노라우레이트, 디글리세린 모노카프리네이트, N-알킬 살리실산 아마이드, 예를 들어 n-옥틸 살리실산 아마이드 또는 n-데실 살리실산 아마이드, 할로겐화 자일렌 및 크레졸 유도체, 예를 들어 p-클로로-메타-크레졸 또는 p-클로로-메타-자일렌, 마늘(Allium sativum), 금잔화(Calendula officinalis), 카모밀라 레큐티타(Chamomilla recutita), 에키나세아 푸르푸라(Echinacea Purpura), 히솝(Hyssopus Officinalis), 멜라류카 알테르니폴리아(Melaleuca alternifolia) 추출물 또는 티트리 오일, 카네이션 에센스, 멘톨 및 민트 에센스로 구성되는 그룹으로부터 선택된다.
마찬가지로, 또 다른 특정 실시 형태에서, NO-합성효소-저해제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 비티스 비니페라(Vitis vinifera), 올리브(Olea europaea) 또는 은행나무(Gingko biloba) 추출물로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 박리제 및/또는 각질용해제 및/또는 각질제거제는, 이들만으로 제한되지 않는 예를 들어, 하이드록시산 및 이의 유도체, β-하이드록시산, 특히 살리실산 및 이의 유도체, 또는 겐티식산; α-하이드록시산 및 이의 염, 예를 들어 글리콜산, 암모늄 글리콜레이트, 락트산, 2-하이드록시옥타노산, α-하이드록시카프릴산, 만델산, 시트르산, 말산 또는 타르타르산; α- 및 β-하이드록시부티르산; 폴리하이드록시산, 예를 들어 글루콘산, 글루쿠론산 또는 사카르산; 케토산, 예를 들어 피루브산, 글리옥실산; 피롤리딘카복실산; 시스테산 및 유도체; 알도비온산; 아젤라산 및 이의 유도체, 예를 들어 아젤로일 디글리시네이트; 아스코르빈산 및 이의 유도체, 예를 들어 6-O-팔미토일아스코르빈산, 아스코르빌 글루코사이드, 디팔미토일아스코르빈산, 아스코르빈산-2-포스페이트의 마그네슘 염(MAP), 아스코르빈산-2-포스페이트의 나트륨 염(NAP), 아스코르빌 테트라이소팔미테이트(VCIP); 니코틴산, 이의 에스테르 및 니코틴아마이드(비타민 B3 또는 비타민 PP로도 호칭됨); 노르디하이드로구아이아레트산; 요소; 올리고푸코스; 신남산; 자스몬산의 유도체; 하이드록시 스틸벤, 예를 들어 레스베라트롤; 사카룸 오피시나룸(Saccarum officinarum) 추출물; 코르네오데스모좀의 분해 또는 박리에 관여하는 효소, 예를 들어 글리코시다제, 각질층 키모트립신-관련 효소(SCCE) 또는 다른 프로테아제, 예를 들어 트립신, 키모트립신, 수틸라인, 파파인 또는 브로멜라인; 킬레이트제, 예를 들어 에틸렌디아민테트라아세테이트(EDTA) 및 이의 염, 아미노설폰 화합물, 예를 들어 4-(2-하이드록시에틸)피페라진-1-에탄설폰산(HEPES) 또는 소디움 메틸글리신 디아세테이트(BASF에서 시판하는 TRILON® M); 2-옥소티아졸리딘-4-카복실산(프로시스테인) 유도체; O-옥타노일-6-D-말토스 및 N-아세틸글루코사민과 같은 당 유도체; SILAB에서 Recoverine® [INCl: 물(Aqua), 유럽종 밤(Castanea Sativa) 종자 추출물]라는 이름으로 시판하는 것과 같은 밤 추출물(Castanea sativa); SILAB에서 Exfolactive® [INCl: 가수분해된 오푼티아 피쿠스 인디카(Opuntia Ficus Indica) 꽃 추출물]로 시판하는 것과 같은 부채선인장 추출물(Opuntia ficus - indica); 또는 Degussa/Evonik에서 시판하는 Phytosphingosine SLC® [INCl: 살리실로일 피토스핑고신], 필-모이스트 [INCl: 글리세린, 파파인, 판토텐산 칼슘, 잔탄 검, 카프릴릴 글리콜, 요소, 마그네슘 락테이트, 에틸헥실글리세린, 칼륨 락테이트, 세린, 알라닌, 프롤린, 염화마그네슘, 구연산나트륨]; 사포라 자포니카(Saphora japonica), 파파야, 파인애플, 호박 또는 고구마 추출물 또는 추출물의 조합 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 항염제 및/또는 진통제는, 이들만으로 제한되지 않는 예를 들어, 마데카소사이드 추출물, 에키나세아 추출물, 아마란스 종자 오일, 샌달 우드 오일, 복숭아 나무 잎 추출물, 알로에 베라(Aloe vera), 아니카(Arnica Montana), 머거워트(Artemisia vulgaris), 아사룸 막시뭄(Asarum maximum), 금잔화(Calendula officinalis), 고추(Capsicum), 센티페다 쿤닝하미이(Centipeda cunninghamii), 카모밀라 레큐티타(Chamomilla recutita), 크리눔 아시아티쿰(Crinum asiaticum), 미국 조롱나무(Hamamelis virginiana), 악마의 발톱(Harpagophytum procumbens), 망종화(Hypericum perforatum), 릴리움 칸디둠(Lilium candidum), 당아욱(Malva sylvestris), 티트리(Melaleuca alternifolia), 스위트 마죠람(Origanum majorana), 오레가노(Origanum vulgare), 프루누스 라우로세라수스(Prunus laurocerasus), 로즈마리(Rosmarinus officialis), 백버들(Salix alba), 밀크티슬(Silybum marianum), 휘브휴(Tanacetum parthenium), 타임(Thymus vulgaris), 운카리아 구이아넨시스(Uncaria guianensis) 또는 박시눔 미르틸루스(Vaccinum myrtillus) 추출물, 모메타손 푸로에이트, 프레드니솔론, 사이클로옥시게나제 또는 리폭시게나제 저해제를 포함하는 비스테로이드성 항염제, 벤지다민, 아세틸살리실산, 로즈마린산, 우르솔산, 글리시리지네이트 유도체, α-비사볼롤, 아줄렌 및 유사체, 세리코사이드, 루스코게닌, 에스신, 스콜린, 루틴 및 유사체, 하이드로코티손, 클로베타솔, 덱사메타손, 프레드니손, 파라세타몰, 아목시프린, 베노릴레이트, 콜린 살리실레이트, 파이슬라민, 메틸 살리실레이트, 마그네슘 살리실레이트, 살살레이트, 디클로페낙, 아세클로페낙, 아세메타신, 브롬페낙, 에토돌락, 인도메타신, 옥사메타신, 프로글루메타신, 술린닥, 톨메틴, 이부프로펜, 덱시부프로펜, 카르프로펜, 펜부펜, 페노프로펜, 플루비프로펜, 케토프로펜, 덱스케토프로펜, 케토롤락, 록소프로펜, 나프록센, 미로프로펜, 옥사프로진, 프라노프로펜, 티아프로펜산, 수프로펜, 메페남산, 메클로페나메이트, 메클로페남산, 플루페남산, 톨페남산, 나부메톤, 페닐부타존, 아자프로파존, 클로페존, 케부존, 메타미졸, 모페부타존, 옥시펜부타존, 페나존, 설핀피라존, 피록시캄, 로르녹시캄, 멜록시캄, 테녹시캄, 셀레콕시브, 에토리콕시브, 루미라콕시브, 파레콕시브, 로페콕시브, 발데콕시브, 니메술리드, 나프록시노드, 플루프로콰존 또는 리코펠론, 오메가-3 및 오메가-6 지방산, 모르핀, 코데인, 옥시코돈, 하이드로코돈, 디아모르핀, 페티딘, 트라마돌, 부페노르핀, 벤조카인, 리도카인, 클로로프로카인, 테트라카인, 프로카인, 아미트립틸린, 카바마제핀, 가바펜틴, 프레가발린, 비사볼롤, Neutrazen™ [INCI: 물, 부틸렌 글리콜, 덱스트란, 팔미토일 트리펩티드-8](Atrium Innovations/Unipex Group에서 시판), Meliprene® [INCI: 덱스트란, 아세틸 헵타펩티드-1](Institut Europeen de Biologie Cellulaire/Unipex Group에서 시판), Skinasensyl™ [INCI: 아세틸 테트라펩티드-15] 또는 Anasensyl™ [INCI: 만니톨, 암모늄 글리시리제이트, 카페인, 히포카스타눔(마로니에) 추출물](Laboratoires Serobiologiques/Cognis에서 시판), Calmosensine™ [INCI: 아세틸 디펩티드-1](Sederma에서 시판), 코엔자임 Q10 또는 알킬글리세린 에테르로 구성되는 그룹으로부터 선택된다.
또한, 다른 특정 실시 형태에서, 미백 또는 피부 탈색제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 서양톱풀(Achillea millefolium), 알로에 베라(Aloe vera), 아라디락타 인디카(Aradirachta indica), 아스무나 자포니카(Asmuna japonica), 아우토카르푸스 인시수스(Autocarpus incises), 비덴스 필로사(Bidens pilosa), 브로우소네티아 파피리페라(Broussonetia papyrifera), 클로렐라 불가리스(Chlorella vulgaris), 승마(Cimicifuga racemosa), 엠블리카 오피시날리스(Emblica officinalis), 감초(Glycyrrhiza glabra), 감초(Glycyrrhiza uralensis), 일렉스 푸르푸레아(Ilex purpurea), 리구스티쿰 루시둠(Ligusticum lucidum), 리구스티쿰 발리치이(Ligusticum wallichii), 미트라카르푸스 스카버(Mitracarpus scaber), 모린다 시트리폴리아(Morinda citrifolia), 뽕나무(Morus alba), 산뽕나무(Morus bombycis), 나린지 크레눌라타(Naringi crenulata), 자두(Prunus domesticus), 개별꽃(Pseudostellariae radix), 소리쟁이(Rumex crispus), 루멕스 오씨덴탈리스(Rumex occidentalis), 무환자나무(Sapindus mukurossi), 삭시프라기아 사르멘토사(Saxifragia sarmentosa), 스쿠텔라리아 갈레리쿨라테(Scutellaria Galericulate), 돌나물(Sedum sarmentosum Bunge), 스텔라리아 메디카(Stellaria medica), 밀(Triticum Vulgare), 우바 우르시(Uva ursi) 또는 휘타니아 솜니페라(Whitania somnifera) 추출물, 플라보노이드, 대두 추출물, 레몬 추출물, 오렌지 추출물, 은행 추출물, 오이 추출물, 제라늄 추출물, 양딸기 추출물, 캐럽 추출물, 계피 추출물, 마죠람 추출물, 로즈마리 추출물, 정향 추출물, 가용성 감초 추출물 또는 블랙베리 잎 추출물, 리포크로만-6 [INCI: 디메틸메톡시 크로마놀] 또는 Chromabright™ [INCI: 디메틸메톡시 크로마닐 팔미테이트](Lipotec에서 시판), Actiwhite™ LS9808 [INCI: 물, 글리세린, 슈크로스 디라우레이트, 폴리소르베이트 20, 완두(Pisum sativum, 완두콩) 추출물] 또는 Dermawhite® NF LS9410 [INCI: 만니톨, 알기닌 HCI, 페닐알라닌, 디소디움 EDTA, 구연산나트륨, 코지산, 시트르산, 효모 추출물](Laboratoires Serobiologiques/Cognis에서 시판), Lumiskin™ [INCI: 카프릴릭/카프릭 트리글리세라이드, 디아세틸-볼딘], Melaclear™ [INCI: 글리세린, 물, 디티아옥탄디올, 글루콘산, 수틸라인, 베타-카로틴], O.D.A.white™ [INCI: 옥타데센디오산] 또는 Etioline™ [INCI: 글리세린, 부틸렌 글리콜, 악토스타필로스 우바 우르시(Arctostaphylos uva ursi) 잎 추출물, 미트라카르푸스 스카버(Mitracarpus scaber) 추출물](Sederma에서 시판), Sepiwhite™ MSH [INCI: 운데실레노일 페닐알라닌](Seppic에서 시판), 아크로막실 [INCI: 물, 브라시카 나푸스(Brassica napus) 추출물](Vincience에서 시판), Gigawhite™ [INCI: 물, 글리세린, 당아욱(Malva sylvestris, 아욱) 추출물, 페퍼민트(Mentha piperita) 잎 추출물, 앵초(Primula veris) 추출물, 성모초(Alchemilla vulgaris) 추출물, 베로니카 오피시날리스(Veronica officinalis) 추출물, 레몬밤(Melissa officinalis) 잎 추출물, 서양톱풀(Achillea millefolium) 추출물], Melawhite® [INCI: 백혈구 추출물, AHA] 또는 Melfade®-J [INCI: 물, 악토스타필로스 우바-우르시 잎 추출물, 글리세린, 마그네슘 아스코르빌 포스페이트](Pentapharm에서 시판), Albatin® [INCI: 아미노에틸포스포릭산, 부틸렌 글리콜, 물](Exsymol에서 시판), Tyrostat™-11 [INCI: 물, 글리세린, 루멕스 오시덴탈리스(Rumex occidentalis) 추출물] 또는 Melanostatine®-5 [INCI: 덱스트란, 노나펩티드-1](Atrium Innovations에서 시판), 아르부틴 및 이의 이성체, 코지산 및 이의 유도체, 아스코르빈산 및 이의 유도체, 예를 들어 6-O-팔미토일아스코르빈산, 아스코르빌 글루코사이드, 디팔미토일아스코르빈산, 아스코르빈산-2-포스페이트의 마그네슘 염(MAP), 아스코르빈산-2-포스페이트의 나트륨 염(NAP), 아스코르빌 테트라이소팔미테이트(VCIP); 레티놀 및 이의 유도체로 트레티노인 및 이소트레티노인을 포함하는 것, 이데베논, 하이드록시벤조산 및 이의 유도체, 나이아신아마이드, 리퀴리틴, 레조르시놀 및 이의 유도체, 하이드로퀴논, α-토코페롤, γ-토코페롤, 아젤라산, 아젤로일 디글리시네이트, 레스베라트롤, 리놀레인산, α-리포산, 디하이드로리포산, α-하이드록시산, β-하이드록시산, 엘라그산, 페룰산, 신남산, 올레아놀산, 알로에신 및 이의 유도체 및/또는 세린 프로테아제 저해제, 이들만으로 제한되지 않는 예를 들어 트립타제, 트립신 또는 PAR-2 저해제로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 멜라닌 합성 자극제, 프로색소침착제, 셀프-태닝제 및/또는 멜라닌세포 증식 자극제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 시트루스 아우란티움 둘시스 프룻(Citrus Aurantium Dulcis Fruit), 콜레우스(Coleus forskohlii), 콜레우스 에스퀴롤리이(Coleus Esquirolii), 콜레우스 스쿠텔라리오데스(Coleus Scutellariodes), 콜레우스 크산탄투스(Coleus Xanthanthus), 발로타 니그라(Ballota nigra), 발로타 라나타(Ballota lanata), 발로타 수아벨렌스(Ballota suavelens), 마루비움 실레네움(Marrubium cylleneum), 시스투스 크레티쿠스(Cistus creticus), 암피아키리스 아모에나(Amphiachyris amoena), 아스터 오하라이(Aster oharai), 오토스테지아 프루티코사(Otostegia fruticosa), 플렉트란투스 바르바투스(Plectranthus barbatus), 할리미움 비스코숨(Halimium viscosum) 또는 라릭스 라리세마(Larix laricema) 추출물, 디하이드록시아세톤 및 이의 유도체, 당, 이들만으로 제한되지 않는 예를 들어, 에리쓰룰로스, 멜라닌 및 이의 유도체로서 멜라닌 폴리머 및 수용성 저분자량을 갖는 멜라닌 유도체를 포함하는 것, 폴스콜린 및 이의 유도체로서 데아세틸폴스콜린 및 이소폴스콜린을 포함하는 것, 타이로신 및 이의 유도체로서 아세틸 타이로신, 올레오일 타이로신, 3-아미노 타이로신 및 3-니트로타이로신을 포함하는 것, CuCl2와 같은 구리 염, 카로티노이드, 칸타잔틴, 디하이드록시인돌 카복실산의 폴리머, 3,4-디하이드록시벤조산, 3-아미노-4-하이드록시벤조산, 알로인, 에모딘, 알리자린, 디하이드록시페닐알라닌, 4,5-디하이드록시나프탈렌-2-설폰산, 3-디메틸아미노페놀 또는 p-아미노벤조산, Melatime™ [INCI: 아세틸 트리펩티드-40](Lipotec에서 시판), Heliostatine IS™ [INCI: 완두(Pisum Sativum) 추출물](Vincience/ISP에서 시판), 베지탄 [INCI: 디하이드록시아세톤] 또는 베지탄 프리미엄 [INCI: 디하이드록시아세톤, 멜라닌](Soliance에서 시판), 멜라노브론즈 [INCI: 비텍스 아그누스 카스투스(Vitex Agnus Castus) 추출물, 아세틸 타이로신](Mibelle Biochemistry에서 시판), Melitane® [INCI: 아세틸 헥사펩티드-1](Institut Europeen de Biologie Cellulaire/Unipex Innovations에서 시판), Actibronze® [INCI: 가수분해된 밀 단백질, 아세틸 타이로신, 카퍼 글루코네이트] 또는 Instabronze® [INCI: 디하이드록시아세톤, 타이로신](Alban Muller에서 시판), 탈리탄 [INCI: 가수분해된 알긴, 황산마그네슘, 황산망간](CODIF에서 시판), Tyrosilane® [INCI: 메틸실라놀 아세틸타이로신](Exsymol에서 시판), Tyr-Excel™ [INCI: 올레오일 타이로신, 수세미오이(Luffa Cylindrica) 종자 오일, 올레산] 또는 Tyr-OI [INCI: 올레오일 타이로신, 부틸렌 글리콜, 올레산](Sederma/Croda에서 시판), 브론징 S.F. [INCI 제안: 부티릴 펜타펩티드](Infinitec Activos에서 시판) 또는 Biotanning® [INCI: 가수분해된 시트루스 아우란티움 둘시스 프룻(Citrus Aurantium Dulcis Fruit) 추출물](Silab에서 시판)로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 항-주름 및/또는 항-노화 약제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 비티스 비니페라(Vitis vinifera), 로사 카니나(Rosa canina), 울금(Curcuma longa), 이리스 팔리다(Iris pallida), 카카오(Theobroma cacao), 은행나무(Ginkgo biloba), 레온토포디움 알피눔(Leontopodium Alpinum) 또는 두날리엘라 살리나(Dunaliella salina) 추출물, Matrixyl® [INCI: 팔미토일 펜타펩티드-4], Matrixyl 3000® [INCI: 팔미토일 테트라펩티드-7, 팔미토일 올리고펩티드], Essenskin™ [INCI: 칼슘 하이드록시메티오닌], 레노베이지 [INCI: 테프레논] 또는 Dermaxyl® [INCI: 팔미토일 올리고펩티드](Sederma에서 시판), Vialox® [INCI: 펜타펩티드-3], Syn®-Ake® [INCI: 디펩티드 디아미노부티로일 벤질아마이드 디아세테이트], Syn®-Coll [INCI: 팔미토일 트리펩티드-5], 피탈루로네이트 [INCI: 구주 콩나무(Ceratonia Siliqua) 검] 또는 Preregen® [INCI: 글리신 소야(대두) 단백질, 산화환원효소](Pentapharm/DSM에서 시판), Myoxinol™ [INCI: 가수분해된 히비스쿠스 에스쿨렌투스(Hibiscus Esculentus) 추출물], Syniorage™ [INCI: 아세틸 테트라펩티드-11], Dermican™ [INCI: 아세틸 테트라펩티드-9] 또는 DN-AGE™ LS [INCI: 카시아 알라타(Cassia Alata) 잎 추출물](Laboratoires Serobiologiques/Cognis에서 시판), Algisum C® [INCI: 메틸실라놀 만누로네이트] 또는 Hydroxyprolisilane CN® [INCI: 메틸실라놀 하이드록시프롤린 아스파테이트](Exsymol에서 시판), Argireline® [INCI: 아세틸 헥사펩티드-8], SNAP-7 [INCI: 아세틸 헵타펩티드-4], SNAP-8 [INCI: 아세틸 옥타펩티드-3], Leuphasyl® [INCI: 펜타펩티드-18], Aldenine® [INCI: 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-1], Preventhelia® [INCI: 디아미노프로피오노일 트리펩티드-33], Decorinyl™ [INCI: 트리펩티드-10 시트룰린], Trylagen® [INCI: 슈도알테로모나스 발효 추출물, 가수분해된 밀 단백질, 가수분해된 대두 단백질, 트리펩티드-10 시트룰린, 트리펩티드-1], Eyeseryl® [INCI: 아세틸 테트라펩티드-5], 펩티드 AC29 [INCI: 아세틸 트리펩티드-30 시트룰린], 리포크로만-6 [INCI: 디메틸메톡시 크로마놀], Chromabright™ [INCI: 디메틸메톡시 크로마닐 팔미테이트], Antarcticine® [INCI: 슈도알테로모나스 발효 추출물], Vilastene™ [INCI: 리진 HCI, 레시틴, 트리펩티드-10 시트룰린], dGlyage™ [INCI: 리진 HCI, 레시틴, 트리펩티드-9 시트룰린], Relistase™ [INCI: 아세틸알기닐트립토필 디페닐글리신] 또는 Inyline™ [INCI: 아세틸 헥사펩티드-30](Lipotec에서 시판), Kollaren® [INCI: 트리펩티드-1, 덱스트란](Institut Europeen de Biologie Cellulaire에서 시판), Collaxyl® IS [INCI: 헥사펩티드-9], Laminixyl IS™ [INCI: 헵타펩티드], Orsirtine™ GL [INCI: 오리자 사티바(Oryza Sativa, 쌀) 추출물], D'Orientine™ IS [INCI: 페닉스 닥틸리페라(Phoenix Dactylifera, 대추야자) 종자 추출물], Phytoquintescine™ [INCI: 외알밀(Triticum Monococcum) 추출물] 또는 Quintescine™ IS [INCI: 디펩티드-4](Vincience/ISP에서 시판), BONT-L-펩티드 [INCI: 팔미토일 헥사펩티드-19](Infinitec Activos에서 시판), Deepaline™ PVB [INCI: 팔미토일 가수분해된 밀 단백질] 또는 Sepilift® DPHP [INCI: 디팔미토일 하이드록시프롤린](Seppic에서 시판), Gatuline® Expression [INCI: 아크멜라 올레라세아(Acmella oleracea) 추출물, Gatuline® In-Tense [INCI: 금유구(Spilanthes Acmella) 꽃 추출물] 또는 Gatuline® Age Defense 2 [INCI: 페르시아 호두(Juglans Regia, 호두) 종자 추출물](Gattefosse에서 시판), Thalassine™ [INCI: 해조류 추출물](Biotechmarine에서 시판), ChroNOIine™ [INCI: 카프로오일 테트라펩티드-3] 또는 티물렌-4 [INCI: 아세틸 테트라펩티드-2](Atrium Innovations/Unipex Group에서 시판), EquiStat [INCI: 피루스 말루스(Pyrus Malus) 과실 추출물, 글리신 소야 종자 추출물] 또는 Juvenesce [INCI: 에톡시디글리콜 및 카프릴릭 트리글리세라이드, 레티놀, 우르솔산, 피토나디온, 일로마스타트](Coletica에서 시판), Ameliox [INC1: 카르노신, 토코페롤, 밀크티슬(Silybum Marianum) 과실 추출물] 또는 PhytoCellTec Malus Domestica [INCI: 말루스 도메스티카(Malus Domestica) 과실 세포 배양물](Mibelle Biochemistry에서 시판), Bioxilift [INCI: 핌피넬라 아니숨(Pimpinella Anisum) 추출물] 또는 SMS Anti-Wrinkle® [INCI: 아노나 스콰모사(Annona Squamosa) 종자 추출물](Silab에서 시판), Ca2 + 채널 차단제, 이들만으로 제한되지 않는 예를 들어 알베린, 망간 또는 마그네슘 염, 특정 2급 또는 3급 아민, 레티놀 및 이의 유도체, 레스베라트롤, 이데베논, 코엔자임 Q10 및 이의 유도체, 보스웰산 및 이의 유도체, GHK 및 이의 유도체 및/또는 염, 카르노신 및 이의 유도체, DNA 수복 효소, 이들만으로 제한되지 않는 예를 들어 포토리아제 또는 T4 엔도뉴클레아제 V, 또는 클로라이드 채널 차단제로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 지질용해제 또는 지질용해 자극제, 정맥강화제 및/또는 항-셀룰라이트제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 시호(Bupleurum Chinensis), 세크로피아 오브투시폴리아(Cecropia Obtusifolia), 맨드라미(Celosia Cristata), 병풀(Centella Asiatica), 명아주(Chenopodium Quinoa), 감국(Chrysanthellum Indicum), 광귤(Citrus Aurantium Amara), 커피나무(Coffea Arabica), 콜레우스(Coleus Forskohlii), 코미포라 뮈라(Commiphora Myrrha), 크리쓰뭄 마리티뭄(Crithmim Maritimum), 유게니아 카리오필루스(Eugenia Caryophyllus), 은행나무(Ginkgo Biloba), 아이비(Hedera Helix; 아이비 추출물), 로젤(Hibiscus Sabdariffa), 일렉스 파라구아리엔시스(Ilex Paraguariensis), 라미나리아 디기타타(Laminaria Digitata), 넬룸비움 스페시오숨(Nelumbium Speciosum), 파울리니아 쿠파나(Paullinia Cupana), 볼도(Peumus Boldus), 필라칸타 피브로사(Phyllacantha Fibrosa), 꿀풀(Prunella Vulgaris), 아몬드(Prunus Amygdalus Dulcis), 루스쿠스(Ruscus Aculeatus)(부처브룸 추출물), 삼부쿠스 니그라(Sambucus Nigra), 스피룰리나(Spirulina Platensis Algae), 운카리아 토멘토사(Uncaria Tomentosa) 또는 마편초(Verbena Officinalis) 추출물, 디하이드로미리세틴, 코엔자임 A, 리파제, 글라우신, 에스쿨린, 비스나딘, Regu®-Shape [INCI: 이성화된 리놀레산, 레시틴, 글리세린, 폴리소르베이트 80](Pentapharm/DSM에서 시판), UCPeptide™ V [INCI: 펜타펩티드] 또는 AT Peptide™ IS [INCI: 트리펩티드-3](Vincience/ISP에서 시판, Liporeductyl® [INCI: 카페인, 부처브룸(Ruscus Aculeatus) 뿌리 추출물, TEA-하이드로요오다이드, 카르니틴, 아이비(Hedera Helix) 추출물, 에스신, 트리펩티드-1](Lipotec에서 시판), 아디포슬림 [INCI: 소르비탄 라우레이트, 라우로일 프롤린](SEPPIC에서 시판), 카페인, 카르니틴, 에스신 및/또는 트리에탄올아민 요오다이드로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 열 쇼크 단백질 합성 자극제는, 이들만으로 제한되지 않는 예를 들어, 부채선인장(Opuntia ficus - indica), 백버들(Salix alba), 루피너스 종(Lupinus spp .), 호밀(Secale cereale) 추출물, 포르피라(Porphyra) 속으로부터의 적색 해조류 추출물, 알테미아(Artemia) 속으로부터의 갑각류 추출물, 호호바 종자 오일, 포도씨유, 녹차 추출물, 게라닐게라닐아세톤, 셀라스트롤, 아연 및 이의 염, 2-사이클로펜텐-1-온, 프로테아좀 저해제, 이들만으로 제한되지 않는 예를 들어 보르테조미브; 프로스타글란딘 및 이의 유도체, 하이드록실아민 및 이의 유도체, 이들만으로 제한되지 않는 예를 들어 비모클로몰; 찰콘 및 이의 유도체, 고삼투압성 작용제, 이들만으로 제한되지 않는 예를 들어 소르비톨 및 이의 유도체, 만니톨 및 이의 유도체 또는 글리세롤 및 이의 유도체, 이소소르비드, 요소 또는 살리실산 및 이의 유도체, Thermostressine™ [INCI: 아세틸 테트라펩티드-22], 또는 이의 혼합물로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 모발 성장 유도제, 모세 순환 및/또는 미세순환에 작용하는 약제, 또는 모발 손실 지연제는, 이들만으로 제한되지 않는 예를 들어, 투실라고 파르파라(Tussilago farfara) 또는 서양톱풀(Achillea millefolium) 추출물, 메틸 또는 헥실 니코티네이트와 같은 C3-C6 알킬 니코티네이트, 벤질 니코티네이트, 또는 토코페릴 니코티네이트와 같은 니코틴산 에스테르; 비오틴, 5α-리덕타제-저해제, 항염제, 레티노이드, 이들만으로 제한되지 않는 예를 들어, 올-트랜스-레티노산 또는 트레티노인, 이소트레티노인, 레티놀 또는 비타민 A, 및 이의 유도체, 예를 들어 아연 염 아세테이트, 팔미테이트, 프로피오네이트, 모트레티니드, 에트레티네이트 및 트랜스-레티노에이트; 항균제, 칼슘 채널 차단제, 이들만으로 제한되지 않는 예를 들어, 신나리진 및 딜티아젬; 호르몬, 이들만으로 제한되지 않는 예를 들어, 에스트리올, 이의 유사체 또는 티록신, 이의 유사체 및/또는 염; 항남성호르몬 약제, 이들만으로 제한되지 않는 예를 들어, 옥센돌론, 스피로노락톤 또는 디에틸스틸베스트롤; 항-라디칼 약제, 에스테르화된 올리고사카라이드, 이들만으로 제한되지 않는 예를 들어, EP 0211610 및 EP 0064012에 기재된 것들; 헥소사카르산 유도체, 이들만으로 제한되지 않는 예를 들어, 글루코사카르산 또는 EP 0375388에 기재된 것들; 글루코시다제 저해제, 이들만으로 제한되지 않는 예를 들어, D-글루카로-1,5-락탐 또는 EP 0334586에 기재된 것들; 글리코사미노글리카나제 및 프로테오글리카나제 저해제, 이들만으로 제한되지 않는 예를 들어, L-갈락토노-1,4-락톤 또는 EP 0277428에 기재된 것들; 타이로신 카나제 저해제, 이들만으로 제한되지 않는 예를 들어, 1-아마이도-1-시아노(3,4-디하이드록시페닐)에틸렌 또는 EP 0403238에 기재된 것들, 디아족사이드, 이들만으로 제한되지 않는 예를 들어, 7-(아세틸티오)-4',5'-디하이드로스피로[안드로스트-4-엔-17,2'-(3H)푸란]-3-온, 3-메틸-7-클로로[2H]-1,2,4-벤조티아디아진 또는 스피로옥사진의 1,1-디옥사이드; 포스포리피드, 이들만으로 제한되지 않는 예를 들어, 레시틴; 살리실산 및 이의 유도체, 하이드록시카복실 또는 케토 카복실산 및 이의 에스테르, 락톤 및 이들의 염; 안트랄린, 에이코사-5,8,11-트리에노산 및 이의 에스테르 또는 아마이드, 미녹시딜 및 유도체 또는 혼합물로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 체모 성장 저해 또는 지연제는, 이들만으로 제한되지 않는 예를 들어, 액티빈 또는 액티빈 효능제, 쿠에르세틴, 쿠르쿠민, 갈란긴, 피세틴, 미리세틴, 아피게닌과 같은 플라보조이드; 프로필 갈레이트, 노르디하이드로구아이아레트산, 카페산, 타이로신 키나제 저해제, 예를 들어 라벤더스틴, 에르브스타틴, 티르포스틴, 벤조퀴논-안사마이신 헤르비마이신 A, 티아졸리딘디온, 페나조신, 2,3-디하이드로-2-티옥소-1H-인돌-3-알카노산, 티오리다진과 같은 페노티아진 유도체; 스핑고신 및 이의 유도체, 스타우로스포린 및 이의 유도체, 글리시레틴산, 라우릴 이소퀴놀리늄 브로마이드, Decelerine™ [INCI: 라우릴 이소퀴놀리움 브로마이드, 슈도알테로모나스 발효 추출물](Lipotec에서 시판) 또는 세린 프로테아제 저해제, 트립신 및/또는 이의 혼합물로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 화장품 및/또는 흡착제 및/또는 체취 마스킹 탈취제 및/또는 발한억제제, 방향성 물질 및/또는 방향성 오일은, 이들만으로 제한되지 않는 예를 들어, 리시놀레산의 아연염 복합체, 스티락스, 비생물산의 유도체, 세이지 에센스, 카모마일 에센스, 카네이션 에센스, 레몬 밤 에센스, 민트 에센스, 계피 잎 에센스, 라임 꽃 에센스, 주니퍼 베리 에센스, 베티버 에센스, 유향 에센스, 풍자향 에센스, 라다넘 에센스, 라벤더 에센스, 페퍼민트 에센스, 베르가못 오렌지, 디하이드로미르세놀, 릴리알, 리랄, 시트로넬롤, 레몬 에센스, 만다린 에센스, 오렌지 에센스, 라벤더 에센스, 뮈스까, 제라늄 버본 에센스, 아니스 열매, 실란트로, 쿠민, 주니퍼, 플뢰르-드-리스, 라일락, 장미, 자스민, 등자 꽃(bitter orange blossom) 추출물; 벤질 아세테이트, p-tert-부틸사이클로헥실 아세테이트, 리날릴 아세테이트, 페닐에틸 아세테이트, 에틸메틸페닐 글리시네이트, 리날릴 벤조에이트, 벤질 포르메이트, 알릴 사이클로헥실 프로피오네이트, 스티랄릴 프로피오네이트, 벤질 살리실레이트, 벤질 에틸 에테르, 8 내지 18 탄소 원자를 갖는 선형 알칸, 시트랄, 리시놀레산, 시트로넬랄, 시트로넬릴 옥시아세트알데하이드, 시클라멘 알데하이드, 하이드록시시트로넬랄, 부르게오날, 이오논, 메틸 세드릴 케톤, 아네톨, 유게놀, 이소유게놀, 게라니올, 리날로올, 테르피네올, 페닐에틸 알코올, α-헥실신남알데하이드, 게라니올, 벤질아세톤, 시클라멘 알데하이드, 암브록산, 인돌, 헤디온, 산델리스, 사이클로버탈, β-다마스콘, 알릴 아밀 글리콜레이트, 디하이드로미르세놀, 페녹시에틸 이소부티레이트, 사이클로헥실 살리실레이트, 페닐아세트산, 게라닐 아세테이트, 로밀라트, 이로틸, 플로라메이트, 활성 수렴성 제품, 예를 들어 염화알루미늄, 알루미늄 클로로하이드레이트, 알루미늄 디클로로하이드레이트, 알루미늄 세스퀴클로로하이드레이트, 알루미늄 하이드록시알란토이네이트, 알루미늄 클로로타르트레이트, 알루미늄 및 지르코늄 트리클로로하이드레이트, 알루미늄 및 지르코늄 테트타클로로하이드레이트, 알루미늄 및 지르코늄 펜타클로로하이드레이트 및/또는 이의 혼합물로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서 항산화제는, 이들만으로 제한되지 않는 예를 들어, 부틸하이드록시톨루엔(BHT), 부틸하이드록시아니솔(BHA), tert-부틸하이드로퀴논(TBHQ), 2,6,-디-tert-부틸-4-메틸페놀, 갈릭산 에스테르, 예를 들어 프로필 갈레이트, 프로부콜, 폴리페놀, 아스코르빈산 및 이의 염, 카탈라제, 수퍼옥사이드 디스뮤타제 및 퍼옥시다제와 같은 효소; 시트르산, 시트레이트, 모노글리세라이드 에스테르, 칼슘 메타비설페이트, 락트산, 말산, 숙신산, 타르타르산, 비타민 A 또는 β-카로틴, 비타민 E 및 C, 비타민 E 아세테이트와 같은 토코페롤, 아스코르빌 팔미테이트 및 아스코르빌 아세테이트와 같은 아스코르빈산 에스테르, 아연, 구리, 만니톨, 환원된 글루타치온, 크립토잔틴, 아스타잔틴 및 리코펜과 같은 카로티노이드; 시스테인, 요산, 카르니틴, 타우린, 타이로신, 루테인, 제아잔틴, N-아세틸-시스테인, 카르노신, γ-글루타밀시스테인, 쿠에르세틴, 락토페린, 디하이드로리포산, 차 카테킨, 레티닐 팔미테이트 및 이의 유도체, 비설페이트, 메타비설파이트 및 소디움 설파이트, 크로만, 크로멘 및 이의 유사체, 리포크로만-6 [INCI: 디메틸메톡시 크로마놀], EDTA와 같은 금속 킬레이트제, 소르비톨, 포스포산 또는 dGlyage™ [INCI: 리진 HCl, 레시틴, 트리펩티드-9 시트룰린]; 은행나무(Ginkgo Biloba) 추출물, 세이지, 석류, 로즈마리, 오레가노, 생강, 마죠람, 크랜베리, 포도, 토마토, 녹차 또는 홍차와 같은 식물 추출물; 올레오레진 추출물, 바닐린, 엘라그산 및 레스베라트롤과 같은 페놀을 함유하는 식물 추출물; 3급 부틸하이드로퀴논 또는 이의 혼합물, 셀레늄, 카드뮴, 바나듐 또는 아연과 같은 2가의 금속 염; α-리포산, 코엔자임 Q, 이데베논 또는 이의 유도체로 구성되는 그룹으로부터 선택된다.
특정 실시 형태에서, 땀-분해 효소 저해제는, 이들만으로 제한되지 않는 예를 들어, 트리메틸 시트레이트, 트리프로필 시트레이트, 트리이소프로필 시트레이트, 트리부틸 시트레이트 또는 트리에틸 시트레이트와 같은 트리알킬 시트레이트; 라노스테린 설페이트 또는 포스페이트, 콜레스테린, 캄페스테린, 스티그마스테린 및 시토스테린; 글루타르산, 모노에틸 글루타레이트, 디에틸 글루타레이트, 아디프산, 모노에틸 아디페이트, 디에틸 아디페이트와 같은 디카복실산 및 이의 에스테르; 말론산 및 디에틸 말로네이트, 하이드록시카복실산 및 이들의 에스테르, 예를 들어 말산, 타르타르산 또는 디에틸 타르타레이트, 징크 글리시네이트 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
또 다른 특정 실시 형태에서, 자외선을 차단할 수 있는 약제는, 이들만으로 제한되지 않는 예를 들어, A 및/또는 B 자외선에 대하여 활성인 유기 또는 미네랄 광보호제, 예를 들어 치환된 벤조트리아졸, 치환된 디페닐아크릴레이트, 유기 니켈 복합체, 움벨리페론, 우로칸산, 비페닐 유도체, 스틸벤, 3-벤질리덴 캄포, 및 이의 유도체, 예를 들어 3-(4-메틸벤질리덴)캄포; 4-아미노벤조산의 유도체, 2-에틸헥실 4-(디메틸아미노)벤조에이트, 2-옥틸 4-(디메틸아미노)벤조에이트 및 아밀 4-(디메틸아미노)벤조에이트; 신남산 에스테르, 예를 들어 2-에틸헥실 4-메톡시신나메이트 또는 디에틸아미노 하이드록시벤조일 헥실 벤조에이트, 프로필 4-메톡시신나메이트, 이소아밀 4-메톡시신나메이트, 2-에틸헥실 (옥토크릴렌즈) 2-시아노-3,3-페닐 신나메이트; 살리실산 에스테르, 예를 들어 2-에틸헥실 살리실레이트, 4-이소프로필벤질 살리실레이트, 호모멘틸 살리실레이트; 벤조페논 유도체, 예를 들어 2-하이드록시-4-메톡시벤조페논, 2-하이드록시-4-메톡시-4'-메틸벤조페논, 2,2'-디하이드록시-4-메톡시벤조페논; 벤잘말론산 에스테르, 예를 들어 디-2-에틸헥실 4-메톡시벤잘말로네이트; 트리아진 유도체, 예를 들어 2,4,6-트리아닐리노, p-카보-2'-에틸-1'-헥실옥시-1,3,5-트리아진, 옥틸 트리아존 또는 디옥틸 부타마이도 트리아존; 프로판-1,3-디온, 예를 들어 1-(4-tert-부틸페닐)-3-(4'-메톡시페닐)프로판-1,3-디온; 케토트리사이클로(5.2.1.0)데칸 유도체; 2-페닐벤즈이미다졸-5-설폰산; 벤조페논 설폰산 유도체, 예를 들어 2-하이드록시-4-메톡시벤조페논-5-설폰산 및 이의 염; 4-(2-옥소-3-보르닐리덴메틸)벤젠설폰산, 벤조일 메탄 유도체, 예를 들어 벤조일 메탄 2-메틸-5-(2-옥소-3-보르틸리덴메틸)설폰산, 예를 들어 1-(4'-tert-부틸페닐)-3-(4'-메톡시페닐)프로판-1,3-디온, 4-tert-부틸-4'-메톡시디벤조일메탄, 1-페닐-3-(4'-이소프로필페닐)-프로판-1,3-디온, 에나민 화합물, 안트라닐레이트, 실리콘, 벤즈이미다졸 유도체, 이미다졸린, 벤조일 유도체, Chromabright™ [INCI: 디메틸메톡시 크로마닐 팔미테이트] 또는 Preventhelia® [INCI: 디아미노프로피오노일 트리펩티드-33](둘 다 Lipotec에서 시판), 금속 옥사이드, 예를 들어 산화아연, 티타늄, 철, 지르코늄, 규소, 망간, 알루미늄 및 세륨; 실리케이트, 탈크, 황산바륨, 스테아린산아연, 탄소 나노튜브 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
추가로, 또 다른 특정 실시 형태에서, 케라틴세포 분화 자극 또는 조절제는, 이들만으로 제한되지 않는 예를 들어, 칼슘과 같은 미네랄, 레티놀 또는 트레티노인과 같은 레티노이드, 칼시트리올, 칼시포트리올 또는 타칼시톨과 같은 비타민 D3 유사체, SILAB에서 Structurin® [INCI: 가수분해된 루핀 단백질]의 이름으로 시판하는 것과 같은 루핀(Lupinus albus) 추출물, Vincience/ISP에서 Phytocohesine PSP® [INCI: 베타-시토스테롤 황산나트륨]의 이름으로 시판하는 것과 같은 β-시토스테롤 설페이트, Solabia에서 Phytovityl C® [INCI: 물(Aqua), 제아 메이스 추출물]의 이름으로 시판하는 것과 같은 옥수수(Zea Mays) 추출물, 달팽이 점액(Helix Aspersa Muller) 당복합체(glycoconjugates) 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택된다.
마찬가지로, 또 다른 특정 실시 형태에서, 근이완제, 근육 수축 억제제, 아세틸콜린 수용체 군집 억제제 및/또는 항콜린효능제는, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 벨라돈나(Atropa belladonna), 사리풀(Hyoscyamus niger), 맨드레이크(Mandragora officinarum), 콘도덴드론 토멘토숨(Chondodendron tomentosum), 브루그만시아(Brugmansia) 속, 또는 다투라(Datura) 속 식물의 추출물, 클로스트리듐 보툴리눔(Clostridium botulinum) 독소, 단백질 SNAP-25로부터 유래된 펩티드 또는 Inyline™ [INCI: 아세틸 헥사펩티드-30](Lipotec에서 시판), 바클로펜, 카비도파, 레보도파, 브로모크립틴, 클로르페네신, 클로르족사존, 도네페질, 메페녹살론, 레저핀, 테트라베나진, 단트롤렌, 티오콜키코사이드, 티자니딘, 클로니딘, 프로사이클리딘, 글리코피롤레이트, 아트로핀, 히오시아민, 벤즈트로핀, 스코폴라민, 프로메타진, 디펜히드라민, 디멘히드리네이트, 디사이클로민, 사이클로벤자프린, 오르페나드린, 플라복세이트, 사이클로펜톨레이트, 이프라트로피움, 옥시부티닌, 피렌제핀, 티오트로피움, 트리헥시페니딜, 톨테로딘, 트로피카마이드, 솔리페나신, 다리페나신, 메베베린, 트리메타판, 아트라큐리움, 시사트라큐리움, 독사큐리움, 파자디니움, 메토큐린, 미바큐리움, 판큐로니움, 피페큐로니움, 라파큐로니움, 투보큐라닌, 디메틸 튜보큐라닌, 로큐로니움, 베큐로니움, 숙사메토니움, 18-메톡시코로나리딘, 카리소프로돌, 페바르바메이트, 메프로바메이트, 메토카르바몰, 펜프로바메이트, 티바메이트, 항경련제, 예를 들어 레베티라세탐, 스티리펜톨, 페노바르비탈, 메틸페노바르비탈, 펜토바르비탈, 메타르비탈, 바르벡사클론, 피리미돈, 카바마제핀, 옥스카바제핀, 벤조디아제핀, 이들만으로 제한되지 않는 예를 들어, 클로나제팜, 클록사졸람, 클로라제페이트, 디아제팜, 플루토프라제팜, 로라제팜, 미다졸람, 니트라제팜, 니메타제팜, 페나제팜, 테마제팜, 테트라제팜 또는 클로바잠으로 구성되는 그룹으로부터 선택된다.
또 다른 실시 형태에서, 본 발명의 나노캡슐은, 마이크로에멀젼의 수성 상중 또는 지질 매트릭스에서 현탁액 또는 용액 중 나노캡슐의 내부에서 발견될 수 있는, 임의의 특성의 소수성, 친수성 또는 양친매성의 보조제 및/또는 다른 약제학적 활성 성분을 포함한다. 특히, 약제학적 활성 성분 및/또는 보조제는, 이들만으로 제한되지 않는 예를 들어, 제산제, 위궤양 및 위식도 역류 질환에 대한 약제, 진경제, 진통제, 항콜린효능 약물, 추진 약물, 항구토제, 구토방지 약물, 담즙 치료용 약제, 간 치료용 약제, 항지방간제, 완화제, 지사제, 장관 흡착제, 항추진제, 항염성 약물, 비만에 대한 활성 성분, 효소, 혈당강하제, 인슐린 및 유사체, 비타민, 단백질, 미네랄, 동화작용 스테로이드, 항혈전제, 항섬유소용해제, 지혈제, 항부정맥 약제, 강심제, 심장 글리코사이드, 혈관확장제, 항아드레날린효능 약제, 항고혈압 약물, 이뇨제, 칼륨-절약 약제, 항치질약, 항정맥류 치료 약제, 모세혈관 안정화 약제, 레닌-안지오텐신 시스템에 작용하는 약제, 베타-차단제, 선택적 칼슘-채널 차단제, 비-선택적 칼슘-채널 차단제, ACE 저해제, 안지오텐신 II 저해제, 지질 조정 약제, 항진균제, 치유 약제, 항소양제, 항히스타민제, 마취제, 항건선제, 화학요법 약물, 코르티코스테로이드, 방부제, 소독제, 항-여드름 약제, 부인과용 제품, 자궁수축제, 피임제, 안드로겐, 에스트로겐, 프로제스타겐, 배란 자극제, 고나도트로핀, 항안드로겐제, 비뇨기용 제품, 진경제, 경증의 전립선 비대증에 사용되는 약물, 호르몬제, 호르몬 길항제, 항생제, 테트라사이클린, 안페니콜, 베타-락탐 항균제, 페니실린, 설폰아마이드, 트리메토프림, 마크로라이드, 린코사마이드, 스트렙토그라민, 항균성 아미노글리코사이드, 항균성 퀴놀론, 항바이러스제, 면역 혈청, 면역글로불린, 항종양 약제, 면역조절 약제, 알킬화제, 항대사성 물질, 식물 알칼로이드 및 다른 천연 제품, 세포독성 항생제, 면역억제제, 근골격계 장애용 약물, 항류마티스제, 근육이완제, 뼈 구조 및 미네랄화에 영향을 주는 약제, 신경계에 작용하는 약물, 전신 마취제, 국소 마취제, 오피오이드, 항편두통 약제, 항경련제, 항콜린효능 약제, 도파민효능 약제, 항정신병약, 항불안제, 최면제, 진정제, 항우울제, 정신자극제, 항-치매 약물, 부교감신경 모방제, 중독성 장애에 사용하는 약물, 항-현기증 약제, 항기생충 약제, 살충제, 해충 퇴치제, 비충혈 완화제, 점액용해제, 기침 억제제, 안과 활성 성분, 이과 활성 성분, 항녹내장 약물, 축동제, 산동제, 안근마비제 및/또는 이의 혼합물로 구성되는 그룹으로부터 선택된다.
또 다른 실시 형태에서, 화장품 및/또는 약제학적 활성 성분 및/또는 보조제를 함유하는 본 발명의 나노캡슐은 제조 전 또는 후에 섬유 재료의 천연 또는 합성 섬유로 도입될 수 있다. 본 발명에서 섬유 재료는 직물, 부직포, 의복 및 의료 기구로 이해된다. 이들 섬유 재료는 신체의 피부에 직접 접촉하여, 직물, 부직포 또는 의료 기구와의 결합 시스템의 생분해에 의해, 또는 이들과 신체 사이의 마찰, 신체 수분, 피부의 pH 또는 체온으로 인해 본 발명의 전달 시스템으로 도입된 활성 성분을 방출한다. 전달 시스템의 부동화를 위한 수단 및 직물, 부직포, 의복, 의료 기구의 예는 선행기술(J. Cont . Release 2004, 97, 313-320)에서 발견될 수 있다. 바람직한 섬유 재료에서 전달 시스템의 부동화 수단은 풀라드(foulard), 염욕(exhaustion bath) 또는 스프레이에 의한 적용이다. 천연 및/또는 합성 섬유는 무엇보다도 모, 면, 실크, 나일론 섬유, 셀룰로스, 폴리아마이드 또는 폴리에스테르일 수 있다. 섬유 재료 중에서 바람직한 직물, 부직포, 의복 및 의료 기구는 붕대, 거즈, t-셔츠, 양말, 타이즈, 속옷, 거들, 장갑, 기저귀, 생리대, 드레싱, 침대보, 와입스(wipes), 하이드로겔, 접착성 패치, 비-접착성 패치, 마이크로-일렉트릭 패치 및/또는 안면 마스크이다.
또 다른 태양에 따라, 본 발명은 본 발명의 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물과 관련된다.
본 발명의 나노캡슐은 고형 유기 폴리머 또는 고형 미네랄 지지체, 이들만으로 제한되지 않는 예를 들면 무엇보다도, 탈크, 벤토나이트, 실리카, 전분 또는 말토덱스트린으로 흡착될 수 있다.
본 발명의 나노캡슐은 임의의 형태의 기능성 식품 또는 강화 식품으로, 또는 경구용 화장품 또는 뉴트리코스메틱으로 도입될 수 있고, 경구용 조성물 또는 영양 보충제를 위한 통상의 부형제 및 보조제, 이들만으로 제한되지 않는 예를 들어, 지방 성분, 수성 성분, 습윤제, 보존제, 텍스처라이저, 향미제, 방향제, 항산화제, 그리고 식품 산업에서 통상적으로 사용되는 식품 착색제와 함께 제형화될 수 있다.
본 발명의 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물은 본 분야의 기술자에게 알려진 통상적인 방법에 의해 제조될 수 있다. 본 발명의 나노캡슐을 도입하는 화장품, 약제학적 및/또는 식이성 조성물은 임의의 종류의 농축, 용해, 희석, 분산, 분쇄, 스프레이 과정, 또는 본 분야의 기술자에게 알려진 임의의 다른 유사한 공정을 수행하지 않고 적용할 수 있는 최종 조성물이거나, 최종 조성물을 얻는 목적으로 본 분야의 기술자에게 알려진 임의의 다른 공정이나 이전 공정의 하나 또는 몇 가지를 실시하게 되는 중간 조성물일 수 있다.
본 발명의 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물은 국소 또는 경피 투여에 의해, 경구적으로, 또는 임의의 다른 종류의 적절한 경로, 예를 들어 비경구로 투여될 수 있고, 원하는 투여 방법의 제형화를 위해 필요한 화장품으로 및/또는 약제학적으로 허용 가능한 부형제가 포함될 것이다. 본 발명에서, “비경구(parenteral)”라는 용어는 코, 귀, 눈, 직장, 요도 및 질 경로, 피하, 피부내, 정맥내와 같은 혈관내, 근육내, 안내, 유리체내, 각막내, 척수내, 골수내, 두개내, 자궁경부내, 뇌내, 뇌막내, 관절내, 간내, 흉내, 기관내, 척추강내 및 복막내 주사 뿐 아니라 임의의 다른 유사한 주사 또는 주입 기술을 포함한다.
본 발명의 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물은 원하는 투여 방법의 제형화를 위해 필요한 화장품으로 및/또는 약제학적으로 허용 가능한 부형제를 임의로 포함하는 다른 종류의 국소 및 경피 적용 조성물에 사용될 수 있다. 국소 또는 경피 적용 조성물은 임의의 고형, 액체 또는 반-고형 제형, 이들만으로 제한되지 않는 예를 들어 크림, 복합 에멀젼, 이들만으로 제한되지 않는 예를 들어 수성 에멀젼 중의 오일 및/또는 실리콘, 유중수 및/또는 실리콘 에멀젼, 물/오일/물 또는 물/실리콘/물 타입 에멀젼, 및 오일/물/오일 또는 실리콘/물/실리콘 타입 에멀젼, 무수 조성물, 수성 분산액, 오일, 밀크, 발삼, 폼, 로션, 겔, 크림 겔, 하이드로알코올 용액, 하이드로글리콜 용액, 하이드로겔, 리니먼트, 세라, 비누, 샴푸, 컨디셔너, 세럼, 다당류 필름, 연고, 무스, 포마드, 산제, 바, 펜슬 및 스프레이 또는 에어졸로 제공될 수 있으며, 이들은 리브-온(leave-on) 및 린스-오프(rinse-off) 제형을 포함한다. 이들 국소 및 경피 적용 제형은 본 분야의 기술자에게 알려진 기술에 의해 다른 종류의 고형 액세서리, 이들만으로 제한되지 않는 예를 들어 붕대, 거즈, t-셔츠, 양말, 타이즈, 속옷, 거들, 장갑, 기저귀, 생리대, 드레싱, 침대보, 와입스, 접착성 패치, 비-접착성 패치, 마이크로일렉트릭 패치 또는 안면 마스크로 도입되거나, 메이크-업 파운데이션, 예를 들면 무엇보다도, 액체 파운데이션 및 콤팩트 파운데이션, 메이크-업 제거 로션, 메이크-업 제거 밀크, 언더-아이 컨실러, 아이새도우, 립스틱, 입술 보호제, 립글로스 및 파우더와 같은 다른 메이크-업 제품으로 도입될 수 있다. 본 발명의 화장품 또는 피부약제학적 조성물은 또한, 무엇보다도 네일 바니쉬, 네일 바니쉬 제거 로션 및 큐티클 제거 로션과 같은 네일 및 큐티클의 케어 및/또는 처치를 위한 제품으로 도입될 수 있다.
본 발명의 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물은 경구 투여를 위한 다른 종류의 제형으로, 바람직하게는 경구 화장품 또는 약물, 이들만으로 제한되지 않는 예를 들어, 젤라틴 캡슐, 연질 캡슐, 경질 캡슐을 포함하는 캡슐, 당의정을 포함하는 정제, 산제, 과립제, 추잉검, 용액제, 현탁제, 에멀젼, 시럽제, 다당류 필름, 젤리 또는 젤라틴 및 본 분야의 기술자에게 알려진 임의의 다른 형태로 사용될 수 있다.
또 다른 특정 실시 형태에서, 본 발명의 나노캡슐을 포함하는 조성물은 섬유 재료의 처리를 위해 사용될 수 있고, 에멀젼, 린스 보조제, 린스제, 섬유 유연제, 스프레이, 액체 비누 또는 겔의 제조에 있어서 세제 및 액체 형태의 세정제에서, 또는 분말, 과립 또는 압축 제품과 같은 고형 형태에서 발견될 수 있다. 또한, 이들 조성물은 다른 성분, 이들만으로 제한되지 않는 예를 들어 계면활성제, 경피 흡수 증가제, 섬유 재료 전 처리제, 마스크 처리제, 연마제, 연수제, 섬유 유연제, 용매 또는 가용화제, 감촉 및 마감 변화제, 방오제, 정전기방지제, 효소, 다림질 보조제, 색 및/또는 착색제 브라이트닝제, 샤인제(shine agents), 옵티칼 클리어링제(optical clearing agents), 재침착 억제제(graying inhibitors) 또는 때를 느슨하게 하는 화합물, 색 전이 억제제, 포바이징(phobizing) 및 함침제, 팽윤 또는 농후제, 농도-발생제, 실리콘제, 마이크로캡슐의 경피 흡수 증가제, 미백제 및 섬유 재료 표백 활성화제, 친수화제 및/또는 이의 혼합물을 포함한다.
본 발명의 또 다른 태양은 본 발명의 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물의 피부, 두피, 모발 및 네일의 케어 및/또는 치료를 위한 용도와 관련된다. 바람직하게는, 피부, 모발, 두피 및/또는 네일의 케어 및/또는 치료는 피부 노화의 방지 및/또는 치료, 피부 및/또는 두피의 치유, 피부 질병의 피부과학적 치료, 세포염의 예방 및/또는 치료, 피부 태닝, 피부 라이트닝 또는 미백 및 모발 손실의 예방 및/또는 치료로 구성되는 그룹으로부터 선택된다.
본 발명에서, “노화(aging)”라는 용어는 나이(시간에 따른 노화)에 따라, 또는 태양(광노화) 또는 담배 연기, 냉기 또는 바람의 극한 기후 조건, 화학적 오염원 또는 오염에 노출되는 것에 의해 피부가 경험하는 변화와 관련되며, 촉각에 의해 감지될 수 있는 것, 이들만으로 제한되지 않는 예를 들어 주름, 미세선, 골, 불균일 또는 거침과 같은 피부에서의 불연속성의 전개, 모공 크기의 증가, 탄력 손실, 강도 손실, 매끄러움의 손실, 변형으로부터의 회복 능력의 손실, 피부의 처짐, 예를 들면 무엇보다도, 볼 처짐, 눈 아래 주머니가 나타나거나 이중턱이 나타나는 것, 피부 색상의 변화, 예를 들면 무엇보다도, 반점, 적색화, 눈 아래 주머니, 검버섯이나 주근깨와 같은 과도색소침착 부위의 출현, 비정상적 분화, 과각화, 탄력섬유증, 각화증, 모발 손실, 오렌지-껍질 피부, 콜라겐 구조의 손실 및 각질층, 피부, 표피, 혈관계(예를 들어, 거미 혈관이나 말초혈관확장증의 출현) 또는 피부 근처 조직의 다른 조직학적 변화뿐만 아니라 모든 외적인 가시적 변화를 포함한다.
본 발명의 또 다른 태양은, 본 발명의 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물의 섬유 재료의 처리를 위한 용도와 관련된다.
이하에서 제공되는 다음의 특정 실시예는 본 발명의 특성을 예시하기 위한것이다. 이들 실시예는 전적으로 예시 목적을 위해 포함되며 본원에서 청구하는 발명에 대한 한정으로 해석되어서는 안된다.
실시예
일반적인 방법론
모든 시약들 및 용매들은 합성 등급이고 임의의 추가적 처리 없이 사용된다.
고압 균질화는 Microfluidics의 “M110-Y” 모델 미세유동화기에서 실시되었다. 마이크로에멀젼의 형성을 위한 Ultraturrax 믹서는 Miccra RT의 “D-8” 모델이다.
마이크로에멀젼의 형성에서 친수성 열불안정성 펩티드는 복합 코아세르베이션에 의해 나노캡슐화되었다. 나노캡슐의 지질 매트릭스는 액체 지질 또는 오일만을 포함하고, 따라서 전 공정을 통해 열을 적용할 필요가 없으며 펩티드의 분해가 방지되었다.
실시예
1
액체 지질을 포함하는
코아세르베이트
나노캡슐에서 이들의 후속 캡슐화를 위한 친수성 펩티드의
마이크로에멀젼의
제조
실시예
1-a. 펩티드 H-
Dpr
-
Ala
-
Asn
-
His
-
OH
의
마이크로에멀젼
듀코세이트 [INCI: 디에틸헥실 소디움 설포숙시네이트] 및 이소스테아린산 [INCI: 이소스테아린산] (상 A)을 적절한 용기 내에서 함께 혼합하였다.
다른 용기에는 펩티드 H-Dpr-Ala-Asn-His-OH를 에탄올 [INCI: 알코올]에 용해시켰다. 일단 용해된 후에 물을 첨가하였다 (상 B).
교반 하에 상 B를 상 A에 천천히 가하였다.
실시예
1-b. 펩티드
Ac
-
Arg
-
Asn
-
His
-
Cit
-
NH
2
의
마이크로에멀젼
듀코세이트 [INCI: 디에틸헥실 소디움 설포숙시네이트] 및 이소스테아린산 [INCI: 이소스테아린산] (상 A)을 적절한 용기 내에서 함께 혼합하였다.
다른 용기에는 펩티드 Ac-Arg-Asn-His-Cit-NH2를 물에 용해시켰다. 일단 용해된 후에 에탄올 [INCI: 알코올]을 첨가하였다 (상 B).
교반 하에 상 B를 상 A에 천천히 가하였다.
실시예
2
액체 지질만을 포함하는 친수성
마이크로에멀젼화된
펩티드와의
코아세르베이트
나노캡슐의 제조
적절한 용기 내에 다음을 이 순서로 첨가하였다: 물, 아미겔 [INCI: 균핵 검], 히알루론산 [INCI: 히알루론산 나트륨], 제메아 [INCI: 프로판디올] 및 페녹시에탄올 [INCI: 페녹시에탄올] (성분 A). 그리고 이 혼합물을 균질화에 도달할 때까지 교반하였다.
다른 용기에 실시예 1에 따라 제조된 해당 펩티드의 마이크로에멀젼, 대두 오일 [INCI: 글리신 소야(대두) 오일], Arlacel 83 [INCI: 소르비탄 세스퀴올레이트], 및 Arlamol HD [INCI: 이소헥사데칸](성분 B)을 혼합하였다.
다음에, 성분 B의 혼합물을 성분 A의 혼합물에 에멀젼이 형성될 때까지 터빈으로 교반하면서 가하였다.
마지막으로, 혼합물을 미세유동화기 내에서 가압하여 입구 압력 80 bar 및 출구 압력 15000 psi로 3 사이클 동안 균질화하였다. 전 공정에 걸쳐 샘플은 물/글리콜 냉장 순환에 의해 25℃로 유지되었다.
다음에, 물 중의 Quat Soy LDMA 25 [INCI: 라우릴디모늄 하이드록시프로필 가수분해된 대두 단백질](성분 C)를 교반 하에 적가하였다.
펩티드 H-Dpr-Ala-Asn-His-OH에 대해서는, 실시예 1-a에 따라 제조된 마이크로에멀젼이 사용되었다.
얻어진 현탁액에서, 펩티드 H-Dpr-Ala-Asn-His-OH를 포함하고 동적 레이저광 산란(Dynamic Laser Light Scattering)에 의해 측정된 캡슐의 평균 크기는 235㎚였다.
펩티드 Ac-Arg-Asn-His-Cit-NH2에 대해서는, 실시예 1-b에 따라 제조된 마이크로에멀젼이 사용되었다.
얻어진 현탁액에서, 펩티드 Ac-Arg-Asn-His-Cit-NH2를 포함하고 동적 레이저광 산란(Dynamic Laser Light Scattering)에 의해 측정된 캡슐의 평균 크기는 303㎚였다.
펩티드의 캡슐화에 있어서, 캡슐화 및 비-캡슐화된 활성 성분의 분리는 바스켓 원심분리 기술[David W. Fry et al . Analytical Biochemistry 90: 809-815 (1978)]에 의해 실시되었다. 일단 양쪽 분획이 분리된 후, 비-캡슐화된 부분을 HPLC에 의해 분석하였다. 어떤 경우에도 분산액의 수성 상에서 펩티드 존재가 검출되지 않았으며, 따라서 캡슐화 효율은 거의 100%였다.
Claims (19)
- 액체 지질 중 물의 마이크로에멀젼을 포함하고 내부 수성 상에 용해된 적어도 하나의 친수성 활성 성분을 포함하는 폴리머 코팅된 나노캡술.
- 제1항에 있어서,
액체 지질은 식물성 오일, 대두유, 해바라기씨유, 옥수수유, 올리브유, 야자유, 면실유, 평지유, 낙화생유, 코코넛유, 피마자유, 아마인유, 보라지유, 달맞이꽃유, 수산 오일, 어유, 해조류 오일, 석유로부터 유래된 오일, 광유, 액체 파라핀, 바세린, 단쇄 지방산 알코올, 중쇄 지방족 분지 지방산 알코올, 단쇄 알코올과의 지방산 에스테르, 이소프로필 미리스테이트, 이소프로필 팔미테이트, 이소프로필 스테아레이트, 디부틸 아디페이트, 중쇄 트리글리세라이드, 카프릭 및 카프릴릭 트리글리세라이드, C12-C16 옥타노에이트, 지방산 알코올 에테르, 디옥틸 에테르 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택되는 나노캡슐. - 제1항에 있어서,
코팅의 폴리머는 단백질, 다당류, 폴리에스테르, 폴리아크릴레이트, 폴리시아노아크릴레이트, 코폴리머 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택되는 나노캡슐. - 제3항에 있어서,
코팅의 폴리머는 젤라틴, 알부민, 대두 단백질, 완두콩 단백질, 잠두 단백질, 감자 단백질, 밀 단백질, 유청 단백질, β-락토글로불린, 카제이네이트, 밀 전분, 옥수수 전분, 제인, 알기네이트, 카라기난, 펙틴, 아라비노갈락탄, 아라비아검, 잔탄검, 메스키트검, 트라가칸트검, 갈락토만난, 구아검, 캐럽시드검, 키토산, 한천, 폴리(L-리진), 덱스트란 설페이트 소디움, 카복시메틸 갈락토만난, 카복시메틸 셀룰로스, 메틸 셀룰로스, 에틸 셀룰로스, 하이드록시프로필메틸 셀룰로스, 셀룰로스 니트레이트, 셀룰로스 아세테이트 부티레이트, 셀룰로스 아세테이트 프탈레이트, 셀룰로스 하이드록시프로필 메틸 프탈레이트, 셀룰로스 하이드록시프로필 메틸 아세테이트 숙시네이트, 폴리비닐 아세테이트 프탈레이트, 폴리(ε-카프로락톤), 폴리(p-디옥사논), 폴리(δ-발레로락톤), 폴리(β-하이드록시부티레이트), 폴리(β-하이드록시부티레이트) 및 β-하이드록시발레레이트 코폴리머, 폴리(β-하이드록시프로피오네이트), 메틸아크릴산 코폴리머, 디메틸아미노에틸 메타크릴레이트 코폴리머, 트리메틸암모늄 에틸 메타크릴레이트 코폴리머, 락트산 및 글리콜산 폴리머 및 코폴리머, 락트산 및 글리콜산 및 폴리에틸렌 글리콜 폴리머 및 코폴리머 및 이들의 혼합물로 구성되는 그룹으로부터 선택되는 나노캡슐. - 제1항에 있어서,
코팅의 폴리머는 양이온 폴리머인 나노캡슐. - 제5항에 있어서,
양이온 폴리머는 셀룰로스의 양이온 유도체, 4급화된 하이드록시에틸 셀룰로스, 양이온 전분, 디알릴 암모늄 및 아크릴아마이드염 코폴리머; 4급화된 비닐피롤리돈/비닐이미다졸 폴리머, 폴리글리콜과 아민의 축합 산물, 폴리쿼터늄 폴리머 및 코폴리머, 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-16, 폴리쿼터늄-10 Merquats로 불리우는 폴리머, 폴리쿼터늄-4 코폴리머, 디코코일에틸하이드록시에틸암모늄, 셀룰로스 골격 및 4급 암모늄 그룹과의 그래프트 코폴리머; 4급화된 콜라겐 폴리펩티드, 라우릴디모늄 하이드록시프로필 가수분해된 콜라겐, 4급화된 밀 폴리펩티드, 폴리에틸렌이민, 양이온 실리콘 폴리머, 아마이도메티콘 또는 쿼터늄-22 실리콘, 아디프산 및 디메틸아미노 하이드록시프로필 디에틸렌트리아민 코폴리머, 디메틸디알릴암모늄 클로라이드와의 아크릴산 코폴리머, 양이온 키틴 유도체, 키토산 및 이의 유도체, 양이온 디할로겐 알킬렌의 축합 산물, 비스디알킬아민과 디브로모부탄의 축합 산물, 비스-디메틸아미노-1,3-프로판, 양이온 구아검의 유도체, 구아-하이드록시프로필트리모늄, 4급 암모늄염 폴리머, 아자로스와 같은 천연 유도체의 4급화된 다당류 폴리머, 젤라틴의 양이온 단백질, 아라비아 검의 양이온 단백질, 폴리아마이드의 양이온 폴리머, 폴리시아노아크릴레이트의 양이온 폴리머, 폴리락타이드의 양이온 폴리머, 폴리글리콜라이드의 양이온 폴리머, 폴리아닐린의 양이온 폴리머, 폴리피롤의 양이온 폴리머, 폴리비닐피롤리돈의 양이온 폴리머, 아미노 실리콘 폴리머 및 코폴리머의 양이온 폴리머, 폴리스티렌의 양이온 폴리머, 폴리비닐 알코올의 양이온 폴리머, 폴리스티렌 및 말레인산 무수물 코폴리머의 양이온 폴리머, 메틸 비닐 에테르의 양이온 폴리머, 에폭시 수지의 양이온 폴리머, 스티렌 및 메틸 메타크릴레이트 코폴리머의 양이온 폴리머, 양이온 디메틸아미노 메타크릴레이트, 폴리아크릴레이트 및 폴리메타크릴레이트, 폴리에틸렌 글리콜 유도체로 임의로 치환된 폴리아민 유도체, 양이온인 pH 조건 하에서의 폴리아미노산, 폴리에틸렌이민, 친수성 우레탄 폴리머 및 폴리비닐피롤리돈(PVP)의 4급화된 유도체, 그리고 이들 양이온 그룹의 임의의 혼합물로 구성되는 그룹으로부터 선택되는 나노캡슐. - 제1항에 있어서,
친수성 활성 성분은 아미노산, 펩티드, 단백질, 가수분해된 단백질, 효소, 호르몬, 비타민, 미네랄염, 당, 뉴클레오티드, 핵산, 생물학적 및 생물기술적 기원의 추출물 및 분자, 백신, 합성 또는 부분적 합성 친수성 분자 및/또는 이의 혼합물로 구성되는 그룹으로부터 선택되는 나노캡슐. - 제1항에 있어서,
친수성 활성 성분의 양은 0.00001 내지 50 중량% 범위인 나노캡슐. - 제1항에 있어서,
다른 화장품, 약제학적 및/또는 식이성 활성 성분 및/또는 보조제를 포함하는 나노캡슐. - 제9항에 있어서,
화장품 및/또는 식이성 활성 성분 및/또는 보조제는 계면활성제, 습윤제 또는 수분을 보유하는 물질, 보습제 또는 유연제, 치유 자극제, 보조 치유제, 재상피화 자극제, 보조 재상피화제, 피부 또는 표피 거대분자 합성제, 고화 및/또는 재치밀화 및/또는 재구성 약제, 사이토카인 성장 인자, 모세혈관 순환 및/또는 미소순환에 작용하는 약제, 항-당화제, 유리 라디칼 청소제 및/또는 항-환경 오염 약제, 반응성 카보닐종 청소제, 5α-리덕타제-저해제, 리질- 및/또는 프롤릴 하이드록실라제 저해제, 디펜신 합성-자극제, 항균제 및/또는 정균제 및/또는 항미생물제 및/또는 살균제 및/또는 살진균제 및/또는 정진균제 및/또는 미생물-억제제, 항바이러스제, 항기생충제, 항히스타민제, NO-합성 저해제, 박리제 또는 각질용해제 및/또는 각질제거제, 여드름방지제, 항-건선제, 항-비듬제, 항염증제 및/또는 진통제, 마취제, 항-주름 및/또는 항-노화제, 화장품 및/또는 흡착성 및/또는 체취 마스킹 탈취제, 발한억제제, 방향 물질 및/또는 방향 오일 및/또는 분리된 방향성 화합물, 항-산화제, 혈관 투과성 억제제, 가수분해성 표피 효소, 미백 또는 피부 탈색제, 땀-분해 효소 저해제, 자외선 차단제, 케라틴세포 분화 자극 또는 조절제, 항-소양제, 멜라닌 합성 자극 또는 저해제, 프로색소침착제, 셀프-태닝제, 멜라닌세포 증식 자극제, 액체 추진제, 비타민, 아미노산, 단백질, 생물폴리머, 겔화 폴리머, 피부 이완제, 눈 아래 주머니 감소 또는 치료 가능 약제, 민감성 피부 케어 및/또는 치료용 약제, 수렴제, 피지 생산 조절제, 튼살 억제제, 지질용해제 또는 지질용해 자극제, 정맥강화제, 항-셀룰라이트제, 진정제, 세포 대사에 작용하는 약제, 피부-표피 연결부 개선제, 모발 성장 유도 또는 모발-손실 지연제, 체모 성장 저해 또는 지연제, 열 쇼크 단백질 합성 자극제, 근육 이완제, 근육 수축 억제제, 아세틸콜린 수용체 군집 억제제, 항콜린효능제, 엘라스타제 저해제, 기질 금속단백질가수분해효소 저해제, 킬레이트제, 식물 추출물, 에센셜 오일, 수산 추출물, 미네랄 염, 세포 추출물, 유화제, 지질 및 각질층 성분, 세라마이드, 지방산 합성 자극제, 생물-발효 공정으로부터 얻은 약제 및/또는 이들의 혼합물로 구성되는 그룹으로부터 선택되는 나노캡슐. - 제9항에 있어서,
약제학적 활성 성분 및/또는 보조제는 제산제, 위궤양 및 위식도 역류 질환에 대한 약제, 진경제, 진통제, 항콜린효능 약물, 추진 약물, 항구토제, 구토방지 약물, 담즙 치료용 약제, 간 치료용 약제, 항지방간제, 완화제, 지사제, 장관 흡착제, 항추진제, 항염성 약물, 비만에 대한 활성 성분, 효소, 혈당강하제, 인슐린 및 유사체, 비타민, 단백질, 미네랄, 동화작용 스테로이드, 항혈전제, 항섬유소용해제, 지혈제, 항부정맥 약제, 강심제, 심장 글리코사이드, 혈관확장제, 항아드레날린효능 약제, 항고혈압 약물, 이뇨제, 칼륨-절약 약제, 항치질약, 항정맥류 치료 약제, 모세혈관 안정화 약제, 레닌-안지오텐신 시스템에 작용하는 약제, 베타-차단제, 선택적 칼슘-채널 차단제, 비-선택적 칼슘-채널 차단제, ACE 저해제, 안지오텐신 II 저해제, 지질 조정 약제, 항진균제, 치유 약제, 항소양제, 항히스타민제, 마취제, 항건선제, 화학요법 약물, 코르티코스테로이드, 방부제, 소독제, 항-여드름 약제, 부인과용 제품, 자궁수축제, 피임제, 안드로겐, 에스트로겐, 프로제스타겐, 배란 자극제, 고나도트로핀, 항안드로겐제, 비뇨기용 제품, 진경제, 경증의 전립선 비대증에 사용되는 약물, 호르몬제, 호르몬 길항제, 항생제, 테트라사이클린, 안페니콜, 베타-락탐 항균제, 페니실린, 설폰아마이드, 트리메토프림, 마크로라이드, 린코사마이드, 스트렙토그라민, 항균성 아미노글리코사이드, 항균성 퀴놀론, 항바이러스제, 면역 혈청, 면역글로불린, 항종양 약제, 면역조절 약제, 알킬화제, 항대사성 물질, 식물 알칼로이드 및 다른 천연 제품, 세포독성 항생제, 면역억제제, 근골격계 장애용 약물, 항류마티스제, 근육이완제, 뼈 구조 및 미네랄화에 영향을 주는 약제, 신경계에 작용하는 약물, 전신 마취제, 국소 마취제, 오피오이드, 항편두통 약제, 항경련제, 항콜린효능 약제, 도파민효능 약제, 항정신병약, 항불안제, 최면제, 진정제, 항우울제, 정신자극제, 항-치매 약물, 부교감신경 모방제, 중독성 장애에 사용하는 약물, 항-현기증 약제, 항기생충 약제, 살충제, 해충 퇴치제, 비충혈 완화제, 점액용해제, 기침 억제제, 안과 활성 성분, 이과 활성 성분, 항녹내장 약물, 축동제, 산동제, 안근마비제 및/또는 이의 혼합물로 구성되는 그룹으로부터 선택되는 나노캡슐. - 제1항에 따른 나노캡슐의 제조 방법에 있어서, 폴리머 코팅이 단순 또는 복합 코아세르베이션에 의해 제조되는 방법.
- 제1항 내지 제12항 중 어느 한 항에 따른 나노캡슐을 포함하는 화장품, 약제학적 및/또는 식이성 조성물.
- 제13항에 있어서,
나노캡슐이 탈크, 벤토나이트, 실리카, 전분 또는 말토덱스트린으로 구성되는 그룹으로부터 선택되는 고형 미네랄 지지체 또는 고형 유기 폴리머로 흡착되는 조성물. - 제13항에 있어서,
이 조성물이 크림, 복합 에멀젼, 무수 조성물, 수성 분산액, 오일, 밀크, 발삼, 폼, 로션, 겔, 크림 겔, 하이드로알코올 용액, 하이드로글리콜 용액, 하이드로겔, 리니먼트, 세라, 비누, 샴푸, 컨디셔너, 세럼, 연고, 무스, 포마드, 산제, 바, 펜슬, 분무제, 에어졸, 캡슐, 젤라틴 캡슐, 연질 캡슐, 경질 캡슐, 정제, 당의정, 과립제, 추잉검, 용액제, 현탁제, 에멀젼, 시럽제, 다당류 필름, 젤리 및 젤라틴으로 구성되는 그룹으로부터 선택되는 제형으로 제공되는 조성물. - 제13항에 있어서,
이 조성물이 언더-아이 컨실러, 메이크-업 파운데이션, 메이크-업 제거 로션, 메이크-업 제거 밀크, 아이새도우, 립스틱, 립글로스, 입술 보호제 및 파우더로 구성되는 그룹으로부터 선택되는 제품으로 도입되는 조성물. - 제13항에 있어서,
나노캡슐이 직물, 부직포 또는 의료 기구로 도입되는 조성물. - 제13항에 따른 화장품, 약제학적 및/또는 식이성 조성물의 피부, 두피, 모발 및 네일의 케어 및/또는 치료를 위한 용도.
- 제13항에 따른 화장품 및/또는 약제학적 조성물의 섬유 재료의 처리를 위한 용도.
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PCT/EP2011/004700 WO2012038061A2 (en) | 2010-09-21 | 2011-09-20 | Nanocapsules containing microemulsions |
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WO2023132553A1 (ko) * | 2022-01-06 | 2023-07-13 | 코스맥스 주식회사 | 피부 흡수 증진을 위한 양이온성 리포좀 및 이의 제조 방법 |
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BR112013006269B1 (pt) | 2022-07-26 |
BR112013006269A2 (pt) | 2020-05-26 |
JP6087282B2 (ja) | 2017-03-01 |
WO2012038061A3 (en) | 2012-06-07 |
ES2732908T3 (es) | 2019-11-26 |
MY166518A (en) | 2018-07-05 |
ES2386177B1 (es) | 2013-09-23 |
EP2618926A2 (en) | 2013-07-31 |
US20130216596A1 (en) | 2013-08-22 |
EP2618926B1 (en) | 2019-05-08 |
SG188427A1 (en) | 2013-04-30 |
MX2013003137A (es) | 2013-10-17 |
MX354840B (es) | 2018-03-21 |
JP2013537206A (ja) | 2013-09-30 |
ES2386177A1 (es) | 2012-08-10 |
WO2012038061A2 (en) | 2012-03-29 |
KR101979462B1 (ko) | 2019-05-16 |
US10758490B2 (en) | 2020-09-01 |
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