DE60215530D1 - Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält - Google Patents

Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält

Info

Publication number
DE60215530D1
DE60215530D1 DE60215530T DE60215530T DE60215530D1 DE 60215530 D1 DE60215530 D1 DE 60215530D1 DE 60215530 T DE60215530 T DE 60215530T DE 60215530 T DE60215530 T DE 60215530T DE 60215530 D1 DE60215530 D1 DE 60215530D1
Authority
DE
Germany
Prior art keywords
new
gen
remedy
active ingredients
glycolipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60215530T
Other languages
English (en)
Other versions
DE60215530T2 (de
Inventor
Takashi Yamamura
Sachiko Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan As Represented By President Of National Jp
Original Assignee
JAPAN GOVERNMENT
National Center of Neurology and Psychiatry
Daiichi Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JAPAN GOVERNMENT, National Center of Neurology and Psychiatry, Daiichi Asubio Pharma Co Ltd filed Critical JAPAN GOVERNMENT
Publication of DE60215530D1 publication Critical patent/DE60215530D1/de
Application granted granted Critical
Publication of DE60215530T2 publication Critical patent/DE60215530T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60215530T 2001-08-16 2002-08-14 Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält Expired - Lifetime DE60215530T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001247055 2001-08-16
JP2001247055 2001-08-16
PCT/JP2002/008280 WO2003016326A1 (fr) 2001-08-16 2002-08-14 Glycolipide et agent therapeutique pour maladies auto-immunes le contenant en tant qu'ingredient actif

Publications (2)

Publication Number Publication Date
DE60215530D1 true DE60215530D1 (de) 2006-11-30
DE60215530T2 DE60215530T2 (de) 2007-05-31

Family

ID=19076468

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60215530T Expired - Lifetime DE60215530T2 (de) 2001-08-16 2002-08-14 Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält

Country Status (15)

Country Link
US (1) US8367623B2 (de)
EP (1) EP1437358B1 (de)
JP (1) JP4064346B2 (de)
KR (1) KR100880063B1 (de)
CN (1) CN100439383C (de)
AT (1) ATE342910T1 (de)
AU (1) AU2002327097B2 (de)
BR (1) BR0211968A (de)
CA (1) CA2459482C (de)
DE (1) DE60215530T2 (de)
DK (1) DK1437358T3 (de)
ES (1) ES2274080T3 (de)
HU (1) HU229345B1 (de)
NO (1) NO326398B1 (de)
WO (1) WO2003016326A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
HUE037560T2 (hu) 2003-02-14 2018-09-28 Japan President Nat Ct Neurology & Psychiatry Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására
WO2006026389A2 (en) * 2004-08-27 2006-03-09 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
US20080145931A1 (en) 2004-10-07 2008-06-19 Argos Therapeutics, Inc. Mature Dendritic Cell Compositions and Methods of Culturing Same
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
JP5090928B2 (ja) * 2004-12-28 2012-12-05 ザ ロックフェラー ユニバーシティ Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体
JP4909264B2 (ja) * 2005-04-01 2012-04-04 独立行政法人理化学研究所 経鼻ワクチン
KR20080021761A (ko) * 2005-07-01 2008-03-07 국립 정신.신경센터 총장이 대표하는 일본국 당지질 유도체 및 이것을 유효 성분으로 하는 치료제
JPWO2007049819A1 (ja) * 2005-10-28 2009-04-30 国立精神・神経センター総長 Ｎｋｔ細胞の機能を抑制する糖脂質誘導体を有効成分とする治療剤
US8163705B2 (en) 2006-02-28 2012-04-24 Riken Glycolipid and use thereof
CA2655947C (en) 2006-06-30 2016-08-02 The Scripps Research Institute Compositions comprising nkt cell agonist compounds and methods of use
KR100868959B1 (ko) * 2006-12-30 2008-11-17 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
CA2678618C (en) 2007-02-21 2019-03-12 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cd1d molecules
AU2008326138B2 (en) * 2007-10-12 2013-10-17 Luigi Panza Analogues of glycolipids useful as immunoadjuvants
DK2385980T3 (en) * 2009-01-08 2018-07-30 Albert Einstein College Medicine Inc BACTERIA VACCINES WITH CELL-WALL-ASSOCIATED CERAMIDE-LIKE GLYCOLIPIDS AND APPLICATIONS THEREOF
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
JP6202339B2 (ja) * 2013-12-19 2017-09-27 国立研究開発法人国立精神・神経医療研究センター ＧＭ−ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
EP3111945B1 (de) 2014-02-26 2021-07-14 National University Corporation Hokkaido University Dendritische zellen zur verwendung in der behandlung von herzinfarkt
WO2021010344A1 (ja) 2019-07-12 2021-01-21 国立大学法人九州大学 心筋収縮改善治療法および心筋細胞死抑制法の開発

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5827828A (ja) * 1981-08-11 1983-02-18 Mitsubishi Electric Corp 燃料噴射装置
DK84691D0 (da) 1991-05-07 1991-05-07 Karsten Buschard Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
JPH0559081A (ja) * 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
GB9207182D0 (en) * 1992-04-01 1992-05-13 Enzymatix Ltd Glycolipids and their preparation
TW261533B (de) 1992-07-16 1995-11-01 Kirin Brewery
CA2142153A1 (en) * 1994-03-04 1995-09-05 Jacques Banville Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
CN1058498C (zh) * 1994-05-31 2000-11-15 生化学工业株式会社 糖脂类似物
DE19602108A1 (de) * 1996-01-22 1997-07-24 Beiersdorf Ag Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen
JP4451933B2 (ja) * 1996-12-27 2010-04-14 住友化学株式会社 遺伝子操作による植物へのｐｐｏ阻害性除草剤耐性付与法
WO1998044928A1 (en) 1997-04-10 1998-10-15 Kirin Beer Kabushiki Kaisha NKT CELL ACTIVATORS CONTAINING α-GLYCOSYLCERAMIDES
US6589940B1 (en) * 1997-06-06 2003-07-08 Dynavax Technologies Corporation Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
TW575420B (en) * 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
US7273711B1 (en) * 1998-12-02 2007-09-25 The Regents Of The University Of California Diagnosis of human glycosylation disorders
JP2002284692A (ja) * 2001-03-26 2002-10-03 Kirin Brewery Co Ltd α−グリコシルセラミドによる移植片対宿主病（ＧＶＨＤ）の抑制

Also Published As

Publication number Publication date
KR100880063B1 (ko) 2009-01-22
HU229345B1 (en) 2013-11-28
EP1437358B1 (de) 2006-10-18
KR20040039287A (ko) 2004-05-10
NO20040653L (no) 2004-05-07
EP1437358A4 (de) 2004-11-24
HUP0500127A3 (en) 2009-12-28
ES2274080T3 (es) 2007-05-16
WO2003016326A1 (fr) 2003-02-27
JP4064346B2 (ja) 2008-03-19
CA2459482A1 (en) 2003-02-27
CN100439383C (zh) 2008-12-03
ATE342910T1 (de) 2006-11-15
NO326398B1 (no) 2008-11-24
HUP0500127A2 (en) 2006-09-28
BR0211968A (pt) 2004-09-28
CA2459482C (en) 2010-09-28
CN1568328A (zh) 2005-01-19
JPWO2003016326A1 (ja) 2004-12-02
DE60215530T2 (de) 2007-05-31
US20060148723A1 (en) 2006-07-06
US8367623B2 (en) 2013-02-05
AU2002327097B2 (en) 2007-05-24
EP1437358A1 (de) 2004-07-14
DK1437358T3 (da) 2007-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASUBIO PHARMA CO., LTD., TOKYO, JP

Owner name: JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL , JP

8327 Change in the person/name/address of the patent owner

Owner name: JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL , JP