KR20000052709A - 와튼제대교질에서 분리된 세포를 이용하여 연골 조직을 생산 - Google Patents
와튼제대교질에서 분리된 세포를 이용하여 연골 조직을 생산 Download PDFInfo
- Publication number
- KR20000052709A KR20000052709A KR1019990703506A KR19997003506A KR20000052709A KR 20000052709 A KR20000052709 A KR 20000052709A KR 1019990703506 A KR1019990703506 A KR 1019990703506A KR 19997003506 A KR19997003506 A KR 19997003506A KR 20000052709 A KR20000052709 A KR 20000052709A
- Authority
- KR
- South Korea
- Prior art keywords
- cells
- chondrocytes
- immature
- wharton
- cartilage tissue
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Physical Education & Sports Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/735,620 US5919702A (en) | 1996-10-23 | 1996-10-23 | Production of cartilage tissue using cells isolated from Wharton's jelly |
US8/735,620 | 1996-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20000052709A true KR20000052709A (ko) | 2000-08-25 |
Family
ID=24956535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019990703506A KR20000052709A (ko) | 1996-10-23 | 1997-10-23 | 와튼제대교질에서 분리된 세포를 이용하여 연골 조직을 생산 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5919702A (ja) |
EP (1) | EP0939803A1 (ja) |
JP (1) | JP2001502905A (ja) |
KR (1) | KR20000052709A (ja) |
AU (1) | AU731827B2 (ja) |
CA (1) | CA2269121A1 (ja) |
NZ (1) | NZ335531A (ja) |
WO (1) | WO1998017791A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100539371B1 (ko) * | 2002-10-21 | 2005-12-27 | 메디칸(주) | 인체 세포의 체외배양 방법 |
KR20190135733A (ko) * | 2018-05-29 | 2019-12-09 | 한국과학기술연구원 | 가압환경 세포의 배양 장치 및 배양 방법 |
Families Citing this family (118)
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US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
US20050043234A1 (en) * | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
US6613278B1 (en) * | 1998-11-13 | 2003-09-02 | Regeneration Technologies, Inc. | Tissue pooling process |
DE19752900A1 (de) * | 1997-11-28 | 1999-06-02 | Biotechnolog Forschung Gmbh | Knochenmatrix und/oder osteogene Zellen, deren Verwendung, therapeutische Zubereitung und Kit |
US6066495A (en) * | 1998-03-05 | 2000-05-23 | Tissue Engineering, Inc. | Methods and apparatus for the conditioning of ligament replacement tissue |
US6637437B1 (en) * | 1998-04-08 | 2003-10-28 | Johns Hopkins University | Cell-culture and polymer constructs |
DE19835368C1 (de) * | 1998-08-05 | 2000-02-10 | Juergen Steinmeyer | Verfahren zur Herstellung einer Knorpelzellsuspension |
WO2000017321A2 (en) * | 1998-09-18 | 2000-03-30 | Massachusetts Institute Of Technology | Use of growth factors and hormones for expansion of mammalian cells and tissue engineering |
ATE283349T1 (de) * | 1999-10-06 | 2004-12-15 | Tigenix Nv | Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebe |
EP1099443A1 (en) | 1999-11-11 | 2001-05-16 | Sulzer Orthopedics Ltd. | Transplant/implant device and method for its production |
WO2001035968A1 (en) * | 1999-11-19 | 2001-05-25 | Children's Medical Center Corporation | Methods for inducing chondrogenesis and producing de novo cartilage in vitro |
US20020041900A1 (en) * | 2000-05-01 | 2002-04-11 | Ole Olsen | Chondrocyte cultures and fractions therefrom |
US7553664B2 (en) | 2000-05-31 | 2009-06-30 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Three-dimensional skin model |
WO2002017983A1 (fr) * | 2000-08-28 | 2002-03-07 | Osteogenesis Co., Ltd. | Compositions medicinales pour la formation de tissu autour d'un os ou d'une dent, procede de preparation desdites compositions, substances a injecter pour la formation de tissu autour d'un os ou d'une dent et procede de preparation desdites substances |
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US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
JP2004528021A (ja) * | 2001-02-14 | 2004-09-16 | アンスロジェネシス コーポレーション | 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞 |
KR101012952B1 (ko) * | 2001-02-14 | 2011-02-08 | 안트로제네시스 코포레이션 | 산후 포유류의 태반, 이의 용도 및 태반 줄기세포 |
US20070082052A1 (en) * | 2001-02-23 | 2007-04-12 | Bonassar Lawrence J | Tympanic membrane repair constructs |
WO2002067856A2 (en) * | 2001-02-23 | 2002-09-06 | University Of Massachusetts | Injection molding of living tissues |
WO2002067812A2 (en) * | 2001-02-23 | 2002-09-06 | University Of Massachusetts | Tympanic membrane patch |
FR2821853B1 (fr) * | 2001-03-09 | 2003-05-16 | Natural Implant Sa | Bioreacteur pour tissu cultive en couche mince et utilisations |
US7459307B2 (en) * | 2001-08-14 | 2008-12-02 | Medipost Co., Ltd | Composition for treatment of articular cartilage damage |
DE10203644A1 (de) * | 2002-01-30 | 2003-08-07 | Fraunhofer Ges Forschung | Kryokonservierung an textilen Geweben |
US7736892B2 (en) * | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
US20040254640A1 (en) * | 2002-03-01 | 2004-12-16 | Children's Medical Center Corporation | Needle punched textile for use in growing anatomical elements |
ES2422881T3 (es) * | 2002-06-20 | 2013-09-16 | Augustinus Bader | Uso de eritropoyetina para la regeneración de tejido in vivo |
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US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
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1997
- 1997-10-23 WO PCT/US1997/018862 patent/WO1998017791A1/en not_active Application Discontinuation
- 1997-10-23 EP EP97912786A patent/EP0939803A1/en not_active Withdrawn
- 1997-10-23 NZ NZ335531A patent/NZ335531A/xx unknown
- 1997-10-23 CA CA002269121A patent/CA2269121A1/en not_active Abandoned
- 1997-10-23 KR KR1019990703506A patent/KR20000052709A/ko not_active Application Discontinuation
- 1997-10-23 AU AU49888/97A patent/AU731827B2/en not_active Expired
- 1997-10-23 JP JP10519528A patent/JP2001502905A/ja active Pending
Cited By (2)
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KR100539371B1 (ko) * | 2002-10-21 | 2005-12-27 | 메디칸(주) | 인체 세포의 체외배양 방법 |
KR20190135733A (ko) * | 2018-05-29 | 2019-12-09 | 한국과학기술연구원 | 가압환경 세포의 배양 장치 및 배양 방법 |
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JP2001502905A (ja) | 2001-03-06 |
AU4988897A (en) | 1998-05-15 |
EP0939803A1 (en) | 1999-09-08 |
WO1998017791A1 (en) | 1998-04-30 |
CA2269121A1 (en) | 1998-04-30 |
NZ335531A (en) | 2000-09-29 |
US5919702A (en) | 1999-07-06 |
AU731827B2 (en) | 2001-04-05 |
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