NZ335531A - Composition and methods of producing human cartilage tissue - Google Patents

Composition and methods of producing human cartilage tissue

Info

Publication number
NZ335531A
NZ335531A NZ335531A NZ33553197A NZ335531A NZ 335531 A NZ335531 A NZ 335531A NZ 335531 A NZ335531 A NZ 335531A NZ 33553197 A NZ33553197 A NZ 33553197A NZ 335531 A NZ335531 A NZ 335531A
Authority
NZ
New Zealand
Prior art keywords
chondrocytes
cartilage tissue
composition
methods
producing human
Prior art date
Application number
NZ335531A
Inventor
Anthony F Purchio
Brian A Naughton
Roman Julia San
Original Assignee
Advanced Tissue Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Tissue Sciences Inc filed Critical Advanced Tissue Sciences Inc
Publication of NZ335531A publication Critical patent/NZ335531A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The isolation and use of pre-chondrocytes from the umbilical cord, specifically from Wharton's jelly, that give rise to chondrocytes that produce cartilage tissue. The isolated pre-chondrocytes, or the chondrocytes to which they give rise, can be mitotically expanded in culture and used in the production of new cartilage tissue for therapeutic use. "Banks" of pre-chondrocytes or chondrocytes can be stored frozen, and thawed and used to produce new cartilage tissue as needed.
NZ335531A 1996-10-23 1997-10-23 Composition and methods of producing human cartilage tissue NZ335531A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/735,620 US5919702A (en) 1996-10-23 1996-10-23 Production of cartilage tissue using cells isolated from Wharton's jelly
PCT/US1997/018862 WO1998017791A1 (en) 1996-10-23 1997-10-23 Production of cartilage tissue using cells isolated from wharton's jelly

Publications (1)

Publication Number Publication Date
NZ335531A true NZ335531A (en) 2000-09-29

Family

ID=24956535

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ335531A NZ335531A (en) 1996-10-23 1997-10-23 Composition and methods of producing human cartilage tissue

Country Status (8)

Country Link
US (1) US5919702A (en)
EP (1) EP0939803A1 (en)
JP (1) JP2001502905A (en)
KR (1) KR20000052709A (en)
AU (1) AU731827B2 (en)
CA (1) CA2269121A1 (en)
NZ (1) NZ335531A (en)
WO (1) WO1998017791A1 (en)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528483B2 (en) 1995-06-07 2003-03-04 André Beaulieu Method of producing concentrated non-buffered solutions of fibronectin
US20050043234A1 (en) 1996-10-16 2005-02-24 Deisher Theresa A. Novel FGF homologs
US6613278B1 (en) * 1998-11-13 2003-09-02 Regeneration Technologies, Inc. Tissue pooling process
DE19752900A1 (en) * 1997-11-28 1999-06-02 Biotechnolog Forschung Gmbh Bone matrix and / or osteogenic cells, their use, therapeutic preparation and kit
US6066495A (en) * 1998-03-05 2000-05-23 Tissue Engineering, Inc. Methods and apparatus for the conditioning of ligament replacement tissue
US6637437B1 (en) * 1998-04-08 2003-10-28 Johns Hopkins University Cell-culture and polymer constructs
DE19835368C1 (en) * 1998-08-05 2000-02-10 Juergen Steinmeyer Process for the preparation of a cartilage cell suspension
ATE311437T1 (en) * 1998-09-18 2005-12-15 Massachusetts Inst Technology USE OF GROWTH FACTORS AND HORMONES TO PRODUCE HUMAN CHONDROCYTES AND CARTILAGE TISSUE PRODUCTION
DE20023640U1 (en) * 1999-10-06 2005-06-23 Tigenix N.V. Detecting an embryonic cell surface marker e.g. cartilage-derived morphogenic protein CDMP-1 so as to positively identify viable precursor cells that have entered a post-natal differentiation pathway
EP1099443A1 (en) 1999-11-11 2001-05-16 Sulzer Orthopedics Ltd. Transplant/implant device and method for its production
WO2001035968A1 (en) * 1999-11-19 2001-05-25 Children's Medical Center Corporation Methods for inducing chondrogenesis and producing de novo cartilage in vitro
US20020041900A1 (en) * 2000-05-01 2002-04-11 Ole Olsen Chondrocyte cultures and fractions therefrom
ATE308610T1 (en) 2000-05-31 2005-11-15 Fraunhofer Ges Forschung THREE-DIMENSIONAL SKIN MODEL
AU2001280164A1 (en) * 2000-08-28 2002-03-13 Osteogenesis Co., Ltd. Medicinal compositions for forming tissue around bone or tooth, process for preparing the same, injections for forming tissue around bone or tooth and process for preparing the same
WO2002046373A1 (en) 2000-12-06 2002-06-13 Hariri Robert J Method of collecting placental stem cells
JP2002233567A (en) * 2000-12-06 2002-08-20 Mitsuo Ochi Tissue equivalent for transplantation and its method of manufacture
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2316919B1 (en) * 2001-02-14 2015-10-07 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
ES2558626T3 (en) * 2001-02-14 2016-02-05 Anthrogenesis Corporation Placenta post-partum of mammals, their use and placental stem cells thereof
US20070082052A1 (en) * 2001-02-23 2007-04-12 Bonassar Lawrence J Tympanic membrane repair constructs
WO2002067812A2 (en) * 2001-02-23 2002-09-06 University Of Massachusetts Tympanic membrane patch
AU2002252025A1 (en) 2001-02-23 2002-09-12 University Of Massachusetts Injection molding of living tissues
FR2821853B1 (en) * 2001-03-09 2003-05-16 Natural Implant Sa BIOREACTOR FOR THIN FILM CULTIVE TISSUE AND USES
KR100494265B1 (en) * 2001-08-14 2005-06-13 메디포스트(주) Composition for treatment of articular cartilage damage
DE10203644A1 (en) * 2002-01-30 2003-08-07 Fraunhofer Ges Forschung Cryopreservation on textile fabrics
US7736892B2 (en) 2002-02-25 2010-06-15 Kansas State University Research Foundation Cultures, products and methods using umbilical cord matrix cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
US20040254640A1 (en) * 2002-03-01 2004-12-16 Children's Medical Center Corporation Needle punched textile for use in growing anatomical elements
AU2003253015A1 (en) * 2002-06-20 2004-01-06 Bionethos Holding Gmbh Method and device for multiplying and differentiating cells in the presence of growth factors and of a biological matrix or of a supporting structure
WO2004017972A1 (en) * 2002-08-23 2004-03-04 Law Peter K Biologic skin repair and enhancement
EP1551426B1 (en) * 2002-10-07 2014-06-25 ZymoGenetics, Inc. Methods of administering fgf18
KR100539371B1 (en) * 2002-10-21 2005-12-27 메디칸(주) In vitro cultured human preadipocyte for human soft tissue volume replacement with injectable material as a scaffold
US20040115804A1 (en) * 2002-12-13 2004-06-17 Yu-Show Fu Cell system for generating somatic cells
US20040127402A1 (en) * 2002-12-27 2004-07-01 Vad Vijay B. Injectible composition and method for treating degenerative animal joints
DE602004028803D1 (en) * 2003-02-11 2010-10-07 John E Davies PRECURSOR CELLS FROM THE WHARTON SULCE OF HUMAN NECK LOCKS
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
WO2005001081A1 (en) * 2003-06-27 2005-01-06 UNIVERSITé LAVAL Method of isolating cells from umbilical cord
US7875272B2 (en) * 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
EP1641913B1 (en) * 2003-06-27 2016-01-06 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
WO2006071794A2 (en) * 2004-12-23 2006-07-06 Ethicon Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
EP1678295B1 (en) 2003-10-08 2013-03-06 Vet-Stem Inc Methods of preparing and using stem cell compositions and kits comprising the same
EP2338442B1 (en) 2003-12-11 2013-01-30 Isto Technologies Inc. Particulate cartilage system
JP2005176663A (en) * 2003-12-17 2005-07-07 Ikushu Fu Cell line for producing somatic cell
EP2597149A1 (en) * 2004-08-16 2013-05-29 CellResearch Corporation Pte Ltd Isolation, cultivation and uses of stem/progenitor cells
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US20060166361A1 (en) * 2004-12-21 2006-07-27 Agnieszka Seyda Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006101548A2 (en) * 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
WO2006071773A2 (en) * 2004-12-23 2006-07-06 Ethicon Incoporated Treatment of osteochondral diseases using postpartum-derived cells and products thereof
WO2006071778A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
EP1831355A2 (en) * 2004-12-23 2007-09-12 Ethicon, Inc. Soft tissue repair and regeneration using postpartum-derived cells and cell products
GB0511723D0 (en) * 2005-06-09 2005-07-13 Smith & Nephew Placental stem cells
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
NZ612132A (en) 2005-10-13 2015-01-30 Anthrogenesis Corp Immunomodulation using placental stem cells
CN103555655B (en) 2005-10-21 2018-02-27 细胞研究私人有限公司 The application of ancestral cells and its cell of differentiation is separated and cultivated from umbilical cord amniotic membrane
WO2007070870A1 (en) * 2005-12-16 2007-06-21 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
JP5179376B2 (en) * 2005-12-19 2013-04-10 エシコン・インコーポレイテッド In vitro growth of postpartum-extracted cells in roller bottles
CA2634820C (en) 2005-12-22 2021-05-25 Jane Ennis Viable cells from frozen umbilical cord tissue
SG170789A1 (en) * 2005-12-28 2011-05-30 Ethicon Inc Treatment of peripheral vascular disease using postpartum-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
EP1976978A2 (en) 2005-12-29 2008-10-08 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
CN108559725A (en) 2005-12-29 2018-09-21 人类起源公司 placental stem cell populations
US8157774B1 (en) 2006-03-16 2012-04-17 Deka Products Limited Partnership Apparatus for stem cell collection and methods thereof
PL2029149T3 (en) * 2006-05-05 2017-12-29 John E. Davies Immune privileged and modulatory progenitor cells
AU2007258514A1 (en) * 2006-06-09 2007-12-21 Anthrogenesis Corporation Placental niche and use thereof to culture stem cells
US20080003205A1 (en) * 2006-06-26 2008-01-03 University Of Massachusetts Tympanic Membrane Repair Constructs
CN104099290A (en) 2006-10-23 2014-10-15 人类起源公司 Methods and compositions for treatment of bone defects with placental cell populations
ES2524443T3 (en) 2006-11-13 2014-12-09 DePuy Synthes Products, LLC In vitro expansion of postpartum cells using microcarriers
US20080132803A1 (en) * 2006-11-30 2008-06-05 Hyman Friedlander Method and system for doing business by mining the placental-chord complex
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
EP2119767B1 (en) * 2007-01-23 2016-01-20 Yokohama City University Method for preparation of cartilage cell
EP3103462A1 (en) 2007-02-12 2016-12-14 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
WO2008116160A1 (en) * 2007-03-22 2008-09-25 Kansas State University Research Foundation Use of umbilical cord matrix cells
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
WO2008137115A1 (en) 2007-05-03 2008-11-13 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US9744043B2 (en) 2007-07-16 2017-08-29 Lifenet Health Crafting of cartilage
KR20190132556A (en) 2007-09-28 2019-11-27 안트로제네시스 코포레이션 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
WO2009046335A1 (en) * 2007-10-05 2009-04-09 Ethicon, Incorporated Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
JP5773366B2 (en) 2008-04-21 2015-09-02 ティシュー リジェネレイション セラピューティックス、インコーポレイテッド Human umbilical cord perivascular cells genetically modified for prevention or treatment of biological or chemical agents
EP2291514B1 (en) 2008-05-22 2020-12-23 Vesta Therapeutics, Inc. Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
US20090317448A1 (en) * 2008-06-18 2009-12-24 University Of Massachusetts Tympanic membrane patch
NZ591294A (en) 2008-08-20 2012-10-26 Anthrogenesis Corp Treatment of stroke using isolated placental cells
MX339624B (en) 2008-08-20 2016-06-02 Anthrogenesis Corp Improved cell composition and methods of making the same.
AU2009283161A1 (en) 2008-08-22 2010-02-25 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
JP5702723B2 (en) 2008-09-04 2015-04-15 ザ ジェネラル ホスピタル コーポレイション Hydrogels for strengthening and repairing vocal cords and soft tissues
AU2008362567B2 (en) * 2008-10-10 2015-11-12 Histocell S.L. New biomaterial based on wharton's jelly from the human umbilical cord
JP5869342B2 (en) 2008-11-19 2016-02-24 アンスロジェネシス コーポレーション Amnion-derived adherent cells
US11248211B2 (en) * 2008-11-25 2022-02-15 Kolon Tissuegene, Inc. Primed cell therapy
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
CN102387807A (en) 2008-12-19 2012-03-21 先进科技及再生医学有限责任公司 Treatment of lung and pulmonary diseases and disorders
US8722034B2 (en) * 2009-03-26 2014-05-13 Depuy Synthes Products Llc hUTC as therapy for Alzheimer's disease
CA2787992A1 (en) 2010-01-26 2011-08-04 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
US10226480B2 (en) * 2010-03-30 2019-03-12 Histocell, S.L. Biomaterial from Wharton's jelly umbilical cord
TW201703777A (en) 2010-04-07 2017-02-01 安瑟吉納西斯公司 Angiogenesis using placental stem cells
US8562973B2 (en) 2010-04-08 2013-10-22 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
PL2576768T3 (en) 2010-06-01 2017-10-31 Auxocell Laboratories Inc Native wharton's jelly stem cells and their purification
MX342995B (en) 2010-07-13 2016-10-21 Anthrogenesis Corp Methods of generating natural killer cells.
JP2012031127A (en) * 2010-08-03 2012-02-16 Nagoya Univ Composition including umbilical cord matrix stromal cell
AU2011352036A1 (en) 2010-12-31 2013-07-18 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
CN113559126A (en) 2011-06-01 2021-10-29 人类起源公司 Treatment of pain using placental stem cells
US9925221B2 (en) 2011-09-09 2018-03-27 Celularity, Inc. Treatment of amyotrophic lateral sclerosis using placental stem cells
JP6301263B2 (en) 2011-12-23 2018-03-28 デピュイ・シンセス・プロダクツ・インコーポレイテッド Detection of human umbilical cord tissue-derived cells
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9763983B2 (en) 2013-02-05 2017-09-19 Anthrogenesis Corporation Natural killer cells from placenta
AU2015287920A1 (en) * 2014-07-08 2017-01-19 Mimedx Group, Inc. Micronized wharton's jelly
TWI566774B (en) * 2014-10-06 2017-01-21 佛教慈濟醫療財團法人花蓮慈濟醫院 Composition for treatment of joint disease and method thereof
US10542743B2 (en) 2015-01-05 2020-01-28 Hygieia Therapeutics Sdn Bhd Isolation, expansion and characterization of wharton's jelly mesenchymal stem cells
EP3423119A4 (en) 2016-03-04 2020-02-19 The Board of Regents of The University of Texas System Devices and methods for umbilical cord processing
US11723635B2 (en) 2017-09-05 2023-08-15 The Board Of Regents Of The University Of Texas System Devices and methods for umbilical cord processing
US20200339947A1 (en) 2017-12-22 2020-10-29 Chiesi Farmaceutici S.P.A. Mesenchymal stromal cells and methods for obtaining mesenchymal stromal cells from umbilical cord
US10961502B2 (en) * 2018-03-12 2021-03-30 P.E. Asia Biomedicine Co., Ltd. Method for preparing collagen having regeneration and repair effects from Wharton's Jelly mesenchymal stem cells
KR102110252B1 (en) * 2018-05-29 2020-05-14 한국과학기술연구원 Culturing device for cell under compressed circumstance and culturing method for the same
WO2021003254A1 (en) * 2019-07-01 2021-01-07 Auxocell Laboratories, Inc. Cryopreservation medium comprising a tissue extract
WO2024024708A1 (en) * 2022-07-26 2024-02-01 国立大学法人大阪大学 Composition for cartilage repair and method for manufacturing same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
IL68218A (en) * 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US4846835A (en) * 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair

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