KR102092427B1 - 시린지 - Google Patents
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- KR102092427B1 KR102092427B1 KR1020147036866A KR20147036866A KR102092427B1 KR 102092427 B1 KR102092427 B1 KR 102092427B1 KR 1020147036866 A KR1020147036866 A KR 1020147036866A KR 20147036866 A KR20147036866 A KR 20147036866A KR 102092427 B1 KR102092427 B1 KR 102092427B1
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
- A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1861116T3 (pl) | 2005-03-25 | 2016-02-29 | Regeneron Pharma | Formulacje antagonistów VEGF |
| US7608261B2 (en) | 2006-06-16 | 2009-10-27 | Regeneron Pharmacuticals, Inc. | VEGF antagonist formulations suitable for intravitreal administration |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| JP6095678B2 (ja) | 2011-11-11 | 2017-03-15 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | 薬剤パッケージ用の不動態化、pH保護又は滑性皮膜、被覆プロセス及び装置 |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| HUE055994T2 (hu) | 2012-06-01 | 2022-01-28 | Novartis Ag | Fecskendõ |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| WO2014164928A1 (en) | 2013-03-11 | 2014-10-09 | Sio2 Medical Products, Inc. | Coated packaging |
| US10251815B2 (en) * | 2013-03-13 | 2019-04-09 | Rush University Medical Center | Delivery device and storage system for oropharyngeal administration of mother's colostrum and milk |
| US20140350518A1 (en) * | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
| US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
| US11066745B2 (en) | 2014-03-28 | 2021-07-20 | Sio2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| RU2702748C2 (ru) * | 2014-05-12 | 2019-10-11 | Формикон Аг | Предварительно заполненный пластиковый шприц, содержащий антагонист vegf |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| TWI806150B (zh) | 2014-11-07 | 2023-06-21 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| EP3058974A1 (en) | 2015-02-19 | 2016-08-24 | Sanofi-Aventis Deutschland GmbH | Injection device with supplementary device |
| JP6800161B2 (ja) | 2015-03-23 | 2020-12-16 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 注射デバイス |
| MA41906A (fr) | 2015-04-10 | 2018-02-13 | Dompe Farm Spa | Dispositif de distribution de gouttes oculaires |
| RU2734958C2 (ru) * | 2015-11-18 | 2020-10-26 | Формикон Аг | Предварительно заполненная фармацевтическая упаковка, содержащая жидкий состав на основе антагониста vegf |
| RU2018121813A (ru) * | 2015-11-18 | 2019-12-19 | Формикон Аг | Предварительно заполненный пластиковый шприц, содержащий антагонист vegf |
| CA3005132A1 (en) | 2015-11-18 | 2017-05-26 | Sio2 Medical Products, Inc. | Coated syringe for ophthalmic formulations containing a vegf antagonist |
| HRP20231379T1 (hr) | 2015-12-03 | 2024-02-16 | Regeneron Pharmaceuticals, Inc. | Postupci dovođenja u vezu genskih varijanti s kliničkim ishodom kod pacijenata koji pate od starosne makularne degeneracije liječenih anti-vegf-om |
| CA3010056A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| WO2017180480A1 (en) * | 2016-04-15 | 2017-10-19 | Santen Pharmaceuticals Co., Ltd. | Accurate, precise microliter dosing syringe |
| US20170349313A1 (en) * | 2016-06-01 | 2017-12-07 | Centurion Medical Products Corporation | Methods for manufacturing non-glass prefilled syringes |
| US10774229B2 (en) | 2016-06-17 | 2020-09-15 | Kao Corporation | Aqueous ink |
| TWI737742B (zh) * | 2016-06-22 | 2021-09-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素的預填充式注射器系統、具有其之套組以及其之使用 |
| ITUA20162072A1 (it) * | 2016-06-30 | 2017-12-30 | Platinum Corp Srl | Dropper a volume controllato |
| WO2018037467A1 (ja) | 2016-08-22 | 2018-03-01 | 富士機械製造株式会社 | 過酸化水素水の製造方法及び殺菌対象物の殺菌方法 |
| US10537683B2 (en) | 2016-11-03 | 2020-01-21 | Johnson & Johnson Surgical Vision, Inc. | Syringe finger grip |
| KR20230079456A (ko) | 2017-03-27 | 2023-06-07 | 리제너론 파아마슈티컬스, 인크. | 살균 방법 |
| CA3061891A1 (en) | 2017-04-12 | 2018-10-18 | Urigen Pharmaceuticals, Inc. | Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability |
| EP3618893B1 (en) | 2017-05-05 | 2023-03-29 | Alcon Inc. | A syringe comprising a collapsible plunger |
| US20200237997A1 (en) | 2017-05-24 | 2020-07-30 | Formycon Ag | Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist |
| EP3630062A2 (en) | 2017-05-24 | 2020-04-08 | SiO2 Medical Products, Inc. | Sterilizable pharmaceutical package for ophthalmic formulations |
| US11090445B2 (en) | 2017-06-16 | 2021-08-17 | Credence Medsystems, Inc. | System and method for safety syringe |
| WO2019040790A1 (en) | 2017-08-23 | 2019-02-28 | Merakris Therapeutics, Llc | COMPOSITIONS CONTAINING AMNIOTIC COMPONENTS AND METHODS FOR THEIR PREPARATION AND USE |
| FR3072297B1 (fr) * | 2017-10-17 | 2023-05-12 | Edix Sa | Dispositif d'injection manuelle |
| CN117065152A (zh) | 2017-12-13 | 2023-11-17 | 里珍纳龙药品有限公司 | 用于精确剂量输送的装置和方法 |
| US12485226B2 (en) | 2018-02-02 | 2025-12-02 | F. Hoffmann-La Roche Ag | Prefilled syringe and method of sterilizing a prefilled syringe |
| CN112203679A (zh) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| CA3096847A1 (en) * | 2018-04-09 | 2019-10-17 | Sio2 Medical Products, Inc. | Stretchable plunger assemblies |
| EP3784314B1 (en) * | 2018-04-24 | 2025-09-24 | W. L. Gore & Associates, Inc. | Medical delivery devices with inhibited oxygen permeation |
| IL318714A (en) | 2018-05-10 | 2025-03-01 | Regeneron Pharma | Formulations that include high concentrations of VEGF receptor fusion protein |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| US20210260300A1 (en) * | 2018-06-01 | 2021-08-26 | Sun Pharma Advanced Research Company Limited | An injection device |
| SG11202104174UA (en) * | 2018-10-26 | 2021-05-28 | Singapore Health Serv Pte Ltd | Device and method for ophthalmic extraction and injection |
| CA3239521A1 (en) | 2018-11-13 | 2020-05-22 | Credence Medsystems, Inc. | System and method for multiple site injection |
| WO2020109343A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Combination therapy for treatment of macular degeneration |
| WO2020109344A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Occular administration device for antisense oligonucleotides |
| KR20210106476A (ko) | 2018-12-18 | 2021-08-30 | 노파르티스 아게 | 고농도의 항-vegf 항체를 함유하는 단백질 용액 제형 |
| CN109498264B (zh) * | 2018-12-21 | 2020-01-14 | 南通市第一人民医院 | 一种眼科手术用取硅油装置 |
| EP3689397B1 (de) * | 2019-01-31 | 2025-04-23 | SCHOTT Pharma Schweiz AG | Spritzenkörper, spritze und injektionsvorrichtung zum injizieren eines hochviskosen mediums |
| GB201902355D0 (en) * | 2019-02-21 | 2019-04-10 | New Injection Systems Ltd | Modular auto injector |
| FR3093004B1 (fr) * | 2019-02-21 | 2023-04-07 | Dev Techniques Plastiques | Procede de preparation d’une seringue |
| EP3930734A4 (en) | 2019-02-28 | 2022-12-07 | Merakris Therapeutics, LLC | EXTRACELLULAR VESICLES DERIVED FROM AMBIENT WATER AND THEIR USES IN WOUND HEALING |
| SG11202110788RA (en) | 2019-03-29 | 2021-10-28 | Kortuc Inc | Hydrogen peroxide solution-prefilled syringe having excellent hydrogen peroxide preservability by virtue of silicone oil (oil composition containing said silicone oil) |
| EP3955994A1 (en) | 2019-04-18 | 2022-02-23 | Boehringer Ingelheim International GmbH | Administration device for administration of a fluid |
| PE20240329A1 (es) | 2019-06-05 | 2024-02-27 | Regeneron Pharma | Dispositivos y metodos para administracion de dosis de precision |
| MX2022001330A (es) * | 2019-08-01 | 2022-03-04 | Gennova Biopharmaceuticals Ltd | Composicion oftalmica de bevacizumab. |
| EP4025272A1 (en) * | 2019-09-03 | 2022-07-13 | Amgen Inc. | Injection device for drug delivery and packaging for the injection device |
| US20220332792A1 (en) * | 2019-09-04 | 2022-10-20 | University Of Massachusetts | Adeno-associated virus vector platform for delivery of kh902 (conbercept) and uses thereof |
| JP7704740B2 (ja) | 2019-09-16 | 2025-07-08 | アムジエン・インコーポレーテツド | 薬物送達デバイスの外部滅菌の方法 |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| WO2021097353A2 (en) | 2019-11-14 | 2021-05-20 | Congruence Medical Solutions, Llc | Variable dosing syringe |
| WO2021108530A1 (en) * | 2019-11-26 | 2021-06-03 | University Of Massachusetts | Recombinant adeno-associated virus for delivery of kh902 (conbercept) and uses thereof |
| US20230010593A1 (en) * | 2019-12-05 | 2023-01-12 | Hoffmann-La Roche Inc. | Syringe and tightness testing method |
| JP7640549B2 (ja) * | 2019-12-12 | 2025-03-05 | ノバルティス アーゲー | 注射デバイス及び注射溶液移し替えシステム |
| WO2021192637A1 (ja) * | 2020-03-24 | 2021-09-30 | テルモ株式会社 | 注射器バレル用グリップおよびバレル組立体ならびにシリンジ |
| WO2021257911A1 (en) | 2020-06-17 | 2021-12-23 | Credence Medsystems, Inc. | System and method for microdose injection |
| CA3193701A1 (en) | 2020-10-30 | 2022-05-05 | Axel Roth | Administration device for in particular intravitreal administration of a fluid |
| WO2022117556A1 (en) | 2020-12-01 | 2022-06-09 | Boehringer Ingelheim International Gmbh | Administration device for in particular intravitreal administration of a fluid |
| KR102720956B1 (ko) | 2020-12-15 | 2024-10-24 | 삼천당제약주식회사 | 안과용 제형을 포함하는 시린지 |
| US20240189517A1 (en) * | 2020-12-29 | 2024-06-13 | W.L. Gore & Associates, Inc. | Drug injection stopper with thin film lubricant |
| KR102419910B1 (ko) * | 2021-04-15 | 2022-07-14 | 주식회사 알테오젠 | 저용량 약액 충전 사전 충전형 주사기 및 그 제조방법 |
| US20250041523A1 (en) * | 2021-12-01 | 2025-02-06 | Sanofi Winthrop Industrie | A Lubricating Shuttle |
| CN114146220B (zh) | 2022-02-10 | 2022-04-29 | 中国远大集团有限责任公司 | 一种包含无菌pcl微球的美容产品 |
| WO2024137753A1 (en) | 2022-12-20 | 2024-06-27 | W. L. Gore & Associates, Inc. | Low insertion force syringe stoppers, assemblies, and associated methods |
| EP4480517A1 (de) | 2023-06-20 | 2024-12-25 | Ypsomed AG | Autoinjektor zur intravitrealen injektion |
| CA3237624A1 (en) * | 2023-07-28 | 2025-04-24 | Genentech, Inc. | NEW USES FOR OMALIZUMAB |
| CN117942456B (zh) * | 2024-03-27 | 2024-07-12 | 山东永聚医药科技股份有限公司 | 缓释型非牛顿流体制剂用预灌封注射器及其制备工艺 |
| KR102828906B1 (ko) * | 2024-11-18 | 2025-07-04 | 주식회사 비에스리서치 | 실리콘 오일이 미적용된 프리필드 시린지 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007035621A1 (en) * | 2005-09-16 | 2007-03-29 | (Osi) Eyetech, Inc. | Ophthalmic syringe |
| US20110257601A1 (en) | 2006-06-16 | 2011-10-20 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations for intravitreal administration |
| US20110276005A1 (en) * | 2008-12-03 | 2011-11-10 | Taisei Kako Co., Ltd. | Syringe |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US31789A (en) | 1861-03-26 | Bread-slicebi | ||
| DE2629557B2 (de) | 1976-07-01 | 1980-05-14 | Paul E. Dr.Med. 8000 Muenchen Doerr | Einmai-Injektionsspritze |
| JPH0747045B2 (ja) * | 1986-10-15 | 1995-05-24 | 株式会社大協精工 | 積層した注射器用滑栓 |
| US4946441A (en) | 1988-07-21 | 1990-08-07 | Maurice Laderoute | Limited use hypodermic syringe |
| JPH0725963Y2 (ja) | 1989-11-06 | 1995-06-14 | 清坤 曽 | 緊急避難装置 |
| EP0511402B1 (en) * | 1990-11-17 | 1997-09-10 | Santen Seiyaku Kabushiki Kaisha | Double-chamber type syringe barrel |
| US5236604A (en) * | 1991-05-29 | 1993-08-17 | Sherwood Medical Company | Serum separation blood collection tube and the method of using thereof |
| JP3186422B2 (ja) | 1993-05-14 | 2001-07-11 | 武田薬品工業株式会社 | プラスチゾル |
| US5405326A (en) | 1993-08-26 | 1995-04-11 | Habley Medical Technology Corporation | Disposable safety syringe with retractable shuttle for luer lock needle |
| US5795337A (en) | 1994-02-14 | 1998-08-18 | Becton Dickinson And Company | Syringe assembly and syringe stopper |
| US5688252A (en) | 1994-09-30 | 1997-11-18 | Takeda Chemical Industries, Ltd. | Syringe |
| US5667495A (en) | 1995-04-21 | 1997-09-16 | Becton Dickinson France S.A. | Backstop device for a syringe |
| US5607400A (en) * | 1995-05-19 | 1997-03-04 | Becton, Dickinson And Company | Pre-fillable syringe and stopper assembly therefor |
| DE19622283A1 (de) | 1996-05-23 | 1997-11-27 | Schering Ag | Verfahren zur terminalen Sterilisierung von befüllten Spritzen |
| JP4078406B2 (ja) * | 1997-01-22 | 2008-04-23 | 有限会社コーキ・エンジニアリング | 注射器のシリンダの製造方法 |
| DK1325932T5 (da) | 1997-04-07 | 2005-10-03 | Genentech Inc | Anti-VEGF antistoffer |
| JP3387775B2 (ja) | 1997-05-22 | 2003-03-17 | 株式会社大協精工 | 注射器用密封栓及びプレフィルド注射器 |
| US6200627B1 (en) * | 1998-03-17 | 2001-03-13 | Becton, Dickinson And Company | Low silicone glass prefillable syringe |
| WO1999055402A1 (en) * | 1998-04-30 | 1999-11-04 | Abbott Laboratories | Syringe assembly |
| USD430015S (en) | 1998-06-11 | 2000-08-29 | Pharmacia & Upjohn Ab | Blister pack for a syringe |
| JP2001104480A (ja) * | 1999-10-05 | 2001-04-17 | Daikyo Seiko Ltd | プラスチック製プレフィルド注射器の密封に使用するゴム製ピストン |
| JP2001340455A (ja) | 2000-05-31 | 2001-12-11 | Yoshino Kogyosho Co Ltd | シリンジ容器 |
| JP2002177388A (ja) | 2000-12-15 | 2002-06-25 | Daikyo Seiko Ltd | 医薬・医療用既充填注射器 |
| JP2002241264A (ja) * | 2001-02-19 | 2002-08-28 | Asahi Kasei Corp | エルカトニンのプレフィルドシリンジ製剤 |
| EP1477195A4 (en) * | 2001-12-27 | 2005-03-30 | Showa Pharm Chem Ind | CARTRIDGE SYRINGE, CARTRIDGE ASSEMBLY AND OPHTHALMIC SYRINGE CONTAINING SUCH A SYRINGE |
| JP4141156B2 (ja) * | 2002-03-15 | 2008-08-27 | 日本ベクトン・ディッキンソン株式会社 | プランジャ後退制限機構付きプレフィルドシリンジ |
| US6688252B1 (en) | 2002-12-11 | 2004-02-10 | Gary Caravella | Boat cover |
| JP2006519070A (ja) | 2003-02-27 | 2006-08-24 | バクスター・インターナショナル・インコーポレイテッド | 注射器のためのピストンアセンブリ |
| JP2004313369A (ja) | 2003-04-15 | 2004-11-11 | Menicon Co Ltd | カートリッジ注入器、カートリッジ及び該注入器を備えた眼科用注入器セット |
| FR2855413B1 (fr) | 2003-05-26 | 2005-12-30 | Becton Dickinson France | Seringue pre-remplie avec coiffe anti effraction |
| JP2007520276A (ja) * | 2004-01-12 | 2007-07-26 | アイサイエンス・インターベンショナル・コーポレーション | 粘性材料のための注入器 |
| US8124207B2 (en) | 2004-03-02 | 2012-02-28 | Sakhrani Vinay G | Article with lubricated surface and method |
| PL1767546T3 (pl) | 2004-06-08 | 2012-07-31 | Chengdu Kanghong Biotechnologies Co Ltd | Hamujące angiogenezę białka chimeryczne i ich zastosowanie |
| AU2005299701B2 (en) * | 2004-10-21 | 2011-11-17 | Genentech, Inc. | Method for treating intraocular neovascular diseases |
| WO2006088650A2 (en) * | 2005-02-02 | 2006-08-24 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a vegf inhibitor |
| US20080312607A1 (en) | 2005-05-31 | 2008-12-18 | Baxter International Inc. | Polypropylene Hollow Barrel with Sliding Coated Rubber Piston |
| US20060293270A1 (en) * | 2005-06-22 | 2006-12-28 | Adamis Anthony P | Methods and compositions for treating ocular disorders |
| US20070060887A1 (en) * | 2005-08-22 | 2007-03-15 | Marsh David A | Ophthalmic injector |
| FR2890316B1 (fr) * | 2005-09-02 | 2007-10-05 | Aguettant Soc Par Actions Simp | Seringue destinee a etre remplie puis sterilisee par autoclavage a la vapeur. |
| WO2007035623A1 (en) | 2005-09-17 | 2007-03-29 | Technology Group Northwest Inc. | System and method for foiling code-injection attacks in a computing device |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| ZA200803814B (en) * | 2005-10-14 | 2010-02-24 | Alcon Inc | Method for treating primary and secondary forms of glaucoma |
| AT502791B1 (de) * | 2006-04-06 | 2007-05-15 | Pharma Consult Ges M B H & Co | Injektionsspritze |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| JP2009535371A (ja) * | 2006-05-04 | 2009-10-01 | フォベア、ファルマスティカル、ソシエテ、アノニム | 血管新生性疾患の治療のための方法 |
| JP4131001B2 (ja) | 2006-07-28 | 2008-08-13 | 大成化工株式会社 | 定量吐出装置 |
| CN200973886Y (zh) * | 2006-11-20 | 2007-11-14 | 骆忠林 | 一种注射器 |
| WO2008077155A1 (en) | 2006-12-21 | 2008-06-26 | Genentech, Inc. | Sterilization of objects containing biological molecules |
| US8529521B2 (en) | 2007-04-23 | 2013-09-10 | Ultimed Inc. | Low-dosage syringe |
| CN100563736C (zh) * | 2007-06-02 | 2009-12-02 | 丁锐 | 一次性防刺伤注射器 |
| JP5393660B2 (ja) | 2007-06-12 | 2014-01-22 | ベクトン・ディキンソン・アンド・カンパニー | 不能化機構付き注射器 |
| ES2376761T3 (es) * | 2007-07-31 | 2012-03-16 | Al.Chi.Mi.A. S.R.L. | Método para realizar un dispositivo para tratamientos oftálmicos |
| WO2009030976A1 (en) | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device and smooth coating therefor |
| WO2009030975A1 (en) | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device comprising a siliconized chamber and a coated closure means |
| DE102008005938A1 (de) * | 2008-01-24 | 2009-07-30 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Vorgefüllte Spritze und Verfahren zum Verpacken einer Spritze |
| WO2009092608A1 (de) | 2008-01-24 | 2009-07-30 | Meflex Telecontrol Gmbh & Co. Kg | Abschlusskappe für ein antriebskabel, antriebskabel, verfahren zur herstellung einer abschlusskappe sowie verfahren zur herstellung eines antriebskabels |
| CA2714006A1 (en) | 2008-02-07 | 2009-08-13 | Amgen Inc. | Stabilized protein compositions |
| CA2728145A1 (en) | 2008-06-17 | 2009-12-23 | Denki Kagaku Kogyo Kabushiki Kaisha | Injector |
| WO2009158613A1 (en) | 2008-06-26 | 2009-12-30 | West Pharmaceutical Services, Inc. | Method of coating polyxylylene onto flouropolymer surfaces and devices coated thereby |
| US8221353B2 (en) | 2008-10-21 | 2012-07-17 | KMG Pharma, Inc | Intravitreal injection device and system |
| CN102272148A (zh) | 2008-11-03 | 2011-12-07 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
| WO2010127029A1 (en) * | 2009-05-01 | 2010-11-04 | Ophthotech Corporation | Methods for treating or preventing ophthalmological diseases |
| CN102458471A (zh) * | 2009-05-28 | 2012-05-16 | 葛兰素集团有限公司 | 用于治疗或预防眼病的TNFα拮抗剂和VEGF拮抗剂的组合 |
| EP2266647A1 (en) * | 2009-06-25 | 2010-12-29 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for drug delivery device |
| AR078060A1 (es) | 2009-07-14 | 2011-10-12 | Novartis Ag | Descontaminacion de superficie de contenedores previamente llenados en empaque secundario |
| US8722178B2 (en) | 2009-10-29 | 2014-05-13 | W. L. Gore & Associates, Inc. | Syringe stopper |
| CN201578690U (zh) | 2010-01-21 | 2010-09-15 | 王建友 | 一种注射器 |
| WO2011123722A1 (en) | 2010-03-31 | 2011-10-06 | Ocuject, Llc | Device and method for intraocular drug delivery |
| US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
| JP2012045046A (ja) | 2010-08-24 | 2012-03-08 | Gc Corp | 歯科用シリンジ |
| FR2966044B1 (fr) | 2010-10-18 | 2012-11-02 | Sanofi Pasteur | Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium |
| CN103415313B (zh) | 2011-03-01 | 2017-06-13 | 泰尔茂株式会社 | 注射器及注射器组装体 |
| ES2726805T3 (es) | 2011-04-25 | 2019-10-09 | Icon Bioscience Inc | Guías de dosis para jeringa de inyección |
| US20130012918A1 (en) | 2011-07-07 | 2013-01-10 | Gary Foster | Steady grip ophthalmic surgical syringe and method |
| JP6144264B2 (ja) | 2011-09-27 | 2017-06-07 | ベクトン ディキンソン フランス | 医療用注射装置においてプラズマ処理したシリコーンオイルのコーティングとしての使用 |
| US9421129B2 (en) | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
| US10780228B2 (en) | 2012-05-07 | 2020-09-22 | Medline Industries, Inc. | Prefilled container systems |
| HUE055994T2 (hu) | 2012-06-01 | 2022-01-28 | Novartis Ag | Fecskendõ |
| DE202012011016U1 (de) | 2012-07-03 | 2012-11-28 | Novartis Ag | Aflibercept-Spritze |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| AU2013100071C4 (en) | 2012-07-03 | 2013-05-02 | Novartis Ag | Device |
| US20160015898A1 (en) * | 2013-03-01 | 2016-01-21 | Sio2 Medical Products, Inc. | Plasma or cvd pre-treatment for lubricated pharmaceutical package, coating process and apparatus |
-
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- 2012-07-03 JO JOP/2020/0175A patent/JOP20200175A1/ar unknown
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- 2013-01-23 DE DE201320000688 patent/DE202013000688U1/de not_active Expired - Lifetime
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007035621A1 (en) * | 2005-09-16 | 2007-03-29 | (Osi) Eyetech, Inc. | Ophthalmic syringe |
| US20110257601A1 (en) | 2006-06-16 | 2011-10-20 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations for intravitreal administration |
| US20110276005A1 (en) * | 2008-12-03 | 2011-11-10 | Taisei Kako Co., Ltd. | Syringe |
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