HK1251593A1 - Bace1抑制劑肽 - Google Patents
Bace1抑制劑肽Info
- Publication number
- HK1251593A1 HK1251593A1 HK18111170.9A HK18111170A HK1251593A1 HK 1251593 A1 HK1251593 A1 HK 1251593A1 HK 18111170 A HK18111170 A HK 18111170A HK 1251593 A1 HK1251593 A1 HK 1251593A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitor peptides
- bace1 inhibitor
- bace1
- peptides
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15178162 | 2015-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1251593A1 true HK1251593A1 (zh) | 2019-02-01 |
Family
ID=53776361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18111170.9A HK1251593A1 (zh) | 2015-07-24 | 2018-08-30 | Bace1抑制劑肽 |
Country Status (6)
Country | Link |
---|---|
US (1) | US10947272B2 (zh) |
EP (1) | EP3325500A1 (zh) |
JP (1) | JP6814754B2 (zh) |
CN (1) | CN107849092A (zh) |
HK (1) | HK1251593A1 (zh) |
WO (1) | WO2017016982A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019094608A1 (en) | 2017-11-08 | 2019-05-16 | Denali Therapeutics Inc. | Anti-bace1 antibodies and methods of use thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004035606A2 (en) | 2002-10-15 | 2004-04-29 | Bristol-Myers Squibb Company | Bace binding peptides and uses thereof |
US20070149763A1 (en) | 2003-10-15 | 2007-06-28 | Bristol-Myers Squibb Company | Beta secretase exosite binding peptides and methods for identifying beta secretase modulators |
DE602005016658D1 (de) * | 2004-04-08 | 2009-10-29 | Jadolabs Gmbh | Dreigeteilte konjugate mit einer struktur, die mit zellmembran-rafts interagieren und ihre verwendung |
AU2005259499A1 (en) | 2004-06-29 | 2006-01-12 | Jado Technologies Gmbh | Use of steroid-derived pharmaceutical compositions for treating disorders relating to pathological processes in lipid rafts |
KR20140041590A (ko) | 2011-06-07 | 2014-04-04 | 에프. 호프만-라 로슈 아게 | [1,3]옥사진 |
EP2766028B1 (en) | 2011-10-14 | 2017-08-16 | F. Hoffmann-La Roche AG | Peptide inhibitors of bace1 |
CN104368009B (zh) * | 2014-06-25 | 2018-01-30 | 中国人民解放军第二军医大学 | 一种双功能肽修饰的阿尔茨海默病靶向基因递释复合物及其制备方法 |
KR102379309B1 (ko) | 2014-09-15 | 2022-03-28 | 베로나 파마 피엘씨 | Rpl554를 포함하는 액상 흡입제 |
US9962360B2 (en) | 2014-09-25 | 2018-05-08 | The Hospital For Sick Children | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
JP6691914B2 (ja) | 2014-11-28 | 2020-05-13 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ペプチド |
-
2016
- 2016-07-21 WO PCT/EP2016/067447 patent/WO2017016982A1/en active Application Filing
- 2016-07-21 EP EP16744696.2A patent/EP3325500A1/en not_active Withdrawn
- 2016-07-21 US US15/735,394 patent/US10947272B2/en active Active
- 2016-07-21 CN CN201680040557.5A patent/CN107849092A/zh active Pending
- 2016-07-21 JP JP2017567791A patent/JP6814754B2/ja active Active
-
2018
- 2018-08-30 HK HK18111170.9A patent/HK1251593A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP6814754B2 (ja) | 2021-01-20 |
WO2017016982A1 (en) | 2017-02-02 |
JP2018523636A (ja) | 2018-08-23 |
US20180179252A1 (en) | 2018-06-28 |
EP3325500A1 (en) | 2018-05-30 |
CN107849092A (zh) | 2018-03-27 |
US10947272B2 (en) | 2021-03-16 |
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