CN1568328A - 新的糖脂及其作为有效成分的用于自体免疫疾病的药物 - Google Patents
新的糖脂及其作为有效成分的用于自体免疫疾病的药物 Download PDFInfo
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- CN1568328A CN1568328A CNA028203615A CN02820361A CN1568328A CN 1568328 A CN1568328 A CN 1568328A CN A028203615 A CNA028203615 A CN A028203615A CN 02820361 A CN02820361 A CN 02820361A CN 1568328 A CN1568328 A CN 1568328A
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- compound
- glycolipid
- galactosyl
- triol
- synthetic
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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Abstract
Description
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP247055/2001 | 2001-08-16 | ||
JP2001247055 | 2001-08-16 |
Publications (2)
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CN1568328A true CN1568328A (zh) | 2005-01-19 |
CN100439383C CN100439383C (zh) | 2008-12-03 |
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CNB028203615A Expired - Lifetime CN100439383C (zh) | 2001-08-16 | 2002-08-14 | 糖脂及其作为有效成分的用于自体免疫疾病的药物 |
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US (1) | US8367623B2 (zh) |
EP (1) | EP1437358B1 (zh) |
JP (1) | JP4064346B2 (zh) |
KR (1) | KR100880063B1 (zh) |
CN (1) | CN100439383C (zh) |
AT (1) | ATE342910T1 (zh) |
AU (1) | AU2002327097B2 (zh) |
BR (1) | BR0211968A (zh) |
CA (1) | CA2459482C (zh) |
DE (1) | DE60215530T2 (zh) |
DK (1) | DK1437358T3 (zh) |
ES (1) | ES2274080T3 (zh) |
HU (1) | HU229345B1 (zh) |
NO (1) | NO326398B1 (zh) |
WO (1) | WO2003016326A1 (zh) |
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US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
HUE037560T2 (hu) | 2003-02-14 | 2018-09-28 | Japan President Nat Ct Neurology & Psychiatry | Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására |
WO2006026389A2 (en) * | 2004-08-27 | 2006-03-09 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
US20080145931A1 (en) | 2004-10-07 | 2008-06-19 | Argos Therapeutics, Inc. | Mature Dendritic Cell Compositions and Methods of Culturing Same |
US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Nkt細胞に対する抗原としての糖脂質及びその類似体 |
JP4909264B2 (ja) * | 2005-04-01 | 2012-04-04 | 独立行政法人理化学研究所 | 経鼻ワクチン |
KR20080021761A (ko) * | 2005-07-01 | 2008-03-07 | 국립 정신.신경센터 총장이 대표하는 일본국 | 당지질 유도체 및 이것을 유효 성분으로 하는 치료제 |
JPWO2007049819A1 (ja) * | 2005-10-28 | 2009-04-30 | 国立精神・神経センター総長 | Nkt細胞の機能を抑制する糖脂質誘導体を有効成分とする治療剤 |
US8163705B2 (en) | 2006-02-28 | 2012-04-24 | Riken | Glycolipid and use thereof |
CA2655947C (en) | 2006-06-30 | 2016-08-02 | The Scripps Research Institute | Compositions comprising nkt cell agonist compounds and methods of use |
KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
CA2678618C (en) | 2007-02-21 | 2019-03-12 | Vaccinex, Inc. | Modulation of nkt cell activity with antigen-loaded cd1d molecules |
AU2008326138B2 (en) * | 2007-10-12 | 2013-10-17 | Luigi Panza | Analogues of glycolipids useful as immunoadjuvants |
DK2385980T3 (en) * | 2009-01-08 | 2018-07-30 | Albert Einstein College Medicine Inc | BACTERIA VACCINES WITH CELL-WALL-ASSOCIATED CERAMIDE-LIKE GLYCOLIPIDS AND APPLICATIONS THEREOF |
US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
JP6202339B2 (ja) * | 2013-12-19 | 2017-09-27 | 国立研究開発法人国立精神・神経医療研究センター | GM−CSF産生T細胞制御剤、及びTh1/Th2免疫バランス調節剤 |
EP3111945B1 (en) | 2014-02-26 | 2021-07-14 | National University Corporation Hokkaido University | Dendritic cells for use in the treatment of myocardial infarction |
WO2021010344A1 (ja) | 2019-07-12 | 2021-01-21 | 国立大学法人九州大学 | 心筋収縮改善治療法および心筋細胞死抑制法の開発 |
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JPS5827828A (ja) * | 1981-08-11 | 1983-02-18 | Mitsubishi Electric Corp | 燃料噴射装置 |
DK84691D0 (da) | 1991-05-07 | 1991-05-07 | Karsten Buschard | Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater |
JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
GB9207182D0 (en) * | 1992-04-01 | 1992-05-13 | Enzymatix Ltd | Glycolipids and their preparation |
TW261533B (zh) | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
CA2142153A1 (en) * | 1994-03-04 | 1995-09-05 | Jacques Banville | Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors |
CN1058498C (zh) * | 1994-05-31 | 2000-11-15 | 生化学工业株式会社 | 糖脂类似物 |
DE19602108A1 (de) * | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen |
JP4451933B2 (ja) * | 1996-12-27 | 2010-04-14 | 住友化学株式会社 | 遺伝子操作による植物へのppo阻害性除草剤耐性付与法 |
WO1998044928A1 (en) | 1997-04-10 | 1998-10-15 | Kirin Beer Kabushiki Kaisha | NKT CELL ACTIVATORS CONTAINING α-GLYCOSYLCERAMIDES |
US6589940B1 (en) * | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
TW575420B (en) * | 1997-09-22 | 2004-02-11 | Kirin Brewery | Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides |
US7273711B1 (en) * | 1998-12-02 | 2007-09-25 | The Regents Of The University Of California | Diagnosis of human glycosylation disorders |
JP2002284692A (ja) * | 2001-03-26 | 2002-10-03 | Kirin Brewery Co Ltd | α−グリコシルセラミドによる移植片対宿主病(GVHD)の抑制 |
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- 2002-08-14 BR BR0211968-4A patent/BR0211968A/pt not_active IP Right Cessation
- 2002-08-14 AT AT02760637T patent/ATE342910T1/de not_active IP Right Cessation
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Also Published As
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KR100880063B1 (ko) | 2009-01-22 |
HU229345B1 (en) | 2013-11-28 |
EP1437358B1 (en) | 2006-10-18 |
KR20040039287A (ko) | 2004-05-10 |
NO20040653L (no) | 2004-05-07 |
EP1437358A4 (en) | 2004-11-24 |
HUP0500127A3 (en) | 2009-12-28 |
ES2274080T3 (es) | 2007-05-16 |
WO2003016326A1 (fr) | 2003-02-27 |
JP4064346B2 (ja) | 2008-03-19 |
CA2459482A1 (en) | 2003-02-27 |
CN100439383C (zh) | 2008-12-03 |
ATE342910T1 (de) | 2006-11-15 |
NO326398B1 (no) | 2008-11-24 |
HUP0500127A2 (en) | 2006-09-28 |
DE60215530D1 (de) | 2006-11-30 |
BR0211968A (pt) | 2004-09-28 |
CA2459482C (en) | 2010-09-28 |
JPWO2003016326A1 (ja) | 2004-12-02 |
DE60215530T2 (de) | 2007-05-31 |
US20060148723A1 (en) | 2006-07-06 |
US8367623B2 (en) | 2013-02-05 |
AU2002327097B2 (en) | 2007-05-24 |
EP1437358A1 (en) | 2004-07-14 |
DK1437358T3 (da) | 2007-02-05 |
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