IL252773A0 - Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors - Google Patents
Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitorsInfo
- Publication number
- IL252773A0 IL252773A0 IL252773A IL25277317A IL252773A0 IL 252773 A0 IL252773 A0 IL 252773A0 IL 252773 A IL252773 A IL 252773A IL 25277317 A IL25277317 A IL 25277317A IL 252773 A0 IL252773 A0 IL 252773A0
- Authority
- IL
- Israel
- Prior art keywords
- pyrazolopyrimidines
- ubiquitin
- pyrrolo
- inhibitors
- specific protease
- Prior art date
Links
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
- 102000018390 Ubiquitin-Specific Proteases Human genes 0.000 title 1
- 108010066496 Ubiquitin-Specific Proteases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098141P | 2014-12-30 | 2014-12-30 | |
| PCT/US2015/067831 WO2016109515A1 (en) | 2014-12-30 | 2015-12-29 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL252773A0 true IL252773A0 (en) | 2017-08-31 |
Family
ID=55310894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL252773A IL252773A0 (en) | 2014-12-30 | 2017-06-08 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US9902728B2 (OSRAM) |
| EP (2) | EP3240791B1 (OSRAM) |
| JP (1) | JP6649388B2 (OSRAM) |
| KR (1) | KR102581827B1 (OSRAM) |
| CN (1) | CN107406451B (OSRAM) |
| AR (1) | AR103297A1 (OSRAM) |
| AU (2) | AU2015374170B2 (OSRAM) |
| CA (1) | CA2972797C (OSRAM) |
| CL (1) | CL2017001687A1 (OSRAM) |
| CO (1) | CO2017006997A2 (OSRAM) |
| EA (1) | EA038204B1 (OSRAM) |
| EC (1) | ECSP17049010A (OSRAM) |
| ES (1) | ES2768996T3 (OSRAM) |
| IL (1) | IL252773A0 (OSRAM) |
| MA (1) | MA40706A1 (OSRAM) |
| MX (2) | MX373788B (OSRAM) |
| PH (1) | PH12017501224A1 (OSRAM) |
| SA (1) | SA517381839B1 (OSRAM) |
| SG (1) | SG11201704897QA (OSRAM) |
| TW (2) | TWI698436B (OSRAM) |
| WO (1) | WO2016109515A1 (OSRAM) |
| ZA (1) | ZA201704746B (OSRAM) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12021552978A1 (en) | 2011-09-02 | 2022-08-22 | Incyte Holdings Corp | Heterocyclylamines as pi3k inhibitors |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| EP3200589A4 (en) | 2014-09-10 | 2018-07-25 | Temple University Of The Commonwealth System Of Higher Education | Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| JP2018504430A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ７阻害物質としてのキナゾリノン及びアザキナゾリノン |
| US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| LT3262046T (lt) | 2015-02-27 | 2021-01-11 | Incyte Corporation | Pi3k inhibitoriaus druskos ir jų gamybos būdai |
| WO2017144633A1 (en) * | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Glycosidase inhibitors |
| WO2017201683A1 (en) * | 2016-05-25 | 2017-11-30 | Merck Sharp & Dohme Corp. | Substituted tetrahydroisoquinoline compounds useful as gpr120 agonists |
| PE20220948A1 (es) | 2016-06-10 | 2022-05-31 | Servier Lab | Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
| FR3052452B1 (fr) * | 2016-06-10 | 2018-06-22 | Les Laboratoires Servier | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3061177B1 (fr) * | 2016-12-28 | 2019-09-27 | Les Laboratoires Servier | Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| EP3481803B1 (en) | 2016-07-08 | 2020-09-02 | Mayo Foundation for Medical Education and Research | Methods and materials for treating cancer |
| GB201612938D0 (en) * | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| SG10202104386UA (en) | 2016-10-28 | 2021-05-28 | Icahn School Med Mount Sinai | Compositions and methods for treating ezh2-mediated cancer |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| JP2020514252A (ja) | 2016-12-08 | 2020-05-21 | アイカーン スクール オブ メディスン アット マウント シナイ | Ｃｄｋ４／６媒介性がんを治療するための組成物および方法 |
| CN108239082B (zh) * | 2016-12-26 | 2021-01-05 | 成都先导药物开发股份有限公司 | 一种抑制rock的化合物及其应用 |
| JP7365238B2 (ja) | 2017-03-21 | 2023-10-19 | テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用 |
| WO2018175188A1 (en) | 2017-03-21 | 2018-09-27 | Temple University-Of The Commonwealth System Of Higher Education | Novel modulators of the sigma-2 receptor and their method of use |
| NZ763299A (en) | 2017-09-14 | 2025-09-26 | Daiichi Sankyo Co Ltd | Compound having cyclic structure |
| WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE |
| EP3700901A1 (en) | 2017-10-24 | 2020-09-02 | Genentech, Inc. | (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof |
| EP3717482A1 (en) | 2017-11-29 | 2020-10-07 | Les Laboratoires Servier SAS | New piperidinyl derivatives as inhibitors of ubiquitin specific protease 7 |
| ES2908773T3 (es) | 2017-12-15 | 2022-05-03 | Pyramid Biosciences Inc | Derivados de 5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(1H-pirazol-1-il)pirazolo[1,5-a]pirimidina y compuestos relacionados como inhibidores de Trk quinasa para el tratamiento del cáncer |
| CA3085460A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| GB201801562D0 (en) | 2018-01-31 | 2018-03-14 | Almac Diagnostics Ltd | Pharmaceutical compounds |
| CA3092677A1 (en) | 2018-03-06 | 2019-09-12 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (akt) degradation / disruption compounds and methods of use |
| WO2019183523A1 (en) | 2018-03-23 | 2019-09-26 | Genentech, Inc. | Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl) |
| US11779018B2 (en) | 2018-03-30 | 2023-10-10 | Sumitomo Chemical Company, Limited | Heterocyclic compound and arthropod pest control composition containing same |
| AU2019260016B2 (en) | 2018-04-25 | 2022-11-17 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides |
| CN112996518A (zh) | 2018-06-21 | 2021-06-18 | 西奈山伊坎医学院 | Wd40重复结构域蛋白5(wdr5)降解/破坏化合物和使用方法 |
| UY38291A (es) * | 2018-07-05 | 2020-06-30 | Servier Lab | Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas |
| JP7508449B2 (ja) | 2018-10-22 | 2024-07-01 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｕｓｐ７の阻害 |
| KR102712818B1 (ko) | 2018-12-06 | 2024-09-30 | 한국화학연구원 | Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도 |
| CN113395965A (zh) * | 2018-12-06 | 2021-09-14 | 阿尔麦克探索有限公司 | 用于治疗的usp19抑制剂 |
| MX2021006540A (es) * | 2018-12-06 | 2021-07-07 | Almac Discovery Ltd | Compuestos farmaceuticos y su uso como inhibidores de proteasa 19 especifica de ubiquitina (usp19). |
| CN109666005A (zh) * | 2018-12-14 | 2019-04-23 | 上海毕得医药科技有限公司 | 一种2-溴恶唑-5-甲酸乙酯的合成方法 |
| JP7536767B2 (ja) | 2018-12-31 | 2024-08-20 | バイオメア フュージョン，インコーポレイテッド | メニン－ｍｌｌ相互作用の不可逆的阻害剤 |
| US11174263B2 (en) | 2018-12-31 | 2021-11-16 | Biomea Fusion, Inc. | Inhibitors of menin-MLL interaction |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| WO2020165315A1 (en) | 2019-02-14 | 2020-08-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of usp7 inhibitors for the treatment of acute myeloid leukemia (aml) |
| CN109912598B (zh) * | 2019-03-27 | 2022-09-13 | 四川大学华西医院 | 防治炎症反应的核苷类衍生物及其应用 |
| CN113423709B (zh) * | 2019-04-11 | 2024-02-09 | 四川科伦博泰生物医药股份有限公司 | 三嗪酮并咪唑类化合物及其医药用途 |
| EP3965824B1 (en) | 2019-05-06 | 2025-01-08 | Icahn School of Medicine at Mount Sinai | Heterobifunctional compounds as degraders of hpk1 |
| CN112608320B (zh) * | 2020-01-16 | 2023-03-17 | 中国药科大学 | 哌啶类化合物及其制备方法和医药用途 |
| GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
| JP7767301B2 (ja) * | 2020-04-15 | 2025-11-11 | ピラミッド バイオサイエンシズ インコーポレイテッド | チロシン受容体キナーゼ阻害剤を調製する方法 |
| JP7677584B2 (ja) * | 2020-04-27 | 2025-05-15 | オートタック インコーポレーテッド | Ｕｂｒボックスドメインリガンドとしての化合物 |
| US12103924B2 (en) | 2020-06-01 | 2024-10-01 | Icahn School Of Medicine At Mount Sinai | Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use |
| AR123313A1 (es) * | 2020-08-24 | 2022-11-16 | Adama Makhteshim Ltd | Proceso para la preparación de pirazoles sustituidos |
| WO2022159650A1 (en) * | 2021-01-22 | 2022-07-28 | Icahn School Of Medicine At Mount Sinai | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF eEF1A2 |
| JP7649386B2 (ja) | 2021-03-10 | 2025-03-19 | ジュニャーナ セラピューティクス インコーポレイテッド | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| WO2022253188A1 (en) * | 2021-05-31 | 2022-12-08 | Impact Therapeutics (Shanghai) , Inc | Nitrogen-containing fused heteroaromatic bicyclic compounds as usp1 inhibitors and the use thereof |
| EP4373487A4 (en) * | 2021-07-19 | 2025-10-29 | Baylor College Medicine | CORONAVIRUS MAJOR PROTEASE INHIBITORS AND THEIR METHODS OF USE |
| CN118401507A (zh) * | 2021-07-20 | 2024-07-26 | 丹娜法伯癌症研究院 | 靶向泛素特异性蛋白酶7（usp7）的抑制剂 |
| TW202320796A (zh) | 2021-08-11 | 2023-06-01 | 美商拜歐米富士恩股份有限公司 | 用於糖尿病的menin-mll相互作用之共價抑制劑 |
| TW202313004A (zh) | 2021-08-20 | 2023-04-01 | 美商拜歐米富士恩股份有限公司 | Ｍｅｎｉｎ－ｍｌｌ相互作用之不可逆抑制劑的結晶形式 |
| GB202200753D0 (en) * | 2022-01-21 | 2022-03-09 | Almac Discovery Ltd | Pharmaceutical compounds |
| CN114957248B (zh) * | 2022-05-09 | 2023-12-29 | 南开大学 | 一种吡咯并嘧啶化合物及其制备方法、药物组合物和应用 |
| TW202430528A (zh) | 2023-01-18 | 2024-08-01 | 美商拜歐米富士恩股份有限公司 | Ｎ－［４－［４－（４－嗎啉基）－７ｈ－吡咯並［２，３－ｄ］嘧啶－６－基］苯基］－４－［［３（ｒ）－［（１－氧代－２－丙烯－１－基）氨基］－１－哌啶基］甲基］－２－吡啶甲醯胺的結晶形式作為ｍｅｎｉｎ－ｍｌｌ相互作用的共價抑制劑 |
| EP4467535A1 (en) | 2023-05-25 | 2024-11-27 | Basf Se | Lactam pesticidal compounds |
| WO2024240859A1 (en) | 2023-05-25 | 2024-11-28 | Basf Se | Lactam pesticidal compounds |
| TW202515554A (zh) * | 2023-08-11 | 2025-04-16 | 美商杰那醫療公司 | Slc6a19功能之含雙環雜芳基之哌啶抑制劑 |
| CN118496138B (zh) * | 2024-07-10 | 2024-12-03 | 西北农林科技大学深圳研究院 | 一种l-氮杂环丁烷-2-羧酸的合成方法 |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985863A (en) | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
| US6008217A (en) | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5874424A (en) | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| IN151496B (OSRAM) | 1980-02-26 | 1983-05-07 | Chamanlal Jagannath Shishoo | |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| JP2777159B2 (ja) | 1988-12-22 | 1998-07-16 | エーザイ株式会社 | 環状アミン誘導体を含有する医薬 |
| US5124335A (en) | 1991-01-30 | 1992-06-23 | Merck & Co., Inc. | Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists |
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US20120165319A1 (en) | 1995-12-20 | 2012-06-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1 beta converting enzyme |
| FR2750862B1 (fr) | 1996-07-12 | 1998-10-16 | Dupin Jean Pierre | Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques |
| ATE224643T1 (de) | 1997-05-08 | 2002-10-15 | Aventis Cropscience Uk Ltd | Verwendung von thienopyrimidinen als fungizide |
| US6444816B1 (en) | 1997-10-27 | 2002-09-03 | Dr. Reddy's Research Foundation | Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof |
| WO1999008501A2 (en) | 1998-04-23 | 1999-02-25 | Dr. Reddy's Research Foundation | New heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
| US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| US20030153598A1 (en) | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
| US20060183776A9 (en) | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
| AU2001249091A1 (en) | 2000-03-03 | 2001-09-17 | Eisai Co. Ltd. | Novel methods using cholinesterase inhibitors |
| ATE273980T1 (de) | 2000-06-07 | 2004-09-15 | Almirall Prodesfarma Sa | 6-phenylpyrrolopyrimidindion derivate |
| WO2002000655A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors |
| JP2002105081A (ja) | 2000-07-28 | 2002-04-10 | Nikken Chem Co Ltd | 新規チオフェンニ環化合物 |
| PE20020394A1 (es) * | 2000-08-18 | 2002-06-21 | Agouron Pharma | Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 |
| US20020169175A1 (en) | 2001-02-05 | 2002-11-14 | Dr. Reddy's Laboratories Ltd. | Pharmaceutically acceptable salts of heterocyclic compounds |
| US6960595B2 (en) | 2001-03-23 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | 5-6 to 5-7 Heterobicycles as factor Xa inhibitors |
| WO2003024456A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating and preventing migraines |
| AU2002340232A1 (en) | 2001-10-17 | 2003-04-28 | Eisai Co., Ltd. | Methods for treating substance abuse with cholinesterase inhibitors |
| ATE425152T1 (de) | 2002-03-13 | 2009-03-15 | Janssen Pharmaceutica Nv | Aminocarbonylderivate als histone-deacetylase- inhibitoren |
| AU2003228796A1 (en) | 2002-05-01 | 2003-11-17 | Eisai Co., Ltd. | Cholinesterase inhibitors to prevent injuries caused by chemicals |
| US20070053976A1 (en) | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
| WO2004034963A2 (en) | 2002-05-17 | 2004-04-29 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| WO2004014908A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
| WO2004014916A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| EP1553947A4 (en) * | 2002-10-21 | 2006-11-29 | Bristol Myers Squibb Co | QUINAZOLINONES AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS |
| WO2004058727A1 (en) | 2002-12-20 | 2004-07-15 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
| ES2289377T3 (es) | 2003-03-18 | 2008-02-01 | The Jordanian Pharmaceutical Manufacturing Co. Ltd. | Nuevas pirazolopirimidonas y su uso como inhibidores de pde. |
| WO2004111014A1 (en) | 2003-06-06 | 2004-12-23 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as modulators of atp-binding cassette transporters |
| US7557113B2 (en) | 2003-08-26 | 2009-07-07 | Teijin Pharma Limited | Substituted pyrrolo[3,2-d]pyrimidine derivatives |
| PE20050347A1 (es) | 2003-08-26 | 2005-05-04 | Teijin Pharma Ltd | Derivados de pirrolopirimidina |
| US20050187147A1 (en) | 2003-09-22 | 2005-08-25 | Newman Michael J. | Compositions and methods for increasing drug efficiency |
| US20050148534A1 (en) | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| US7868205B2 (en) | 2003-09-24 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP1729761A4 (en) | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | TREATMENT OF CADASIL WITH CHOLINESTERASE INHIBITORS |
| US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| ES2425476T3 (es) | 2004-04-02 | 2013-10-15 | Prana Biotechnology Limited | Compuestos neurológicamente activos |
| US20080045500A1 (en) | 2004-07-01 | 2008-02-21 | Eisai R&D Management Co., Ltd. | Nerve Regeneration Stimulator |
| US20060172992A1 (en) | 2004-08-13 | 2006-08-03 | Eisai Co., Ltd. | Therapeutic agent for overactive bladder resulting from cerebral infarction |
| US20060135507A1 (en) | 2004-08-13 | 2006-06-22 | Osamu Yokoyama | Therapeutic agent for overactive bladder involved in aging |
| AU2005278959A1 (en) | 2004-08-31 | 2006-03-09 | Astrazeneca Ab | Quinazolinone derivatives and their use as B-Raf inhibitors |
| US20080064680A1 (en) | 2004-09-14 | 2008-03-13 | Bamdad Cynthia C | Methods for Diagnosis and Treatment of Cancer |
| JP2006176503A (ja) | 2004-11-26 | 2006-07-06 | Tohoku Univ | 脳血管障害を伴うアルツハイマー病治療薬 |
| BRPI0518651A2 (pt) | 2004-12-24 | 2008-12-02 | Dainippon Sumitomo Pharma | composto, uma prà-droga do mesmo, ou um sal do composto ou prà-droga farmaceuticamente aceitÁvel, composiÇço farmacÊutica, inibidor de dipeptidil peptidase iv, uso de um composto, uma prà-droga do mesmo ou um sal do composto ou prà-droga farmaceuticamente aceitÁvel, e, mÉtodo para tratar diabetes |
| WO2006118320A1 (ja) | 2005-04-28 | 2006-11-09 | Takeda Pharmaceutical Company Limited | チエノピリミドン化合物 |
| GB0510204D0 (en) | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| US7745447B2 (en) | 2005-10-26 | 2010-06-29 | Bristol-Myers Squibb Company | Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists |
| US8618115B2 (en) | 2005-10-26 | 2013-12-31 | Bristol-Myers Squibb Company | Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them |
| AU2006327069A1 (en) | 2005-12-23 | 2007-06-28 | Novartis Ag | Condensed heterocyclic compounds useful as DPP-IV inhibitors |
| WO2008024978A2 (en) | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Tetrahydroindolone and tetrahydroindazolone derivatives |
| WO2008094909A2 (en) | 2007-01-29 | 2008-08-07 | Xenon Pharmaceuticals Inc. | Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions |
| WO2008112715A2 (en) | 2007-03-12 | 2008-09-18 | Vm Discovery Inc. | Novel agents of calcium ion channel modulators |
| CN101730703B (zh) | 2007-03-16 | 2012-12-26 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂 |
| US20100184706A1 (en) * | 2007-03-20 | 2010-07-22 | Bachovchin William W | Fap-activated chemotherapeutic compounds, and methods of use thereof |
| WO2008138126A1 (en) | 2007-05-09 | 2008-11-20 | Neuromed Pharmaceuticals Ltd. | Bicyclic pyrimidine derivatives as calcium channel blockers |
| RU2341527C1 (ru) | 2007-07-17 | 2008-12-20 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ |
| RU2345996C1 (ru) | 2007-07-17 | 2009-02-10 | Андрей Александрович Иващенко | Аннелированные азагетероциклические амиды, включающие пиримидиновый фрагмент, способ их получения и применения |
| CA2706018C (en) * | 2007-11-30 | 2015-11-24 | Boehringer Ingelheim International Gmbh | 1, 5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders |
| UA105362C2 (en) * | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| US20090253704A1 (en) | 2008-04-04 | 2009-10-08 | Dmitry Koltun | PYRROLOTRIAZINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| CA2737219C (en) | 2008-08-11 | 2017-02-28 | Tracy Keller | Halofuginone analogs for inhibition of trna synthetases and uses thereof |
| US20110082158A1 (en) | 2008-10-01 | 2011-04-07 | Aleem Gangjee | Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same |
| EP2381775A4 (en) | 2008-12-23 | 2012-08-15 | Harvard College | INHIBITORS OF NECROPTOSIS OF SMALL MOLECULAR SIZE |
| CA2755117C (en) | 2009-03-13 | 2018-09-11 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds |
| EP2471791B1 (en) | 2009-08-26 | 2014-11-12 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring derivative and use thereof |
| JP2013507417A (ja) | 2009-10-13 | 2013-03-04 | エム・エス・ディー・オス・ベー・フェー | アセチルコリン受容体に関連する疾患の処置のための縮合アジン誘導体 |
| US20130085133A1 (en) | 2010-02-08 | 2013-04-04 | Sourthern Research Institute Office of Commercialization and Intellectual Prop. | Anti-viral treatment and assay to screenfor anti-viral agent |
| US8575114B2 (en) | 2010-03-23 | 2013-11-05 | Albany Molecular Research, Inc. | SGLT-2 inhibitors, methods of making them, and uses thereof |
| US8765773B2 (en) | 2010-10-18 | 2014-07-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012075393A2 (en) | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
| JP2014515345A (ja) * | 2011-01-10 | 2014-06-30 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 脂肪酸シンターゼ阻害剤としてのピリミジノン誘導体 |
| GB201107768D0 (en) | 2011-05-10 | 2011-06-22 | Univ Manchester | Riboswitches |
| EP2565186A1 (en) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| TW201348226A (zh) | 2012-02-28 | 2013-12-01 | Amgen Inc | 作為ｐｉｍ抑制劑之醯胺 |
| GB201205164D0 (en) | 2012-03-23 | 2012-05-09 | Almac Discovery Ltd | Pharmaceutical compounds |
| JP2016504365A (ja) | 2012-12-28 | 2016-02-12 | アメリカ合衆国 | Ｕｓｐ１／ｕａｆ１デユビキチナーゼ複合体阻害剤及びその使用 |
| KR101446680B1 (ko) | 2013-02-08 | 2014-10-07 | 한국과학기술연구원 | ｍＧｌｕＲ1 길항제로 작용하는 사이에노피리미디논 유도체 |
| CN103833646A (zh) | 2014-02-28 | 2014-06-04 | 广东工业大学 | 一种脂肪氨基取代喹唑啉酮衍生物及其制备方法和应用 |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| JP2018504430A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ７阻害物質としてのキナゾリノン及びアザキナゾリノン |
-
2015
- 2015-12-28 TW TW104144096A patent/TWI698436B/zh active
- 2015-12-28 TW TW109118957A patent/TWI770525B/zh active
- 2015-12-28 AR ARP150104312A patent/AR103297A1/es unknown
- 2015-12-29 WO PCT/US2015/067831 patent/WO2016109515A1/en not_active Ceased
- 2015-12-29 CA CA2972797A patent/CA2972797C/en active Active
- 2015-12-29 MA MA40706A patent/MA40706A1/fr unknown
- 2015-12-29 EP EP15832772.6A patent/EP3240791B1/en active Active
- 2015-12-29 JP JP2017535007A patent/JP6649388B2/ja active Active
- 2015-12-29 SG SG11201704897QA patent/SG11201704897QA/en unknown
- 2015-12-29 ES ES15832772T patent/ES2768996T3/es active Active
- 2015-12-29 US US14/982,127 patent/US9902728B2/en active Active
- 2015-12-29 KR KR1020177021230A patent/KR102581827B1/ko active Active
- 2015-12-29 MX MX2017008604A patent/MX373788B/es active IP Right Grant
- 2015-12-29 EA EA201791507A patent/EA038204B1/ru unknown
- 2015-12-29 AU AU2015374170A patent/AU2015374170B2/en active Active
- 2015-12-29 EP EP19207235.3A patent/EP3623372A1/en active Pending
- 2015-12-29 CN CN201580077002.3A patent/CN107406451B/zh active Active
-
2017
- 2017-06-08 IL IL252773A patent/IL252773A0/en unknown
- 2017-06-23 CL CL2017001687A patent/CL2017001687A1/es unknown
- 2017-06-27 MX MX2020002963A patent/MX2020002963A/es unknown
- 2017-06-29 PH PH12017501224A patent/PH12017501224A1/en unknown
- 2017-06-29 SA SA517381839A patent/SA517381839B1/ar unknown
- 2017-07-12 CO CONC2017/0006997A patent/CO2017006997A2/es unknown
- 2017-07-13 ZA ZA2017/04746A patent/ZA201704746B/en unknown
- 2017-07-28 EC ECIEPI201749010A patent/ECSP17049010A/es unknown
-
2018
- 2018-01-18 US US15/874,163 patent/US10377760B2/en active Active
-
2019
- 2019-07-19 US US16/517,149 patent/US10934299B2/en active Active
-
2021
- 2021-01-20 AU AU2021200346A patent/AU2021200346A1/en not_active Abandoned
- 2021-02-26 US US17/186,915 patent/US12018030B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201704746B (en) | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors | |
| IL282103B1 (en) | Furinones as ubiquitin-specific protease 1 inhibitors | |
| IL248970A0 (en) | Pyrazolopyridine and pyrazolopyrimidine type substances and their uses | |
| IL252135B (en) | Triazolopyrimidine compounds and their uses | |
| IL247949A0 (en) | New histories of pyrazolopyrimidines and their use as malt1 inhibitors | |
| IL253117A0 (en) | Abrasive articles and methods of their production | |
| IL248211A0 (en) | mdm2 inhibitors and therapeutic methods using them | |
| HUE058120T2 (hu) | Új JAK1-szelektív inhibitorok és alkalmazásuk | |
| EP3105010A4 (en) | Abrasive article and method of using the same | |
| ZA201704300B (en) | Nitrification inhibitor compositions and methods for preparing the same | |
| IL252686A0 (en) | Pyrazolopyridineamines as inhibitors of mknk1 and mknk2 | |
| SG11201607461PA (en) | Polishing composition and polishing method using the same | |
| GB201410226D0 (en) | Methods and arrays for use in the same | |
| IL252866B (en) | History of imidazopyridazine as pi3k beta inhibitors | |
| PL3240655T3 (pl) | Artykuły ścierne i sposoby ich formowania | |
| AU2014903744A0 (en) | Nitrification inhibitors and formulations |