DK4003999T3 - 1-(6-(methoxy)pyridazin-3-yl)cyklopropan-1-carboxamidderivater som autotaxin (atx) modulatorer til behandlingen af inflammatoriske luftvejssygdomme - Google Patents
1-(6-(methoxy)pyridazin-3-yl)cyklopropan-1-carboxamidderivater som autotaxin (atx) modulatorer til behandlingen af inflammatoriske luftvejssygdomme Download PDFInfo
- Publication number
- DK4003999T3 DK4003999T3 DK20743688.2T DK20743688T DK4003999T3 DK 4003999 T3 DK4003999 T3 DK 4003999T3 DK 20743688 T DK20743688 T DK 20743688T DK 4003999 T3 DK4003999 T3 DK 4003999T3
- Authority
- DK
- Denmark
- Prior art keywords
- autotaxin
- atx
- pyridazin
- cyclopropane
- modulators
- Prior art date
Links
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title 2
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title 2
- HTJLHYXAWOOQGK-UHFFFAOYSA-N 1-(6-methoxypyridazin-3-yl)cyclopropane-1-carboxamide Chemical class COC1=CC=C(N=N1)C1(CC1)C(=O)N HTJLHYXAWOOQGK-UHFFFAOYSA-N 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19187614 | 2019-07-22 | ||
| PCT/EP2020/070552 WO2021013832A1 (en) | 2019-07-22 | 2020-07-21 | 1-(6-(methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4003999T3 true DK4003999T3 (da) | 2024-07-08 |
Family
ID=67438399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20743688.2T DK4003999T3 (da) | 2019-07-22 | 2020-07-21 | 1-(6-(methoxy)pyridazin-3-yl)cyklopropan-1-carboxamidderivater som autotaxin (atx) modulatorer til behandlingen af inflammatoriske luftvejssygdomme |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11465982B2 (da) |
| EP (1) | EP4003999B1 (da) |
| JP (2) | JP2022541308A (da) |
| KR (1) | KR20220035952A (da) |
| CN (1) | CN114206871B (da) |
| AU (1) | AU2020317642A1 (da) |
| BR (1) | BR112022001176A2 (da) |
| CA (1) | CA3146439A1 (da) |
| DK (1) | DK4003999T3 (da) |
| FI (1) | FI4003999T3 (da) |
| LT (1) | LT4003999T (da) |
| MX (1) | MX2022000956A (da) |
| PT (1) | PT4003999T (da) |
| RS (1) | RS65579B1 (da) |
| SI (1) | SI4003999T1 (da) |
| TW (1) | TW202120493A (da) |
| WO (1) | WO2021013832A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7214860B2 (ja) | 2018-10-29 | 2023-01-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なピリダジン |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
| US11485727B2 (en) | 2019-07-22 | 2022-11-01 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101331768B1 (ko) * | 2005-11-08 | 2013-11-22 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제 |
| WO2008071646A1 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim International Gmbh | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
| US9273011B2 (en) | 2011-10-28 | 2016-03-01 | Inhibitaxin Limited | Substituted pyridazines for the treatment of pain |
| JP6339595B2 (ja) * | 2013-03-14 | 2018-06-06 | ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． | 炎症性障害の治療のための化合物及びその医薬組成物 |
| WO2014202458A1 (en) | 2013-06-19 | 2014-12-24 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201503141D0 (en) * | 2015-02-03 | 2015-04-08 | Fosbel Inc | Integral self-supporting refractory checker brick modules for glass furnace regenerator structures, and methods of forming same |
| GB201603745D0 (en) * | 2016-03-04 | 2016-04-20 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
| KR101798840B1 (ko) * | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| EP4219452A1 (en) * | 2018-07-27 | 2023-08-02 | Mitsubishi Tanabe Pharma Corporation | Novel 3,5-disubstituted pyridine and 3,5-disubstituted pyridazine derivatives and pharmaceutical use of same |
| JP7214860B2 (ja) | 2018-10-29 | 2023-01-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なピリダジン |
| US11465982B2 (en) | 2019-07-22 | 2022-10-11 | Boehringer Ingelheim International Gmbh | Pyridazines |
| US20220281838A1 (en) | 2019-07-22 | 2022-09-08 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for thetreatment of inflammatory airway or fibrotic diseases |
| US11485727B2 (en) | 2019-07-22 | 2022-11-01 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators |
-
2020
- 2020-07-20 US US16/932,886 patent/US11465982B2/en active Active
- 2020-07-21 WO PCT/EP2020/070552 patent/WO2021013832A1/en unknown
- 2020-07-21 EP EP20743688.2A patent/EP4003999B1/en active Active
- 2020-07-21 AU AU2020317642A patent/AU2020317642A1/en active Pending
- 2020-07-21 BR BR112022001176A patent/BR112022001176A2/pt unknown
- 2020-07-21 DK DK20743688.2T patent/DK4003999T3/da active
- 2020-07-21 RS RS20240624A patent/RS65579B1/sr unknown
- 2020-07-21 MX MX2022000956A patent/MX2022000956A/es unknown
- 2020-07-21 TW TW109124576A patent/TW202120493A/zh unknown
- 2020-07-21 CN CN202080056003.0A patent/CN114206871B/zh active Active
- 2020-07-21 FI FIEP20743688.2T patent/FI4003999T3/fi active
- 2020-07-21 SI SI202030431T patent/SI4003999T1/sl unknown
- 2020-07-21 LT LTEPPCT/EP2020/070552T patent/LT4003999T/lt unknown
- 2020-07-21 PT PT207436882T patent/PT4003999T/pt unknown
- 2020-07-21 CA CA3146439A patent/CA3146439A1/en active Pending
- 2020-07-21 KR KR1020227005766A patent/KR20220035952A/ko unknown
- 2020-07-21 JP JP2022503970A patent/JP2022541308A/ja not_active Ceased
-
2022
- 2022-08-30 US US17/899,207 patent/US20230022770A1/en active Pending
-
2023
- 2023-04-20 JP JP2023069369A patent/JP2023116435A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220035952A (ko) | 2022-03-22 |
| RS65579B1 (sr) | 2024-06-28 |
| LT4003999T (lt) | 2024-05-27 |
| CN114206871B (zh) | 2024-03-29 |
| TW202120493A (zh) | 2021-06-01 |
| JP2023116435A (ja) | 2023-08-22 |
| US20230022770A1 (en) | 2023-01-26 |
| JP2022541308A (ja) | 2022-09-22 |
| SI4003999T1 (sl) | 2024-06-28 |
| US20210024492A1 (en) | 2021-01-28 |
| BR112022001176A2 (pt) | 2022-05-03 |
| FI4003999T3 (fi) | 2024-05-10 |
| CN114206871A (zh) | 2022-03-18 |
| US11465982B2 (en) | 2022-10-11 |
| MX2022000956A (es) | 2022-02-14 |
| AU2020317642A1 (en) | 2022-03-03 |
| EP4003999B1 (en) | 2024-05-01 |
| EP4003999A1 (en) | 2022-06-01 |
| CA3146439A1 (en) | 2021-01-28 |
| WO2021013832A1 (en) | 2021-01-28 |
| PT4003999T (pt) | 2024-05-20 |
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