KR102095699B1 - 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법 - Google Patents

트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법 Download PDF

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KR102095699B1
KR102095699B1 KR1020147016462A KR20147016462A KR102095699B1 KR 102095699 B1 KR102095699 B1 KR 102095699B1 KR 1020147016462 A KR1020147016462 A KR 1020147016462A KR 20147016462 A KR20147016462 A KR 20147016462A KR 102095699 B1 KR102095699 B1 KR 102095699B1
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delete delete
ttr
rnai agent
nucleotides
artificial sequence
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KR20140092921A (ko
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칼란토타틸 지. 라제브
트레이시 짐머만
무티아 마노하란
마르틴 마이에르
사티아나라야나 쿠치만치
클라우스 카리쎄
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알닐람 파마슈티칼스 인코포레이티드
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KR1020147016462A 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법 Active KR102095699B1 (ko)

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KR1020207008667A KR102263352B1 (ko) 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법

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Application Number Priority Date Filing Date Title
US201161561710P 2011-11-18 2011-11-18
US61/561,710 2011-11-18
US201261615618P 2012-03-26 2012-03-26
US61/615,618 2012-03-26
US201261680098P 2012-08-06 2012-08-06
US61/680,098 2012-08-06
PCT/US2012/065691 WO2013075035A1 (en) 2011-11-18 2012-11-16 Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases

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KR102095699B1 true KR102095699B1 (ko) 2020-04-02

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KR1020227011273A Pending KR20220045091A (ko) 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법
KR1020147016462A Active KR102095699B1 (ko) 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법
KR1020207008667A Active KR102263352B1 (ko) 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법
KR1020217016903A Active KR102385013B1 (ko) 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법

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KR1020207008667A Active KR102263352B1 (ko) 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법
KR1020217016903A Active KR102385013B1 (ko) 2011-11-18 2012-11-16 트랜스티레틴（ＴＴＲ） 관련 질병을 치료하기 위한 ＲＮＡｉ 제제, 조성 및 그의 사용방법

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US20050244869A1 (en) * 2004-04-05 2005-11-03 Brown-Driver Vickie L Modulation of transthyretin expression
HRP20150796T1 (hr) 2008-10-20 2015-09-11 Alnylam Pharmaceuticals, Inc. Pripravci i postupci za inhibiciju ekspresije transtiretina
NZ603339A (en) 2010-04-29 2015-01-30 Isis Pharmaceuticals Inc Modulation of transthyretin expression
EP2751270B1 (en) 2011-08-29 2018-08-22 Ionis Pharmaceuticals, Inc. Oligomer-conjugate complexes and their use
MY167390A (en) * 2011-11-18 2018-08-16 Alnylam Pharmaceuticals Inc Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases
KR20250133484A (ko) * 2011-11-18 2025-09-05 알닐람 파마슈티칼스 인코포레이티드 변형된 ＲＮＡｉ 제제
DK2879718T3 (da) 2012-08-06 2023-06-19 Alnylam Pharmaceuticals Inc Proces til fremstilling af kulhydratkonjugerede RNA-stoffer
HUE035887T2 (en) 2012-12-05 2018-05-28 Alnylam Pharmaceuticals Inc PCSK9 iRNA preparations and methods for their use
PL2970974T3 (pl) * 2013-03-14 2018-01-31 Alnylam Pharmaceuticals Inc Kompozycje komponentu C5 dopełniacza iRNA i sposoby ich zastosowania
KR102482890B1 (ko) 2013-05-01 2022-12-30 아이오니스 파마수티컬즈, 인코포레이티드 아포지질단백질 (a) 발현을 조절하는 조성물 및 방법
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