AU2015374170B2 - Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors - Google Patents

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors Download PDF

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Publication number
AU2015374170B2
AU2015374170B2 AU2015374170A AU2015374170A AU2015374170B2 AU 2015374170 B2 AU2015374170 B2 AU 2015374170B2 AU 2015374170 A AU2015374170 A AU 2015374170A AU 2015374170 A AU2015374170 A AU 2015374170A AU 2015374170 B2 AU2015374170 B2 AU 2015374170B2
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methyl
pyrimidin
pyrazolo
alkyl
aryl
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AU2015374170A1 (en
Inventor
Alexandre Joseph Buckmelter
Ann-Marie Campbell
Justin A. Caravella
R. Bruce DIEBOLD
Anna Ericsson
Bruce Follows
David Joseph Guerin
Stephanos Ioannidis
JR. David R. LANCIA
Darby Rye Schmidt
Adam Charles Talbot
Minghua Wang
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Valo Early Discovery Inc
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Valo Early Discovery Inc
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Assigned to VALO EARLY DISCOVERY, INC. reassignment VALO EARLY DISCOVERY, INC. Request for Assignment Assignors: FORMA THERAPEUTICS, INC.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2015374170A 2014-12-30 2015-12-29 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors Active AU2015374170B2 (en)

Priority Applications (1)

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AU2021200346A AU2021200346A1 (en) 2014-12-30 2021-01-20 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098141P 2014-12-30 2014-12-30
US62/098,141 2014-12-30
PCT/US2015/067831 WO2016109515A1 (en) 2014-12-30 2015-12-29 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

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AU2015374170A1 AU2015374170A1 (en) 2017-07-27
AU2015374170B2 true AU2015374170B2 (en) 2020-10-22

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AU2021200346A Abandoned AU2021200346A1 (en) 2014-12-30 2021-01-20 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

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US (4) US9902728B2 (OSRAM)
EP (2) EP3623372A1 (OSRAM)
JP (1) JP6649388B2 (OSRAM)
KR (1) KR102581827B1 (OSRAM)
CN (1) CN107406451B (OSRAM)
AR (1) AR103297A1 (OSRAM)
AU (2) AU2015374170B2 (OSRAM)
CA (1) CA2972797C (OSRAM)
CL (1) CL2017001687A1 (OSRAM)
CO (1) CO2017006997A2 (OSRAM)
EA (1) EA038204B1 (OSRAM)
EC (1) ECSP17049010A (OSRAM)
ES (1) ES2768996T3 (OSRAM)
IL (1) IL252773A0 (OSRAM)
MA (1) MA40706A1 (OSRAM)
MX (2) MX373788B (OSRAM)
PH (1) PH12017501224A1 (OSRAM)
SA (1) SA517381839B1 (OSRAM)
SG (1) SG11201704897QA (OSRAM)
TW (2) TWI770525B (OSRAM)
WO (1) WO2016109515A1 (OSRAM)
ZA (1) ZA201704746B (OSRAM)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US12509420B2 (en) 2021-04-27 2025-12-30 Autotac Inc. Compound as a UBR box domain ligand

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