AR119453A1 - Derivados de piridazina - Google Patents

Derivados de piridazina

Info

Publication number
AR119453A1
AR119453A1 ARP200102049A ARP200102049A AR119453A1 AR 119453 A1 AR119453 A1 AR 119453A1 AR P200102049 A ARP200102049 A AR P200102049A AR P200102049 A ARP200102049 A AR P200102049A AR 119453 A1 AR119453 A1 AR 119453A1
Authority
AR
Argentina
Prior art keywords
group
fluoro
methyl
pyridazine derivatives
alkyl
Prior art date
Application number
ARP200102049A
Other languages
English (en)
Inventor
Christian Andreas Kuttruff
Tom Bretschneider
Cdrickx Godbout
Hannes Fiepko Koolman
Domnic Martyres
Gerald Juergen Roth
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR119453A1 publication Critical patent/AR119453A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en donde A es piridilo sustituido con uno o dos miembros del grupo que consiste en fluoro y F₁₋₇-fluoro-C₁₋₃-alquilo; E se selecciona del grupo que consiste en fenilo y piridilo opcionalmente sustituido con uno o dos miembros del grupo que consiste en fluoro y F₁₋₇-fluoro-C₁₋₃-alquilo; K se selecciona del grupo que consiste en los compuestos del grupo de fórmulas (2); R³ se selecciona del grupo que consiste en R⁴(O)C-, oxetanilo, metilo, R⁵(O)C(CH₃)N- y R⁵(O)CHN-; R⁴ es metilo; R⁵ es metilo.
ARP200102049A 2019-07-22 2020-07-21 Derivados de piridazina AR119453A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19187617 2019-07-22

Publications (1)

Publication Number Publication Date
AR119453A1 true AR119453A1 (es) 2021-12-22

Family

ID=67438402

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102049A AR119453A1 (es) 2019-07-22 2020-07-21 Derivados de piridazina

Country Status (31)

Country Link
US (2) US11485727B2 (es)
EP (2) EP4364805A3 (es)
JP (2) JP2022541065A (es)
KR (1) KR20220038438A (es)
CN (2) CN114206876B (es)
AR (1) AR119453A1 (es)
AU (1) AU2020316643A1 (es)
BR (1) BR112021026887A2 (es)
CA (1) CA3145868A1 (es)
CL (1) CL2022000112A1 (es)
CO (1) CO2022000243A2 (es)
CR (1) CR20220022A (es)
DK (1) DK4003998T3 (es)
DO (1) DOP2022000008A (es)
EC (1) ECSP22003856A (es)
ES (1) ES2977909T3 (es)
FI (1) FI4003998T3 (es)
HR (1) HRP20240697T1 (es)
HU (1) HUE066770T2 (es)
IL (1) IL289788A (es)
JO (1) JOP20220012A1 (es)
LT (1) LT4003998T (es)
MA (1) MA56631B1 (es)
MX (1) MX2022000958A (es)
PE (1) PE20220964A1 (es)
PL (1) PL4003998T3 (es)
PT (1) PT4003998T (es)
RS (1) RS65498B1 (es)
SI (1) SI4003998T1 (es)
UA (1) UA128544C2 (es)
WO (1) WO2021013830A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021004860A (es) * 2018-10-29 2021-06-15 Boehringer Ingelheim Int Piridazinas novedosas.
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
KR102587919B1 (ko) * 2022-07-22 2023-10-11 주식회사 넥스트젠바이오사이언스 신규한 헤테로사이클릭 화합물 및 이를 포함하는 오토탁신 저해용 약학 조성물
WO2024205327A1 (ko) * 2023-03-31 2024-10-03 주식회사 넥스트젠바이오사이언스 신규한 아자바이사이클 유도체 및 이를 포함하는 오토탁신 저해용 약학 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007003580A1 (es) * 2006-12-11 2009-03-27 Boehringer Ingelheim Int Compuestos derivados de piridazina, antagonistas de mch; composicion farmaceutica que comprende a dicho compuesto; procedimiento de preparacion; y uso del compuesto en el tratamiento de trastornos metabolicos y/o trastornos alimentarios como obesidad, bulimia, anorexia, hiperfagia, diabetes.
TW200944520A (en) * 2008-01-29 2009-11-01 Glaxo Group Ltd Spiro compounds as NPY Y5 receptor antagonists
US9273011B2 (en) * 2011-10-28 2016-03-01 Inhibitaxin Limited Substituted pyridazines for the treatment of pain
ES2824723T3 (es) 2013-03-14 2021-05-13 Galapagos Nv Nuevos compuestos y composiciones farmacéuticas de los mismos para el tratamiento de trastornos inflamatorios
JP6435323B2 (ja) 2013-06-19 2018-12-05 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 炎症性障害の治療のための新規化合物及びその医薬組成物
GB201503141D0 (en) * 2015-02-03 2015-04-08 Fosbel Inc Integral self-supporting refractory checker brick modules for glass furnace regenerator structures, and methods of forming same
GB201603745D0 (en) * 2016-03-04 2016-04-20 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis
WO2017192304A1 (en) * 2016-05-02 2017-11-09 Inception 1, Inc. Arylcarboxamides and uses thereof
KR101798840B1 (ko) * 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
EP3831812B1 (en) * 2018-07-27 2023-05-10 Mitsubishi Tanabe Pharma Corporation Novel 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same
MX2021004860A (es) 2018-10-29 2021-06-15 Boehringer Ingelheim Int Piridazinas novedosas.
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
HUE066940T2 (hu) 2019-07-22 2024-09-28 Boehringer Ingelheim Int Gmbh N-metil, N-(6-(metoxi)piridazin-3-il)amin-származékok, mint autotaxin (ATX) modulátorok gyulladásos légúti vagy fibrotikus betegségek kezelésére

Also Published As

Publication number Publication date
EP4003998B1 (en) 2024-03-27
WO2021013830A1 (en) 2021-01-28
JP2023116436A (ja) 2023-08-22
JOP20220012A1 (ar) 2023-01-30
FI4003998T3 (fi) 2024-04-24
JP7559131B2 (ja) 2024-10-01
IL289788A (en) 2022-03-01
EP4364805A2 (en) 2024-05-08
CN114206876A (zh) 2022-03-18
US11485727B2 (en) 2022-11-01
ECSP22003856A (es) 2022-02-25
LT4003998T (lt) 2024-05-10
AU2020316643A1 (en) 2022-02-17
CN114206876B (zh) 2024-05-14
PE20220964A1 (es) 2022-06-10
RS65498B1 (sr) 2024-06-28
MA56631B1 (fr) 2024-05-31
UA128544C2 (uk) 2024-08-07
CR20220022A (es) 2022-03-02
US20210024495A1 (en) 2021-01-28
US20230100516A1 (en) 2023-03-30
JP2022541065A (ja) 2022-09-21
EP4003998A1 (en) 2022-06-01
CL2022000112A1 (es) 2022-10-21
EP4364805A3 (en) 2024-08-21
HRP20240697T1 (hr) 2024-08-16
BR112021026887A2 (pt) 2022-04-26
CA3145868A1 (en) 2021-01-28
MX2022000958A (es) 2022-02-14
TW202120492A (zh) 2021-06-01
PL4003998T3 (pl) 2024-07-08
PT4003998T (pt) 2024-04-26
ES2977909T3 (es) 2024-09-02
HUE066770T2 (hu) 2024-09-28
CN118666853A (zh) 2024-09-20
SI4003998T1 (sl) 2024-06-28
KR20220038438A (ko) 2022-03-28
CO2022000243A2 (es) 2022-01-17
DK4003998T3 (da) 2024-06-10
DOP2022000008A (es) 2022-03-15

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