BR112021026531A2 - Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2 - Google Patents

Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2

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Publication number
BR112021026531A2
BR112021026531A2 BR112021026531A BR112021026531A BR112021026531A2 BR 112021026531 A2 BR112021026531 A2 BR 112021026531A2 BR 112021026531 A BR112021026531 A BR 112021026531A BR 112021026531 A BR112021026531 A BR 112021026531A BR 112021026531 A2 BR112021026531 A2 BR 112021026531A2
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BR
Brazil
Prior art keywords
preventing
treating
tyrosine kinase
compound
pharmaceutical composition
Prior art date
Application number
BR112021026531A
Other languages
English (en)
Inventor
Xiangyang Chen
Yucheng Pang
Original Assignee
Guangzhou Innocare Pharma Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Innocare Pharma Tech Co Ltd filed Critical Guangzhou Innocare Pharma Tech Co Ltd
Publication of BR112021026531A2 publication Critical patent/BR112021026531A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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Abstract

composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2. compostos heterocíclicos mostrados na fórmula (i) adequados para inibir ou regular a atividade de janus cinase (jak), particularmente tirosina cinase 2 (tyk2). os compostos são úteis para prevenir e/ou tratar doenças mediadas por jak relevantes, tais como doenças autoimunes, doenças inflamatórias e cânceres.
BR112021026531A 2019-06-28 2020-06-24 Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2 BR112021026531A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
PCT/CN2020/098105 WO2020259584A1 (en) 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity

Publications (1)

Publication Number Publication Date
BR112021026531A2 true BR112021026531A2 (pt) 2022-02-15

Family

ID=73869063

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021026531A BR112021026531A2 (pt) 2019-06-28 2020-06-24 Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2

Country Status (10)

Country Link
US (1) US20220112200A1 (pt)
EP (1) EP3990449A4 (pt)
JP (1) JP7560136B2 (pt)
KR (1) KR20220042344A (pt)
CN (2) CN112142743A (pt)
AU (1) AU2020301437A1 (pt)
BR (1) BR112021026531A2 (pt)
CA (1) CA3144799A1 (pt)
MX (1) MX2021015969A (pt)
WO (1) WO2020259584A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
KR20240111312A (ko) 2021-10-25 2024-07-16 카이메라 쎄라퓨틱스 인코포레이티드 Tyk2 분해제 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103298794A (zh) 2010-11-09 2013-09-11 塞尔卓姆有限公司 作为tyk2抑制剂的吡啶化合物及其氮杂类似物
US9586962B2 (en) * 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
US9187453B2 (en) 2012-03-28 2015-11-17 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN105622638B (zh) * 2014-10-29 2018-10-02 广州必贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
EP3319960B1 (en) * 2015-07-09 2020-11-18 Merck Patent GmbH Pyrimidine derivatives as btk inhibitors and uses thereof
US11649251B2 (en) * 2017-09-20 2023-05-16 Kura Oncology, Inc. Substituted inhibitors of menin-MLL and methods of use
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

Also Published As

Publication number Publication date
TW202115034A (zh) 2021-04-16
CA3144799A1 (en) 2020-12-30
US20220112200A1 (en) 2022-04-14
CN114096532B (zh) 2023-12-01
EP3990449A4 (en) 2023-07-26
CN112142743A (zh) 2020-12-29
WO2020259584A1 (en) 2020-12-30
CN114096532A (zh) 2022-02-25
JP2022540353A (ja) 2022-09-15
MX2021015969A (es) 2022-04-18
EP3990449A1 (en) 2022-05-04
KR20220042344A (ko) 2022-04-05
AU2020301437A1 (en) 2022-02-17
JP7560136B2 (ja) 2024-10-02

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