MX2018002183A - Composiciones y metodos para tratamiento del dolor. - Google Patents
Composiciones y metodos para tratamiento del dolor.Info
- Publication number
- MX2018002183A MX2018002183A MX2018002183A MX2018002183A MX2018002183A MX 2018002183 A MX2018002183 A MX 2018002183A MX 2018002183 A MX2018002183 A MX 2018002183A MX 2018002183 A MX2018002183 A MX 2018002183A MX 2018002183 A MX2018002183 A MX 2018002183A
- Authority
- MX
- Mexico
- Prior art keywords
- fusion proteins
- engineered fusion
- toxins
- compositions
- pain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/07—Bacillus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
En la presente se describen proteínas de fusión modificadas que se unen y dirigen a neuronas nocirreceptoras, composiciones que comprenden estas proteínas de fusión modificadas y métodos para tratar el dolor utilizando estas proteínas de fusión modificadas o composiciones que contienen las proteínas de fusión modificadas. Las proteínas de fusión modificadas contienen dominios derivados de toxinas proteicas como la toxina de ántrax, familia de toxinas de clostridium botulinum, toxinas con disulfuro y toxinas de tipo de componente AB.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562210610P | 2015-08-27 | 2015-08-27 | |
PCT/US2016/049106 WO2017035508A1 (en) | 2015-08-27 | 2016-08-26 | Compositions and methods for treatment of pain |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018002183A true MX2018002183A (es) | 2018-05-28 |
Family
ID=58101095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018002183A MX2018002183A (es) | 2015-08-27 | 2016-08-26 | Composiciones y metodos para tratamiento del dolor. |
Country Status (11)
Country | Link |
---|---|
US (4) | US11753633B2 (es) |
EP (2) | EP3341391A4 (es) |
JP (2) | JP2018530315A (es) |
KR (2) | KR20180070563A (es) |
CN (2) | CN108350039A (es) |
AU (2) | AU2016312685A1 (es) |
BR (2) | BR112018003794A2 (es) |
CA (2) | CA2994560A1 (es) |
EA (1) | EA201890587A1 (es) |
MX (1) | MX2018002183A (es) |
WO (2) | WO2017035508A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201718627A (zh) * | 2015-06-11 | 2017-06-01 | 梅茲製藥有限兩合公司 | 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞 |
EP3341391A4 (en) | 2015-08-27 | 2019-03-06 | President and Fellows of Harvard College | COMPOSITIONS AND METHODS OF PAIN TREATMENT |
GB201607901D0 (en) * | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
AU2017292922B9 (en) * | 2016-07-08 | 2022-05-12 | Children's Medical Center Corporation | A novel botulinum neurotoxin and its derivatives |
CN112105379A (zh) * | 2017-09-29 | 2020-12-18 | 儿童医学中心公司 | 神经毒素样毒素及其用途 |
AU2019211190B2 (en) | 2018-01-29 | 2021-07-08 | Ipsen Biopharm Limited | Non-neuronal SNARE-cleaving botulinum neurotoxins |
WO2019158745A1 (de) * | 2018-02-16 | 2019-08-22 | Bontana Therapies Gmbh | Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung |
JP2021525514A (ja) * | 2018-05-30 | 2021-09-27 | ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロントThe Governing Council Of The University Of Toronto | 受容体−リガンド相互作用に関連付けられるタンパク質を同定するための方法及びキット |
WO2020116686A1 (ko) * | 2018-12-06 | 2020-06-11 | 고려대학교 산학협력단 | 인간 항-antxr 키메라 항원 수용체 및 이의 용도 |
EP4093434A4 (en) * | 2020-01-21 | 2024-06-26 | Trustees of Dartmouth College | IMMUNOLOGY-OPTIMIZED BOTULINUM TOXIN LIGHT CHAIN VARIANTS |
WO2021156890A2 (en) * | 2020-02-03 | 2021-08-12 | Premas Biotech Private Limited | Recombinant expression platform, constructs and methods for expression of difficult to express proteins (dte-ps) |
US20230165812A1 (en) * | 2020-02-27 | 2023-06-01 | President And Fellows Of Harvard College | Nociceptor neurons control cancer immunosurveillance |
KR20240051355A (ko) * | 2022-10-12 | 2024-04-22 | 주식회사 알케미어 | 보툴리눔 독소의 경쇄 변이체 |
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EP3341391A4 (en) | 2015-08-27 | 2019-03-06 | President and Fellows of Harvard College | COMPOSITIONS AND METHODS OF PAIN TREATMENT |
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2016
- 2016-08-26 EP EP16840234.5A patent/EP3341391A4/en active Pending
- 2016-08-26 JP JP2018510813A patent/JP2018530315A/ja active Pending
- 2016-08-26 WO PCT/US2016/049106 patent/WO2017035508A1/en active Application Filing
- 2016-08-26 JP JP2018511085A patent/JP2018525021A/ja active Pending
- 2016-08-26 US US15/755,544 patent/US11753633B2/en active Active
- 2016-08-26 CA CA2994560A patent/CA2994560A1/en not_active Abandoned
- 2016-08-26 BR BR112018003794A patent/BR112018003794A2/pt not_active Application Discontinuation
- 2016-08-26 KR KR1020187008538A patent/KR20180070563A/ko unknown
- 2016-08-26 KR KR1020187008537A patent/KR20180050679A/ko unknown
- 2016-08-26 CN CN201680062362.0A patent/CN108350039A/zh active Pending
- 2016-08-26 AU AU2016312685A patent/AU2016312685A1/en not_active Abandoned
- 2016-08-26 AU AU2016310521A patent/AU2016310521A1/en not_active Abandoned
- 2016-08-26 US US15/755,543 patent/US10704035B2/en active Active
- 2016-08-26 CA CA2994729A patent/CA2994729A1/en not_active Abandoned
- 2016-08-26 MX MX2018002183A patent/MX2018002183A/es unknown
- 2016-08-26 CN CN201680062855.4A patent/CN108602861A/zh active Pending
- 2016-08-26 WO PCT/US2016/049099 patent/WO2017035507A1/en active Application Filing
- 2016-08-26 EP EP16840235.2A patent/EP3341392A4/en active Pending
- 2016-08-26 BR BR112018003782A patent/BR112018003782A2/pt not_active Application Discontinuation
- 2016-08-26 EA EA201890587A patent/EA201890587A1/ru unknown
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2020
- 2020-05-27 US US16/884,893 patent/US11104892B2/en active Active
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2021
- 2021-08-13 US US17/402,323 patent/US20220033795A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112018003782A2 (pt) | 2018-09-25 |
US20180251740A1 (en) | 2018-09-06 |
CA2994729A1 (en) | 2017-03-02 |
AU2016310521A1 (en) | 2018-03-01 |
WO2017035507A1 (en) | 2017-03-02 |
KR20180050679A (ko) | 2018-05-15 |
JP2018525021A (ja) | 2018-09-06 |
US20180244731A1 (en) | 2018-08-30 |
CA2994560A1 (en) | 2017-03-02 |
EP3341391A1 (en) | 2018-07-04 |
JP2018530315A (ja) | 2018-10-18 |
US11753633B2 (en) | 2023-09-12 |
EP3341392A1 (en) | 2018-07-04 |
US20220033795A1 (en) | 2022-02-03 |
AU2016312685A1 (en) | 2018-03-01 |
KR20180070563A (ko) | 2018-06-26 |
WO2017035508A1 (en) | 2017-03-02 |
US10704035B2 (en) | 2020-07-07 |
EP3341391A4 (en) | 2019-03-06 |
US11104892B2 (en) | 2021-08-31 |
CN108602861A (zh) | 2018-09-28 |
US20200362325A1 (en) | 2020-11-19 |
BR112018003794A2 (pt) | 2018-09-25 |
CN108350039A (zh) | 2018-07-31 |
EP3341392A4 (en) | 2019-01-23 |
EA201890587A1 (ru) | 2018-09-28 |
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