KR102581827B1 - 유비퀴틴-특이적 프로테아제 7 억제제로서의 피롤로 및 피라졸로피리미딘 - Google Patents

유비퀴틴-특이적 프로테아제 7 억제제로서의 피롤로 및 피라졸로피리미딘 Download PDF

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KR102581827B1
KR102581827B1 KR1020177021230A KR20177021230A KR102581827B1 KR 102581827 B1 KR102581827 B1 KR 102581827B1 KR 1020177021230 A KR1020177021230 A KR 1020177021230A KR 20177021230 A KR20177021230 A KR 20177021230A KR 102581827 B1 KR102581827 B1 KR 102581827B1
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methyl
pyrazolo
pyrimidin
phenyl
hydroxypiperidin
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KR20170106981A (ko
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스테파노스 이오안니디스
아담 찰스 탈보트
브루스 팔로우스
알렉산드레 조셉 벅멜터
밍화 왕
안-마리 캠벨
다비 라이 슈미트
데이비드 조셉 궤린
저스틴 에이. 카라벨라
알. 브루스 디볼드
안나 에릭슨
주니어 데이비드 알. 랜시아
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포르마 세라퓨틱스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177021230A 2014-12-30 2015-12-29 유비퀴틴-특이적 프로테아제 7 억제제로서의 피롤로 및 피라졸로피리미딘 Active KR102581827B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098141P 2014-12-30 2014-12-30
US62/098,141 2014-12-30
PCT/US2015/067831 WO2016109515A1 (en) 2014-12-30 2015-12-29 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

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KR20170106981A KR20170106981A (ko) 2017-09-22
KR102581827B1 true KR102581827B1 (ko) 2023-09-25

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US (4) US9902728B2 (OSRAM)
EP (2) EP3240791B1 (OSRAM)
JP (1) JP6649388B2 (OSRAM)
KR (1) KR102581827B1 (OSRAM)
CN (1) CN107406451B (OSRAM)
AR (1) AR103297A1 (OSRAM)
AU (2) AU2015374170B2 (OSRAM)
CA (1) CA2972797C (OSRAM)
CL (1) CL2017001687A1 (OSRAM)
CO (1) CO2017006997A2 (OSRAM)
EA (1) EA038204B1 (OSRAM)
EC (1) ECSP17049010A (OSRAM)
ES (1) ES2768996T3 (OSRAM)
IL (1) IL252773A0 (OSRAM)
MA (1) MA40706A1 (OSRAM)
MX (2) MX373788B (OSRAM)
PH (1) PH12017501224A1 (OSRAM)
SA (1) SA517381839B1 (OSRAM)
SG (1) SG11201704897QA (OSRAM)
TW (2) TWI770525B (OSRAM)
WO (1) WO2016109515A1 (OSRAM)
ZA (1) ZA201704746B (OSRAM)

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