CY1118284T1 - Βεσυλικα και τοσυλικα αλατα ενος παραγωγου διυδροκιναζολινης και χρηση αυτων ως αντιικων παραγοντων - Google Patents

Βεσυλικα και τοσυλικα αλατα ενος παραγωγου διυδροκιναζολινης και χρηση αυτων ως αντιικων παραγοντων

Info

Publication number
CY1118284T1
CY1118284T1 CY20161100699T CY161100699T CY1118284T1 CY 1118284 T1 CY1118284 T1 CY 1118284T1 CY 20161100699 T CY20161100699 T CY 20161100699T CY 161100699 T CY161100699 T CY 161100699T CY 1118284 T1 CY1118284 T1 CY 1118284T1
Authority
CY
Cyprus
Prior art keywords
agents
toylic
dyydrokinazoline
besylic
antique
Prior art date
Application number
CY20161100699T
Other languages
English (en)
Inventor
Welljanne Märtens
Christian Schickaneder
Original Assignee
Aicuris Anti-Infective Cures Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Anti-Infective Cures Gmbh filed Critical Aicuris Anti-Infective Cures Gmbh
Publication of CY1118284T1 publication Critical patent/CY1118284T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups

Abstract

Η εφεύρεση αφορά βεσυλικά και τοσυλικά άλατα του {8-φθορο-2-[4-(3-μεθοξυ-φαινυλο)πιπεραζιν-1-υλο]-3-[2-μεθοξυ-5-(τριφθορομεθυλο)φαινυλο]-3,4-διυδροκιναζο-λιν-4-υλ}οξικού οξέος, καθώς και τις επιδιαλυτωμένες μορφές τους, την χρήση τους για την θεραπεία ιικών λοιμώξεων και/ή για την προφύλαξη από ιικές λοιμώξεις, καθώς και την χρήση τους για την παραγωγή φαρμάκων για την θεραπεία νόσων και/ή για την προφύλαξη από νόσους, ιδιαιτέρως την χρήση ως αντιικών παραγόντων, ιδιαιτέρως κατά των κυτταρομεγαλοϊών.
CY20161100699T 2012-02-29 2016-07-18 Βεσυλικα και τοσυλικα αλατα ενος παραγωγου διυδροκιναζολινης και χρηση αυτων ως αντιικων παραγοντων CY1118284T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012101673A DE102012101673A1 (de) 2012-02-29 2012-02-29 Salze eines Dihydrochinazolinderivats
PCT/EP2013/054109 WO2013127968A1 (de) 2012-02-29 2013-02-28 Besylat- und tosylatsalze eines dihydrochinazolinderivates und ihre verwendung als antivirale mittel

Publications (1)

Publication Number Publication Date
CY1118284T1 true CY1118284T1 (el) 2017-06-28

Family

ID=47884256

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100699T CY1118284T1 (el) 2012-02-29 2016-07-18 Βεσυλικα και τοσυλικα αλατα ενος παραγωγου διυδροκιναζολινης και χρηση αυτων ως αντιικων παραγοντων

Country Status (19)

Country Link
US (4) US9512085B2 (el)
EP (1) EP2820000B1 (el)
JP (1) JP6235493B2 (el)
CN (1) CN104144916B (el)
CA (1) CA2865534C (el)
CY (1) CY1118284T1 (el)
DE (1) DE102012101673A1 (el)
DK (1) DK2820000T3 (el)
ES (1) ES2583360T3 (el)
HK (1) HK1205511A1 (el)
HR (1) HRP20160886T1 (el)
HU (1) HUE027751T2 (el)
LT (1) LT2820000T (el)
PL (1) PL2820000T3 (el)
PT (1) PT2820000T (el)
RS (1) RS54989B1 (el)
SI (1) SI2820000T1 (el)
SM (1) SMT201600343B (el)
WO (1) WO2013127968A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
RS58882B1 (sr) * 2013-06-19 2019-08-30 Aicuris Anti Infective Cures Gmbh Amorfni letermovir i njegove čvrste farmaceutske formulacije za oralno davanje
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2017091453A1 (en) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
EP3753942B1 (en) * 2018-02-08 2024-01-03 Phaeno Therapeutics Co., Ltd. Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor
IT202000017617A1 (it) 2020-07-21 2022-01-21 Olon Spa Procedimento per la preparazione di un intermedio utilizzato nella sintesi del letermovir
US20230312485A1 (en) 2020-08-17 2023-10-05 Lupin Limited A precipitation process for amorphous letermovir
CN113880776B (zh) * 2021-11-16 2023-06-16 山东诚创蓝海医药科技有限公司 一种莱特莫韦中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) * 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
RS58882B1 (sr) 2013-06-19 2019-08-30 Aicuris Anti Infective Cures Gmbh Amorfni letermovir i njegove čvrste farmaceutske formulacije za oralno davanje

Also Published As

Publication number Publication date
US20170362186A1 (en) 2017-12-21
CN104144916A (zh) 2014-11-12
LT2820000T (lt) 2016-11-10
DK2820000T3 (en) 2016-07-25
CN104144916B (zh) 2016-08-24
US20150045371A1 (en) 2015-02-12
HRP20160886T1 (hr) 2016-09-23
JP6235493B2 (ja) 2017-11-22
EP2820000A1 (de) 2015-01-07
CA2865534C (en) 2019-04-02
CA2865534A1 (en) 2013-09-06
SMT201600343B (el) 2016-11-10
US10287254B2 (en) 2019-05-14
RS54989B1 (sr) 2016-11-30
US20170114026A1 (en) 2017-04-27
PT2820000T (pt) 2016-07-20
PL2820000T3 (pl) 2017-07-31
JP2015508800A (ja) 2015-03-23
WO2013127968A1 (de) 2013-09-06
ES2583360T3 (es) 2016-09-20
HUE027751T2 (en) 2016-10-28
DE102012101673A1 (de) 2013-08-29
USRE49897E1 (en) 2024-04-02
US9512085B2 (en) 2016-12-06
HK1205511A1 (zh) 2015-12-18
EP2820000B1 (de) 2016-04-20
SI2820000T1 (sl) 2016-08-31

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