BR112021026887A2 - Derivados de n-metila, n-(6-(metóxi)piridazin-3-il amina como moduladores de autotaxina (atx) para o trata-mento de doenças fibróticas ou das vias aérea inflamatórias - Google Patents
Derivados de n-metila, n-(6-(metóxi)piridazin-3-il amina como moduladores de autotaxina (atx) para o trata-mento de doenças fibróticas ou das vias aérea inflamatóriasInfo
- Publication number
- BR112021026887A2 BR112021026887A2 BR112021026887A BR112021026887A BR112021026887A2 BR 112021026887 A2 BR112021026887 A2 BR 112021026887A2 BR 112021026887 A BR112021026887 A BR 112021026887A BR 112021026887 A BR112021026887 A BR 112021026887A BR 112021026887 A2 BR112021026887 A2 BR 112021026887A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyridazin
- methoxy
- methyl
- autotaxin
- atx
- Prior art date
Links
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title abstract 3
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title abstract 3
- 230000003176 fibrotic effect Effects 0.000 title abstract 3
- 230000002757 inflammatory effect Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023504 respiratory system disease Diseases 0.000 abstract 2
- FTIABAXDLCWYMS-UHFFFAOYSA-N 1-[6-[4-[[[6-[[6-(trifluoromethyl)pyridin-3-yl]methoxy]pyridazin-3-yl]amino]methyl]phenyl]-2,6-diazaspiro[3.3]heptan-2-yl]ethanone Chemical compound FC(C1=CC=C(C=N1)COC1=CC=C(N=N1)NCC1=CC=C(C=C1)N1CC2(CN(C2)C(C)=O)C1)(F)F FTIABAXDLCWYMS-UHFFFAOYSA-N 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
- 206010042953 Systemic sclerosis Diseases 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
derivados de n-metila, n-(6-(metóxi)piridazin-3-il amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou das vias aérea inflamatórias. a presente invenção refere-se a derivados de n-metila, n-(6-(metóxi)piridazin-3-il) amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou das vias aéreas inflamatóriastal como por exemplo, doença de pulmão idiopática (iff) ou esclerose sistêmica (ssc). a presente descrição divulga a preparação de compostos exemplares (por exemplo, págs. de 57 a 75; exemplos 1.1 a 5) bem como seus dados biológicos relevantes (por exemplo, págs. de 15 a 21, tabelas de 1 a 9). um composto exemplar é, por exemplo, 1-(6-(4-(((6-((6-(trifluorometil)piridin-3-ill)metóxi)piridazin-3-il)amino)metil)fenil)-2,6-diazaespiro [3.3]heptan-2-il)etan-1-ona (exemplo l.1).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19187617 | 2019-07-22 | ||
| PCT/EP2020/070547 WO2021013830A1 (en) | 2019-07-22 | 2020-07-21 | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021026887A2 true BR112021026887A2 (pt) | 2022-04-26 |
Family
ID=67438402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021026887A BR112021026887A2 (pt) | 2019-07-22 | 2020-07-21 | Derivados de n-metila, n-(6-(metóxi)piridazin-3-il amina como moduladores de autotaxina (atx) para o trata-mento de doenças fibróticas ou das vias aérea inflamatórias |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11485727B2 (pt) |
| EP (2) | EP4003998B1 (pt) |
| JP (2) | JP2022541065A (pt) |
| KR (1) | KR20220038438A (pt) |
| CN (1) | CN114206876B (pt) |
| AR (1) | AR119453A1 (pt) |
| AU (1) | AU2020316643A1 (pt) |
| BR (1) | BR112021026887A2 (pt) |
| CA (1) | CA3145868A1 (pt) |
| CL (1) | CL2022000112A1 (pt) |
| CO (1) | CO2022000243A2 (pt) |
| CR (1) | CR20220022A (pt) |
| DO (1) | DOP2022000008A (pt) |
| EC (1) | ECSP22003856A (pt) |
| FI (1) | FI4003998T3 (pt) |
| IL (1) | IL289788A (pt) |
| JO (1) | JOP20220012A1 (pt) |
| LT (1) | LT4003998T (pt) |
| MX (1) | MX2022000958A (pt) |
| PE (1) | PE20220964A1 (pt) |
| PT (1) | PT4003998T (pt) |
| TW (1) | TW202120492A (pt) |
| WO (1) | WO2021013830A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021004860A (es) | 2018-10-29 | 2021-06-15 | Boehringer Ingelheim Int | Piridazinas novedosas. |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
| KR102587919B1 (ko) * | 2022-07-22 | 2023-10-11 | 주식회사 넥스트젠바이오사이언스 | 신규한 헤테로사이클릭 화합물 및 이를 포함하는 오토탁신 저해용 약학 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010512366A (ja) * | 2006-12-11 | 2010-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｃｈ拮抗活性を有する新規ピリダジン誘導体及びこれらの化合物を含む薬物 |
| TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| IN2014DN03063A (pt) * | 2011-10-28 | 2015-05-15 | Inhibitaxin Ltd | |
| KR102231637B1 (ko) | 2013-03-14 | 2021-03-25 | 갈라파고스 엔.브이. | 염증 질환의 치료를 위한 화합물 및 그의 약학 조성물 |
| WO2014202458A1 (en) | 2013-06-19 | 2014-12-24 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201503141D0 (en) * | 2015-02-03 | 2015-04-08 | Fosbel Inc | Integral self-supporting refractory checker brick modules for glass furnace regenerator structures, and methods of forming same |
| GB201603745D0 (en) * | 2016-03-04 | 2016-04-20 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
| WO2017192304A1 (en) * | 2016-05-02 | 2017-11-09 | Inception 1, Inc. | Arylcarboxamides and uses thereof |
| KR101798840B1 (ko) * | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| AR115852A1 (es) * | 2018-07-27 | 2021-03-03 | Mitsubishi Tanabe Pharma Corp | Piridina 3,5-disustituida y derivados de piridazina 3,5-disustituida y su uso farmacéutico |
| MX2021004860A (es) | 2018-10-29 | 2021-06-15 | Boehringer Ingelheim Int | Piridazinas novedosas. |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
| AU2020318697A1 (en) | 2019-07-22 | 2022-01-27 | Boehringer Ingelheim International Gmbh | N-methyl, N-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases |
-
2020
- 2020-07-20 US US16/932,882 patent/US11485727B2/en active Active
- 2020-07-21 CA CA3145868A patent/CA3145868A1/en active Pending
- 2020-07-21 JP JP2022503996A patent/JP2022541065A/ja not_active Ceased
- 2020-07-21 TW TW109124572A patent/TW202120492A/zh unknown
- 2020-07-21 KR KR1020227005957A patent/KR20220038438A/ko unknown
- 2020-07-21 JO JOP/2022/0012A patent/JOP20220012A1/ar unknown
- 2020-07-21 PT PT207436874T patent/PT4003998T/pt unknown
- 2020-07-21 LT LTEPPCT/EP2020/070547T patent/LT4003998T/lt unknown
- 2020-07-21 FI FIEP20743687.4T patent/FI4003998T3/fi active
- 2020-07-21 MX MX2022000958A patent/MX2022000958A/es unknown
- 2020-07-21 AR ARP200102049A patent/AR119453A1/es unknown
- 2020-07-21 WO PCT/EP2020/070547 patent/WO2021013830A1/en active Application Filing
- 2020-07-21 EP EP20743687.4A patent/EP4003998B1/en active Active
- 2020-07-21 EP EP24157589.3A patent/EP4364805A2/en active Pending
- 2020-07-21 AU AU2020316643A patent/AU2020316643A1/en active Pending
- 2020-07-21 PE PE2022000105A patent/PE20220964A1/es unknown
- 2020-07-21 CR CR20220022A patent/CR20220022A/es unknown
- 2020-07-21 CN CN202080051863.5A patent/CN114206876B/zh active Active
- 2020-07-21 BR BR112021026887A patent/BR112021026887A2/pt unknown
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2022
- 2022-01-12 IL IL289788A patent/IL289788A/en unknown
- 2022-01-14 CO CONC2022/0000243A patent/CO2022000243A2/es unknown
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- 2022-09-23 US US17/934,625 patent/US20230100516A1/en active Pending
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2023
- 2023-04-20 JP JP2023069392A patent/JP2023116436A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023116436A (ja) | 2023-08-22 |
| CN114206876A (zh) | 2022-03-18 |
| JP2022541065A (ja) | 2022-09-21 |
| EP4003998B1 (en) | 2024-03-27 |
| EP4364805A2 (en) | 2024-05-08 |
| CN114206876B (zh) | 2024-05-14 |
| AU2020316643A1 (en) | 2022-02-17 |
| FI4003998T3 (fi) | 2024-04-24 |
| ECSP22003856A (es) | 2022-02-25 |
| KR20220038438A (ko) | 2022-03-28 |
| US20230100516A1 (en) | 2023-03-30 |
| JOP20220012A1 (ar) | 2023-01-30 |
| PE20220964A1 (es) | 2022-06-10 |
| CL2022000112A1 (es) | 2022-10-21 |
| AR119453A1 (es) | 2021-12-22 |
| TW202120492A (zh) | 2021-06-01 |
| IL289788A (en) | 2022-03-01 |
| CO2022000243A2 (es) | 2022-01-17 |
| LT4003998T (lt) | 2024-05-10 |
| US20210024495A1 (en) | 2021-01-28 |
| WO2021013830A1 (en) | 2021-01-28 |
| EP4003998A1 (en) | 2022-06-01 |
| CR20220022A (es) | 2022-03-02 |
| US11485727B2 (en) | 2022-11-01 |
| CA3145868A1 (en) | 2021-01-28 |
| MX2022000958A (es) | 2022-02-14 |
| DOP2022000008A (es) | 2022-03-15 |
| PT4003998T (pt) | 2024-04-26 |
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