CN110741004B - 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 - Google Patents
用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 Download PDFInfo
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- CN110741004B CN110741004B CN201780087131.XA CN201780087131A CN110741004B CN 110741004 B CN110741004 B CN 110741004B CN 201780087131 A CN201780087131 A CN 201780087131A CN 110741004 B CN110741004 B CN 110741004B
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311248251.7A CN117510491A (zh) | 2016-12-23 | 2017-12-22 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438803P | 2016-12-23 | 2016-12-23 | |
| US62/438,803 | 2016-12-23 | ||
| US201762582698P | 2017-11-07 | 2017-11-07 | |
| US62/582,698 | 2017-11-07 | ||
| PCT/US2017/068322 WO2018119448A1 (en) | 2016-12-23 | 2017-12-22 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311248251.7A Division CN117510491A (zh) | 2016-12-23 | 2017-12-22 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110741004A CN110741004A (zh) | 2020-01-31 |
| CN110741004B true CN110741004B (zh) | 2023-10-17 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780087131.XA Active CN110741004B (zh) | 2016-12-23 | 2017-12-22 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
| CN202311248251.7A Pending CN117510491A (zh) | 2016-12-23 | 2017-12-22 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311248251.7A Pending CN117510491A (zh) | 2016-12-23 | 2017-12-22 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
Country Status (12)
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| US (1) | US10723717B2 (enExample) |
| EP (1) | EP3558994A4 (enExample) |
| JP (3) | JP7679173B2 (enExample) |
| KR (3) | KR102839545B1 (enExample) |
| CN (2) | CN110741004B (enExample) |
| AU (2) | AU2017382436C1 (enExample) |
| BR (1) | BR112019012878A2 (enExample) |
| CA (1) | CA3047784A1 (enExample) |
| CO (1) | CO2019007894A2 (enExample) |
| IL (3) | IL294423B2 (enExample) |
| MX (2) | MX2019007649A (enExample) |
| WO (1) | WO2018119448A1 (enExample) |
Families Citing this family (145)
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| CA2894994C (en) | 2012-12-21 | 2019-11-12 | National Institute Of Radiological Sciences | Compounds for imaging tau proteins that accumulate in brain |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US11352351B2 (en) | 2015-01-20 | 2022-06-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| US10772962B2 (en) | 2015-08-19 | 2020-09-15 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| WO2018053354A1 (en) | 2016-09-15 | 2018-03-22 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
| KR20230127371A (ko) | 2016-11-01 | 2023-08-31 | 아비나스 오퍼레이션스, 인코포레이티드 | 타우(Tau)-단백질 표적화 프로탁(PROTAC) 및 관련 사용 방법 |
| IL297717A (en) | 2016-12-01 | 2022-12-01 | Arvinas Operations Inc | History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| MX2019007649A (es) | 2016-12-23 | 2019-09-10 | Arvinas Operations Inc | Compuestos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma acelerado rapidamente. |
| WO2018118598A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| WO2018119441A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Egfr proteolysis targeting chimeric molecules and associated methods of use |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| IL300417A (en) | 2017-01-26 | 2023-04-01 | Arvinas Operations Inc | Bifunctional benzothiophene compounds, preparations containing them and their use in therapy |
| EP3577109A4 (en) | 2017-01-31 | 2020-11-18 | Arvinas Operations, Inc. | CEREMONY LIGANDS AND BIFUNCTIONAL COMPOUNDS CONTAINING THEM |
| CN110545853A (zh) * | 2017-04-28 | 2019-12-06 | 石英治疗有限公司 | Raf降解偶联化合物 |
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