KR20000005238A - 세펨 화합물 및 그 화합물을 함유하는 약제 - Google Patents

세펨 화합물 및 그 화합물을 함유하는 약제

Info

Publication number
KR20000005238A
KR20000005238A KR1019980707925A KR19980707925A KR20000005238A KR 20000005238 A KR20000005238 A KR 20000005238A KR 1019980707925 A KR1019980707925 A KR 1019980707925A KR 19980707925 A KR19980707925 A KR 19980707925A KR 20000005238 A KR20000005238 A KR 20000005238A
Authority
KR
South Korea
Prior art keywords
compound
formula
mmol
added
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019980707925A
Other languages
English (en)
Korean (ko)
Inventor
야스히로 니시타니
고지 이시쿠라
Original Assignee
시오노 요시히코
시오노기세이야쿠가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시오노 요시히코, 시오노기세이야쿠가부시키가이샤 filed Critical 시오노 요시히코
Publication of KR20000005238A publication Critical patent/KR20000005238A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019980707925A 1996-04-04 1997-04-04 세펨 화합물 및 그 화합물을 함유하는 약제 Ceased KR20000005238A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP96-82531 1996-04-04
JP8253196 1996-04-04

Publications (1)

Publication Number Publication Date
KR20000005238A true KR20000005238A (ko) 2000-01-25

Family

ID=13777098

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980707925A Ceased KR20000005238A (ko) 1996-04-04 1997-04-04 세펨 화합물 및 그 화합물을 함유하는 약제

Country Status (11)

Country Link
US (2) US6214818B1 (enExample)
EP (3) EP1544197A1 (enExample)
JP (1) JP4064462B2 (enExample)
KR (1) KR20000005238A (enExample)
CN (2) CN1088711C (enExample)
AT (1) ATE341554T1 (enExample)
AU (1) AU2178497A (enExample)
CA (1) CA2250002C (enExample)
DE (1) DE69736775T2 (enExample)
ES (1) ES2273364T3 (enExample)
WO (1) WO1997037996A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022469A1 (en) * 1996-11-22 1998-05-28 Meiji Seika Kaisha, Ltd. Cephem intermediates and process for producing the same
EP1394159A1 (fr) * 2002-08-13 2004-03-03 Warner-Lambert Company LLC Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
TW200637559A (en) * 2005-03-29 2006-11-01 Shionogi & Co 3-propenylcefem derivative
US20080021026A1 (en) * 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
CN101153028B (zh) * 2006-09-30 2010-12-15 山东轩竹医药科技有限公司 具有抗菌抗病毒活性的化合物
SMT201800171T1 (it) 2011-07-29 2018-07-17 Karyopharm Therapeutics Inc Modulatori di trasporto nucleare contenenti idrazide e loro usi
KR102022715B1 (ko) * 2011-07-29 2019-09-18 카리오팜 쎄라퓨틱스, 인코포레이티드 핵 수송 조절인자 및 이의 용도
EP2753326A4 (en) 2011-09-09 2015-04-15 Cubist Pharm Inc METHOD FOR THE TREATMENT OF INTRAPULMONARY INFECTIONS
MX364992B (es) 2012-05-09 2019-05-17 Biogen Ma Inc Moduladores del transporte nuclear y usos de los mismos.
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
NZ700372A (en) 2013-03-15 2016-01-29 Merck Sharp & Dohme Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
WO2014144772A1 (en) 2013-03-15 2014-09-18 Karyopharm Therapeutics Inc. Methods of promoting wound healing using crm1 inhibitors
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US9738624B2 (en) 2013-06-21 2017-08-22 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
EP4112615A1 (en) 2014-08-15 2023-01-04 Karyopharm Therapeutics Inc. Compositions comprising one crystalline form of selinexor
MA43530A (fr) 2015-12-31 2018-11-07 Karyopharm Therapeutics Inc Modulateurs de transport nucléaire et leurs utilisations
MA43529A (fr) 2015-12-31 2018-11-07 Karyopharm Therapeutics Inc Modulateurs de transport nucléaire et leurs utilisations
WO2018098472A1 (en) 2016-11-28 2018-05-31 Karyopharm Therapeutics Inc. Crm1 inhibitors for treating epilepsy

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5271239A (en) * 1975-12-10 1977-06-14 Matsushita Electric Ind Co Ltd Electron beam sensitive material
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
JPS6064988A (ja) * 1983-09-21 1985-04-13 Sankyo Co Ltd セフアロスポリン誘導体
JPS60237090A (ja) * 1984-02-21 1985-11-25 Takeda Chem Ind Ltd セフエム化合物
GB8520155D0 (en) * 1985-08-10 1985-09-18 Beecham Group Plc Compounds
JPS62158290A (ja) * 1985-12-28 1987-07-14 Banyu Pharmaceut Co Ltd 新規セフアロスポリン誘導体
JPS62158291A (ja) * 1986-01-07 1987-07-14 Sagami Chem Res Center セフアロスポリン誘導体
JPH0459730A (ja) * 1990-06-26 1992-02-26 Dai Ichi Seiyaku Co Ltd セフェム系抗生物質含有凍結乾燥製剤
US5202321A (en) * 1991-06-13 1993-04-13 Merck Frosst Canada, Inc. Thiopyrano[2,3,4-c,d]indoles as inhibitors of leukotriene biosynthesis
JPH05217239A (ja) * 1991-10-31 1993-08-27 Sony Corp 光磁気ディスク記録再生装置
EP0554004A3 (en) * 1992-01-27 1993-11-24 Katayama Seisakusho Cephem compounds and antibacterial agents
JPH0741485A (ja) * 1993-07-30 1995-02-10 Katayama Seiyakushiyo:Kk セフェム誘導体およびそれを含有する抗菌剤

Also Published As

Publication number Publication date
DE69736775T2 (de) 2007-08-23
ES2273364T3 (es) 2007-05-01
CA2250002A1 (en) 1997-10-16
WO1997037996A1 (en) 1997-10-16
ATE341554T1 (de) 2006-10-15
AU2178497A (en) 1997-10-29
EP1544197A1 (en) 2005-06-22
DE69736775D1 (de) 2006-11-16
EP0893446B1 (en) 2006-10-04
CN1290702A (zh) 2001-04-11
EP0893446A4 (enExample) 1999-01-27
CN1215403A (zh) 1999-04-28
CN1129596C (zh) 2003-12-03
CN1088711C (zh) 2002-08-07
JP4064462B2 (ja) 2008-03-19
CA2250002C (en) 2008-03-25
US6458950B1 (en) 2002-10-01
EP1671966A1 (en) 2006-06-21
EP0893446A1 (en) 1999-01-27
US6214818B1 (en) 2001-04-10

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