BR112021026267A2 - Derivados de n-metil, n-((6-(metoxi)piridazin-3-il)amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou inflamatórias das vias aéreas - Google Patents

Derivados de n-metil, n-((6-(metoxi)piridazin-3-il)amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou inflamatórias das vias aéreas

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Publication number
BR112021026267A2
BR112021026267A2 BR112021026267A BR112021026267A BR112021026267A2 BR 112021026267 A2 BR112021026267 A2 BR 112021026267A2 BR 112021026267 A BR112021026267 A BR 112021026267A BR 112021026267 A BR112021026267 A BR 112021026267A BR 112021026267 A2 BR112021026267 A2 BR 112021026267A2
Authority
BR
Brazil
Prior art keywords
pyridazin
methoxy
autotaxin
atx
fibrotic
Prior art date
Application number
BR112021026267A
Other languages
English (en)
Inventor
Andreas KUTTRUFF Christian
Cédrickx Godbout
Juergen Roth Gerald
Fiepko Koolman Hannes
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112021026267A2 publication Critical patent/BR112021026267A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

derivados de n-metil, n-((6-(metoxi)piridazin-3-il)amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou inflamatórias das vias aéreas. a presente invenção se refere a derivados de n-metil, n-((6-(metoxi)piridazin-3-il)amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou inflamatórias das vias aéreas tal como, por exemplo, doença idiopática do pulmão (iff) ou esclerose sistêmica (ssc). a presente descrição descreve a preparação de compostos exemplificativos (por exemplo, páginas 37 a 45; exemplos 1.1 a 1.13) bem como seus dados biológicos relevantes (por exemplo, páginas 12 a 17, tabelas 1 a 9). um composto exemplificativo é, por exemplo, 1-[4-(4-{1-[(6-{[6-(trifluorometila)piridina-3-il]metoxi}piridazin-3-il)amino]ciclopropil}-fenil) piperazin-1-il]etan-1-ona (exemplo 1.1).
BR112021026267A 2019-07-22 2020-07-21 Derivados de n-metil, n-((6-(metoxi)piridazin-3-il)amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou inflamatórias das vias aéreas BR112021026267A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19187616 2019-07-22
PCT/EP2020/070553 WO2021013833A1 (en) 2019-07-22 2020-07-21 N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases

Publications (1)

Publication Number Publication Date
BR112021026267A2 true BR112021026267A2 (pt) 2022-05-31

Family

ID=67438401

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021026267A BR112021026267A2 (pt) 2019-07-22 2020-07-21 Derivados de n-metil, n-((6-(metoxi)piridazin-3-il)amina como moduladores de autotaxina (atx) para o tratamento de doenças fibróticas ou inflamatórias das vias aéreas

Country Status (12)

Country Link
US (1) US20220281838A1 (pt)
EP (1) EP4003978B1 (pt)
JP (1) JP7240554B2 (pt)
KR (1) KR20220035950A (pt)
CN (1) CN114127054B (pt)
AU (1) AU2020318697A1 (pt)
BR (1) BR112021026267A2 (pt)
CA (1) CA3145960A1 (pt)
CL (1) CL2022000111A1 (pt)
IL (1) IL289800A (pt)
MX (1) MX2022000955A (pt)
WO (1) WO2021013833A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020089098A1 (en) 2018-10-29 2020-05-07 Boehringer Ingelheim International Gmbh Novel pyridazines
US11485727B2 (en) 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2771325B1 (en) * 2011-10-28 2017-06-28 Inhibitaxin Limited Pyridazine derivatives useful in therapy
PT2970255T (pt) * 2013-03-14 2017-09-05 Galapagos Nv Compostos e as suas composições farmacêuticas para o tratamento de doenças inflamatórias
WO2014179144A1 (en) * 2013-04-29 2014-11-06 E. I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds
US9796719B2 (en) * 2013-06-19 2017-10-24 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2020089098A1 (en) * 2018-10-29 2020-05-07 Boehringer Ingelheim International Gmbh Novel pyridazines

Also Published As

Publication number Publication date
KR20220035950A (ko) 2022-03-22
EP4003978A1 (en) 2022-06-01
WO2021013833A1 (en) 2021-01-28
CL2022000111A1 (es) 2022-10-21
CA3145960A1 (en) 2021-01-28
CN114127054B (zh) 2024-04-09
EP4003978B1 (en) 2024-05-01
JP7240554B2 (ja) 2023-03-15
IL289800A (en) 2022-03-01
MX2022000955A (es) 2022-02-14
CN114127054A (zh) 2022-03-01
US20220281838A1 (en) 2022-09-08
AU2020318697A1 (en) 2022-01-27
JP2022541613A (ja) 2022-09-26

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