SG11201704897QA - Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors - Google Patents
Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitorsInfo
- Publication number
- SG11201704897QA SG11201704897QA SG11201704897QA SG11201704897QA SG11201704897QA SG 11201704897Q A SG11201704897Q A SG 11201704897QA SG 11201704897Q A SG11201704897Q A SG 11201704897QA SG 11201704897Q A SG11201704897Q A SG 11201704897QA SG 11201704897Q A SG11201704897Q A SG 11201704897QA
- Authority
- SG
- Singapore
- Prior art keywords
- pyrazolopyrimidines
- ubiquitin
- pyrrolo
- inhibitors
- specific protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462098141P | 2014-12-30 | 2014-12-30 | |
PCT/US2015/067831 WO2016109515A1 (en) | 2014-12-30 | 2015-12-29 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201704897QA true SG11201704897QA (en) | 2017-07-28 |
Family
ID=55310894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201704897QA SG11201704897QA (en) | 2014-12-30 | 2015-12-29 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
Country Status (22)
Country | Link |
---|---|
US (4) | US9902728B2 (en) |
EP (2) | EP3623372A1 (en) |
JP (1) | JP6649388B2 (en) |
KR (1) | KR102581827B1 (en) |
CN (1) | CN107406451B (en) |
AR (1) | AR103297A1 (en) |
AU (2) | AU2015374170B2 (en) |
CA (1) | CA2972797C (en) |
CL (1) | CL2017001687A1 (en) |
CO (1) | CO2017006997A2 (en) |
EA (1) | EA038204B1 (en) |
EC (1) | ECSP17049010A (en) |
ES (1) | ES2768996T3 (en) |
HK (1) | HK1246284A1 (en) |
IL (1) | IL252773A0 (en) |
MA (1) | MA40706A1 (en) |
MX (2) | MX2017008604A (en) |
PH (1) | PH12017501224A1 (en) |
SA (1) | SA517381839B1 (en) |
SG (1) | SG11201704897QA (en) |
TW (2) | TWI770525B (en) |
WO (1) | WO2016109515A1 (en) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102371532B1 (en) | 2011-09-02 | 2022-03-07 | 인사이트 홀딩스 코포레이션 | Heterocyclylamines as pi3k inhibitors |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
EP3200589A4 (en) | 2014-09-10 | 2018-07-25 | Temple University Of The Commonwealth System Of Higher Education | Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
TWI770525B (en) | 2014-12-30 | 2022-07-11 | 美商瓦洛健康公司 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
MA41291A (en) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | PYRROLOTRIAZINONE AND IMIDAZOTRIAZINONE DERIVATIVES AS UBIQUE-SPECIFIC PROTEASE INHIBITORS No. 7 (USP7) FOR THE TREATMENT OF CANCER |
JP2018504430A (en) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス,インコーポレイテッド | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
JP2018504432A (en) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス,インコーポレイテッド | Isothiazolopyrimidinone, pyrazolopyrimidinone and pyrrolopyrimidinone as ubiquitin-specific protease 7 inhibitors |
US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
NZ734993A (en) | 2015-02-27 | 2024-03-22 | Incyte Holdings Corp | Salts of pi3k inhibitor and processes for their preparation |
WO2017144633A1 (en) * | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Glycosidase inhibitors |
WO2017201683A1 (en) * | 2016-05-25 | 2017-11-30 | Merck Sharp & Dohme Corp. | Substituted tetrahydroisoquinoline compounds useful as gpr120 agonists |
FR3061177B1 (en) * | 2016-12-28 | 2019-09-27 | Les Laboratoires Servier | NOVEL HETERO (ARYL) -SUBSTITUTED PIPERIDINYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
FR3052452B1 (en) * | 2016-06-10 | 2018-06-22 | Les Laboratoires Servier | NOVEL PIPERIDINYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
RU2742271C2 (en) | 2016-06-10 | 2021-02-04 | Ле Лаборатуар Сервье | Novel (hetero)aryl-substituted piperidinyl derivatives, a method for production thereof and pharmaceutical compositions containing them |
WO2018009812A1 (en) | 2016-07-08 | 2018-01-11 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
GB201612938D0 (en) * | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
SG11201903483VA (en) | 2016-10-28 | 2019-05-30 | Icahn School Med Mount Sinai | Compositions and methods for treating ezh2-mediated cancer |
TW201822637A (en) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | Substituted sulfonamides for controlling animal pests |
AU2017370694A1 (en) | 2016-12-08 | 2019-07-25 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating CDK4/6-mediated cancer |
CN108239082B (en) * | 2016-12-26 | 2021-01-05 | 成都先导药物开发股份有限公司 | Compound for inhibiting ROCK and application thereof |
EP3600290A4 (en) | 2017-03-21 | 2020-08-12 | Temple University - Of The Commonwealth System of Higher Education | Novel modulators of the sigma-2 receptor and their method of use |
EP3600289A4 (en) | 2017-03-21 | 2020-08-05 | Temple University - Of The Commonwealth System of Higher Education | 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents |
MX2020002944A (en) | 2017-09-14 | 2020-09-28 | Daiichi Sankyo Co Ltd | Compound having cyclic structure. |
EP3700901A1 (en) | 2017-10-24 | 2020-09-02 | Genentech, Inc. | (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof |
WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-hydroxypyrrolidin-2-yl)-hydroxamate compounds and methods of use thereof |
EA202091260A1 (en) * | 2017-11-29 | 2020-09-07 | Ле Лаборатуар Сервье | NEW PIPERIDINYL DERIVATIVES AS INHIBITORS OF UBIKVITIN-SPECIFIC PROTEASE 7 |
EA202091475A1 (en) | 2017-12-15 | 2020-09-09 | Пирамид Байосайенсиз, Инк. | 5- (2- (2,5-DIFLUOROPHENYL) PYRROLIDIN-1-YL) -3- (1H-PYRAZOL-1-YL) PYRAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS AS TRK KINASE INHIBITORS FOR TREATMENT CANCER |
CA3085460A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors |
GB201801562D0 (en) * | 2018-01-31 | 2018-03-14 | Almac Diagnostics Ltd | Pharmaceutical compounds |
WO2019173516A1 (en) | 2018-03-06 | 2019-09-12 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (akt) degradation / disruption compounds and methods of use |
WO2019183523A1 (en) | 2018-03-23 | 2019-09-26 | Genentech, Inc. | Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl) |
JP7301042B2 (en) | 2018-03-30 | 2023-06-30 | 住友化学株式会社 | Heterocyclic compound and harmful arthropod control composition containing the same |
IL310857A (en) | 2018-04-25 | 2024-04-01 | Bayer Ag | Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides |
UY38291A (en) * | 2018-07-05 | 2020-06-30 | Servier Lab | NEW AMINO-PYRIMIDONYL DERIVATIVES A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
CA3121376A1 (en) * | 2018-12-06 | 2020-06-11 | Almac Discovery Limited | Pharmaceutical compounds and their use as inhibitors of ubiquitin specific protease 19 (usp19) |
CN109666005A (en) * | 2018-12-14 | 2019-04-23 | 上海毕得医药科技有限公司 | A kind of synthetic method of 2- bromine oxazole -5- Ethyl formate |
CN114040760A (en) | 2018-12-31 | 2022-02-11 | 拜欧米富士恩公司 | Irreversible inhibitors of the MENIN-MLL interaction |
WO2020142559A1 (en) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Inhibitors of menin-mll interaction |
US20220125760A1 (en) | 2019-02-14 | 2022-04-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of usp7 inhibitors for the treatment of acute myeloid leukemia (aml) |
CN109912598B (en) * | 2019-03-27 | 2022-09-13 | 四川大学华西医院 | Nucleoside derivative for preventing and treating inflammatory reaction and application thereof |
WO2020207352A1 (en) * | 2019-04-11 | 2020-10-15 | 四川科伦博泰生物医药股份有限公司 | Triazine benzimidazole compounds and medical use thereof |
CN112608320B (en) * | 2020-01-16 | 2023-03-17 | 中国药科大学 | Piperidine compound and preparation method and medical application thereof |
GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
WO2021211882A1 (en) * | 2020-04-15 | 2021-10-21 | Pyramid Biosciences, Inc. | Methods for preparing tyrosine receptor kinase inhibitors |
CN115715285A (en) * | 2020-04-27 | 2023-02-24 | 奧土择破利悟 | Compounds as UBR box domain ligands |
AR123313A1 (en) * | 2020-08-24 | 2022-11-16 | Adama Makhteshim Ltd | PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRAZOLES |
WO2022159650A1 (en) * | 2021-01-22 | 2022-07-28 | Icahn School Of Medicine At Mount Sinai | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF eEF1A2 |
AU2022315201A1 (en) * | 2021-07-20 | 2024-01-18 | Dana-Farber Cancer Institute, Inc. | Inhibitors targeting ubiquitin specific protease 7 (usp7) |
CA3229150A1 (en) | 2021-08-20 | 2023-02-23 | Biomea Fusion, Inc. | Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cance |
GB202200753D0 (en) | 2022-01-21 | 2022-03-09 | Almac Discovery Ltd | Pharmaceutical compounds |
CN114957248B (en) * | 2022-05-09 | 2023-12-29 | 南开大学 | Pyrrolo pyrimidine compound and preparation method, pharmaceutical composition and application thereof |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US5985863A (en) | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
US5874424A (en) | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6008217A (en) | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
IN151496B (en) | 1980-02-26 | 1983-05-07 | Chamanlal Jagannath Shishoo | |
FI95572C (en) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt |
JP2777159B2 (en) | 1988-12-22 | 1998-07-16 | エーザイ株式会社 | Pharmaceuticals containing cyclic amine derivatives |
US5124335A (en) | 1991-01-30 | 1992-06-23 | Merck & Co., Inc. | Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists |
US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US20120165319A1 (en) | 1995-12-20 | 2012-06-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1 beta converting enzyme |
FR2750862B1 (en) | 1996-07-12 | 1998-10-16 | Dupin Jean Pierre | USE OF FUSED DIAZOTA HETEROCYCLES WITH AN AROMATIC OR HETEROAROMATIC SYSTEM FOR THE TREATMENT OF THROMBO-EMBOLIC DISEASES |
DK0982992T3 (en) | 1997-05-08 | 2002-10-14 | Aventis Cropscience Uk Ltd | Use of thienopyrimidines as fungicides |
US6444816B1 (en) | 1997-10-27 | 2002-09-03 | Dr. Reddy's Research Foundation | Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof |
DE69828445D1 (en) | 1998-04-23 | 2005-02-03 | Reddys Lab Ltd Dr | HETEROCYCLIC COMPOUNDS, AND THEIR USE IN MEDICAMENTS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF |
US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
US20060183776A9 (en) | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
ES2275670T3 (en) | 2000-03-03 | 2007-06-16 | EISAI R&D MANAGEMENT CO., LTD. | NEW METHODS USING CHOLESTERASE INHIBITORS. |
US20030153598A1 (en) | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
JP2003535864A (en) | 2000-06-07 | 2003-12-02 | アルミラル プロデスファルマ ソシエダ アノニマ | 6-Phenylpyrrolopyrimidinedione derivative |
AU2001268712A1 (en) | 2000-06-23 | 2002-01-08 | Bristol-Myers Squibb Company | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors |
JP2002105081A (en) | 2000-07-28 | 2002-04-10 | Nikken Chem Co Ltd | Bicyclic compound of thiophene |
PE20020394A1 (en) | 2000-08-18 | 2002-06-21 | Agouron Pharma | PIRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, MODULATE AND / OR INHIBIT THE ACTIVITY OF ERAB / HADH2 |
US20020169175A1 (en) | 2001-02-05 | 2002-11-14 | Dr. Reddy's Laboratories Ltd. | Pharmaceutically acceptable salts of heterocyclic compounds |
US6960595B2 (en) | 2001-03-23 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | 5-6 to 5-7 Heterobicycles as factor Xa inhibitors |
WO2003024456A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating and preventing migraines |
WO2003032914A2 (en) | 2001-10-17 | 2003-04-24 | Eisai Co., Ltd. | Methods for treating substance abuse with cholinesterase inhibitors |
ATE521592T1 (en) | 2002-03-13 | 2011-09-15 | Janssen Pharmaceutica Nv | HISTONE DEACETYLASE INHIBITORS |
GB2405336A (en) | 2002-05-01 | 2005-03-02 | Eisai Co Ltd | Cholinesterase inhibitors to prevent injuries caused by chemicals |
US20070053976A1 (en) | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
AU2003298514A1 (en) | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
AU2003253165A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
WO2004014908A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
EP1553947A4 (en) | 2002-10-21 | 2006-11-29 | Bristol Myers Squibb Co | Quinazolinones and derivatives thereof as factor xa inhibitors |
AU2003299791A1 (en) | 2002-12-20 | 2004-07-22 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
EP1460077B1 (en) | 2003-03-18 | 2007-08-01 | The Jordanian Pharmaceutical Manufacturing Co. Ltd. | Novel pyrazolopyrimidones and their use as PDE inhibitors |
WO2004111014A1 (en) | 2003-06-06 | 2004-12-23 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as modulators of atp-binding cassette transporters |
EP1661896A4 (en) | 2003-08-26 | 2008-07-16 | Teijin Pharma Ltd | Pyrrolopyrimidinethione derivative |
US7557113B2 (en) | 2003-08-26 | 2009-07-07 | Teijin Pharma Limited | Substituted pyrrolo[3,2-d]pyrimidine derivatives |
WO2005035003A2 (en) | 2003-09-22 | 2005-04-21 | Dihedron Corporation | Compositions and methods for increasing drug efficiency |
US20050148534A1 (en) | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
KR101153335B1 (en) | 2003-09-24 | 2012-07-05 | 메틸진 인코포레이티드 | Inhibitors of histone deacetylase |
US20080312189A1 (en) | 2004-03-05 | 2008-12-18 | Eisai Co., Ltd. | Cadasil Treatment with Cholinesterase Inhibitors |
US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
NZ551004A (en) | 2004-04-02 | 2010-07-30 | Prana Biotechnology Ltd | Neurologically-active compounds |
JPWO2006004201A1 (en) | 2004-07-01 | 2008-04-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Nerve regeneration promoter |
US20060172992A1 (en) | 2004-08-13 | 2006-08-03 | Eisai Co., Ltd. | Therapeutic agent for overactive bladder resulting from cerebral infarction |
US20060135507A1 (en) | 2004-08-13 | 2006-06-22 | Osamu Yokoyama | Therapeutic agent for overactive bladder involved in aging |
CN101048388A (en) | 2004-08-31 | 2007-10-03 | 阿斯利康(瑞典)有限公司 | Quinazolinone derivatives and their use as B-Raf inhibitors |
JP5635726B2 (en) * | 2004-09-14 | 2014-12-03 | ミネルバ バイオテクノロジーズ コーポレーション | Cancer diagnosis and treatment method |
JP2006176503A (en) | 2004-11-26 | 2006-07-06 | Tohoku Univ | Therapeutic agent for alzheimer's disease accompanied with cerebrovascular disorder |
MX2007007483A (en) | 2004-12-24 | 2007-07-20 | Dainippon Sumitomo Pharma Co | Bicyclic pyrrole derivatives. |
JP5000490B2 (en) | 2005-04-28 | 2012-08-15 | 武田薬品工業株式会社 | Thienopyrimidone compounds |
GB0510204D0 (en) | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
US7745447B2 (en) | 2005-10-26 | 2010-06-29 | Bristol-Myers Squibb Company | Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists |
AR056155A1 (en) | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | ANTAGONISTS OF NON-BASIC MELANINE CONCENTRATION HORMONE RECEIVER 1 |
WO2007071738A1 (en) | 2005-12-23 | 2007-06-28 | Novartis Ag | Condensed heterocyclic compounds useful as dpp-iv inhibitors |
US20080119457A1 (en) | 2006-08-24 | 2008-05-22 | Serenex, Inc. | Benzene, Pyridine, and Pyridazine Derivatives |
AR065081A1 (en) | 2007-01-29 | 2009-05-13 | Xenon Pharmaceuticals Inc | FUSIONATED QUINAZOLINONA AND PIRIMIDONA COMPOUNDS AND PHARMACEUTICAL COMPOSITION |
CN101686952A (en) | 2007-03-12 | 2010-03-31 | Vm生物医药公司 | Novel agents of calcium ion channel modulators |
WO2008113255A1 (en) | 2007-03-16 | 2008-09-25 | The Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla | Benzamide derivatives with anti-proliferative activity, pharmaceutical preparations thereof |
WO2008116053A2 (en) * | 2007-03-20 | 2008-09-25 | Trustees Of Tufts College | Fap-activated chemotherapeutic compounds, and methods of use thereof |
WO2008138126A1 (en) | 2007-05-09 | 2008-11-20 | Neuromed Pharmaceuticals Ltd. | Bicyclic pyrimidine derivatives as calcium channel blockers |
RU2341527C1 (en) | 2007-07-17 | 2008-12-20 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Annelated asaheterocycles including pyrimidine fragment, method of production thereof and pi3k kinase inhibitors |
RU2345996C1 (en) | 2007-07-17 | 2009-02-10 | Андрей Александрович Иващенко | Annelated azaheterocyclic amides, which include pyrimidine fragment, method of obtaining and their application |
US8648085B2 (en) * | 2007-11-30 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders |
UA105362C2 (en) * | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
WO2009124259A1 (en) | 2008-04-04 | 2009-10-08 | Cv Therapeutics, Inc. | Pyrrolotriazinone derivatives for use as stearoyl coa desaturase inhibitors |
CA2737219C (en) | 2008-08-11 | 2017-02-28 | Tracy Keller | Halofuginone analogs for inhibition of trna synthetases and uses thereof |
US20110082158A1 (en) | 2008-10-01 | 2011-04-07 | Aleem Gangjee | Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same |
CN102316735A (en) | 2008-12-23 | 2012-01-11 | 哈佛大学校长及研究员协会 | The micromolecular inhibitor of gangrenosum acne apoptosis |
BRPI1009398A2 (en) | 2009-03-13 | 2016-03-08 | Advinus Therapeutics Private Ltd | substituted fused pyrimidine compounds |
JP5722781B2 (en) | 2009-08-26 | 2015-05-27 | 武田薬品工業株式会社 | Fused heterocyclic derivatives and uses thereof |
BR112012008518A2 (en) | 2009-10-13 | 2016-04-05 | Msd Oss Bv | heterocyclic derivative and pharmaceutical composition |
WO2011097607A1 (en) | 2010-02-08 | 2011-08-11 | Southern Research Institute | Anti-viral treatment and assay to screen for anti-viral agent |
US8575114B2 (en) | 2010-03-23 | 2013-11-05 | Albany Molecular Research, Inc. | SGLT-2 inhibitors, methods of making them, and uses thereof |
WO2012054332A1 (en) | 2010-10-18 | 2012-04-26 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
WO2012075393A2 (en) | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
JP2014515345A (en) * | 2011-01-10 | 2014-06-30 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Pyrimidinone derivatives as fatty acid synthase inhibitors |
GB201107768D0 (en) | 2011-05-10 | 2011-06-22 | Univ Manchester | Riboswitches |
EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
US9394297B2 (en) | 2012-02-28 | 2016-07-19 | Amgen Inc. | Amides as pim inhibitors |
GB201205164D0 (en) | 2012-03-23 | 2012-05-09 | Almac Discovery Ltd | Pharmaceutical compounds |
JP2016504365A (en) | 2012-12-28 | 2016-02-12 | アメリカ合衆国 | USP1 / UAF1 deubiquitinase complex inhibitor and use thereof |
KR101446680B1 (en) | 2013-02-08 | 2014-10-07 | 한국과학기술연구원 | Thienopyrimidinone derivatives as mGluR1 antagonists |
CN103833646A (en) | 2014-02-28 | 2014-06-04 | 广东工业大学 | Fatty amino substituted quinazolinone derivative and preparation method and application thereof |
TWI770525B (en) | 2014-12-30 | 2022-07-11 | 美商瓦洛健康公司 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
MA41291A (en) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | PYRROLOTRIAZINONE AND IMIDAZOTRIAZINONE DERIVATIVES AS UBIQUE-SPECIFIC PROTEASE INHIBITORS No. 7 (USP7) FOR THE TREATMENT OF CANCER |
JP2018504430A (en) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス,インコーポレイテッド | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
JP2018504432A (en) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス,インコーポレイテッド | Isothiazolopyrimidinone, pyrazolopyrimidinone and pyrrolopyrimidinone as ubiquitin-specific protease 7 inhibitors |
US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
-
2015
- 2015-12-28 TW TW109118957A patent/TWI770525B/en active
- 2015-12-28 TW TW104144096A patent/TWI698436B/en active
- 2015-12-28 AR ARP150104312A patent/AR103297A1/en unknown
- 2015-12-29 CN CN201580077002.3A patent/CN107406451B/en active Active
- 2015-12-29 EP EP19207235.3A patent/EP3623372A1/en active Pending
- 2015-12-29 ES ES15832772T patent/ES2768996T3/en active Active
- 2015-12-29 EA EA201791507A patent/EA038204B1/en unknown
- 2015-12-29 AU AU2015374170A patent/AU2015374170B2/en active Active
- 2015-12-29 US US14/982,127 patent/US9902728B2/en active Active
- 2015-12-29 CA CA2972797A patent/CA2972797C/en active Active
- 2015-12-29 SG SG11201704897QA patent/SG11201704897QA/en unknown
- 2015-12-29 MA MA40706A patent/MA40706A1/en unknown
- 2015-12-29 WO PCT/US2015/067831 patent/WO2016109515A1/en active Application Filing
- 2015-12-29 KR KR1020177021230A patent/KR102581827B1/en active IP Right Grant
- 2015-12-29 JP JP2017535007A patent/JP6649388B2/en active Active
- 2015-12-29 EP EP15832772.6A patent/EP3240791B1/en active Active
- 2015-12-29 MX MX2017008604A patent/MX2017008604A/en active IP Right Grant
-
2017
- 2017-06-08 IL IL252773A patent/IL252773A0/en unknown
- 2017-06-23 CL CL2017001687A patent/CL2017001687A1/en unknown
- 2017-06-27 MX MX2020002963A patent/MX2020002963A/en unknown
- 2017-06-29 SA SA517381839A patent/SA517381839B1/en unknown
- 2017-06-29 PH PH12017501224A patent/PH12017501224A1/en unknown
- 2017-07-12 CO CONC2017/0006997A patent/CO2017006997A2/en unknown
- 2017-07-28 EC ECIEPI201749010A patent/ECSP17049010A/en unknown
-
2018
- 2018-01-18 US US15/874,163 patent/US10377760B2/en active Active
- 2018-05-03 HK HK18105707.3A patent/HK1246284A1/en unknown
-
2019
- 2019-07-19 US US16/517,149 patent/US10934299B2/en active Active
-
2021
- 2021-01-20 AU AU2021200346A patent/AU2021200346A1/en not_active Abandoned
- 2021-02-26 US US17/186,915 patent/US12018030B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1246284A1 (en) | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors | |
IL282103A (en) | Purinones as ubiquitin-specific protease 1 inhibitors | |
HK1248221A1 (en) | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors | |
HK1248222A1 (en) | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors | |
HK1248220A1 (en) | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors | |
IL252135B (en) | Triazolopyrimidine compounds and uses thereof | |
IL248970A0 (en) | Pyrazolopyridines and pyrazolopyrimidines | |
IL247949A0 (en) | Novel pyrazolo pyrimidine derivatives and their use as malt1 inhibitors | |
IL253117A0 (en) | Abrasive articles and methods for forming same | |
ZA201704300B (en) | Nitrification inhibitor compositions and methods for preparing the same | |
IL252686A0 (en) | Pyrazolopyridinamines as mknk1 and mknk2 inhibitors | |
EP3105010A4 (en) | Abrasive article and method of using the same | |
GB201410226D0 (en) | Methods and arrays for use in the same | |
IL252866B (en) | Imidazopyridazine derivatives as pi3kbeta inhibitors | |
PL3240655T3 (en) | Abrasive articles and methods for forming same | |
AU2014903744A0 (en) | Nitrification inhibitors and formulations |