KR101814648B1 - 부타디엔을 생합성하기 위한 미생물 및 방법 - Google Patents

부타디엔을 생합성하기 위한 미생물 및 방법 Download PDF

Info

Publication number
KR101814648B1
KR101814648B1 KR1020127031134A KR20127031134A KR101814648B1 KR 101814648 B1 KR101814648 B1 KR 101814648B1 KR 1020127031134 A KR1020127031134 A KR 1020127031134A KR 20127031134 A KR20127031134 A KR 20127031134A KR 101814648 B1 KR101814648 B1 KR 101814648B1
Authority
KR
South Korea
Prior art keywords
coa
butadiene
crotyl
reductase
kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020127031134A
Other languages
English (en)
Korean (ko)
Other versions
KR20130062939A (ko
Inventor
마크 제이. 버크
안소니 피. 버르가드
준 순
로빈 이. 오스터후트
프리티 파르크야
Original Assignee
게노마티카 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 게노마티카 인코포레이티드 filed Critical 게노마티카 인코포레이티드
Publication of KR20130062939A publication Critical patent/KR20130062939A/ko
Application granted granted Critical
Publication of KR101814648B1 publication Critical patent/KR101814648B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/12—Alkadienes
    • C07C11/16—Alkadienes with four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F136/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds
    • C08F136/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds
    • C08F136/04—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds conjugated
    • C08F136/06—Butadiene
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020127031134A 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법 Active KR101814648B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33181210P 2010-05-05 2010-05-05
US61/331,812 2010-05-05
PCT/US2011/035105 WO2011140171A2 (en) 2010-05-05 2011-05-04 Microorganisms and methods for the biosynthesis of butadiene

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177037394A Division KR20180005263A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법

Publications (2)

Publication Number Publication Date
KR20130062939A KR20130062939A (ko) 2013-06-13
KR101814648B1 true KR101814648B1 (ko) 2018-01-04

Family

ID=45064763

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020127031134A Active KR101814648B1 (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법
KR1020177037394A Ceased KR20180005263A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법
KR1020197001071A Ceased KR20190006103A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020177037394A Ceased KR20180005263A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법
KR1020197001071A Ceased KR20190006103A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법

Country Status (13)

Country Link
US (5) US8580543B2 (enExample)
EP (1) EP2566969B1 (enExample)
JP (3) JP5911847B2 (enExample)
KR (3) KR101814648B1 (enExample)
CN (2) CN103080324B (enExample)
AU (2) AU2011248182A1 (enExample)
BR (1) BR112012028049A2 (enExample)
CA (1) CA2797409C (enExample)
CO (1) CO6630182A2 (enExample)
MX (1) MX336229B (enExample)
SG (2) SG10201503501TA (enExample)
TW (2) TWI575072B (enExample)
WO (1) WO2011140171A2 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155382A1 (en) 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
AU2009327490A1 (en) 2008-12-16 2011-07-28 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
US8420375B2 (en) 2009-06-10 2013-04-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
BR112012014062A2 (pt) 2009-12-10 2017-04-04 Genomatica Inc organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
WO2011140171A2 (en) * 2010-05-05 2011-11-10 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
MX2013001071A (es) * 2010-07-26 2013-06-28 Genomatica Inc Microorganismos y metodos para la biosintesis de aromaticos, 2, 4-pentadienoato y 1, 3-butadieno.
EP2670852A4 (en) * 2011-02-02 2017-04-26 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
US9663801B2 (en) 2011-06-17 2017-05-30 Invista North America S.A.R.L. Methods of producing four carbon molecules
US9422578B2 (en) 2011-06-17 2016-08-23 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
WO2013082542A2 (en) * 2011-12-02 2013-06-06 Invista North America S.A.R.L. Methods for biosynthesizing 1,3butadiene
US9169486B2 (en) * 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
CA2845681A1 (en) * 2011-08-19 2013-02-28 Genomatica, Inc. Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols
US9169496B2 (en) * 2011-10-19 2015-10-27 Scientist of Fortune, S.A. Method for the enzymatic production of butadiene
IN2014CN03791A (enExample) * 2011-11-09 2015-10-16 Amyris Inc
US9518273B2 (en) * 2011-12-16 2016-12-13 Braskem S/A Modified microorganisms and methods of making butadiene using same
EP2794891A2 (en) * 2011-12-20 2014-10-29 Scientist of Fortune S.A. Production of 1,3-dienes by enzymatic conversion of 3-hydroxyalk-4-enoates and/or 3-phosphonoxyalk-4-enoates
US20150017698A1 (en) * 2012-03-02 2015-01-15 Codexis, Inc. a corporation Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate
US20150017696A1 (en) * 2012-03-02 2015-01-15 Codexis, Inc. a corporation Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate
US9803209B2 (en) 2012-05-18 2017-10-31 Novozymes A/S Bacterial mutants with improved transformation efficiency
CN104769119A (zh) * 2012-06-15 2015-07-08 英威达技术有限责任公司 生物合成1,3丁二烯的方法
WO2013192183A1 (en) * 2012-06-18 2013-12-27 Braskem S/A Ap 09 Modified microorganisms and methods of co-producing butadiene with 1-propanol and/or 1,2-propanediol
WO2014036140A2 (en) * 2012-08-28 2014-03-06 Braskem S/A Ap 09 Methods for production of a terpene and a co-product
CN104619721A (zh) 2012-09-27 2015-05-13 诺维信股份有限公司 具有改进的转化效率的细菌突变体
BR112015007443A2 (pt) * 2012-10-02 2017-08-08 Braskem Sa método de coprodução de butadieno e succinato a partir de uma fonte de carbono fermentável, e, microrganismo.
WO2014063156A2 (en) * 2012-10-19 2014-04-24 Braskem S/A Ap 09 Modified microorganisms and methods of using same for producing butadiene and one or more of 1,3-butanediol, 1,4-butanediol, and/or 1,3-propanediol
WO2014066235A1 (en) * 2012-10-22 2014-05-01 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
US20150284743A1 (en) * 2012-11-13 2015-10-08 Global Bioenergies a corporation Methods for the enzymatic production of isoprene from isoprenol
BR112015011318A2 (pt) * 2012-11-21 2017-10-31 Univ California ácidos nuclêicos úteis para a integração dentro da, e expressão de gene na archaea hipertermófila e acidófila
US9777295B2 (en) 2012-11-28 2017-10-03 Invista North America S.A.R.L. Methods for biosynthesis of isobutene
JP6304924B2 (ja) * 2012-11-29 2018-04-04 住友ゴム工業株式会社 サイドウォール用ゴム組成物、及び空気入りタイヤ
WO2014089025A1 (en) * 2012-12-04 2014-06-12 Genomatica, Inc. Increased yields of biosynthesized products
WO2014106122A1 (en) * 2012-12-31 2014-07-03 Genomatica, Inc. Compositions and methods for bio-butadiene production screening
JP2014155455A (ja) * 2013-02-15 2014-08-28 Sekisui Chem Co Ltd 組換え細胞、並びに、クロトニルＣｏＡ又はクロチルアルコールの生産方法
JP2014161252A (ja) * 2013-02-22 2014-09-08 Sekisui Chem Co Ltd 組換え細胞
EP2971021A4 (en) 2013-03-15 2016-12-21 Genomatica Inc MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION
CN105518130A (zh) 2013-06-21 2016-04-20 丹尼斯科美国公司 用于梭菌转化的组合物和方法
US10294496B2 (en) 2013-07-19 2019-05-21 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
BR112016002625A2 (pt) 2013-08-05 2017-09-12 Invista Tech Sarl método para sintetizar enzimaticamente isopreno e hospedeiro recombinante produtor de isopreno
BR112016002626A2 (pt) 2013-08-05 2017-09-12 Invista Tech Sarl método para sintetizar isobuteno e hospedeiro recombinante
PL3077501T3 (pl) 2013-12-03 2022-01-31 Genomatica, Inc. Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa
CA2935069C (en) 2013-12-27 2023-05-09 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
WO2015147644A1 (en) * 2014-03-27 2015-10-01 Photanol B.V. Erythritol production in cyanobacteria
WO2015195689A1 (en) 2014-06-16 2015-12-23 INVISTA Technologies S.á.r.l. Process for producing glutarate and glutaric acid methyl ester
EP3167066A4 (en) * 2014-07-11 2018-03-07 Genomatica, Inc. Microorganisms and methods for the production of butadiene using acetyl-coa
US20170298363A1 (en) 2014-09-18 2017-10-19 Genomatica, Inc Non-natural microbial organisms with improved energetic efficiency
CN104298866B (zh) * 2014-09-30 2017-06-06 杭州电子科技大学 一种克劳斯硫磺回收过程中反应炉动态建模方法
JP6432774B2 (ja) * 2014-12-25 2018-12-05 江南化工株式会社 細胞賦活剤
EP3273782B9 (en) 2015-02-27 2022-07-13 White Dog Labs, Inc. Mixotrophic fermentation method for making acetone, isopropanol, and other bioproducts, and mixtures thereof
US10612051B2 (en) * 2015-03-31 2020-04-07 White Dog Labs, Inc. Method of producing bioproducts
BR112017021667A2 (pt) 2015-04-09 2018-07-24 Genomatica Inc microorganismos modificados & métodos para produção aperfeiçoada de álcool de crotila
WO2016196233A1 (en) 2015-05-30 2016-12-08 Genomatica, Inc. Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and/ crotyl alcohol dehydratases and methods for making and using them
WO2017064606A1 (en) * 2015-10-12 2017-04-20 Reliance Industries Limited Process for preparation of 1,3-butadiene
EP3368548B1 (en) 2015-10-30 2023-08-23 Genomatica, Inc. Methanol dehydrogenase fusion proteins
GB201605354D0 (en) 2016-03-30 2016-05-11 Zuvasyntha Ltd Modified enzyme
WO2018064604A1 (en) 2016-09-30 2018-04-05 Hong Je Cho Phosphorus-containing solid catalysts and reactions catalyzed thereby, including synthesis of p-xylene
JP6317497B2 (ja) * 2017-03-22 2018-04-25 住友ゴム工業株式会社 トレッド用ゴム組成物、及び空気入りタイヤ
JP6317498B2 (ja) * 2017-03-22 2018-04-25 住友ゴム工業株式会社 スタッドレスタイヤ用トレッド用ゴム組成物、及びスタッドレスタイヤ
EP3600587A1 (en) * 2017-03-31 2020-02-05 Genomatica, Inc. Process and systems for obtaining 1,3-butanediol from fermentation broths
US11634733B2 (en) 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN113166784A (zh) 2018-06-26 2021-07-23 基因组股份公司 包括具有合成或增强的甲基营养的那些工程微生物的、具有g3p→3pg酶和/或果糖-1，6-二磷酸酶的工程微生物
WO2021011763A1 (en) * 2019-07-16 2021-01-21 San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation Products of manufacture and methods for methane capturing using biofiltration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111513A1 (en) * 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076948A (en) 1968-10-10 1978-02-28 El Paso Products Company Process for treatment of adipic acid mother liquor
US3513209A (en) 1968-08-19 1970-05-19 Du Pont Method of making 1,4-cyclohexadiene
GB1230276A (enExample) 1968-12-09 1971-04-28
US3965182A (en) 1969-10-02 1976-06-22 Ethyl Corporation Preparation of aniline from phenol and ammonia
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
JPS5543759B2 (enExample) 1972-06-28 1980-11-07
DE2455617C3 (de) 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
US4190495A (en) 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
JPS60114197A (ja) 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 微生物によるジカルボン酸の製造法
US4871667A (en) 1984-11-26 1989-10-03 Agency Of Industrial Science & Technology Process for preparing muconic acid
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
US5143834A (en) 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
ES2036188T3 (es) 1986-06-11 1993-05-16 Michigan Biotechnology Institute Un procedimiento para la produccion de acido succinico por fermentacion anaerobia.
US5168055A (en) 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
US5182199A (en) 1987-05-27 1993-01-26 Hartley Brian S Thermophilic ethanol production in a two-stage closed system
JPH01195596A (ja) 1988-01-30 1989-08-07 Casio Comput Co Ltd 値札システム
US5219757A (en) 1988-04-27 1993-06-15 Daicel Chemical Industries, Ltd. Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone
WO1990012888A1 (en) 1989-04-27 1990-11-01 Biocontrol Systems, Incorporated Precipitate test for microorganisms
US5192673A (en) 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5079143A (en) 1990-05-02 1992-01-07 The Upjohn Company Method of indentifying compounds useful as antiparasitic drugs
DE69126298T2 (de) 1990-10-15 1997-09-04 Daicel Chem Verfahren zur Herstellung optisch aktiven (R)-1,3-Butanediols mittels eines Mikroorganismus der Gattung Rhodococcus
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
US5416020A (en) 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US6136577A (en) 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
FR2702492B1 (fr) 1993-03-12 1995-05-24 Rhone Poulenc Chimie Procédé de production par fermentation d'acide itaconique.
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5700934A (en) 1995-03-01 1997-12-23 Dsm N.V. Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5863782A (en) 1995-04-19 1999-01-26 Women's And Children's Hospital Synthetic mammalian sulphamidase and genetic sequences encoding same
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) * 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
FR2736927B1 (fr) 1995-07-18 1997-10-17 Rhone Poulenc Fibres & Polymer Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
EP0883683A1 (en) 1996-02-27 1998-12-16 Michigan State University Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
DE69638265D1 (de) 1996-07-01 2010-11-11 Emmaus Foundation Inc BIOLOGISCHE HESTELLUNG VON ESSIGSäURE AUS ABGASEN
KR100459818B1 (ko) 1996-09-02 2004-12-03 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 ε-카프로락탐의 제조방법
AU6169498A (en) 1997-02-13 1998-09-08 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
KR100516986B1 (ko) 1997-02-19 2005-09-26 코닌클리즈케 디에스엠 엔.브이. 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법
US6274790B1 (en) 1997-04-14 2001-08-14 The University Of British Columbia Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis
KR19990013007A (ko) 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법
JPH11103863A (ja) 1997-10-08 1999-04-20 Nippon Shokubai Co Ltd マレイン酸異性化酵素遺伝子
US6280986B1 (en) 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
AU760575C (en) 1998-04-13 2005-04-14 University Of Georgia Research Foundation, Inc., The Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
DE19820652A1 (de) 1998-05-08 1999-11-11 Basf Ag Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6444784B1 (en) 1998-05-29 2002-09-03 Exxonmobil Research & Engineering Company Wax crystal modifiers (LAW657)
AU5101599A (en) 1998-07-15 2000-02-07 E.I. Du Pont De Nemours And Company Tetrahydrofolate metabolism enzymes
DE19856136C2 (de) 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
EP1147229A2 (en) 1999-02-02 2001-10-24 Bernhard O. Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6365376B1 (en) 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
AU3516100A (en) 1999-03-05 2000-09-21 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
JP4637372B2 (ja) 1999-05-21 2011-02-23 カーギル ダウ エルエルシー 有機生成物の合成方法および合成材料
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6660857B2 (en) 2000-02-03 2003-12-09 Dsm N.V. Process for the preparation of ε-caprolactam
US6878861B2 (en) 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
DE60121335T2 (de) 2000-07-25 2007-08-02 Emmaus Foundation, Inc., Fayetteville Verfahren zur steigerung der ethanolproduktion bei der mikrobiellen fermentation
JP4490628B2 (ja) 2000-11-20 2010-06-30 カーギル インコーポレイテッド ３−ヒドロキシプロピオン酸および他の有機化合物
AU2002237676A1 (en) 2000-11-22 2002-06-03 Cargill Dow Polymers, Llc Methods and materials for the synthesis of organic products
CN1358841A (zh) 2000-12-11 2002-07-17 云南省微生物研究所 云南链霉菌
CN1491282A (zh) 2000-12-28 2004-04-21 丰田自动车株式会社 异戊二烯醇的制备方法
EP1362319A2 (en) 2001-01-10 2003-11-19 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
WO2002070730A2 (en) 2001-03-01 2002-09-12 The Regents Of The University Of California Models and methods for determining systemic properties of regulated reaction networks
US6743610B2 (en) 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
JP4630486B2 (ja) 2001-05-28 2011-02-09 ダイセル化学工業株式会社 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法
CA2356540A1 (en) 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
EP1483378B1 (en) 2001-11-02 2013-01-02 Rice University Recycling system for manipulation of intracellular nadh availability
EP1575881B1 (en) 2002-01-18 2009-05-27 Novozymes A/S Alanine 2,3- aminomutase
AU2003211492A1 (en) 2002-02-06 2003-09-02 Showa Denko K.K. Alpha-SUBSTITUTED-Alpha,Beta-UNSATURATED CARBONYL COMPOUND REDUCTASE GENE
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
CA2480216A1 (en) 2002-03-29 2003-10-09 Genomatica, Inc. Human metabolic models and methods
WO2003095651A1 (fr) 2002-05-10 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Procede de production d'acide mevalonique
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
US8027821B2 (en) 2002-07-10 2011-09-27 The Penn State Research Foundation Method for determining gene knockouts
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
US7413878B2 (en) 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
JP4592418B2 (ja) 2002-10-04 2010-12-01 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 高収率での１，３−プロパンジオールの生物生産のための方法
WO2004035009A2 (en) 2002-10-15 2004-04-29 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
WO2004044210A2 (en) 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
CA2512815A1 (en) 2003-01-13 2004-07-29 Cargill, Incorporated Method for making industrial chemicals
WO2004074495A1 (ja) 2003-02-24 2004-09-02 Research Institute Of Innovative Technology For The Earth 微生物による高効率水素製造方法
RU2268300C2 (ru) 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA
DE602004026192D1 (de) 2003-07-29 2010-05-06 Res Inst Innovative Tech Earth Transformanten eines coryneformen bakteriums und deren verwendung in verfahren zur produktion von dicarbonsäure
US7927859B2 (en) 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005026349A1 (ja) 2003-09-17 2005-03-24 Mitsubishi Chemical Corporation 非アミノ有機酸の製造方法
US7244610B2 (en) 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
WO2005068643A2 (en) 2004-01-19 2005-07-28 Dsm Ip Assets B.V. Biochemical synthesis of 6-amino caproic acid
US7608700B2 (en) 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
DE102004031177A1 (de) 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
US7262046B2 (en) 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
CA2578028A1 (en) * 2004-08-26 2006-03-09 Costas D. Maranas Method for redesign of microbial production systems
WO2006031424A2 (en) 2004-08-27 2006-03-23 Rice University Mutant e. coli strain with increased succinic acid production
EP1790721A4 (en) 2004-09-09 2008-12-10 Res Inst Innovative Tech Earth DNA FRAGMENT WITH PROMOTER FUNCTION
CN101023178A (zh) 2004-09-17 2007-08-22 莱斯大学 高琥珀酸产出细菌
EP1801227B1 (en) 2004-10-14 2009-04-15 Sumitomo Chemical Company, Limited Method for producing 2-hydroxy-4-(methylthio)butanoic acid
WO2006069174A2 (en) 2004-12-22 2006-06-29 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
DE102005002127A1 (de) * 2005-01-17 2006-07-20 Basf Ag Verfahren zur Herstellung von Butadien aus n-Butan
JP2006204255A (ja) 2005-01-31 2006-08-10 Canon Inc アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法
WO2006109312A2 (en) 2005-04-15 2006-10-19 Vascular Biogenics Ltd. Compositions containing beta 2-glycoprotein i-derived peptides for the prevention and/or treatment of vascular disease
KR100679638B1 (ko) 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
KR100676160B1 (ko) 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
US20070111294A1 (en) 2005-09-09 2007-05-17 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
BRPI0619325B8 (pt) 2005-10-26 2020-11-17 Butamax Advanced Biofuels Llc célula hospedeira microbiana recombinante e método para produção de isobutanol
GB2433260A (en) 2005-12-16 2007-06-20 Mologic Ltd A selectable decarboxylase marker
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
US20100210017A1 (en) 2007-01-12 2010-08-19 Gill Ryan T Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
WO2008115840A2 (en) 2007-03-16 2008-09-25 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
WO2008131286A1 (en) 2007-04-18 2008-10-30 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20080274522A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
CA2691998A1 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
EP2017344A1 (en) 2007-07-20 2009-01-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Production of itaconic acid
CN101970673A (zh) 2007-07-23 2011-02-09 帝斯曼知识产权资产管理有限公司 真核细胞中的丁醇生产
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
BRPI0817545A2 (pt) 2007-10-12 2014-11-25 Univ California Microorganismo recombinante, métodos para produzir um microorganismo recombinante e para produzir isopropanol, vetor recombinante, e, célula hospedeira recombinante.
SG162265A1 (en) * 2007-12-13 2010-07-29 Danisco Us Inc Compositions and methods for producing isoprene
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
US7803589B2 (en) 2008-01-22 2010-09-28 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009151728A2 (en) 2008-03-27 2009-12-17 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
AU2009240505B2 (en) * 2008-04-23 2013-09-05 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
AU2009242615A1 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
US8420759B2 (en) 2008-06-30 2013-04-16 The Goodyear Tire & Rubber Company Polymers of isoprene from renewable resources
EP2313491A4 (en) 2008-07-08 2011-12-07 Opx Biotechnologies Inc METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL
WO2010022763A1 (en) 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
EP2334800B1 (en) * 2008-09-10 2018-12-26 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
CA2737082A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
MY156588A (en) 2008-09-15 2016-03-15 Danisco Us Inc Systems using cell culture for production of isoprene
US8354563B2 (en) 2008-10-16 2013-01-15 Maverick Biofuels, Inc. Methods and apparatus for synthesis of alcohols from syngas
CN102317437B (zh) 2008-12-12 2013-08-21 麦特波力克斯公司 用于制备聚(5-羟基戊酸)和5碳化合物的绿色工艺和组合物
AU2009327490A1 (en) 2008-12-16 2011-07-28 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
US9017983B2 (en) * 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
CN113528417A (zh) 2009-06-04 2021-10-22 基因组股份公司 生产1,4-丁二醇的微生物和相关方法
WO2011052718A1 (ja) 2009-10-30 2011-05-05 ダイセル化学工業株式会社 １，３－ブタンジオール生産機能を付与された遺伝子組換え微生物及びその利用
BR112012014062A2 (pt) 2009-12-10 2017-04-04 Genomatica Inc organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo
WO2011140171A2 (en) 2010-05-05 2011-11-10 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
EP2670852A4 (en) * 2011-02-02 2017-04-26 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
US9169486B2 (en) * 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
US9169496B2 (en) * 2011-10-19 2015-10-27 Scientist of Fortune, S.A. Method for the enzymatic production of butadiene
US20150050708A1 (en) * 2013-03-15 2015-02-19 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation
EP2971021A4 (en) * 2013-03-15 2016-12-21 Genomatica Inc MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111513A1 (en) * 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest

Also Published As

Publication number Publication date
US9732361B2 (en) 2017-08-15
JP2016154551A (ja) 2016-09-01
SG185432A1 (en) 2012-12-28
AU2011248182A1 (en) 2012-11-15
MX2012012827A (es) 2013-01-24
KR20130062939A (ko) 2013-06-13
US10487343B2 (en) 2019-11-26
TWI575072B (zh) 2017-03-21
AU2016201231A1 (en) 2016-03-17
EP2566969B1 (en) 2019-09-04
SG10201503501TA (en) 2015-06-29
BR112012028049A2 (pt) 2015-11-24
CA2797409C (en) 2019-12-24
US20110300597A1 (en) 2011-12-08
MX336229B (es) 2016-01-08
WO2011140171A3 (en) 2012-04-26
US20220025411A1 (en) 2022-01-27
TW201720931A (zh) 2017-06-16
JP2013524853A (ja) 2013-06-20
JP5911847B2 (ja) 2016-04-27
CO6630182A2 (es) 2013-03-01
KR20180005263A (ko) 2018-01-15
TW201139683A (en) 2011-11-16
US20200299736A1 (en) 2020-09-24
US20140155567A1 (en) 2014-06-05
CN103080324A (zh) 2013-05-01
WO2011140171A2 (en) 2011-11-10
US20180155742A1 (en) 2018-06-07
US8580543B2 (en) 2013-11-12
EP2566969A2 (en) 2013-03-13
CN106047782A (zh) 2016-10-26
CN103080324B (zh) 2019-03-08
JP2018196387A (ja) 2018-12-13
KR20190006103A (ko) 2019-01-16
CA2797409A1 (en) 2011-11-10
EP2566969A4 (en) 2014-01-15

Similar Documents

Publication Publication Date Title
KR101814648B1 (ko) 부타디엔을 생합성하기 위한 미생물 및 방법
US20210147881A1 (en) Microorganisms and methods for the biosynthesis of butadiene
AU2013203173B2 (en) Microorganisms and methods for the biosynthesis of butadiene
AU2019204872A1 (en) Microorganisms and methods for the biosynthesis of butadiene
AU2013202445A1 (en) Microorganisms and methods for the biosynthesis of butadiene

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P18-X000 Priority claim added or amended

St.27 status event code: A-2-2-P10-P18-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9