HRP20240697T1 - Derivati n-metil, n-(6-(metoksi)piridazin-3-il) amina kao modulatori autotaksina (atx) za liječenje upalnih bolesti dišnih puteva ili fibroznih bolesti - Google Patents
Derivati n-metil, n-(6-(metoksi)piridazin-3-il) amina kao modulatori autotaksina (atx) za liječenje upalnih bolesti dišnih puteva ili fibroznih bolesti Download PDFInfo
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- HRP20240697T1 HRP20240697T1 HRP20240697TT HRP20240697T HRP20240697T1 HR P20240697 T1 HRP20240697 T1 HR P20240697T1 HR P20240697T T HRP20240697T T HR P20240697TT HR P20240697 T HRP20240697 T HR P20240697T HR P20240697 T1 HRP20240697 T1 HR P20240697T1
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- 201000010099 disease Diseases 0.000 title claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 2
- 230000003176 fibrotic effect Effects 0.000 title claims 2
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title 1
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title 1
- 150000001412 amines Chemical class 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (21)
1. Spoj, naznačen time, da je predstavljen formulom (I)
[image]
u kojoj
A je piridil supstituiran s jednim ili dva člana iz skupine koju sačinjavaju fluoro i F1-7-fluoro-C1-3-alkil;
E se bira iz skupine koju sačinjavaju fenil i piridil opcionalno supstituiran s jednim ili dva člana iz skupine koju sačinjavaju fluoro i F1-7-fluoro-C1-3-alkil;
K se bira iz skupine koja se sastoji od:
[image]
;
R3 se bira iz skupine koju sačinjavaju R4(O)C-, oksetanil, metil, R5(O)C(CH3)N-, i R5(O)CHN-;
R4 je metil;
R5 je metil.
2. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da A je piridil supstituiran s jednim ili dva člana iz skupine koju sačinjavaju F, F1-3-fluoro-C1-alkil.
3. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da se A bira iz skupine koja se sastoji od:
[image]
4. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da se E bira iz skupine koju sačinjavaju fenil i piridil opcionalno supstituiran s jednim ili dva člana iz skupine koju sačinjavaju F, F2HC, i F3C.
5. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da se E bira iz skupine koja se sastoji od:
[image]
.
6. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da se on bira iz skupine koja se sastoji od:
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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i
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.
7. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
8. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
9. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
10. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
11. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
12. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
13. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
14. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
15. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
16. Spoj formule (I) prema patentnom zahtjevu 1, naznačen time, da ima strukturu
[image]
.
17. Sol, prvenstveno farmaceutski prihvatljiva sol, naznačena time, da je od spoja u skladu s bilo kojim od patentnih zahtjeva 6 do 16.
18. Farmaceutski pripravak, naznačen time, da sadrži najmanje jedan spoj formule (I) u skladu s bilo kojim od patentnih zahtjeva 1 do 17, ili njegovu farmaceutski prihvatljivu sol i jednu ili više farmaceutski prihvatljivih pomoćnih tvari.
19. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 17, naznačen time, da je za uporabu kao lijek.
20. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 17, ili njegova farmaceutski prihvatljiva sol, naznačen time, da je za uporabu u liječenju ili prevenciji upalnih bolesti dišnih puteva ili fibroznih bolesti.
21. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 17, ili njegova farmaceutski prihvatljiva sol, naznačen time, da je za uporabu u liječenju ili prevenciji idiopatske plućne bolesti (IPF) ili sistemske skleroze (SSc).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19187617 | 2019-07-22 | ||
| EP20743687.4A EP4003998B1 (en) | 2019-07-22 | 2020-07-21 | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases |
| PCT/EP2020/070547 WO2021013830A1 (en) | 2019-07-22 | 2020-07-21 | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240697T1 true HRP20240697T1 (hr) | 2024-08-16 |
Family
ID=67438402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240697TT HRP20240697T1 (hr) | 2019-07-22 | 2020-07-21 | Derivati n-metil, n-(6-(metoksi)piridazin-3-il) amina kao modulatori autotaksina (atx) za liječenje upalnih bolesti dišnih puteva ili fibroznih bolesti |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US11485727B2 (hr) |
| EP (2) | EP4003998B1 (hr) |
| JP (2) | JP2022541065A (hr) |
| KR (1) | KR20220038438A (hr) |
| CN (2) | CN114206876B (hr) |
| AR (1) | AR119453A1 (hr) |
| AU (1) | AU2020316643A1 (hr) |
| BR (1) | BR112021026887A2 (hr) |
| CA (1) | CA3145868A1 (hr) |
| CL (1) | CL2022000112A1 (hr) |
| CO (1) | CO2022000243A2 (hr) |
| CR (1) | CR20220022A (hr) |
| DK (1) | DK4003998T3 (hr) |
| DO (1) | DOP2022000008A (hr) |
| EC (1) | ECSP22003856A (hr) |
| ES (1) | ES2977909T3 (hr) |
| FI (1) | FI4003998T3 (hr) |
| HR (1) | HRP20240697T1 (hr) |
| HU (1) | HUE066770T2 (hr) |
| IL (1) | IL289788A (hr) |
| JO (1) | JOP20220012A1 (hr) |
| LT (1) | LT4003998T (hr) |
| MA (1) | MA56631B1 (hr) |
| MX (1) | MX2022000958A (hr) |
| PE (1) | PE20220964A1 (hr) |
| PL (1) | PL4003998T3 (hr) |
| PT (1) | PT4003998T (hr) |
| RS (1) | RS65498B1 (hr) |
| SI (1) | SI4003998T1 (hr) |
| UA (1) | UA128544C2 (hr) |
| WO (1) | WO2021013830A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021004860A (es) | 2018-10-29 | 2021-06-15 | Boehringer Ingelheim Int | Piridazinas novedosas. |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
| KR102587919B1 (ko) * | 2022-07-22 | 2023-10-11 | 주식회사 넥스트젠바이오사이언스 | 신규한 헤테로사이클릭 화합물 및 이를 포함하는 오토탁신 저해용 약학 조성물 |
| WO2024205327A1 (ko) * | 2023-03-31 | 2024-10-03 | 주식회사 넥스트젠바이오사이언스 | 신규한 아자바이사이클 유도체 및 이를 포함하는 오토탁신 저해용 약학 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200831485A (en) * | 2006-12-11 | 2008-08-01 | Boehringer Ingelheim Int | New pyridazine derivatives with MCH antagonistic activity and medicaments comprising these compounds |
| TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| US9273011B2 (en) | 2011-10-28 | 2016-03-01 | Inhibitaxin Limited | Substituted pyridazines for the treatment of pain |
| PT3269716T (pt) | 2013-03-14 | 2020-10-09 | Galapagos Nv | Novos compostos e suas composições farmacêuticas para o tratamento de doenças inflamatórias |
| JP6435323B2 (ja) | 2013-06-19 | 2018-12-05 | ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． | 炎症性障害の治療のための新規化合物及びその医薬組成物 |
| GB201503141D0 (en) * | 2015-02-03 | 2015-04-08 | Fosbel Inc | Integral self-supporting refractory checker brick modules for glass furnace regenerator structures, and methods of forming same |
| GB201603745D0 (en) * | 2016-03-04 | 2016-04-20 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
| WO2017192304A1 (en) * | 2016-05-02 | 2017-11-09 | Inception 1, Inc. | Arylcarboxamides and uses thereof |
| KR101798840B1 (ko) * | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| IL279702B2 (en) * | 2018-07-27 | 2024-05-01 | Mitsubishi Tanabe Pharma Corp | Pyridine and pyridazine derivatives are converted in positions 3 and 5 and their pharmaceutical uses |
| MX2021004860A (es) | 2018-10-29 | 2021-06-15 | Boehringer Ingelheim Int | Piridazinas novedosas. |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
| WO2021013833A1 (en) | 2019-07-22 | 2021-01-28 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases |
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2020
- 2020-07-20 US US16/932,882 patent/US11485727B2/en active Active
- 2020-07-21 EP EP20743687.4A patent/EP4003998B1/en active Active
- 2020-07-21 PE PE2022000105A patent/PE20220964A1/es unknown
- 2020-07-21 RS RS20240520A patent/RS65498B1/sr unknown
- 2020-07-21 KR KR1020227005957A patent/KR20220038438A/ko unknown
- 2020-07-21 CN CN202080051863.5A patent/CN114206876B/zh active Active
- 2020-07-21 EP EP24157589.3A patent/EP4364805A3/en active Pending
- 2020-07-21 UA UAA202200670A patent/UA128544C2/uk unknown
- 2020-07-21 DK DK20743687.4T patent/DK4003998T3/da active
- 2020-07-21 HR HRP20240697TT patent/HRP20240697T1/hr unknown
- 2020-07-21 AR ARP200102049A patent/AR119453A1/es unknown
- 2020-07-21 HU HUE20743687A patent/HUE066770T2/hu unknown
- 2020-07-21 AU AU2020316643A patent/AU2020316643A1/en active Pending
- 2020-07-21 BR BR112021026887A patent/BR112021026887A2/pt unknown
- 2020-07-21 ES ES20743687T patent/ES2977909T3/es active Active
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- 2020-07-21 CA CA3145868A patent/CA3145868A1/en active Pending
- 2020-07-21 FI FIEP20743687.4T patent/FI4003998T3/fi active
- 2020-07-21 JO JOP/2022/0012A patent/JOP20220012A1/ar unknown
- 2020-07-21 CN CN202410520327.5A patent/CN118666853A/zh active Pending
- 2020-07-21 WO PCT/EP2020/070547 patent/WO2021013830A1/en active Application Filing
- 2020-07-21 PL PL20743687.4T patent/PL4003998T3/pl unknown
- 2020-07-21 PT PT207436874T patent/PT4003998T/pt unknown
- 2020-07-21 LT LTEPPCT/EP2020/070547T patent/LT4003998T/lt unknown
- 2020-07-21 MX MX2022000958A patent/MX2022000958A/es unknown
- 2020-07-21 JP JP2022503996A patent/JP2022541065A/ja not_active Ceased
- 2020-07-21 CR CR20220022A patent/CR20220022A/es unknown
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2022
- 2022-01-12 IL IL289788A patent/IL289788A/en unknown
- 2022-01-14 CO CONC2022/0000243A patent/CO2022000243A2/es unknown
- 2022-01-17 CL CL2022000112A patent/CL2022000112A1/es unknown
- 2022-01-17 EC ECSENADI20223856A patent/ECSP22003856A/es unknown
- 2022-01-19 DO DO2022000008A patent/DOP2022000008A/es unknown
- 2022-09-23 US US17/934,625 patent/US20230100516A1/en active Pending
-
2023
- 2023-04-20 JP JP2023069392A patent/JP7559131B2/ja active Active
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