KR20040039287A - 신규한 당지질 및 이것을 유효성분으로 하는 자기면역질환 치료약 - Google Patents
신규한 당지질 및 이것을 유효성분으로 하는 자기면역질환 치료약 Download PDFInfo
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- KR20040039287A KR20040039287A KR10-2004-7002291A KR20047002291A KR20040039287A KR 20040039287 A KR20040039287 A KR 20040039287A KR 20047002291 A KR20047002291 A KR 20047002291A KR 20040039287 A KR20040039287 A KR 20040039287A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- galactosyl
- synthesis
- glycolipid
- active ingredient
- Prior art date
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- 229930186217 Glycolipid Natural products 0.000 title claims abstract description 51
- 208000023275 Autoimmune disease Diseases 0.000 title claims abstract description 33
- 239000004480 active ingredient Substances 0.000 title claims abstract description 10
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- 230000000246 remedial effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 8
- 125000003550 alpha-D-galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims description 34
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
Description
Claims (8)
- 하기식(I)로 표시되는 당지질:(식중, R1은 알도피라노스 잔기를 나타내고, R2는 수소원자 또는 수산기를 나타내고, R3은 -CH2-, -CH(OH)-CH2-, 또는 -CH=CH-를 나타내고, R4는 수소원자 또는 CH3를 나타내고, x는 0~35이고, y 및 z는 y+z=0~3을 만족시키는 정수를 나타낸다.)
- 제 1항에 있어서, 상기 R1이 α-D-갈락토피라노실을 나타내는 당지질.
- 제 2항에 있어서, 상기 R3이 -CH2-, 또는 -CH(OH)-CH2-를 나타내고, x가 10~32인 당지질.
- 제 3항에 있어서, 상기 R3이 -CH(OH)-CH2-를 나타내는 당지질.
- 제 1항 내지 제 4항 중 어느 한 항에 있어서, 상기 R2및 R4가 수소원자를 나타내고, x가 11~23이고, z가 0인 당지질.
- 제 1항 내지 제 5항 중 어느 한 항에 기재된 당지질을 유효성분으로서 함유하는 자기면역질환을 위한 치료약.
- 제 1항 내지 제 5항 중 어느 한 항에 기재된 당지질을 유효성분으로서 함유하는 Th1/Th2 면역밸런스가 Th1에 편향한 질환, 또는 Th1세포가 병태를 악화시키는 질환의 치료약.
- 제 1항 내지 제 5항 중 어느 한 항에 기재된 당지질을 유효성분으로서 함유하는 선택적 IL-4산생유도제.
Applications Claiming Priority (3)
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JPJP-P-2001-00247055 | 2001-08-16 | ||
JP2001247055 | 2001-08-16 | ||
PCT/JP2002/008280 WO2003016326A1 (fr) | 2001-08-16 | 2002-08-14 | Glycolipide et agent therapeutique pour maladies auto-immunes le contenant en tant qu'ingredient actif |
Publications (2)
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KR20040039287A true KR20040039287A (ko) | 2004-05-10 |
KR100880063B1 KR100880063B1 (ko) | 2009-01-22 |
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KR1020047002291A KR100880063B1 (ko) | 2001-08-16 | 2002-08-14 | 신규한 당지질 및 이것을 유효성분으로 하는 자기면역질환 치료약 |
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US (1) | US8367623B2 (ko) |
EP (1) | EP1437358B1 (ko) |
JP (1) | JP4064346B2 (ko) |
KR (1) | KR100880063B1 (ko) |
CN (1) | CN100439383C (ko) |
AT (1) | ATE342910T1 (ko) |
AU (1) | AU2002327097B2 (ko) |
BR (1) | BR0211968A (ko) |
CA (1) | CA2459482C (ko) |
DE (1) | DE60215530T2 (ko) |
DK (1) | DK1437358T3 (ko) |
ES (1) | ES2274080T3 (ko) |
HU (1) | HU229345B1 (ko) |
NO (1) | NO326398B1 (ko) |
WO (1) | WO2003016326A1 (ko) |
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AU2005280163B2 (en) * | 2004-08-27 | 2011-11-24 | Albert Einstein College Of Medicine, Inc. | Ceramide derivatives as modulators of immunity and autoimmunity |
US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
JP5269412B2 (ja) | 2004-10-07 | 2013-08-21 | アルゴス セラピューティクス,インコーポレイティド | 成熟樹状細胞組成物およびその培養方法 |
US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Nkt細胞に対する抗原としての糖脂質及びその類似体 |
JP4909264B2 (ja) * | 2005-04-01 | 2012-04-04 | 独立行政法人理化学研究所 | 経鼻ワクチン |
US20090227781A1 (en) * | 2005-07-01 | 2009-09-10 | Sachiko Miyake | Glycolipid Derivative and Drug Containing the Same as Active Component |
KR20080059611A (ko) * | 2005-10-28 | 2008-06-30 | 국립 정신.신경센터 총장이 대표하는 일본국 | Nkt 세포의 기능을 억제하는 당지질 유도체를 유효성분으로 하는 치료제 |
US8163705B2 (en) | 2006-02-28 | 2012-04-24 | Riken | Glycolipid and use thereof |
JP5564672B2 (ja) | 2006-06-30 | 2014-07-30 | ザ スクリプス リサーチ インスティテュート | アジュバント及びその使用方法 |
KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
EP2112930B1 (en) | 2007-02-21 | 2017-01-11 | Vaccinex, Inc. | Modulation of nkt cell activity with antigen-loaded cdid molecules |
CA2702344C (en) * | 2007-10-12 | 2016-09-27 | Luigi Panza | Analogues of glycolipids useful as immunoadjuvants |
KR101928684B1 (ko) * | 2009-01-08 | 2018-12-12 | 앨버트 아인슈타인 컬리지 오브 메디신, 인크. | 세포벽 결합 세라미드 유사 당지질을 갖는 박테리아 백신 및 이의 용도 |
US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
JP6202339B2 (ja) * | 2013-12-19 | 2017-09-27 | 国立研究開発法人国立精神・神経医療研究センター | GM−CSF産生T細胞制御剤、及びTh1/Th2免疫バランス調節剤 |
KR102376846B1 (ko) | 2014-02-26 | 2022-03-21 | 국립대학법인 홋가이도 다이가쿠 | 수지상 세포를 함유하는 의약 및 그 제조 방법 |
EP3984597A4 (en) | 2019-07-12 | 2023-07-12 | Kyushu University, National University Corporation | DEVELOPMENT OF A THERAPY TO IMPROVE MYOCARDIAL CONTRACTION AND A METHOD OF INHIBITION OF CARDIOMYOCYTE DEATH |
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Also Published As
Publication number | Publication date |
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ATE342910T1 (de) | 2006-11-15 |
CN100439383C (zh) | 2008-12-03 |
JP4064346B2 (ja) | 2008-03-19 |
KR100880063B1 (ko) | 2009-01-22 |
BR0211968A (pt) | 2004-09-28 |
CA2459482C (en) | 2010-09-28 |
NO326398B1 (no) | 2008-11-24 |
DE60215530D1 (de) | 2006-11-30 |
DE60215530T2 (de) | 2007-05-31 |
WO2003016326A1 (fr) | 2003-02-27 |
ES2274080T3 (es) | 2007-05-16 |
US20060148723A1 (en) | 2006-07-06 |
EP1437358B1 (en) | 2006-10-18 |
EP1437358A1 (en) | 2004-07-14 |
CN1568328A (zh) | 2005-01-19 |
DK1437358T3 (da) | 2007-02-05 |
NO20040653L (no) | 2004-05-07 |
AU2002327097B2 (en) | 2007-05-24 |
US8367623B2 (en) | 2013-02-05 |
EP1437358A4 (en) | 2004-11-24 |
JPWO2003016326A1 (ja) | 2004-12-02 |
HUP0500127A2 (en) | 2006-09-28 |
HUP0500127A3 (en) | 2009-12-28 |
HU229345B1 (en) | 2013-11-28 |
CA2459482A1 (en) | 2003-02-27 |
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