HK1205511A1 - 二氫喹唑啉衍生物的苯磺酸鹽和甲苯磺酸鹽及它們作為抗病毒劑的用途 - Google Patents

二氫喹唑啉衍生物的苯磺酸鹽和甲苯磺酸鹽及它們作為抗病毒劑的用途

Info

Publication number
HK1205511A1
HK1205511A1 HK15106079.4A HK15106079A HK1205511A1 HK 1205511 A1 HK1205511 A1 HK 1205511A1 HK 15106079 A HK15106079 A HK 15106079A HK 1205511 A1 HK1205511 A1 HK 1205511A1
Authority
HK
Hong Kong
Prior art keywords
besylate
antiviral agents
tosylate salts
dihydroquinazoline derivative
dihydroquinazoline
Prior art date
Application number
HK15106079.4A
Other languages
English (en)
Inventor
Welljanne Mrtens
Christian Schickaneder
Ute Kilger
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of HK1205511A1 publication Critical patent/HK1205511A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
HK15106079.4A 2012-02-29 2015-06-25 二氫喹唑啉衍生物的苯磺酸鹽和甲苯磺酸鹽及它們作為抗病毒劑的用途 HK1205511A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012101673A DE102012101673A1 (de) 2012-02-29 2012-02-29 Salze eines Dihydrochinazolinderivats
PCT/EP2013/054109 WO2013127968A1 (de) 2012-02-29 2013-02-28 Besylat- und tosylatsalze eines dihydrochinazolinderivates und ihre verwendung als antivirale mittel

Publications (1)

Publication Number Publication Date
HK1205511A1 true HK1205511A1 (zh) 2015-12-18

Family

ID=47884256

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15106079.4A HK1205511A1 (zh) 2012-02-29 2015-06-25 二氫喹唑啉衍生物的苯磺酸鹽和甲苯磺酸鹽及它們作為抗病毒劑的用途

Country Status (19)

Country Link
US (4) US9512085B2 (zh)
EP (1) EP2820000B1 (zh)
JP (1) JP6235493B2 (zh)
CN (1) CN104144916B (zh)
CA (1) CA2865534C (zh)
CY (1) CY1118284T1 (zh)
DE (1) DE102012101673A1 (zh)
DK (1) DK2820000T3 (zh)
ES (1) ES2583360T3 (zh)
HK (1) HK1205511A1 (zh)
HR (1) HRP20160886T1 (zh)
HU (1) HUE027751T2 (zh)
LT (1) LT2820000T (zh)
PL (1) PL2820000T3 (zh)
PT (1) PT2820000T (zh)
RS (1) RS54989B1 (zh)
SI (1) SI2820000T1 (zh)
SM (1) SMT201600343B (zh)
WO (1) WO2013127968A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
RS58882B1 (sr) * 2013-06-19 2019-08-30 Aicuris Anti Infective Cures Gmbh Amorfni letermovir i njegove čvrste farmaceutske formulacije za oralno davanje
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2017091453A1 (en) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
EP3753942B1 (en) * 2018-02-08 2024-01-03 Phaeno Therapeutics Co., Ltd. Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor
IT202000017617A1 (it) 2020-07-21 2022-01-21 Olon Spa Procedimento per la preparazione di un intermedio utilizzato nella sintesi del letermovir
US20230312485A1 (en) 2020-08-17 2023-10-05 Lupin Limited A precipitation process for amorphous letermovir
CN113880776B (zh) * 2021-11-16 2023-06-16 山东诚创蓝海医药科技有限公司 一种莱特莫韦中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) * 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
RS58882B1 (sr) 2013-06-19 2019-08-30 Aicuris Anti Infective Cures Gmbh Amorfni letermovir i njegove čvrste farmaceutske formulacije za oralno davanje

Also Published As

Publication number Publication date
US20170362186A1 (en) 2017-12-21
CN104144916A (zh) 2014-11-12
LT2820000T (lt) 2016-11-10
DK2820000T3 (en) 2016-07-25
CN104144916B (zh) 2016-08-24
US20150045371A1 (en) 2015-02-12
HRP20160886T1 (hr) 2016-09-23
JP6235493B2 (ja) 2017-11-22
EP2820000A1 (de) 2015-01-07
CA2865534C (en) 2019-04-02
CA2865534A1 (en) 2013-09-06
SMT201600343B (zh) 2016-11-10
US10287254B2 (en) 2019-05-14
RS54989B1 (sr) 2016-11-30
US20170114026A1 (en) 2017-04-27
PT2820000T (pt) 2016-07-20
PL2820000T3 (pl) 2017-07-31
JP2015508800A (ja) 2015-03-23
WO2013127968A1 (de) 2013-09-06
ES2583360T3 (es) 2016-09-20
HUE027751T2 (en) 2016-10-28
DE102012101673A1 (de) 2013-08-29
USRE49897E1 (en) 2024-04-02
US9512085B2 (en) 2016-12-06
EP2820000B1 (de) 2016-04-20
SI2820000T1 (sl) 2016-08-31
CY1118284T1 (el) 2017-06-28

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Free format text: DELETION OF INVENTOR: KILGER, UTE