MX2022000955A - Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vias respiratorias o fibroticas. - Google Patents

Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vias respiratorias o fibroticas.

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Publication number
MX2022000955A
MX2022000955A MX2022000955A MX2022000955A MX2022000955A MX 2022000955 A MX2022000955 A MX 2022000955A MX 2022000955 A MX2022000955 A MX 2022000955A MX 2022000955 A MX2022000955 A MX 2022000955A MX 2022000955 A MX2022000955 A MX 2022000955A
Authority
MX
Mexico
Prior art keywords
pyridazin
methoxy
autotaxin
atx
modulators
Prior art date
Application number
MX2022000955A
Other languages
English (en)
Inventor
Gerald Juergen Roth
Cédrickx Godbout
Christian Andreas Kuttruff
Hannes Fiepko Koolman
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2022000955A publication Critical patent/MX2022000955A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de N-(6-metoxi)pirizadin-3-il) amina, N-metilo como moduladores de autotaxina (ATX) para el tratamiento de enfermedades inflamatorias de las vías respiratorias y fibróticas tales como, por ejemplo, enfermedad pulmonar idiopática (IFF), o esclerosis sistémica (SSc). La presente descripción expone la preparación de compuestos de ejemplo (por ejemplo, páginas 37 a 45; ejemplos 1.1 a 1.13) así como información biológica relevante (por ejemplo, páginas 12 a 17, tablas 1 a 9). Un compuesto de ejemplo es, por ejemplo, 1-[4-(4-{1-[{6-{[6-(trifluorometil)piridin-3-il]metoxi}pi ridazin-3-il)amino]ciclopropil}-fenil)piperazin-1-il]etan-]-1-ona (ejemplo 1.1).
MX2022000955A 2019-07-22 2020-07-21 Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vias respiratorias o fibroticas. MX2022000955A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19187616 2019-07-22
PCT/EP2020/070553 WO2021013833A1 (en) 2019-07-22 2020-07-21 N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases

Publications (1)

Publication Number Publication Date
MX2022000955A true MX2022000955A (es) 2022-02-14

Family

ID=67438401

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022000955A MX2022000955A (es) 2019-07-22 2020-07-21 Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vias respiratorias o fibroticas.

Country Status (14)

Country Link
US (1) US20220281838A1 (es)
EP (1) EP4003978B1 (es)
JP (1) JP7240554B2 (es)
KR (1) KR20220035950A (es)
CN (1) CN114127054B (es)
AU (1) AU2020318697A1 (es)
BR (1) BR112021026267A2 (es)
CA (1) CA3145960A1 (es)
CL (1) CL2022000111A1 (es)
DK (1) DK4003978T3 (es)
IL (1) IL289800A (es)
MX (1) MX2022000955A (es)
PL (1) PL4003978T3 (es)
WO (1) WO2021013833A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210084597A (ko) * 2018-10-29 2021-07-07 베링거 인겔하임 인터내셔날 게엠베하 신규한 피리다진
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
US11485727B2 (en) 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2748656T3 (es) * 2011-10-28 2020-03-17 Inhibitaxin Ltd Derivados de piridazina útiles en terapia
ES2824723T3 (es) * 2013-03-14 2021-05-13 Galapagos Nv Nuevos compuestos y composiciones farmacéuticas de los mismos para el tratamiento de trastornos inflamatorios
WO2014179144A1 (en) * 2013-04-29 2014-11-06 E. I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds
US9796719B2 (en) * 2013-06-19 2017-10-24 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
KR20210084597A (ko) * 2018-10-29 2021-07-07 베링거 인겔하임 인터내셔날 게엠베하 신규한 피리다진

Also Published As

Publication number Publication date
CA3145960A1 (en) 2021-01-28
US20220281838A1 (en) 2022-09-08
IL289800A (en) 2022-03-01
CN114127054A (zh) 2022-03-01
EP4003978A1 (en) 2022-06-01
JP7240554B2 (ja) 2023-03-15
CL2022000111A1 (es) 2022-10-21
PL4003978T3 (pl) 2024-08-26
AU2020318697A1 (en) 2022-01-27
JP2022541613A (ja) 2022-09-26
CN114127054B (zh) 2024-04-09
KR20220035950A (ko) 2022-03-22
BR112021026267A2 (pt) 2022-05-31
DK4003978T3 (da) 2024-07-22
EP4003978B1 (en) 2024-05-01
WO2021013833A1 (en) 2021-01-28

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