WO2003016326A1 - Glycolipide et agent therapeutique pour maladies auto-immunes le contenant en tant qu'ingredient actif - Google Patents

Glycolipide et agent therapeutique pour maladies auto-immunes le contenant en tant qu'ingredient actif Download PDF

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Publication number
WO2003016326A1
WO2003016326A1 PCT/JP2002/008280 JP0208280W WO03016326A1 WO 2003016326 A1 WO2003016326 A1 WO 2003016326A1 JP 0208280 W JP0208280 W JP 0208280W WO 03016326 A1 WO03016326 A1 WO 03016326A1
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
same
autoimmune disease
glycolipid
disease containing
Prior art date
Application number
PCT/JP2002/008280
Other languages
English (en)
French (fr)
Inventor
Takashi Yamamura
Sachiko Miyake
Original Assignee
Daiichi Suntory Pharma Co., Ltd.
Japan As Represented By President Of National Center Of Neurology And Psychiatry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0211968-4A priority Critical patent/BR0211968A/pt
Priority to US10/486,948 priority patent/US8367623B2/en
Priority to DK02760637T priority patent/DK1437358T3/da
Priority to HU0500127A priority patent/HU229345B1/hu
Priority to CA2459482A priority patent/CA2459482C/en
Priority to DE60215530T priority patent/DE60215530T2/de
Application filed by Daiichi Suntory Pharma Co., Ltd., Japan As Represented By President Of National Center Of Neurology And Psychiatry filed Critical Daiichi Suntory Pharma Co., Ltd.
Priority to AU2002327097A priority patent/AU2002327097B2/en
Priority to EP02760637A priority patent/EP1437358B1/en
Priority to JP2003521248A priority patent/JP4064346B2/ja
Priority to KR1020047002291A priority patent/KR100880063B1/ko
Publication of WO2003016326A1 publication Critical patent/WO2003016326A1/ja
Priority to NO20040653A priority patent/NO326398B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PCT/JP2002/008280 2001-08-16 2002-08-14 Glycolipide et agent therapeutique pour maladies auto-immunes le contenant en tant qu'ingredient actif WO2003016326A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US10/486,948 US8367623B2 (en) 2001-08-16 2002-08-14 Glycolipid and medicine for autoimmune disease containing the same as active ingredient
DK02760637T DK1437358T3 (da) 2001-08-16 2002-08-14 Hidtil ukendt glycolipid og medikament til autoimmune sygdomme indeholdende dette som det aktive stof
HU0500127A HU229345B1 (en) 2001-08-16 2002-08-14 Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
CA2459482A CA2459482C (en) 2001-08-16 2002-08-14 Novel glycolipid and medicine for autoimmune disease containing the same as active ingredient
DE60215530T DE60215530T2 (de) 2001-08-16 2002-08-14 Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält
BR0211968-4A BR0211968A (pt) 2001-08-16 2002-08-14 Glicolipìdio útil no tratamento de doenças autoimunes e medicamento do mesmo
AU2002327097A AU2002327097B2 (en) 2001-08-16 2002-08-14 Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
EP02760637A EP1437358B1 (en) 2001-08-16 2002-08-14 Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
JP2003521248A JP4064346B2 (ja) 2001-08-16 2002-08-14 新規な糖脂質及びこれを有効成分とする自己免疫疾患治療薬
KR1020047002291A KR100880063B1 (ko) 2001-08-16 2002-08-14 신규한 당지질 및 이것을 유효성분으로 하는 자기면역질환 치료약
NO20040653A NO326398B1 (no) 2001-08-16 2004-02-13 Nytt glykolipid og medisin for autoimmunsykdom inneholdende det samme som aktiv ingrediens.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001247055 2001-08-16
JP2001-247055 2001-08-16

Publications (1)

Publication Number Publication Date
WO2003016326A1 true WO2003016326A1 (fr) 2003-02-27

Family

ID=19076468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008280 WO2003016326A1 (fr) 2001-08-16 2002-08-14 Glycolipide et agent therapeutique pour maladies auto-immunes le contenant en tant qu'ingredient actif

Country Status (15)

Country Link
US (1) US8367623B2 (ja)
EP (1) EP1437358B1 (ja)
JP (1) JP4064346B2 (ja)
KR (1) KR100880063B1 (ja)
CN (1) CN100439383C (ja)
AT (1) ATE342910T1 (ja)
AU (1) AU2002327097B2 (ja)
BR (1) BR0211968A (ja)
CA (1) CA2459482C (ja)
DE (1) DE60215530T2 (ja)
DK (1) DK1437358T3 (ja)
ES (1) ES2274080T3 (ja)
HU (1) HU229345B1 (ja)
NO (1) NO326398B1 (ja)
WO (1) WO2003016326A1 (ja)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072091A1 (ja) * 2003-02-14 2004-08-26 Daiichi Suntory Pharma Co., Ltd. 糖脂質誘導体及びその製造法並びにそれらの合成中間体及びその製造法
WO2006107097A1 (ja) * 2005-04-01 2006-10-12 Riken 経鼻ワクチン
WO2007004705A1 (ja) * 2005-07-01 2007-01-11 Japan As Represented By President Of National Center Of Neurology And Psychiatry 糖脂質誘導体及びそれを有効成分とする治療剤
WO2007049819A1 (ja) * 2005-10-28 2007-05-03 Japan As Represented By President Of National Center Of Neurology And Psychiatry Nkt細胞の機能を抑制する糖脂質誘導体を有効成分とする治療剤
WO2007099999A1 (ja) * 2006-02-28 2007-09-07 Riken 新規糖脂質及びその用途
WO2007117682A2 (en) 2006-04-07 2007-10-18 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
JP2008511634A (ja) * 2004-08-27 2008-04-17 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 免疫及び自己免疫の調節因子としてのセラミド誘導体
JP2010514758A (ja) * 2006-12-30 2010-05-06 エスエヌユー アールアンドディービー ファウンデーション αガラクトシルセラミド誘導体、その薬学的に許容可能な塩、その製造方法及びそれを有効成分として含む免疫補助用薬学的組成物
EP2251418A1 (en) 2004-10-07 2010-11-17 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
JP2011510910A (ja) * 2007-10-12 2011-04-07 ルイジ パンツァ， 免疫アジュバントとして有用な糖脂質の類似体
JP2015134742A (ja) * 2013-12-19 2015-07-27 国立研究開発法人国立精神・神経医療研究センター ＧＭ−ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
KR20160130403A (ko) 2014-02-26 2016-11-11 국립대학법인 홋가이도 다이가쿠 수지상 세포를 함유하는 의약 및 그 제조 방법
US9603922B2 (en) 2007-02-21 2017-03-28 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CD1d molecules
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
WO2021010344A1 (ja) 2019-07-12 2021-01-21 国立大学法人九州大学 心筋収縮改善治療法および心筋細胞死抑制法の開発

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
JP5090928B2 (ja) * 2004-12-28 2012-12-05 ザ ロックフェラー ユニバーシティ Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体
CA2655947C (en) 2006-06-30 2016-08-02 The Scripps Research Institute Compositions comprising nkt cell agonist compounds and methods of use
DK2385980T3 (en) * 2009-01-08 2018-07-30 Albert Einstein College Medicine Inc BACTERIA VACCINES WITH CELL-WALL-ASSOCIATED CERAMIDE-LIKE GLYCOLIPIDS AND APPLICATIONS THEREOF

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KATSUICHI MIYAMOTO ET AL.: "A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 bias of natural killer T cells", NATURE, vol. 413, 4 October 2001 (2001-10-04), pages 531 - 534, XP002958968 *

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US8034908B2 (en) 2003-02-14 2011-10-11 Japan As Represented By President Of National Center Of Neurology And Psychiatry Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic method thereof
US7732583B2 (en) 2003-02-14 2010-06-08 Japan As Represented By President Of National Center Of Neurology And Psychiatry Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic intermediates, and synthetic method thereof
EP2343306A1 (en) * 2003-02-14 2011-07-13 Japan as represented by President of National Center of Neurology and Psychiatry Ministry of Health Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
WO2004072091A1 (ja) * 2003-02-14 2004-08-26 Daiichi Suntory Pharma Co., Ltd. 糖脂質誘導体及びその製造法並びにそれらの合成中間体及びその製造法
JP2012211182A (ja) * 2004-08-27 2012-11-01 Albert Einstein College Of Medicine Of Yeshiva Univ 免疫及び自己免疫の調節因子としてのセラミド誘導体
JP2008511634A (ja) * 2004-08-27 2008-04-17 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 免疫及び自己免疫の調節因子としてのセラミド誘導体
EP2251418A1 (en) 2004-10-07 2010-11-17 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
WO2006107097A1 (ja) * 2005-04-01 2006-10-12 Riken 経鼻ワクチン
JP4909264B2 (ja) * 2005-04-01 2012-04-04 独立行政法人理化学研究所 経鼻ワクチン
WO2007004705A1 (ja) * 2005-07-01 2007-01-11 Japan As Represented By President Of National Center Of Neurology And Psychiatry 糖脂質誘導体及びそれを有効成分とする治療剤
WO2007049819A1 (ja) * 2005-10-28 2007-05-03 Japan As Represented By President Of National Center Of Neurology And Psychiatry Nkt細胞の機能を抑制する糖脂質誘導体を有効成分とする治療剤
WO2007099999A1 (ja) * 2006-02-28 2007-09-07 Riken 新規糖脂質及びその用途
JP5126684B2 (ja) * 2006-02-28 2013-01-23 独立行政法人理化学研究所 新規糖脂質及びその用途
US8163705B2 (en) 2006-02-28 2012-04-24 Riken Glycolipid and use thereof
WO2007117682A2 (en) 2006-04-07 2007-10-18 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
JP2010514758A (ja) * 2006-12-30 2010-05-06 エスエヌユー アールアンドディービー ファウンデーション αガラクトシルセラミド誘導体、その薬学的に許容可能な塩、その製造方法及びそれを有効成分として含む免疫補助用薬学的組成物
US9603922B2 (en) 2007-02-21 2017-03-28 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CD1d molecules
US8697659B2 (en) 2007-10-12 2014-04-15 Luigi Panza Analogues of glycolipids useful as immunoadjuvants
JP2011510910A (ja) * 2007-10-12 2011-04-07 ルイジ パンツァ， 免疫アジュバントとして有用な糖脂質の類似体
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
US10111950B2 (en) 2013-02-08 2018-10-30 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
JP2015134742A (ja) * 2013-12-19 2015-07-27 国立研究開発法人国立精神・神経医療研究センター ＧＭ−ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
WO2015174278A1 (ja) * 2013-12-19 2015-11-19 国立研究開発法人国立精神・神経医療研究センター ＧＭ－ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
JP2018009011A (ja) * 2013-12-19 2018-01-18 国立研究開発法人国立精神・神経医療研究センター ＧＭ−ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
KR20160130403A (ko) 2014-02-26 2016-11-11 국립대학법인 홋가이도 다이가쿠 수지상 세포를 함유하는 의약 및 그 제조 방법
US10022401B2 (en) 2014-02-26 2018-07-17 National University Corporation Hokkaido University Pharmaceutical containing dendritic cells, and method for producing same
WO2021010344A1 (ja) 2019-07-12 2021-01-21 国立大学法人九州大学 心筋収縮改善治療法および心筋細胞死抑制法の開発

Also Published As

Publication number Publication date
KR100880063B1 (ko) 2009-01-22
HU229345B1 (en) 2013-11-28
EP1437358B1 (en) 2006-10-18
KR20040039287A (ko) 2004-05-10
NO20040653L (no) 2004-05-07
EP1437358A4 (en) 2004-11-24
HUP0500127A3 (en) 2009-12-28
ES2274080T3 (es) 2007-05-16
JP4064346B2 (ja) 2008-03-19
CA2459482A1 (en) 2003-02-27
CN100439383C (zh) 2008-12-03
ATE342910T1 (de) 2006-11-15
NO326398B1 (no) 2008-11-24
HUP0500127A2 (en) 2006-09-28
DE60215530D1 (de) 2006-11-30
BR0211968A (pt) 2004-09-28
CA2459482C (en) 2010-09-28
CN1568328A (zh) 2005-01-19
JPWO2003016326A1 (ja) 2004-12-02
DE60215530T2 (de) 2007-05-31
US20060148723A1 (en) 2006-07-06
US8367623B2 (en) 2013-02-05
AU2002327097B2 (en) 2007-05-24
EP1437358A1 (en) 2004-07-14
DK1437358T3 (da) 2007-02-05

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