ZA200700651B - 3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase - Google Patents

3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase

Info

Publication number
ZA200700651B
ZA200700651B ZA200700651A ZA200700651A ZA200700651B ZA 200700651 B ZA200700651 B ZA 200700651B ZA 200700651 A ZA200700651 A ZA 200700651A ZA 200700651 A ZA200700651 A ZA 200700651A ZA 200700651 B ZA200700651 B ZA 200700651B
Authority
ZA
South Africa
Prior art keywords
inhibitors
substituted
carboxylic acid
acid amides
casein kinase
Prior art date
Application number
ZA200700651A
Other languages
English (en)
Inventor
William Arthur Metz Jr
Ding Fa-Xiang
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of ZA200700651B publication Critical patent/ZA200700651B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
ZA200700651A 2004-08-19 2007-01-22 3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase ZA200700651B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60338004P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
ZA200700651B true ZA200700651B (en) 2008-09-25

Family

ID=35311279

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700651A ZA200700651B (en) 2004-08-19 2007-01-22 3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase

Country Status (27)

Country Link
US (2) US7629376B2 (xx)
EP (1) EP1794122B1 (xx)
JP (1) JP4843608B2 (xx)
KR (2) KR20130038409A (xx)
CN (1) CN101006055B (xx)
AR (1) AR050919A1 (xx)
AT (1) ATE508112T1 (xx)
AU (1) AU2005277523B2 (xx)
BR (1) BRPI0514380A (xx)
CA (1) CA2577667C (xx)
DE (1) DE602005027858D1 (xx)
GT (1) GT200500214A (xx)
HK (1) HK1105196A1 (xx)
IL (1) IL181156A (xx)
JO (1) JO2724B1 (xx)
MA (1) MA28863B1 (xx)
MX (1) MX2007001382A (xx)
NO (1) NO20071466L (xx)
NZ (1) NZ552800A (xx)
PA (1) PA8642901A1 (xx)
PE (1) PE20060498A1 (xx)
RU (1) RU2369599C2 (xx)
SV (1) SV2006002192A (xx)
TW (1) TWI357897B (xx)
UY (1) UY29078A1 (xx)
WO (1) WO2006023467A1 (xx)
ZA (1) ZA200700651B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092660A1 (ja) * 2009-02-12 2010-08-19 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
CA2758974A1 (en) * 2009-04-17 2010-10-21 Cylene Pharmaceuticals, Inc. Method of treating disorders associated with protein kinase ck2 activity
NZ702618A (en) 2012-06-27 2016-12-23 4Sc Discovery Gmbh Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and cns disorders
EP3746438A1 (en) 2018-01-29 2020-12-09 Cadila Healthcare Limited Heterocyclic compounds useful as antibacterial agents
WO2022006377A2 (en) * 2020-07-02 2022-01-06 Mbq Pharma Heterocyclic inhibitors of rho gtpases for the treatment of disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
ATE322016T1 (de) 1999-06-08 2006-04-15 Aventis Pharma Inc Screeningsverfahren zur änderung zirkadiane- rhythmus-eiweisse
WO2004014851A2 (en) * 2002-08-09 2004-02-19 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1747220B1 (en) * 2003-12-11 2009-04-15 Aventis Pharmaceuticals Inc. Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon

Also Published As

Publication number Publication date
WO2006023467A1 (en) 2006-03-02
CA2577667A1 (en) 2006-03-02
BRPI0514380A (pt) 2008-06-10
CA2577667C (en) 2011-01-04
UY29078A1 (es) 2006-03-31
CN101006055A (zh) 2007-07-25
US20090082340A1 (en) 2009-03-26
NO20071466L (no) 2007-04-19
US7629376B2 (en) 2009-12-08
MA28863B1 (fr) 2007-09-03
JO2724B1 (en) 2013-09-15
TWI357897B (en) 2012-02-11
PE20060498A1 (es) 2006-07-10
RU2007109783A (ru) 2008-09-27
IL181156A (en) 2011-09-27
CN101006055B (zh) 2011-06-22
EP1794122A1 (en) 2007-06-13
IL181156A0 (en) 2007-07-04
JP4843608B2 (ja) 2011-12-21
MX2007001382A (es) 2007-04-19
KR20070043012A (ko) 2007-04-24
AU2005277523A1 (en) 2006-03-02
US20080027124A1 (en) 2008-01-31
GT200500214A (es) 2006-03-27
NZ552800A (en) 2010-11-26
JP2008510017A (ja) 2008-04-03
DE602005027858D1 (de) 2011-06-16
US7923466B2 (en) 2011-04-12
KR20130038409A (ko) 2013-04-17
HK1105196A1 (en) 2008-02-06
PA8642901A1 (es) 2006-05-16
SV2006002192A (es) 2006-06-28
EP1794122B1 (en) 2011-05-04
AR050919A1 (es) 2006-12-06
ATE508112T1 (de) 2011-05-15
TW200621711A (en) 2006-07-01
RU2369599C2 (ru) 2009-10-10
AU2005277523B2 (en) 2011-09-29

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