KR970074763A - 불소화된 비타민 d₃ 유사체 - Google Patents

불소화된 비타민 d₃ 유사체 Download PDF

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Publication number
KR970074763A
KR970074763A KR1019970019921A KR19970019921A KR970074763A KR 970074763 A KR970074763 A KR 970074763A KR 1019970019921 A KR1019970019921 A KR 1019970019921A KR 19970019921 A KR19970019921 A KR 19970019921A KR 970074763 A KR970074763 A KR 970074763A
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South Korea
Prior art keywords
hydroxy
hydrogen
analogs
compound
formula
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KR1019970019921A
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KR100237523B1 (ko
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버나드 마이클 헤네시
밀란 라도제 우스코코빅
Original Assignee
클라우스너 프리돌린, 보러 롤란드
에프 호프만-라 롯슈 아게
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Publication of KR970074763A publication Critical patent/KR970074763A/ko
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Publication of KR100237523B1 publication Critical patent/KR100237523B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 과증식성 장애, 종양성 질환 및 피지선 질환의 치료에 유용한 하기 화학식(1)의 화합물을 제공한다 :
상기 식에서, R은 수소, 불소 또는 하이드록시이고; X는 =CH2이거나, 또는 R이 하이드록시일 때 X는 수소 또는 =CH2이다.

Description

불소화된 비타민 D3유사체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 화학식(1)의 화합물 ;
    상기 식에서, R은 수소, 불소 또는 하이드록시이고; X는 =CH2이거나, 또는 R이 하이드록시일 때 X는 수소 또는 =CH2이다.
  2. 과증식성 장애, 종양성 질환 및 피지선 질환을 치료하기 위한, 효과량의 제1항에 따른 화학식(1)의 화합물 및 약학적으로 허용되는 담체를 포함하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970019921A 1996-05-23 1997-05-22 불소화된 비타민 d3 유사체 KR100237523B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1818796P 1996-05-23 1996-05-23
US60/018,187 1996-05-23

Publications (2)

Publication Number Publication Date
KR970074763A true KR970074763A (ko) 1997-12-10
KR100237523B1 KR100237523B1 (ko) 2000-01-15

Family

ID=21786696

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970019921A KR100237523B1 (ko) 1996-05-23 1997-05-22 불소화된 비타민 d3 유사체

Country Status (30)

Country Link
US (1) US5888994A (ko)
EP (1) EP0808831B1 (ko)
JP (1) JP2858571B2 (ko)
KR (1) KR100237523B1 (ko)
CN (1) CN1081184C (ko)
AR (1) AR007240A1 (ko)
AT (1) ATE195514T1 (ko)
AU (1) AU720098B2 (ko)
BR (1) BR9703373A (ko)
CA (1) CA2204478C (ko)
CO (1) CO4840512A1 (ko)
CZ (1) CZ157997A3 (ko)
DE (1) DE69702812T2 (ko)
DK (1) DK0808831T3 (ko)
ES (1) ES2150719T3 (ko)
GR (1) GR3034832T3 (ko)
HR (1) HRP970274A2 (ko)
HU (1) HUP9700927A3 (ko)
IL (1) IL120842A0 (ko)
MA (1) MA24345A1 (ko)
NO (1) NO971934L (ko)
NZ (1) NZ314838A (ko)
PL (1) PL320131A1 (ko)
PT (1) PT808831E (ko)
SG (1) SG50831A1 (ko)
TR (1) TR199700418A2 (ko)
TW (1) TW374762B (ko)
UY (1) UY24563A1 (ko)
YU (1) YU19997A (ko)
ZA (1) ZA974334B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
AU743514B2 (en) * 1997-05-16 2002-01-24 Women & Infants Hospital Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof
DE69834109T2 (de) * 1997-05-16 2007-04-19 Woman & Infants Hospital 3-epi-vitamin d2 verbindungen und ihre anwendungen
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
WO2000051554A2 (en) * 1999-03-05 2000-09-08 Johns Hopkins University Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
SI3095447T1 (sl) 2006-02-03 2022-02-28 Opko Renal, Llc Zdravljenje pomanjkanja vitamina D s 25-hidroksivitaminom D2 in 25-hidroksivitaminom D3
DK2037936T3 (da) 2006-06-21 2014-09-22 Opko Renal Llc Fremgangsmåde til behandling og forebyggelse af sekundær hyperparathyroidisme
ES2403107T3 (es) 2007-04-25 2013-05-14 Cytochroma Inc. Método de tratamiento de insuficiencia y deficiencia de vitamina D
KR20190028822A (ko) 2007-04-25 2019-03-19 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
DK2552484T3 (da) 2010-03-29 2020-04-14 Opko Ireland Global Holdings Ltd Fremgangsmåder og sammensætninger til reducering af parathyroidniveauer
US8754067B2 (en) 2010-11-12 2014-06-17 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
EA201790332A1 (ru) 2014-08-07 2017-06-30 Опко Айэлэнд Глобал Холдингз Лтд. Дополнительная терапия 25-гидроксивитамином d
JP7032322B2 (ja) 2016-03-28 2022-03-08 オプコ アイルランド グローバル ホールディングス リミテッド ビタミンｄ治療法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039671A (en) * 1984-12-19 1991-08-13 Hoffmann-La Roche Inc. Trifluorinated-1α,25S-dihydroxy vitamin D3 compounds
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
US5210237A (en) * 1991-08-27 1993-05-11 Daikin Industries, Ltd. Vitamin d3 analogues
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
GB9206648D0 (en) * 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
DK0580968T3 (da) * 1992-05-20 1996-10-14 Hoffmann La Roche Fluorerede analoger af vitamin D3
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
TW267161B (ko) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5384314B1 (en) * 1994-03-11 1997-08-05 Hoffmann La Roche 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger

Also Published As

Publication number Publication date
TR199700418A3 (tr) 1997-12-21
BR9703373A (pt) 1998-09-15
UY24563A1 (es) 2000-12-29
CA2204478A1 (en) 1997-11-23
AU2357297A (en) 1997-11-27
ZA974334B (en) 1997-11-24
MA24345A1 (fr) 1998-07-01
HU9700927D0 (en) 1997-07-28
CO4840512A1 (es) 1999-09-27
CN1169425A (zh) 1998-01-07
TW374762B (en) 1999-11-21
CA2204478C (en) 2006-11-21
GR3034832T3 (en) 2001-02-28
NZ314838A (en) 1998-01-26
HUP9700927A2 (hu) 1998-01-28
JP2858571B2 (ja) 1999-02-17
TR199700418A2 (xx) 1997-12-21
PL320131A1 (en) 1997-11-24
SG50831A1 (en) 1998-07-20
EP0808831A2 (en) 1997-11-26
DE69702812T2 (de) 2001-01-25
CN1081184C (zh) 2002-03-20
PT808831E (pt) 2000-12-29
NO971934D0 (no) 1997-04-25
CZ157997A3 (en) 1997-12-17
HUP9700927A3 (en) 1999-07-28
KR100237523B1 (ko) 2000-01-15
ATE195514T1 (de) 2000-09-15
NO971934L (no) 1997-11-24
US5888994A (en) 1999-03-30
MX9703776A (es) 1998-06-30
JPH1045712A (ja) 1998-02-17
EP0808831B1 (en) 2000-08-16
DK0808831T3 (da) 2001-01-02
DE69702812D1 (de) 2000-09-21
HRP970274A2 (en) 1998-04-30
AR007240A1 (es) 1999-10-27
EP0808831A3 (en) 1999-02-03
IL120842A0 (en) 1997-09-30
ES2150719T3 (es) 2000-12-01
AU720098B2 (en) 2000-05-25
YU19997A (sh) 1999-07-28

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