LT4003999T - 1-(6-(metoksi)piridazin-3-il)ciklopropan-1-karboksamido dariniai kaip autotaksino (atx) moduliatoriai, skirti uždegiminių kvėpavimo takų ligų gydymui - Google Patents
1-(6-(metoksi)piridazin-3-il)ciklopropan-1-karboksamido dariniai kaip autotaksino (atx) moduliatoriai, skirti uždegiminių kvėpavimo takų ligų gydymuiInfo
- Publication number
- LT4003999T LT4003999T LTEPPCT/EP2020/070552T LTEP2020070552T LT4003999T LT 4003999 T LT4003999 T LT 4003999T LT EP2020070552 T LTEP2020070552 T LT EP2020070552T LT 4003999 T LT4003999 T LT 4003999T
- Authority
- LT
- Lithuania
- Prior art keywords
- autotaxin
- atx
- pyridazin
- cyclopropane
- modulators
- Prior art date
Links
- HTJLHYXAWOOQGK-UHFFFAOYSA-N 1-(6-methoxypyridazin-3-yl)cyclopropane-1-carboxamide Chemical class COC1=CC=C(N=N1)C1(CC1)C(=O)N HTJLHYXAWOOQGK-UHFFFAOYSA-N 0.000 title 1
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title 1
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19187614 | 2019-07-22 | ||
| PCT/EP2020/070552 WO2021013832A1 (en) | 2019-07-22 | 2020-07-21 | 1-(6-(methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT4003999T true LT4003999T (lt) | 2024-05-27 |
Family
ID=67438399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/EP2020/070552T LT4003999T (lt) | 2019-07-22 | 2020-07-21 | 1-(6-(metoksi)piridazin-3-il)ciklopropan-1-karboksamido dariniai kaip autotaksino (atx) moduliatoriai, skirti uždegiminių kvėpavimo takų ligų gydymui |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11465982B2 (lt) |
| EP (1) | EP4003999B1 (lt) |
| JP (2) | JP2022541308A (lt) |
| KR (1) | KR20220035952A (lt) |
| CN (1) | CN114206871B (lt) |
| AU (1) | AU2020317642A1 (lt) |
| BR (1) | BR112022001176A2 (lt) |
| CA (1) | CA3146439A1 (lt) |
| DK (1) | DK4003999T3 (lt) |
| FI (1) | FI4003999T3 (lt) |
| LT (1) | LT4003999T (lt) |
| MX (1) | MX2022000956A (lt) |
| PT (1) | PT4003999T (lt) |
| RS (1) | RS65579B1 (lt) |
| SI (1) | SI4003999T1 (lt) |
| TW (1) | TW202120493A (lt) |
| WO (1) | WO2021013832A1 (lt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE063845T2 (hu) * | 2018-10-29 | 2024-02-28 | Boehringer Ingelheim Int | Újfajta piridazinok |
| US11485727B2 (en) | 2019-07-22 | 2022-11-01 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130042034A (ko) * | 2005-11-08 | 2013-04-25 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제 |
| JP2010512366A (ja) | 2006-12-11 | 2010-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｃｈ拮抗活性を有する新規ピリダジン誘導体及びこれらの化合物を含む薬物 |
| US9273011B2 (en) * | 2011-10-28 | 2016-03-01 | Inhibitaxin Limited | Substituted pyridazines for the treatment of pain |
| EP3760630A1 (en) * | 2013-03-14 | 2021-01-06 | Galapagos N.V. | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| US9796719B2 (en) | 2013-06-19 | 2017-10-24 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201503141D0 (en) * | 2015-02-03 | 2015-04-08 | Fosbel Inc | Integral self-supporting refractory checker brick modules for glass furnace regenerator structures, and methods of forming same |
| GB201603745D0 (en) * | 2016-03-04 | 2016-04-20 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
| KR101798840B1 (ko) * | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| WO2020022470A1 (ja) * | 2018-07-27 | 2020-01-30 | 田辺三菱製薬株式会社 | 新規３，５－二置換ピリジン及び３，５－二置換ピリダジン誘導体及びその医薬用途 |
| HUE063845T2 (hu) | 2018-10-29 | 2024-02-28 | Boehringer Ingelheim Int | Újfajta piridazinok |
| US11485727B2 (en) | 2019-07-22 | 2022-11-01 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
| US20220281838A1 (en) | 2019-07-22 | 2022-09-08 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for thetreatment of inflammatory airway or fibrotic diseases |
-
2020
- 2020-07-20 US US16/932,886 patent/US11465982B2/en active Active
- 2020-07-21 JP JP2022503970A patent/JP2022541308A/ja not_active Ceased
- 2020-07-21 EP EP20743688.2A patent/EP4003999B1/en active Active
- 2020-07-21 BR BR112022001176A patent/BR112022001176A2/pt unknown
- 2020-07-21 WO PCT/EP2020/070552 patent/WO2021013832A1/en active Application Filing
- 2020-07-21 TW TW109124576A patent/TW202120493A/zh unknown
- 2020-07-21 PT PT207436882T patent/PT4003999T/pt unknown
- 2020-07-21 CA CA3146439A patent/CA3146439A1/en active Pending
- 2020-07-21 CN CN202080056003.0A patent/CN114206871B/zh active Active
- 2020-07-21 SI SI202030431T patent/SI4003999T1/sl unknown
- 2020-07-21 DK DK20743688.2T patent/DK4003999T3/da active
- 2020-07-21 RS RS20240624A patent/RS65579B1/sr unknown
- 2020-07-21 KR KR1020227005766A patent/KR20220035952A/ko unknown
- 2020-07-21 MX MX2022000956A patent/MX2022000956A/es unknown
- 2020-07-21 AU AU2020317642A patent/AU2020317642A1/en active Pending
- 2020-07-21 FI FIEP20743688.2T patent/FI4003999T3/fi active
- 2020-07-21 LT LTEPPCT/EP2020/070552T patent/LT4003999T/lt unknown
-
2022
- 2022-08-30 US US17/899,207 patent/US20230022770A1/en active Pending
-
2023
- 2023-04-20 JP JP2023069369A patent/JP2023116435A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2022000956A (es) | 2022-02-14 |
| TW202120493A (zh) | 2021-06-01 |
| SI4003999T1 (sl) | 2024-06-28 |
| US11465982B2 (en) | 2022-10-11 |
| RS65579B1 (sr) | 2024-06-28 |
| BR112022001176A2 (pt) | 2022-05-03 |
| CN114206871A (zh) | 2022-03-18 |
| CA3146439A1 (en) | 2021-01-28 |
| JP2022541308A (ja) | 2022-09-22 |
| PT4003999T (pt) | 2024-05-20 |
| EP4003999B1 (en) | 2024-05-01 |
| US20230022770A1 (en) | 2023-01-26 |
| FI4003999T3 (fi) | 2024-05-10 |
| JP2023116435A (ja) | 2023-08-22 |
| DK4003999T3 (da) | 2024-07-08 |
| CN114206871B (zh) | 2024-03-29 |
| WO2021013832A1 (en) | 2021-01-28 |
| KR20220035952A (ko) | 2022-03-22 |
| AU2020317642A1 (en) | 2022-03-03 |
| US20210024492A1 (en) | 2021-01-28 |
| EP4003999A1 (en) | 2022-06-01 |
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