AR050919A1 - Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie - Google Patents
Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ieInfo
- Publication number
- AR050919A1 AR050919A1 ARP050103442A ARP050103442A AR050919A1 AR 050919 A1 AR050919 A1 AR 050919A1 AR P050103442 A ARP050103442 A AR P050103442A AR P050103442 A ARP050103442 A AR P050103442A AR 050919 A1 AR050919 A1 AR 050919A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocycle
- aryl
- alkenyl
- compounds
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente describe y reivindica compuestos como inhibidores de la caseína cinasa Iépsilon humana, y métodos de uso de dichos compuestos para el tratamiento de enfermedades y trastornos del sistema nervioso central incluyendo trastornos del estado de ánimo y trastornos del sueno. También se describen y reivindican composiciones farmacéuticas que comprenden dichos compuestos. Reivindicacion 1: Un compuesto de formula (1) o de formula (2), o un estereoisomero, un enantiomero, un racemato o un tautomero de dicho compuesto, o una sal farmacéuticamente aceptable del mismo, en las que: X es S o S(O)n; R1 es H o alquilo C1-6; R2 es NR5R6; R3 es arilo o heterociclo; R4 es alquilo C1-6 o halogeno; R5 es H o alquilo C1-6; R6 es H o alquilo C1-6; R7 es CH2NR8R9 donde, R8 es H, alquilo C1-10, cicloalquilo C3-8, arilo, aril(alquilo C1-6), aril(alquenilo C2-6), diaril(alquenilo C2-6), heterociclo, heterociclo(alquilo C1-6), heterociclo(alquenilo C2-6), hidroxi(alquilo C1-6), dihidrox(alquilo C2- 6), acilo, alcoxicarbonilo C1-6, aril(alcoxi C1-6)carbonilo, carbamoil(alquilo C1-6) o P; R9 es H, alquilo C1-10, heterociclo(alquilo C1-6) o heterociclo(alquenilo C2-6); o R8 y R9 junto con el nitrogeno al que están unidos forman un heterociclo; y donde P es Gly, o L- o D-Ala, Val, Leu, Ile, Ser, Cys, Thr, Met, Pro, Phe, Tyr, Trp, His, Lys, Arg, Asp, Gly, Asn o Gln; m es 0, 1 o 2; y n es 1 o 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60338004P | 2004-08-19 | 2004-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050919A1 true AR050919A1 (es) | 2006-12-06 |
Family
ID=35311279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103442A AR050919A1 (es) | 2004-08-19 | 2005-08-16 | Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7629376B2 (es) |
| EP (1) | EP1794122B1 (es) |
| JP (1) | JP4843608B2 (es) |
| KR (2) | KR20130038409A (es) |
| CN (1) | CN101006055B (es) |
| AR (1) | AR050919A1 (es) |
| AT (1) | ATE508112T1 (es) |
| AU (1) | AU2005277523B2 (es) |
| BR (1) | BRPI0514380A (es) |
| CA (1) | CA2577667C (es) |
| DE (1) | DE602005027858D1 (es) |
| GT (1) | GT200500214A (es) |
| HK (1) | HK1105196A1 (es) |
| IL (1) | IL181156A (es) |
| JO (1) | JO2724B1 (es) |
| MA (1) | MA28863B1 (es) |
| MX (1) | MX2007001382A (es) |
| NO (1) | NO20071466L (es) |
| NZ (1) | NZ552800A (es) |
| PA (1) | PA8642901A1 (es) |
| PE (1) | PE20060498A1 (es) |
| RU (1) | RU2369599C2 (es) |
| SV (1) | SV2006002192A (es) |
| TW (1) | TWI357897B (es) |
| UY (1) | UY29078A1 (es) |
| WO (1) | WO2006023467A1 (es) |
| ZA (1) | ZA200700651B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2397481B1 (en) * | 2009-02-12 | 2014-03-12 | Pharmadesign, Inc. | Inhibitor of casein kinase 1delta and casein kinase 1epsilon |
| EP2419101A2 (en) * | 2009-04-17 | 2012-02-22 | Cylene Pharmaceuticals, Inc. | Method of treating disorders associated with protein kinase ck2 activity |
| BR112014032581A8 (pt) | 2012-06-27 | 2018-08-14 | 4Sc Discovery Gmbh | inibidores de bifluorodioxalano-amino-benzimidazol quinase para o tratamento de câncer, distúrbios do snc e inflamação autoimune |
| WO2019145919A1 (en) | 2018-01-29 | 2019-08-01 | Cadila Healthcare Limited | Heterocyclic compounds useful as antibacterial agents |
| WO2022006377A2 (en) * | 2020-07-02 | 2022-01-06 | Mbq Pharma | Heterocyclic inhibitors of rho gtpases for the treatment of disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296471A (en) | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| IL146729A0 (en) * | 1999-06-08 | 2002-07-25 | Aventis Pharma Inc | Screening methods for altering circadian rhythm proteins |
| CA2494962C (en) * | 2002-08-09 | 2011-06-14 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| JP4691506B2 (ja) * | 2003-12-11 | 2011-06-01 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カゼインキナーゼＩεの阻害剤としての置換１Ｈ−ピロロ［３，２−ｂ，３，２−ｃ，及び２，３−ｃ］ピリジン−２−カルボキシアミド及び関連類似物 |
-
2005
- 2005-07-24 JO JO2005108A patent/JO2724B1/en active
- 2005-08-09 GT GT200500214A patent/GT200500214A/es unknown
- 2005-08-10 SV SV2005002192A patent/SV2006002192A/es active IP Right Grant
- 2005-08-16 NZ NZ552800A patent/NZ552800A/en not_active IP Right Cessation
- 2005-08-16 BR BRPI0514380-2A patent/BRPI0514380A/pt not_active IP Right Cessation
- 2005-08-16 RU RU2007109783/04A patent/RU2369599C2/ru not_active IP Right Cessation
- 2005-08-16 CA CA2577667A patent/CA2577667C/en not_active Expired - Fee Related
- 2005-08-16 AR ARP050103442A patent/AR050919A1/es not_active Application Discontinuation
- 2005-08-16 CN CN2005800284407A patent/CN101006055B/zh active Active
- 2005-08-16 EP EP05786210A patent/EP1794122B1/en active Active
- 2005-08-16 KR KR1020137005469A patent/KR20130038409A/ko not_active Application Discontinuation
- 2005-08-16 AU AU2005277523A patent/AU2005277523B2/en not_active Ceased
- 2005-08-16 WO PCT/US2005/029053 patent/WO2006023467A1/en active Application Filing
- 2005-08-16 KR KR1020077003922A patent/KR20070043012A/ko active IP Right Grant
- 2005-08-16 AT AT05786210T patent/ATE508112T1/de not_active IP Right Cessation
- 2005-08-16 DE DE602005027858T patent/DE602005027858D1/de active Active
- 2005-08-16 JP JP2007527928A patent/JP4843608B2/ja not_active Expired - Fee Related
- 2005-08-16 MX MX2007001382A patent/MX2007001382A/es active IP Right Grant
- 2005-08-17 PE PE2005000955A patent/PE20060498A1/es not_active Application Discontinuation
- 2005-08-19 UY UY29078A patent/UY29078A1/es unknown
- 2005-08-19 PA PA20058642901A patent/PA8642901A1/es unknown
- 2005-08-19 TW TW094128283A patent/TWI357897B/zh not_active IP Right Cessation
-
2007
- 2007-01-22 ZA ZA200700651A patent/ZA200700651B/xx unknown
- 2007-02-04 IL IL181156A patent/IL181156A/en not_active IP Right Cessation
- 2007-02-13 US US11/674,385 patent/US7629376B2/en active Active
- 2007-03-14 MA MA29757A patent/MA28863B1/fr unknown
- 2007-03-19 NO NO20071466A patent/NO20071466L/no not_active Application Discontinuation
- 2007-09-27 HK HK07110474.7A patent/HK1105196A1/xx not_active IP Right Cessation
-
2008
- 2008-11-12 US US12/269,216 patent/US7923466B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |