UY39844A - Compuestos para la degradación selectiva de las proteínas irak4 - Google Patents
Compuestos para la degradación selectiva de las proteínas irak4Info
- Publication number
- UY39844A UY39844A UY0001039844A UY39844A UY39844A UY 39844 A UY39844 A UY 39844A UY 0001039844 A UY0001039844 A UY 0001039844A UY 39844 A UY39844 A UY 39844A UY 39844 A UY39844 A UY 39844A
- Authority
- UY
- Uruguay
- Prior art keywords
- irak4
- compounds
- proteins
- dsm
- linker
- Prior art date
Links
- 101000977771 Homo sapiens Interleukin-1 receptor-associated kinase 4 Proteins 0.000 title abstract 4
- 102100023533 Interleukin-1 receptor-associated kinase 4 Human genes 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000008684 selective degradation Effects 0.000 title 1
- 230000015556 catabolic process Effects 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 230000034512 ubiquitination Effects 0.000 abstract 1
- 238000010798 ubiquitination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Compuestos de fórmula (A): IRAK—L—DSM (A), o su sal farmacéuticamente aceptable, en donde DSM es un resto de señalización de degradación que se une covalentemente al enlazador L, donde L es un enlazador que une covalentemente IRAK a DSM; e IRAK es un resto de unión a IRAK4 de Fórmula (I) que se une covalentemente al enlazador L; donde todas las variables se definen en la solicitud. Los compuestos o sus sales farmacéuticamente aceptables pueden activar la ubiquitinación selectiva de las proteínas IRAK4 mediante las vías de ubiquitina-proteosoma (UPP) y provocar la degradación de las proteínas IRAK4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163219160P | 2021-07-07 | 2021-07-07 | |
| US202263354017P | 2022-06-21 | 2022-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY39844A true UY39844A (es) | 2023-01-31 |
Family
ID=82748311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001039844A UY39844A (es) | 2021-07-07 | 2022-07-07 | Compuestos para la degradación selectiva de las proteínas irak4 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20240343733A1 (es) |
| EP (1) | EP4367113A1 (es) |
| JP (1) | JP2024527570A (es) |
| KR (1) | KR20240035526A (es) |
| AU (1) | AU2022308734A1 (es) |
| CA (1) | CA3224732A1 (es) |
| CL (1) | CL2024000020A1 (es) |
| CO (1) | CO2024001193A2 (es) |
| IL (1) | IL309941A (es) |
| MX (1) | MX2024000395A (es) |
| TW (1) | TW202321236A (es) |
| UY (1) | UY39844A (es) |
| WO (1) | WO2023283610A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7555519B2 (ja) * | 2022-02-14 | 2024-09-24 | アストラゼネカ・アクチエボラーグ | Ｉｒａｋ４阻害剤 |
| WO2024133560A1 (en) * | 2022-12-21 | 2024-06-27 | Dark Blue Therapeutics Ltd | Imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives as mllt1 and mllt3 inhibitors |
| EP4389747A1 (en) * | 2022-12-21 | 2024-06-26 | Dark Blue Therapeutics Ltd | Imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives as mllt1 and mllt3 inhibitors |
| EP4428134A1 (en) * | 2023-03-10 | 2024-09-11 | Dark Blue Therapeutics Ltd | Protac degraders of mllt1 and/or mllt3 |
| WO2024183650A1 (zh) * | 2023-03-03 | 2024-09-12 | 上海齐鲁制药研究中心有限公司 | Irak4降解剂及其应用 |
| WO2024209044A1 (en) * | 2023-04-07 | 2024-10-10 | Astrazeneca Ab | Irak4 protacs |
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-
2022
- 2022-07-07 IL IL309941A patent/IL309941A/en unknown
- 2022-07-07 EP EP22748718.8A patent/EP4367113A1/en active Pending
- 2022-07-07 UY UY0001039844A patent/UY39844A/es unknown
- 2022-07-07 JP JP2024500319A patent/JP2024527570A/ja active Pending
- 2022-07-07 TW TW111125548A patent/TW202321236A/zh unknown
- 2022-07-07 WO PCT/US2022/073522 patent/WO2023283610A1/en active Application Filing
- 2022-07-07 MX MX2024000395A patent/MX2024000395A/es unknown
- 2022-07-07 US US18/576,940 patent/US20240343733A1/en active Pending
- 2022-07-07 CA CA3224732A patent/CA3224732A1/en active Pending
- 2022-07-07 AU AU2022308734A patent/AU2022308734A1/en active Pending
- 2022-07-07 KR KR1020247004514A patent/KR20240035526A/ko unknown
-
2024
- 2024-01-04 CL CL2024000020A patent/CL2024000020A1/es unknown
- 2024-02-05 CO CONC2024/0001193A patent/CO2024001193A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL309941A (en) | 2024-03-01 |
| MX2024000395A (es) | 2024-04-05 |
| CA3224732A1 (en) | 2023-01-12 |
| WO2023283610A1 (en) | 2023-01-12 |
| CO2024001193A2 (es) | 2024-05-20 |
| US20240343733A1 (en) | 2024-10-17 |
| CL2024000020A1 (es) | 2024-05-31 |
| TW202321236A (zh) | 2023-06-01 |
| KR20240035526A (ko) | 2024-03-15 |
| AU2022308734A1 (en) | 2024-02-22 |
| EP4367113A1 (en) | 2024-05-15 |
| JP2024527570A (ja) | 2024-07-25 |
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