CO6251286A2 - Sales amino del acido [4, 6-bis(dimetilamino)-2-(4-(4-trifluorometil)benzamido)bencil)pirimidin-5-il]acetico, composiciones farmaceuticas de las mismas y sus usos para el tratamiento de enfermedades mediadas por crth-2 - Google Patents
Sales amino del acido [4, 6-bis(dimetilamino)-2-(4-(4-trifluorometil)benzamido)bencil)pirimidin-5-il]acetico, composiciones farmaceuticas de las mismas y sus usos para el tratamiento de enfermedades mediadas por crth-2Info
- Publication number
- CO6251286A2 CO6251286A2 CO09149186A CO09149186A CO6251286A2 CO 6251286 A2 CO6251286 A2 CO 6251286A2 CO 09149186 A CO09149186 A CO 09149186A CO 09149186 A CO09149186 A CO 09149186A CO 6251286 A2 CO6251286 A2 CO 6251286A2
- Authority
- CO
- Colombia
- Prior art keywords
- benzamido
- pyrimidin
- bis
- pharmaceutical compositions
- pharmaceutically acceptable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proveen sales de amina de ácido {4,6-bis (dimetilamino)-2-(4-(4-(trifluorometil)benzamido)bencil) pirimidin-5-il)acético, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso para tratar, prevenir o aliviar uno o más síntomas de un trastorno o enfermedad mediado por CRTH2. 1.- Una sal de forma cristalina, que comprende una amina farmacéuticamente aceptable y ácido {4,6- bis(dimetilamino)-2-(4(4-(trifluorometil)benzamido)bencil) pirimidin-5-il}acético de la Fórmula I:o un hidrato o solvato farmacéuticamente aceptable del mismo. 2.- Una sal que comprende una amina farmacéuticamente aceptable y ácido {4,6-bis(dimetilamino)-2-(4-(4-(trifluorometil)benzamido)bencil) pirimidin-5-il}acético de la Fórmula I:o un hidrato o solvato farmacéuticamente aceptable del mismo; en donde la amina farmacéuticamente aceptable no es etanolamina, trietilamina, o tris (hidroximetil)aminometano.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93673607P | 2007-06-21 | 2007-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6251286A2 true CO6251286A2 (es) | 2011-02-21 |
Family
ID=39731477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09149186A CO6251286A2 (es) | 2007-06-21 | 2009-12-30 | Sales amino del acido [4, 6-bis(dimetilamino)-2-(4-(4-trifluorometil)benzamido)bencil)pirimidin-5-il]acetico, composiciones farmaceuticas de las mismas y sus usos para el tratamiento de enfermedades mediadas por crth-2 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8278310B2 (es) |
EP (1) | EP2176240A1 (es) |
JP (1) | JP6006914B2 (es) |
KR (1) | KR20100039350A (es) |
CN (4) | CN102898381A (es) |
AR (1) | AR067118A1 (es) |
BR (1) | BRPI0812597A2 (es) |
CA (1) | CA2690436A1 (es) |
CL (1) | CL2008001817A1 (es) |
CO (1) | CO6251286A2 (es) |
EC (1) | ECSP109851A (es) |
HK (1) | HK1144940A1 (es) |
IL (1) | IL202755A0 (es) |
MA (1) | MA31536B1 (es) |
MX (1) | MX2009013813A (es) |
MY (1) | MY149005A (es) |
NZ (1) | NZ581856A (es) |
RU (1) | RU2468013C2 (es) |
TN (1) | TN2009000517A1 (es) |
TW (1) | TWI419693B (es) |
UA (1) | UA101326C2 (es) |
WO (1) | WO2008156781A1 (es) |
ZA (1) | ZA200909110B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1471057T3 (da) | 2003-04-25 | 2006-05-15 | Actimis Pharmaceuticals Inc | Pyrimidinyleddikesyrederivater, der er egnede til behandlingen af sygdomme medieret af CRTH2 |
EP2328876B1 (en) * | 2008-09-02 | 2012-11-21 | Actimis Pharmaceuticals, Inc., | Isotopically enriched pyrimidin-5-yl acetic acid derivatives as crth2 antagonists |
EP2393492A1 (en) * | 2009-02-09 | 2011-12-14 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
WO2011005645A1 (en) | 2009-07-06 | 2011-01-13 | Boehringer Ingelheim International Gmbh | Polymorph of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl] |
EP2504319A1 (en) * | 2009-11-24 | 2012-10-03 | Boehringer Ingelheim International GmbH | Process for preparing a polymorph of the choline salt of a pyrimidin-5-yl acetic acid derivative |
US20120302584A1 (en) | 2009-11-24 | 2012-11-29 | Boehringer Ingelheim International Gmbh | Novel salts forms of pyrimidin-5-yl acetic acid derivative |
JP2013535456A (ja) | 2010-07-28 | 2013-09-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系及び炎症性疾患の治療用医薬組成物 |
JP2013535457A (ja) | 2010-07-28 | 2013-09-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系及び炎症性疾患の治療用医薬組成物 |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
WO2013088109A1 (en) | 2011-12-16 | 2013-06-20 | Oxagen Limited | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
US10181231B2 (en) | 2014-02-18 | 2019-01-15 | Bekey A/S | Controlling access to a location |
CA3056590A1 (en) | 2017-02-15 | 2018-08-23 | Nanyang Technological University | Compounds for treating tuberculosis |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA005245B1 (ru) * | 2000-04-26 | 2004-12-30 | Уорнер-Ламберт Компани | Комбинация карбоксиалкиловых эфиров и гипотензивных агентов и фармацевтическое применение |
US7078690B2 (en) * | 2002-02-04 | 2006-07-18 | Applied Materials, Israel, Ltd. | Monitoring of contact hole production |
DK1471057T3 (da) * | 2003-04-25 | 2006-05-15 | Actimis Pharmaceuticals Inc | Pyrimidinyleddikesyrederivater, der er egnede til behandlingen af sygdomme medieret af CRTH2 |
SE0301569D0 (sv) * | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
AU2006234545A1 (en) * | 2005-04-07 | 2006-10-19 | Teijin Pharma Limited | Crystal of aminopyrrolidine derivative and production method thereof |
RU2468012C2 (ru) * | 2007-06-21 | 2012-11-27 | Актимис Фармасьютикалз, Инк. | Частицы антагониста crth2 |
EP2328876B1 (en) * | 2008-09-02 | 2012-11-21 | Actimis Pharmaceuticals, Inc., | Isotopically enriched pyrimidin-5-yl acetic acid derivatives as crth2 antagonists |
-
2008
- 2008-06-18 JP JP2010513235A patent/JP6006914B2/ja not_active Expired - Fee Related
- 2008-06-18 NZ NZ581856A patent/NZ581856A/en not_active IP Right Cessation
- 2008-06-18 CN CN2012103213763A patent/CN102898381A/zh active Pending
- 2008-06-18 EP EP08768583A patent/EP2176240A1/en not_active Withdrawn
- 2008-06-18 MX MX2009013813A patent/MX2009013813A/es active IP Right Grant
- 2008-06-18 UA UAA201000543A patent/UA101326C2/ru unknown
- 2008-06-18 CN CN2012103215909A patent/CN102875478A/zh active Pending
- 2008-06-18 CN CN2008801019629A patent/CN101772489B/zh not_active Expired - Fee Related
- 2008-06-18 MY MYPI20095423A patent/MY149005A/en unknown
- 2008-06-18 US US12/665,705 patent/US8278310B2/en not_active Expired - Fee Related
- 2008-06-18 RU RU2010101795/04A patent/RU2468013C2/ru not_active IP Right Cessation
- 2008-06-18 KR KR1020107001490A patent/KR20100039350A/ko not_active Application Discontinuation
- 2008-06-18 CA CA2690436A patent/CA2690436A1/en not_active Abandoned
- 2008-06-18 BR BRPI0812597-0A2A patent/BRPI0812597A2/pt not_active IP Right Cessation
- 2008-06-18 WO PCT/US2008/007590 patent/WO2008156781A1/en active Application Filing
- 2008-06-18 CN CN2012103209664A patent/CN102898380A/zh active Pending
- 2008-06-19 CL CL2008001817A patent/CL2008001817A1/es unknown
- 2008-06-20 AR ARP080102675A patent/AR067118A1/es not_active Application Discontinuation
- 2008-06-20 TW TW097123238A patent/TWI419693B/zh not_active IP Right Cessation
-
2009
- 2009-12-10 TN TNP2009000517A patent/TN2009000517A1/fr unknown
- 2009-12-15 IL IL202755A patent/IL202755A0/en unknown
- 2009-12-21 ZA ZA2009/09110A patent/ZA200909110B/en unknown
- 2009-12-30 CO CO09149186A patent/CO6251286A2/es not_active Application Discontinuation
-
2010
- 2010-01-06 EC EC2010009851A patent/ECSP109851A/es unknown
- 2010-01-19 MA MA32540A patent/MA31536B1/fr unknown
- 2010-12-13 HK HK10111559.8A patent/HK1144940A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2010101795A (ru) | 2011-07-27 |
BRPI0812597A2 (pt) | 2015-02-18 |
CL2008001817A1 (es) | 2009-03-13 |
CN102898380A (zh) | 2013-01-30 |
MA31536B1 (fr) | 2010-07-01 |
AR067118A1 (es) | 2009-09-30 |
TWI419693B (zh) | 2013-12-21 |
WO2008156781A1 (en) | 2008-12-24 |
US8278310B2 (en) | 2012-10-02 |
HK1144940A1 (en) | 2011-03-18 |
US20110034482A1 (en) | 2011-02-10 |
JP6006914B2 (ja) | 2016-10-12 |
CN101772489A (zh) | 2010-07-07 |
NZ581856A (en) | 2011-05-27 |
CN101772489B (zh) | 2013-02-20 |
TN2009000517A1 (en) | 2011-03-31 |
CN102898381A (zh) | 2013-01-30 |
AU2008266854A1 (en) | 2008-12-24 |
RU2468013C2 (ru) | 2012-11-27 |
ECSP109851A (es) | 2010-03-31 |
KR20100039350A (ko) | 2010-04-15 |
CN102875478A (zh) | 2013-01-16 |
JP2010530426A (ja) | 2010-09-09 |
TW200911261A (en) | 2009-03-16 |
UA101326C2 (en) | 2013-03-25 |
IL202755A0 (en) | 2010-06-30 |
EP2176240A1 (en) | 2010-04-21 |
MX2009013813A (es) | 2010-02-03 |
CA2690436A1 (en) | 2008-12-24 |
ZA200909110B (en) | 2011-03-30 |
MY149005A (en) | 2013-06-28 |
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