KR20010053252A - ＣＯＸ-2 억제제 및 ｉＮＯＳ 억제제를 포함하는 제약 제제 - Google Patents

ＣＯＸ-2 억제제 및 ｉＮＯＳ 억제제를 포함하는 제약 제제 Download PDF

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Publication number
KR20010053252A
KR20010053252A KR1020007014933A KR20007014933A KR20010053252A KR 20010053252 A KR20010053252 A KR 20010053252A KR 1020007014933 A KR1020007014933 A KR 1020007014933A KR 20007014933 A KR20007014933 A KR 20007014933A KR 20010053252 A KR20010053252 A KR 20010053252A
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KR
South Korea
Prior art keywords
quinazolin
piperidine
amine
spiro
amino
Prior art date
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Withdrawn
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KR1020007014933A
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English (en)
Korean (ko)
Inventor
피터 함레이
알란 틴커
Original Assignee
아스트라제네카 악티에볼라그
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Publication of KR20010053252A publication Critical patent/KR20010053252A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020007014933A 1998-06-29 1999-06-23 ＣＯＸ-2 억제제 및 ｉＮＯＳ 억제제를 포함하는 제약 제제 Withdrawn KR20010053252A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9802333-6 1998-06-29
SE9802333A SE9802333D0 (sv) 1998-06-29 1998-06-29 Novel combination
PCT/SE1999/001144 WO2000000200A1 (en) 1998-06-29 1999-06-23 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR

Publications (1)

Publication Number Publication Date
KR20010053252A true KR20010053252A (ko) 2001-06-25

Family

ID=20411898

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007014933A Withdrawn KR20010053252A (ko) 1998-06-29 1999-06-23 ＣＯＸ-2 억제제 및 ｉＮＯＳ 억제제를 포함하는 제약 제제

Country Status (22)

Country Link
US (1) US6248745B1 (enExample)
EP (1) EP1100505A1 (enExample)
JP (1) JP2002519324A (enExample)
KR (1) KR20010053252A (enExample)
CN (1) CN1313769A (enExample)
AU (1) AU4944799A (enExample)
BR (1) BR9911666A (enExample)
CA (1) CA2334515A1 (enExample)
CZ (1) CZ20004896A3 (enExample)
EE (1) EE200000766A (enExample)
ID (1) ID27394A (enExample)
IL (1) IL140022A0 (enExample)
IN (1) IN2000MU00721A (enExample)
IS (1) IS5794A (enExample)
MX (1) MXPA00012162A (enExample)
NO (1) NO20006559L (enExample)
PL (1) PL345028A1 (enExample)
SE (1) SE9802333D0 (enExample)
SK (1) SK18482000A3 (enExample)
TR (1) TR200003808T2 (enExample)
WO (1) WO2000000200A1 (enExample)
ZA (1) ZA200007076B (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL203262B1 (pl) * 1999-12-08 2009-09-30 Pharmacia Corp Substancja lecznicza celekoksyb, jej zastosowanie i sposób jej wytwarzania, kompozyt celekoksyb-inhibitor krystalizacji i sposób jego wytwarzania, kompozycja farmaceutyczna i sposób jej wytwarzania
RU2002119574A (ru) * 1999-12-23 2004-01-10 Нитромед, Инк. (Us) Нитрозированные и нитрозилированные ингибиторы циклооксигеназы-2, композиции на их основе и способы их применения
EP1406609B1 (en) * 2000-12-21 2006-09-06 Nitromed, Inc. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
EP1469846A2 (en) * 2002-01-07 2004-10-27 Pharmacia Corporation Treatment of pain, inflammation, and inflammation-related disorders with a combination of a cyclooxygenase-2 selective inhibitor and aspirin
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US20040077691A1 (en) * 2002-06-21 2004-04-22 Medinox, Inc. Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP2005538110A (ja) * 2002-07-29 2005-12-15 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
WO2004019986A1 (en) * 2002-08-29 2004-03-11 Schering Aktiengesellschaft Methods of treating acute respiratory distress syndrome
EP1534305B9 (en) 2003-05-07 2007-03-07 Osteologix A/S Treating cartilage / bone conditions with water-soluble strontium salts
KR101052122B1 (ko) 2005-10-25 2011-07-26 시오노기세야쿠 가부시키가이샤 아미노디히드로티아진 유도체
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
EP2083579B1 (en) 2006-10-25 2014-02-12 Huawei Technologies Co., Ltd. Processing location update request method, network entity, congestion control method and apparatus
JP2010516679A (ja) * 2007-01-19 2010-05-20 マリンクロット インコーポレイテッド 診断用および治療用シクロオキシゲナーゼ−２結合リガンド
EP2147914B1 (en) 2007-04-24 2014-06-04 Shionogi&Co., Ltd. Aminodihydrothiazine derivatives substituted with cyclic groups
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
CA2716628A1 (en) * 2008-03-24 2009-10-01 Carolus Therapeutics, Inc. Methods and compositions for treating atherosclerosis and related conditions
MX2010013256A (es) 2008-06-13 2010-12-21 Shionogi & Co Derivado heterociclico que contiene azufre que tiene actividad inhibitoria de beta-secretasa.
JPWO2010047372A1 (ja) 2008-10-22 2012-03-22 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
US8453441B2 (en) 2008-11-06 2013-06-04 Purdue Research Foundation System and method for pump-controlled cylinder cushioning
MY145791A (en) * 2009-05-25 2012-04-30 Liang Woon San A method for producing a nutraceutical composition and the nutraceutical produced by the method
JPWO2011071135A1 (ja) 2009-12-11 2013-04-22 塩野義製薬株式会社 オキサジン誘導体
JPWO2011077726A1 (ja) * 2009-12-24 2013-05-02 塩野義製薬株式会社 ４−アミノ−１，３−チアジンまたはオキサジン誘導体
MY157206A (en) 2010-01-13 2016-05-13 Basf Se Novel mannanase variants
WO2011110932A1 (en) 2010-03-12 2011-09-15 Council Of Scientific & Industrial Research Process for the production of violacein and its derivative deoxyviolacein containing bioactive pigment from chromobacterium sp. (mtcc 5522)
DE102010030500A1 (de) 2010-06-24 2011-12-29 Heliatek Gmbh Verdampfbares organisch halbleitendes Material und dessen Verwendung in einem optoelektronischen Bauelement
EP2634188A4 (en) 2010-10-29 2014-05-07 Shionogi & Co FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
CA2816285A1 (en) 2010-10-29 2012-05-03 Shionogi & Co., Ltd. Naphthyridine derivative
DE102011018604A1 (de) 2011-04-25 2014-02-13 Michael Friebe Medikamenteninfusor für die Anwendung in stark magnetischen Umgebungen
TW201247635A (en) 2011-04-26 2012-12-01 Shionogi & Co Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
EP2713937A1 (de) 2011-06-01 2014-04-09 Josef Schweiger Verbundkrone/verbundbrücke und verfahren zu deren herstellung
BR112014008152A2 (pt) 2011-10-07 2017-04-18 Lonza Ag método para produção de uma proteina de interesse cultivando uma linhagem celular eucariótica recombinante compreendendo uma construção de expressão compreendendo um promotor regulável e uma molécula de ácido nucleico que codifica uma poi sob o controle transcricional de tal promotor
DE102012201426A1 (de) 2012-02-01 2013-08-01 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zum verbinden von kunststoffen und verfahren zum lösen einer verbindung im kunststoffverbund und kunststoffverbund
DE102012007141A1 (de) 2012-04-10 2013-10-10 Bernhard Spindler Jalousierbarer Rollladenpanzer
DE102012106428A1 (de) 2012-07-17 2014-01-23 Reha Technology GmbH Vorrichtung zur therapeutischen Behandlung, System zur gerätegestützten Lokomotionstherapie und Verfahren zur Steuerung der Vorrichtung
DE112013003956T5 (de) 2012-08-08 2015-06-03 Luis Ramiro Medina Terrazas Kompostierung von festen und flüssigen Abfällen und biologisch abbaubaren Schlämmen unter Verwendung von Würmerhumus (Eisenia fostida und ähnlichen Spezies) und Mischungen von Würmerhumus und Magen Material mit einem hohen Mikroorganismen-Anteil
DE102012214452B4 (de) 2012-08-14 2019-08-01 Henkel Ag & Co. Kgaa Vorrichtung zum Auftragen einer fadenförmigen Masse
DE102012016116A1 (de) 2012-08-15 2014-02-20 Josip Fellner 360° Bag ln Box Spendersystem
DE102012214554A1 (de) 2012-08-16 2014-02-20 Robert Bosch Gmbh Verfahren zur Überführung von Batterien in einen entladenen Zustand, Batteriemanagementsystem, Inverter, System zur Erzeugung einer Wechselspannung, Ladestromquelle und Kraftfahrzeug
DE102012108153A1 (de) 2012-09-03 2014-03-06 Ludwig-Maximilians-Universität München Rohling und Verfahren zur Herstellung einer Dentalrestauration durch substraktive Bearbeitung
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
DE102012112186A1 (de) 2012-12-12 2014-06-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Materialverbund, Verfahren zu dessen Herstellung, daraus hergestelltes System und Anwendung desselben
EP2956041A2 (de) 2013-02-15 2015-12-23 Jochen Mertens Mixer mit massnahmen zur reduzierung des eintrages von luftsauerstoff in den mixer-inhalt
DE102013101713B4 (de) 2013-02-21 2020-10-01 Heliatek Gmbh Photoaktives, organisches Material für optoelektronische Bauelemente
DE102013101712B4 (de) 2013-02-21 2020-05-28 Heliatek Gmbh Photoaktives organisches Material für optoelektronische Bauelemente
DE102013102366A1 (de) 2013-03-10 2014-09-11 Informium Ag Vorrichtungen zur Herstellung und zum Auslesen eines Identifikationsmerkmals mit integriertem Kopierschutz
DE102013102364A1 (de) 2013-03-10 2014-09-11 Informium Ag Verfahren zur Herstellung eines Identifikationsmerkmals mit integriertem Kopierschutz
DE102013102365A1 (de) 2013-03-10 2014-09-11 Informium Ag Identifikationsmerkmal mit integriertem Kopierschutz
DE102013004288A1 (de) 2013-03-13 2014-09-18 Matthias Lietzau Fahrzeug Verbindungsfolie
DE202013002767U1 (de) 2013-03-22 2013-05-28 Lorenz-Montagesysteme Gmbh Ausgleichende Seitverbindung von Solarmodulen
DE102013005741B3 (de) 2013-04-05 2014-05-22 IOT - Innovative Oberflächentechnologien GmbH Vorrichtung zur Inertisierung bei UV-Bestrahlung in offenen Durchlaufanlagen
EP2792394B1 (de) 2013-04-16 2016-07-27 Jörg Beutler Interaktive Geschwindigkeitssteuerung
DE102013104501A1 (de) 2013-05-02 2014-11-06 B. Braun Avitum Ag Vorrichtung zur extrakorporalen Blutbehandlung
DE102013008359A1 (de) 2013-05-16 2014-11-20 Sew-Eurodrive Gmbh & Co Kg Energiespeicher, der aus in Reihe geschalten Energiespeicherzellen aufgebaut ist, und Schaltungsanordnung zur passiven Symmetrierung einer Reihenschaltung von Kondensatoren
DE102013008919B4 (de) 2013-05-24 2017-12-07 Magdeburger Windkraftanlagen GmbH Rotorsystem für die Energiewandlung von kinetischer Energie in Fluiden und Massenströmen
DE202013006258U1 (de) 2013-07-11 2013-10-11 IMM Ingenieurbüro GmbH Vorrichtung zum Erzeugen von heizbaren Flächen mit homogener Wärmeverteilung
DE102013110693B4 (de) 2013-09-27 2024-04-25 Heliatek Gmbh Photoaktives, organisches Material für optoelektronische Bauelemente
EP2873807A1 (de) 2013-11-18 2015-05-20 Siemens Aktiengesellschaft Abdeckplatte, Laufschaufel, Radscheibe, Bolzen und Gasturbine
WO2015075040A1 (de) 2013-11-19 2015-05-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum verbinden von silikongummi mit einem substrat
EP2902692B1 (de) 2013-12-06 2017-10-25 MAGNA STEYR Engineering AG & Co KG Bauteil eines Tanksystems
DE202014100570U1 (de) 2014-02-10 2014-03-10 Schlaadt Plastics Gmbh Klappsystem zur Verbindung von Partikelschaumbauteilen mittels eines gegen Verlust gesicherten Steckelements
DE102014004280A1 (de) 2014-03-26 2015-10-01 Florian M. König Impulssignal-Erzeugungsvorrichtung für Zwecke der autonomen Batterieaufladung oder 120-/230-Volt-Lampenversorgung
DE202014003299U1 (de) 2014-04-14 2014-08-25 Antje Koss Stollenschuh mit Wechselstollensystem
DE202014004532U1 (de) 2014-05-28 2014-08-05 Hans-Dieter Cornelius Hygienevorlage
DE102015214641B4 (de) 2014-11-10 2024-10-24 Hermann Roth Zusammensetzung mit Säure und Isochinolinalkaloid
DE102014017938A1 (de) 2014-12-05 2016-06-09 Florian M. König Trichter-turbinenartige Vorrichtung mit elektromagnetischer Rotationssteuerung von Flüssigkeits-Mischvorgängen
DE102015000003A1 (de) 2015-01-02 2016-07-07 Solukon Ingenieure GbR (vertretungsberechtigte Gesellschafter: Andreas Hartmann, 86391 Stadtbergen und Dominik Schmid, 86165 Augsburg) Baubehälter für Produktionsanlagen zur Herstellung von Bauteilen in Schichtbauverfahren
DE102015008129A1 (de) 2015-01-22 2016-07-28 Liebherr-Hausgeräte Lienz Gmbh Verfahren zur Bestimmung der Dämmeigenschaft einer Wandung eines wärmeisolierten Behältnisses
DE102015000887A1 (de) 2015-01-23 2016-07-28 Arnulf Deinzer Zahnreinigungsgerät mit ausfahrbaren Borsten
DE102015015877A1 (de) 2015-12-09 2017-06-14 Bayerisches Zentrum für angewandte Energieforschung, e.V. (ZAE Bayern) Optisch schaltendes Element
DE102016006696A1 (de) 2016-05-27 2017-11-30 Christoph Jaeger Flugautosystem
DE202016004226U1 (de) 2016-07-06 2016-11-11 Helmut Senkel Schienensystem mit verfahrbaren Verbrauchern
CN106279585A (zh) * 2016-08-26 2017-01-04 宁波圣达精工智能科技有限公司 一种阻燃智能密集书架的制备方法
CN108832306B (zh) * 2018-06-13 2023-11-03 中国科学院国家天文台 一种fast反射面中心孔柔性封堵结构

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ119398A3 (cs) 1995-10-17 1998-09-16 Astra Aktiebolag Farmaceuticky účinné sloučeniny na bázi chinazolinu

Also Published As

Publication number Publication date
IL140022A0 (en) 2002-02-10
EE200000766A (et) 2002-06-17
SE9802333D0 (sv) 1998-06-29
NO20006559D0 (no) 2000-12-21
CZ20004896A3 (en) 2001-06-13
ZA200007076B (en) 2002-02-28
PL345028A1 (en) 2001-11-19
US6248745B1 (en) 2001-06-19
EP1100505A1 (en) 2001-05-23
SK18482000A3 (sk) 2001-07-10
TR200003808T2 (tr) 2001-06-21
IN2000MU00721A (enExample) 2005-03-18
WO2000000200A1 (en) 2000-01-06
JP2002519324A (ja) 2002-07-02
CA2334515A1 (en) 2000-01-06
IS5794A (is) 2000-12-27
NO20006559L (no) 2001-02-28
CN1313769A (zh) 2001-09-19
ID27394A (id) 2001-04-05
BR9911666A (pt) 2001-03-20
MXPA00012162A (es) 2001-05-01
AU4944799A (en) 2000-01-17

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