BR112022001176A2 - Derivados de 1-(6-(metoxi)piridazin-3-il)ciclopropano-1-carboxamida como moduladores de autotaxina (atx) para o tratamento de doenças inflamatórias das vias aéreas - Google Patents

Derivados de 1-(6-(metoxi)piridazin-3-il)ciclopropano-1-carboxamida como moduladores de autotaxina (atx) para o tratamento de doenças inflamatórias das vias aéreas

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Publication number
BR112022001176A2
BR112022001176A2 BR112022001176A BR112022001176A BR112022001176A2 BR 112022001176 A2 BR112022001176 A2 BR 112022001176A2 BR 112022001176 A BR112022001176 A BR 112022001176A BR 112022001176 A BR112022001176 A BR 112022001176A BR 112022001176 A2 BR112022001176 A2 BR 112022001176A2
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BR
Brazil
Prior art keywords
pyridazin
cyclopropane
methoxy
autotaxin
atx
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Application number
BR112022001176A
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English (en)
Inventor
Andreas KUTTRUFF Christian
Cédrickx Godbout
Domnic Martyres
Juergen Roth Gerald
Fiepko Koolman Hannes
Tom Bretschneider
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Boehringer Ingelheim Int
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Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112022001176A2 publication Critical patent/BR112022001176A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

derivados de 1-(6-(metoxi)piridazin-3-il)ciclopropano-1 -carboxamida como moduladores de autotaxina (atx) para o tratamento de doenças inflamatórias das vias aéreas. a presente invenção refere-se a derivados de 1-(6-(metoxi)piridazin-3-il)ciclopropano-1-carboxamida como moduladores de autotaxina (atx) para o tratamento de vias aéreas inflamatórias ou doenças fibróticas, tais como, por exemplo, doença pulmonar idiopática (fpi) ou esclerose sistêmica (es). a presente descrição divulga compostos exemplificativos (por exemplo, páginas 50 a 65; exemplos 1.1 a 1.31), bem como dados biológicos relevantes dos mesmos (por exemplo, páginas 14 a 21, tabelas 1 a 9). um composto exemplificativo é, por exemplo, n-(4-(7-acetil-2,7-diazaespiro[3.5]nonan-2-il)benzil)-1-(6-((6-(trifluorometil)piridin-3-il)metoxi)piridazin-3-il)ciclopropano-1-carboxamida (exemplo 1.1).
BR112022001176A 2019-07-22 2020-07-21 Derivados de 1-(6-(metoxi)piridazin-3-il)ciclopropano-1-carboxamida como moduladores de autotaxina (atx) para o tratamento de doenças inflamatórias das vias aéreas BR112022001176A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19187614 2019-07-22
PCT/EP2020/070552 WO2021013832A1 (en) 2019-07-22 2020-07-21 1-(6-(methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway diseases

Publications (1)

Publication Number Publication Date
BR112022001176A2 true BR112022001176A2 (pt) 2022-05-03

Family

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BR112022001176A BR112022001176A2 (pt) 2019-07-22 2020-07-21 Derivados de 1-(6-(metoxi)piridazin-3-il)ciclopropano-1-carboxamida como moduladores de autotaxina (atx) para o tratamento de doenças inflamatórias das vias aéreas

Country Status (17)

Country Link
US (2) US11465982B2 (pt)
EP (1) EP4003999B1 (pt)
JP (2) JP2022541308A (pt)
KR (1) KR20220035952A (pt)
CN (1) CN114206871B (pt)
AU (1) AU2020317642A1 (pt)
BR (1) BR112022001176A2 (pt)
CA (1) CA3146439A1 (pt)
DK (1) DK4003999T3 (pt)
FI (1) FI4003999T3 (pt)
LT (1) LT4003999T (pt)
MX (1) MX2022000956A (pt)
PT (1) PT4003999T (pt)
RS (1) RS65579B1 (pt)
SI (1) SI4003999T1 (pt)
TW (1) TW202120493A (pt)
WO (1) WO2021013832A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7214860B2 (ja) 2018-10-29 2023-01-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なピリダジン
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
US11485727B2 (en) 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators

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KR101331768B1 (ko) * 2005-11-08 2013-11-22 버텍스 파마슈티칼스 인코포레이티드 Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제
WO2008071646A1 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim International Gmbh New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds
US9273011B2 (en) 2011-10-28 2016-03-01 Inhibitaxin Limited Substituted pyridazines for the treatment of pain
JP6339595B2 (ja) * 2013-03-14 2018-06-06 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 炎症性障害の治療のための化合物及びその医薬組成物
WO2014202458A1 (en) 2013-06-19 2014-12-24 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201503141D0 (en) * 2015-02-03 2015-04-08 Fosbel Inc Integral self-supporting refractory checker brick modules for glass furnace regenerator structures, and methods of forming same
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KR101798840B1 (ko) * 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
EP4219452A1 (en) * 2018-07-27 2023-08-02 Mitsubishi Tanabe Pharma Corporation Novel 3,5-disubstituted pyridine and 3,5-disubstituted pyridazine derivatives and pharmaceutical use of same
JP7214860B2 (ja) 2018-10-29 2023-01-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なピリダジン
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
US20220281838A1 (en) 2019-07-22 2022-09-08 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for thetreatment of inflammatory airway or fibrotic diseases
US11485727B2 (en) 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators

Also Published As

Publication number Publication date
KR20220035952A (ko) 2022-03-22
RS65579B1 (sr) 2024-06-28
LT4003999T (lt) 2024-05-27
CN114206871B (zh) 2024-03-29
TW202120493A (zh) 2021-06-01
JP2023116435A (ja) 2023-08-22
US20230022770A1 (en) 2023-01-26
JP2022541308A (ja) 2022-09-22
SI4003999T1 (sl) 2024-06-28
US20210024492A1 (en) 2021-01-28
FI4003999T3 (fi) 2024-05-10
CN114206871A (zh) 2022-03-18
US11465982B2 (en) 2022-10-11
MX2022000956A (es) 2022-02-14
DK4003999T3 (da) 2024-07-08
AU2020317642A1 (en) 2022-03-03
EP4003999B1 (en) 2024-05-01
EP4003999A1 (en) 2022-06-01
CA3146439A1 (en) 2021-01-28
WO2021013832A1 (en) 2021-01-28
PT4003999T (pt) 2024-05-20

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