KR102134418B1 - L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법 - Google Patents

L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법 Download PDF

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KR102134418B1
KR102134418B1 KR1020190071797A KR20190071797A KR102134418B1 KR 102134418 B1 KR102134418 B1 KR 102134418B1 KR 1020190071797 A KR1020190071797 A KR 1020190071797A KR 20190071797 A KR20190071797 A KR 20190071797A KR 102134418 B1 KR102134418 B1 KR 102134418B1
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tyrosine
gene
strain
dna
trp
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KR1020190071797A
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English (en)
Korean (ko)
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송규현
서창일
권나라
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씨제이제일제당 주식회사
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Application filed by 씨제이제일제당 주식회사 filed Critical 씨제이제일제당 주식회사
Priority to PCT/KR2020/007858 priority patent/WO2020256415A1/ko
Priority to CN202080021043.1A priority patent/CN114072492B/zh
Priority to JP2021547750A priority patent/JP7267441B2/ja
Priority to ARP200101706A priority patent/AR119176A1/es
Priority to AU2020295264A priority patent/AU2020295264B2/en
Priority to EP20826047.1A priority patent/EP3901265A4/en
Priority to CA3127994A priority patent/CA3127994A1/en
Priority to US17/430,314 priority patent/US20220195470A1/en
Priority to BR112021015080-3A priority patent/BR112021015080B1/pt
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Publication of KR102134418B1 publication Critical patent/KR102134418B1/ko

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/225—Tyrosine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01051—Prephenate dehydratase (4.2.1.51)
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    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99005—Chorismate mutase (5.4.99.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01013—Prephenate dehydrogenase (NADP+) (1.3.1.13)

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020190071797A 2019-06-17 2019-06-17 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법 KR102134418B1 (ko)

Priority Applications (10)

Application Number Priority Date Filing Date Title
KR1020190071797A KR102134418B1 (ko) 2019-06-17 2019-06-17 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
CN202080021043.1A CN114072492B (zh) 2019-06-17 2020-06-17 生产l-酪氨酸的微生物及利用其生产l-酪氨酸的方法
JP2021547750A JP7267441B2 (ja) 2019-06-17 2020-06-17 Ｌ－チロシンを生産する微生物及びこれを用いたｌ－チロシンの生産方法
ARP200101706A AR119176A1 (es) 2019-06-17 2020-06-17 Microorganismo que produce l-tirosina y método para producir l-tirosina usando el mismo
PCT/KR2020/007858 WO2020256415A1 (ko) 2019-06-17 2020-06-17 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
AU2020295264A AU2020295264B2 (en) 2019-06-17 2020-06-17 L-Tyrosine-Producing Microorganism And Method For Producing L-Tyrosine Using The Same
EP20826047.1A EP3901265A4 (en) 2019-06-17 2020-06-17 MICROORGANISMS FOR PRODUCING L-TYROSINE AND METHOD FOR PRODUCING L-TYROSINE USING THEM
CA3127994A CA3127994A1 (en) 2019-06-17 2020-06-17 L-tyrosine-producing microorganism and method for producing l-tyrosine using the same
US17/430,314 US20220195470A1 (en) 2019-06-17 2020-06-17 L-tyrosine-producing microorganism and method for producing l-tyrosine using the same
BR112021015080-3A BR112021015080B1 (pt) 2019-06-17 2020-06-17 Micro-organismo produtor de l-tirosina, método para produzir ltirosina com o uso do mesmo, cassete de expressão e composição para produzir l-tirosina

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KR1020190071797A KR102134418B1 (ko) 2019-06-17 2019-06-17 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법

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KR102134418B1 true KR102134418B1 (ko) 2020-07-16

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KR1020190071797A KR102134418B1 (ko) 2019-06-17 2019-06-17 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법

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US (1) US20220195470A1 (US06566495-20030520-M00011.png)
EP (1) EP3901265A4 (US06566495-20030520-M00011.png)
JP (1) JP7267441B2 (US06566495-20030520-M00011.png)
KR (1) KR102134418B1 (US06566495-20030520-M00011.png)
CN (1) CN114072492B (US06566495-20030520-M00011.png)
AR (1) AR119176A1 (US06566495-20030520-M00011.png)
AU (1) AU2020295264B2 (US06566495-20030520-M00011.png)
BR (1) BR112021015080B1 (US06566495-20030520-M00011.png)
CA (1) CA3127994A1 (US06566495-20030520-M00011.png)
WO (1) WO2020256415A1 (US06566495-20030520-M00011.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022244932A1 (ko) 2021-05-20 2022-11-24 씨제이제일제당 (주) 신규 프로모터 및 이의 용도

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022244932A1 (ko) 2021-05-20 2022-11-24 씨제이제일제당 (주) 신규 프로모터 및 이의 용도

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AR119176A1 (es) 2021-12-01
BR112021015080A2 (US06566495-20030520-M00011.png) 2021-12-28
CN114072492A (zh) 2022-02-18
CN114072492B (zh) 2024-04-30
AU2020295264B2 (en) 2023-05-18
JP7267441B2 (ja) 2023-05-01
BR112021015080B1 (pt) 2024-01-09
WO2020256415A1 (ko) 2020-12-24
EP3901265A4 (en) 2022-03-30
JP2022521384A (ja) 2022-04-07
AU2020295264A1 (en) 2021-08-12
EP3901265A1 (en) 2021-10-27
CA3127994A1 (en) 2020-12-24

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