AR125026A1 - Inhibidores del sarcómero cardíaco - Google Patents
Inhibidores del sarcómero cardíacoInfo
- Publication number
- AR125026A1 AR125026A1 ARP220100486A ARP220100486A AR125026A1 AR 125026 A1 AR125026 A1 AR 125026A1 AR P220100486 A ARP220100486 A AR P220100486A AR P220100486 A ARP220100486 A AR P220100486A AR 125026 A1 AR125026 A1 AR 125026A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- formula
- cyclohexyl
- halogen
- cardiac sarcomere
- Prior art date
Links
- 230000000747 cardiac effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 210000002235 sarcomere Anatomy 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/499—Spiro-condensed pyrazines or piperazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula [1], o un estereoisómero o tautómero del mismo, o una sal farmacéuticamente aceptable de cualquiera de los precedentes, en donde: R¹ es halógeno o haloalquilo C₁₋₆; R² es H, halógeno, o alquilo C₁₋₆; R³ es: (i) ciclohexilo, en donde el ciclohexilo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre alquilo C₁₋₆ o haloalquilo C₁₋₆, o (ii) alquilo C₁₋₆; y R⁴ es: (i) -C(O)H, (ii) -C(O)NH₂, (iii) un resto de fórmula [2], o (iv) un resto de fórmula [3], con la condición que: (1) cuando R³ es alquilo C₁₋₆, luego R⁴ es el resto de fórmula [2], (2) cuando R³ es isopropilo, luego el número total de átomos halógeno en R¹ y R² es por lo menos dos, y (3) cuando R³ es ciclohexilo sustituido con uno o más sustituyentes independientemente seleccionados entre haloalquilo C₁₋₆, luego R⁴ no es -C(O)H.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163156853P | 2021-03-04 | 2021-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR125026A1 true AR125026A1 (es) | 2023-05-31 |
Family
ID=80937093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220100486A AR125026A1 (es) | 2021-03-04 | 2022-03-03 | Inhibidores del sarcómero cardíaco |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11919909B2 (es) |
| EP (1) | EP4301760A1 (es) |
| JP (1) | JP2024508526A (es) |
| KR (1) | KR20240015622A (es) |
| CN (1) | CN117083275A (es) |
| AR (1) | AR125026A1 (es) |
| AU (1) | AU2022229390A1 (es) |
| BR (1) | BR112023017461A2 (es) |
| CA (1) | CA3209557A1 (es) |
| CL (1) | CL2023002616A1 (es) |
| IL (1) | IL305628A (es) |
| TW (1) | TW202302594A (es) |
| WO (1) | WO2022187501A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7438148B2 (ja) | 2018-06-26 | 2024-02-26 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| KR20210068422A (ko) | 2018-08-31 | 2021-06-09 | 싸이토키네틱스, 인코포레이티드 | 심장 근절 억제제 |
| CA3209557A1 (en) | 2021-03-04 | 2022-09-09 | Bradley P. Morgan | Cardiac sarcomere inhibitors |
| WO2024050539A1 (en) * | 2022-09-02 | 2024-03-07 | Cytokinetics, Incorporated | Crystalline forms of 5-(3,4-difluorobenzyl)-8-((1r,4r)-4-methylcyclohexyl)-6,9-dioxo-2,5,8-triazaspiro[3.5]nonane-2-carbaldehyde |
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| SA08290245B1 (ar) | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
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| CN114539257B (zh) | 2020-11-24 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类螺环衍生物、其制备方法及其在医药上的应用 |
| WO2022111498A1 (zh) | 2020-11-24 | 2022-06-02 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| CA3209557A1 (en) | 2021-03-04 | 2022-09-09 | Bradley P. Morgan | Cardiac sarcomere inhibitors |
-
2022
- 2022-03-03 CA CA3209557A patent/CA3209557A1/en active Pending
- 2022-03-03 WO PCT/US2022/018725 patent/WO2022187501A1/en active Application Filing
- 2022-03-03 IL IL305628A patent/IL305628A/en unknown
- 2022-03-03 BR BR112023017461A patent/BR112023017461A2/pt unknown
- 2022-03-03 EP EP22712689.3A patent/EP4301760A1/en active Pending
- 2022-03-03 AR ARP220100486A patent/AR125026A1/es unknown
- 2022-03-03 JP JP2023553393A patent/JP2024508526A/ja active Pending
- 2022-03-03 TW TW111107659A patent/TW202302594A/zh unknown
- 2022-03-03 CN CN202280017911.8A patent/CN117083275A/zh active Pending
- 2022-03-03 AU AU2022229390A patent/AU2022229390A1/en active Pending
- 2022-03-03 US US17/685,778 patent/US11919909B2/en active Active
- 2022-03-03 KR KR1020237033052A patent/KR20240015622A/ko unknown
-
2023
- 2023-09-01 CL CL2023002616A patent/CL2023002616A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3209557A1 (en) | 2022-09-09 |
| IL305628A (en) | 2023-11-01 |
| CN117083275A (zh) | 2023-11-17 |
| TW202302594A (zh) | 2023-01-16 |
| KR20240015622A (ko) | 2024-02-05 |
| CL2023002616A1 (es) | 2024-02-02 |
| BR112023017461A2 (pt) | 2023-09-26 |
| WO2022187501A1 (en) | 2022-09-09 |
| US20220306642A1 (en) | 2022-09-29 |
| EP4301760A1 (en) | 2024-01-10 |
| JP2024508526A (ja) | 2024-02-27 |
| US11919909B2 (en) | 2024-03-05 |
| AU2022229390A1 (en) | 2023-09-21 |
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