HK1248220A1 - 喹唑啉酮和偶氮喹唑啉作為泛特丁胺蛋白酶7抑制劑 - Google Patents

喹唑啉酮和偶氮喹唑啉作為泛特丁胺蛋白酶7抑制劑

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Publication number
HK1248220A1
HK1248220A1 HK18107585.6A HK18107585A HK1248220A1 HK 1248220 A1 HK1248220 A1 HK 1248220A1 HK 18107585 A HK18107585 A HK 18107585A HK 1248220 A1 HK1248220 A1 HK 1248220A1
Authority
HK
Hong Kong
Prior art keywords
azaquinazolinones
quinazolinones
ubiquitin
inhibitors
specific protease
Prior art date
Application number
HK18107585.6A
Other languages
English (en)
Inventor
Stephanos Ioannidis
Adam Charles Talbot
Bruce Follows
Alexandre Joseph Buckmelter
Minghua Wang
Ann-Marie Campbell
Jr David Lancia
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55404830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1248220(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of HK1248220A1 publication Critical patent/HK1248220A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Psychiatry (AREA)
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HK18107585.6A 2015-02-05 2018-06-11 喹唑啉酮和偶氮喹唑啉作為泛特丁胺蛋白酶7抑制劑 HK1248220A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562112487P 2015-02-05 2015-02-05
PCT/US2016/016542 WO2016126926A1 (en) 2015-02-05 2016-02-04 Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

Publications (1)

Publication Number Publication Date
HK1248220A1 true HK1248220A1 (zh) 2018-10-12

Family

ID=55404830

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107585.6A HK1248220A1 (zh) 2015-02-05 2018-06-11 喹唑啉酮和偶氮喹唑啉作為泛特丁胺蛋白酶7抑制劑

Country Status (5)

Country Link
US (10) US9840491B2 (zh)
EP (1) EP3253738A1 (zh)
JP (1) JP2018504430A (zh)
HK (1) HK1248220A1 (zh)
WO (1) WO2016126926A1 (zh)

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TWI698436B (zh) 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
MA41291A (fr) 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
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AU2019393162A1 (en) * 2018-12-06 2021-06-17 Almac Discovery Limited Pharmaceutical compounds and their use as inhibitors of Ubiquitin Specific Protease 19 (USP19)
EP3923987A1 (en) 2019-02-14 2021-12-22 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of usp7 inhibitors for the treatment of acute myeloid leukemia (aml)
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CN112047933B (zh) * 2020-10-15 2022-06-14 郑州大学 喹唑啉酮类usp7抑制剂及其制备方法和应用
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