KR102839545B1 - 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 - Google Patents

급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법

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KR102839545B1
KR102839545B1 KR1020237026280A KR20237026280A KR102839545B1 KR 102839545 B1 KR102839545 B1 KR 102839545B1 KR 1020237026280 A KR1020237026280 A KR 1020237026280A KR 20237026280 A KR20237026280 A KR 20237026280A KR 102839545 B1 KR102839545 B1 KR 102839545B1
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KR20230119252A (ko
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앤드류 피. 크루
키이스 알. 혼버거
징 왕
한칭 동
이민 치안
크레이그 엠. 크루즈
사울 제이미-피게로아
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아비나스 오퍼레이션스, 인코포레이티드
예일 유니버시티
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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KR1020237026280A 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 Active KR102839545B1 (ko)

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Application Number Priority Date Filing Date Title
KR1020257024694A KR20250117470A (ko) 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662438803P 2016-12-23 2016-12-23
US62/438,803 2016-12-23
US201762582698P 2017-11-07 2017-11-07
US62/582,698 2017-11-07
PCT/US2017/068322 WO2018119448A1 (en) 2016-12-23 2017-12-22 Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
KR1020197021537A KR102564201B1 (ko) 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법

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KR102839545B1 true KR102839545B1 (ko) 2025-07-29

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