UY29078A1 - Amidas del ácido 5 y 6-aminoalquil indol-2-carboxílico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon) - Google Patents
Amidas del ácido 5 y 6-aminoalquil indol-2-carboxílico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon)Info
- Publication number
- UY29078A1 UY29078A1 UY29078A UY29078A UY29078A1 UY 29078 A1 UY29078 A1 UY 29078A1 UY 29078 A UY29078 A UY 29078A UY 29078 A UY29078 A UY 29078A UY 29078 A1 UY29078 A1 UY 29078A1
- Authority
- UY
- Uruguay
- Prior art keywords
- epsilon
- formula
- inhibitors
- amyalalkyl
- cinasa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención describe y reivindica compuestos de fórmula (I) y fórmula (II) como inhibidores de la caseína cinasa IE(epsilon) humana, y métodos de uso de dichos compuestos de fórmula (I) y fórmula (II) para el tratamiento de enfermedades y trastornos del sistema nervioso central incluyendo trastornos del estado de ánimo y trastornos del sueno. También se describen y reivindican composiciones farmacéuticas que comprenden compuestos de fórmula (I) o fórmula (II).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60338004P | 2004-08-19 | 2004-08-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY29078A1 true UY29078A1 (es) | 2006-03-31 |
Family
ID=35311279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY29078A UY29078A1 (es) | 2004-08-19 | 2005-08-19 | Amidas del ácido 5 y 6-aminoalquil indol-2-carboxílico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon) |
Country Status (27)
Country | Link |
---|---|
US (2) | US7629376B2 (es) |
EP (1) | EP1794122B1 (es) |
JP (1) | JP4843608B2 (es) |
KR (2) | KR20070043012A (es) |
CN (1) | CN101006055B (es) |
AR (1) | AR050919A1 (es) |
AT (1) | ATE508112T1 (es) |
AU (1) | AU2005277523B2 (es) |
BR (1) | BRPI0514380A (es) |
CA (1) | CA2577667C (es) |
DE (1) | DE602005027858D1 (es) |
GT (1) | GT200500214A (es) |
HK (1) | HK1105196A1 (es) |
IL (1) | IL181156A (es) |
JO (1) | JO2724B1 (es) |
MA (1) | MA28863B1 (es) |
MX (1) | MX2007001382A (es) |
NO (1) | NO20071466L (es) |
NZ (1) | NZ552800A (es) |
PA (1) | PA8642901A1 (es) |
PE (1) | PE20060498A1 (es) |
RU (1) | RU2369599C2 (es) |
SV (1) | SV2006002192A (es) |
TW (1) | TWI357897B (es) |
UY (1) | UY29078A1 (es) |
WO (1) | WO2006023467A1 (es) |
ZA (1) | ZA200700651B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9018238B2 (en) | 2009-02-12 | 2015-04-28 | Pharmadesign, Inc. | Inhibitor of casein kinase 1δ and casein kinase 1ε |
MX2011010918A (es) * | 2009-04-17 | 2012-02-29 | Cylene Pharmaceuticals Inc | Metodo para el tratamiento de trastornos asociados con la actividad de la cinasa de proteina ck2. |
BR112014032581A8 (pt) | 2012-06-27 | 2018-08-14 | 4Sc Discovery Gmbh | inibidores de bifluorodioxalano-amino-benzimidazol quinase para o tratamento de câncer, distúrbios do snc e inflamação autoimune |
CN111757879A (zh) | 2018-01-29 | 2020-10-09 | 卡地拉健康护理有限公司 | 用作抗菌剂的杂环化合物 |
WO2022006377A2 (en) * | 2020-07-02 | 2022-01-06 | Mbq Pharma | Heterocyclic inhibitors of rho gtpases for the treatment of disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296471A (en) | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
JP4583682B2 (ja) * | 1999-06-08 | 2010-11-17 | アベンティスユービー・セカンド・インコーポレイテッド | 概日リズムタンパク質の変化に関するスクリーニング方法 |
CA2494962C (en) * | 2002-08-09 | 2011-06-14 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
DE602004020685D1 (de) * | 2003-12-11 | 2009-05-28 | Aventis Pharma Inc | Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3-cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i-epsilon |
-
2005
- 2005-07-24 JO JO2005108A patent/JO2724B1/en active
- 2005-08-09 GT GT200500214A patent/GT200500214A/es unknown
- 2005-08-10 SV SV2005002192A patent/SV2006002192A/es active IP Right Grant
- 2005-08-16 EP EP05786210A patent/EP1794122B1/en active Active
- 2005-08-16 AR ARP050103442A patent/AR050919A1/es not_active Application Discontinuation
- 2005-08-16 CN CN2005800284407A patent/CN101006055B/zh not_active Expired - Fee Related
- 2005-08-16 RU RU2007109783/04A patent/RU2369599C2/ru not_active IP Right Cessation
- 2005-08-16 BR BRPI0514380-2A patent/BRPI0514380A/pt not_active IP Right Cessation
- 2005-08-16 DE DE602005027858T patent/DE602005027858D1/de active Active
- 2005-08-16 MX MX2007001382A patent/MX2007001382A/es active IP Right Grant
- 2005-08-16 JP JP2007527928A patent/JP4843608B2/ja not_active Expired - Fee Related
- 2005-08-16 AT AT05786210T patent/ATE508112T1/de not_active IP Right Cessation
- 2005-08-16 WO PCT/US2005/029053 patent/WO2006023467A1/en active Application Filing
- 2005-08-16 KR KR1020077003922A patent/KR20070043012A/ko active IP Right Grant
- 2005-08-16 CA CA2577667A patent/CA2577667C/en not_active Expired - Fee Related
- 2005-08-16 NZ NZ552800A patent/NZ552800A/en not_active IP Right Cessation
- 2005-08-16 KR KR1020137005469A patent/KR20130038409A/ko not_active Application Discontinuation
- 2005-08-16 AU AU2005277523A patent/AU2005277523B2/en not_active Ceased
- 2005-08-17 PE PE2005000955A patent/PE20060498A1/es not_active Application Discontinuation
- 2005-08-19 TW TW094128283A patent/TWI357897B/zh not_active IP Right Cessation
- 2005-08-19 UY UY29078A patent/UY29078A1/es unknown
- 2005-08-19 PA PA20058642901A patent/PA8642901A1/es unknown
-
2007
- 2007-01-22 ZA ZA200700651A patent/ZA200700651B/xx unknown
- 2007-02-04 IL IL181156A patent/IL181156A/en not_active IP Right Cessation
- 2007-02-13 US US11/674,385 patent/US7629376B2/en active Active
- 2007-03-14 MA MA29757A patent/MA28863B1/fr unknown
- 2007-03-19 NO NO20071466A patent/NO20071466L/no not_active Application Discontinuation
- 2007-09-27 HK HK07110474.7A patent/HK1105196A1/xx not_active IP Right Cessation
-
2008
- 2008-11-12 US US12/269,216 patent/US7923466B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PA8675701A1 (es) | Nuevos derivados del fluoreno, composiciones que los contienen y su utilización | |
CY1123625T1 (el) | Συνθεσεις και μεθοδοι για θεραπεια διαταραχων χρησης αλκοολης, πονου και αλλων ασθενειων | |
GT200600193A (es) | Imidazoquinolines como inhibidores de lipidos kinase | |
JO2629B1 (en) | Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon | |
BRPI0409173A (pt) | compostos e composições como inibidores de proteìna quinase | |
ECSP055536A (es) | Derivados de 1-heterociclilalquil-3-sulfonilindol o indazol como ligandos de 5-hidroxitriptamina-6 | |
ECSP055535A (es) | Derivados de 1-heterociclialquil-3-sulfonilazaindol o azaindol como ligandos de 5-hidroxitriptamina-6 | |
DOP2006000169A (es) | Inhibidores espiropiperidina de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
ATE469151T1 (de) | Pyrrolopyridinderivate als proteinkinaseinhibitoren | |
ECSP066391A (es) | [1,8] naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia | |
CY1115188T1 (el) | Πολυκυκλικες ετεροαρυλ-υποκατεστημενες τριαζολες χρησιμες ως αναστολεις του axl | |
BRPI0517015A (pt) | compostos e composições como inibidores de atividade de receptor 1 de canabinóide | |
ECSP045473A (es) | Derivados de 1-(aminoalquil)-3-sulfonilindol y 1-aminoalquil-3-sulfonilindazol como ligandos de 5-hidroxitriptamina-6 | |
CY1109069T1 (el) | Ενωσεις ιμιδαζοπυριδαζινης | |
DE60325379D1 (de) | Zusammensetzung enthaltend 6-Ä3-(1-adamantyl)-4-methoxyphenylÜ-2-naphthanoesäure zur Behandlung dermatologischer Erkrankungen | |
ECSP088283A (es) | Compuestos de piridina 5- (fenilisoxazoliletoxi) -triazol- 3-ilo substituidos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor | |
EA200970302A1 (ru) | Тиофенпиразолопиримидиновые соединения | |
BRPI0515991A (pt) | derivados de bisariluréia substituìda heterocìclica como inibidores de cinase | |
BRPI0417520A (pt) | 1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon | |
ECSP088250A (es) | Derivados de pirazol como agentes terapéuticos | |
UY29078A1 (es) | Amidas del ácido 5 y 6-aminoalquil indol-2-carboxílico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon) | |
CY1112227T1 (el) | Πιπεριδινυλαμινο-πυριδαζινες και η χρηση τους ως ταχεως διασπομενοι ανταγωνιστες υποδοχεα ντοπαμινης 2 | |
DOP2003000587A (es) | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO | |
ECSP066555A (es) | Derivados de morfolina como inhibidores de la reabsorcion de norepinefrina | |
SV2006002304A (es) | "azabenzoxazoles para el tratamiento de trastornos del snc" ref.pc32518a |