MX2023009031A - Compuestos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma acelerado rapidamente. - Google Patents

Compuestos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma acelerado rapidamente.

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Publication number
MX2023009031A
MX2023009031A MX2023009031A MX2023009031A MX2023009031A MX 2023009031 A MX2023009031 A MX 2023009031A MX 2023009031 A MX2023009031 A MX 2023009031A MX 2023009031 A MX2023009031 A MX 2023009031A MX 2023009031 A MX2023009031 A MX 2023009031A
Authority
MX
Mexico
Prior art keywords
target protein
raf
present disclosure
compounds
rapidly accelerated
Prior art date
Application number
MX2023009031A
Other languages
English (en)
Inventor
Yimin Qian
Saul Jaime-Figueroa
Craig M Crews
Andrew P Crew
Hanqing Dong
Keith R Hornberger
Jing Wang
Original Assignee
Arvinas Operations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arvinas Operations Inc filed Critical Arvinas Operations Inc
Publication of MX2023009031A publication Critical patent/MX2023009031A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La presente descripción se refiere a compuestos bifuncionales, que encuentran utilidad como moduladores de Fibrosarcoma Acelerado Rápidamente (RAF, tal como c-RAF, A-RAF y/o B-RAF; la proteína diana). En particular, la presente descripción se dirige a compuestos bifuncionales, que contienen en un extremo un ligando Von Hippel-Lindau, cereblon, Inhibidores de las Proteínas de Apoptosis, u homólogo 2 doble minuto de ratón que se une a la respectiva ligasa de ubiquitina E3 y en el otro extremo una porción que se une a la proteína diana RAF, de manera que la proteína diana se ubica en la proximidad de la ligasa de ubiquitina para efectuar la degradación (e inhibición) de la proteína diana. La presente descripción exhibe una amplia gama de actividades farmacológicas, asociadas con la degradación/inhibició n de la proteína diana. Las enfermedades o trastornos que resultan de la agregación o acumulación de la proteína diana o de la activación constitutiva de la proteína diana, se tratan o se previenen con los compuestos y composiciones de la presente descripción.
MX2023009031A 2016-12-23 2019-06-21 Compuestos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma acelerado rapidamente. MX2023009031A (es)

Applications Claiming Priority (2)

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US201662438803P 2016-12-23 2016-12-23
US201762582698P 2017-11-07 2017-11-07

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MX2023009031A true MX2023009031A (es) 2023-08-09

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MX2019007649A MX2019007649A (es) 2016-12-23 2017-12-22 Compuestos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma acelerado rapidamente.
MX2023009031A MX2023009031A (es) 2016-12-23 2019-06-21 Compuestos y metodos para la degradacion dirigida de polipeptidos de fibrosarcoma acelerado rapidamente.

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US (1) US10723717B2 (es)
EP (1) EP3558994A4 (es)
JP (2) JP2020504741A (es)
KR (2) KR102564201B1 (es)
CN (2) CN117510491A (es)
AU (2) AU2017382436C1 (es)
BR (1) BR112019012878A2 (es)
CA (1) CA3047784A1 (es)
CO (1) CO2019007894A2 (es)
IL (3) IL294423B2 (es)
MX (2) MX2019007649A (es)
WO (1) WO2018119448A1 (es)

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