KR20080111062A - （1­옥사­또는 1­티아­）3­세펨 유도체의 제조 방법 - Google Patents

（1­옥사­또는 1­티아­）3­세펨 유도체의 제조 방법 Download PDF

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Publication number
KR20080111062A
KR20080111062A KR1020087025168A KR20087025168A KR20080111062A KR 20080111062 A KR20080111062 A KR 20080111062A KR 1020087025168 A KR1020087025168 A KR 1020087025168A KR 20087025168 A KR20087025168 A KR 20087025168A KR 20080111062 A KR20080111062 A KR 20080111062A
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KR
South Korea
Prior art keywords
alkyl
formula
oxa
tetrazol
thia
Prior art date
Application number
KR1020087025168A
Other languages
English (en)
Korean (ko)
Inventor
레오네 달’아스타
Original Assignee
카르테시아 에스.에이.에스. 디 엠마누엘라 미글리아바카 앤 씨.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20060466 external-priority patent/ITMI20060466A1/it
Priority claimed from ITMI20061096 external-priority patent/ITMI20061096A1/it
Application filed by 카르테시아 에스.에이.에스. 디 엠마누엘라 미글리아바카 앤 씨. filed Critical 카르테시아 에스.에이.에스. 디 엠마누엘라 미글리아바카 앤 씨.
Publication of KR20080111062A publication Critical patent/KR20080111062A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D505/02—Preparation
    • C07D505/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D505/10—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D505/12—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7
    • C07D505/14—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7 with hetero atoms directly attached in position 7
    • C07D505/16—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020087025168A 2006-03-15 2007-03-14 （1­옥사­또는 1­티아­）3­세펨 유도체의 제조 방법 KR20080111062A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI2006A000466 2006-03-15
ITMI20060466 ITMI20060466A1 (it) 2006-03-15 2006-03-15 Procedimento per la preparazione di 1-oxa-o 1-tia-3-cefen derivati e relativi intermedi
ITMI20061096 ITMI20061096A1 (it) 2006-06-06 2006-06-06 Procedimento per la preparazione di (1-tia-)3-cefem derivati
ITMI2006A001096 2006-06-06

Publications (1)

Publication Number Publication Date
KR20080111062A true KR20080111062A (ko) 2008-12-22

Family

ID=38255802

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087025168A KR20080111062A (ko) 2006-03-15 2007-03-14 （1­옥사­또는 1­티아­）3­세펨 유도체의 제조 방법

Country Status (4)

Country Link
EP (1) EP1996595A2 (ru)
JP (1) JP2009530268A (ru)
KR (1) KR20080111062A (ru)
WO (1) WO2007105253A2 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190029932A (ko) 2017-09-13 2019-03-21 주식회사 동도물산 7α-알콕시옥사세펨 중간체의 제조방법

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787040B (zh) * 2010-03-02 2011-09-07 哈药集团制药总厂 一种头孢美唑钠的制备方法
CN101792454B (zh) * 2010-03-17 2011-12-07 河北九派制药有限公司 7-α氨基7-甲氧基-3-甲基四唑硫甲基头孢烷酸苄酯的制备方法
CN101792455B (zh) * 2010-03-17 2012-07-04 河北九派制药有限公司 一种高纯度7-α氨基7-甲氧基-3-甲基四唑硫甲基头孢烷酸苄酯的制备方法
CN102675342A (zh) * 2011-03-15 2012-09-19 四平市精细化学品有限公司 7β-氨基-7α-甲氧基-3-[（1-甲基-1H-四唑-5-基）硫甲基]-3-头孢烯-4-羧酸二苯甲酯的制备方法
CN102391291B (zh) * 2011-09-21 2014-06-04 河北九派制药有限公司 一种头孢美唑酸的制备方法
WO2014017797A1 (ko) * 2012-07-25 2014-01-30 제일약품주식회사 1-옥사세팔로스포린 유도체의 신규한 제조방법
CN102850379B (zh) * 2012-08-30 2015-08-12 三峡大学 甲氧头孢中间体7-mac的合成方法
CN102952149B (zh) * 2012-11-09 2015-06-24 浙江新和成股份有限公司 一种氟氧头孢中间体的一锅合成法
CN104151324B (zh) * 2014-09-03 2016-08-24 齐鲁天和惠世制药有限公司 一种溶媒结晶法制备氨苄西林钠的方法
CN104327100B (zh) * 2014-09-30 2016-09-28 华北制药河北华民药业有限责任公司 高纯度氟氧头孢钠制备工艺
CN104557978B (zh) * 2014-12-31 2017-07-18 重庆福安药业(集团)股份有限公司 一种头孢美唑钠的制备方法
CN105037393B (zh) * 2015-06-24 2017-11-10 浙江永宁药业股份有限公司 一种氟氧头孢钠的制备方法
CN105399755B (zh) * 2015-11-03 2018-05-11 浙江永宁药业股份有限公司 一种氟氧头孢酸的合成方法
CN107722041B (zh) * 2017-11-12 2020-05-05 广州维奥康药业科技有限公司 头孢美唑酸的制备方法
CN109608478A (zh) * 2018-11-15 2019-04-12 山东晶辉生物技术有限公司 一种氟氧头孢酸的合成方法
CN109970766A (zh) * 2019-04-22 2019-07-05 山西千岫制药有限公司 一种氟氧头孢酸的制备方法
CN110003241A (zh) * 2019-04-23 2019-07-12 山西千岫制药有限公司 一种拉氧头孢母核的制备方法
CN110804635B (zh) * 2019-11-11 2021-08-17 济南康和医药科技有限公司 一种拉氧头孢钠的合成方法
CN114292283A (zh) * 2022-01-24 2022-04-08 广州维奥康药业科技有限公司 一种注射用头孢美唑钠杂质的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5417755B2 (ru) * 1973-11-26 1979-07-02
US4109084A (en) * 1976-12-08 1978-08-22 E. R. Squibb & Sons, Inc. Thiooxime cephalosporin derivatives
JPS59139385A (ja) * 1982-12-23 1984-08-10 Shionogi & Co Ltd フルオロメチルチオオキサセフアロスポリン
JPS6348286A (ja) * 1986-08-15 1988-02-29 Shionogi & Co Ltd イミノ化合物およびその製法
KR20000073152A (ko) * 1999-05-07 2000-12-05 조생현 7-α-메톡시 -세팔로스포란산 유도체의 제조방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190029932A (ko) 2017-09-13 2019-03-21 주식회사 동도물산 7α-알콕시옥사세펨 중간체의 제조방법

Also Published As

Publication number Publication date
WO2007105253A8 (en) 2008-10-30
WO2007105253A3 (en) 2007-11-01
WO2007105253A2 (en) 2007-09-20
JP2009530268A (ja) 2009-08-27
EP1996595A2 (en) 2008-12-03
WO2007105253B1 (en) 2007-12-06

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