IN2014CN03791A - - Google Patents
Info
- Publication number
- IN2014CN03791A IN2014CN03791A IN3791CHN2014A IN2014CN03791A IN 2014CN03791 A IN2014CN03791 A IN 2014CN03791A IN 3791CHN2014 A IN3791CHN2014 A IN 3791CHN2014A IN 2014CN03791 A IN2014CN03791 A IN 2014CN03791A
- Authority
- IN
- India
- Prior art keywords
- host cell
- genetically modified
- heterologous
- heterologous nucleotide
- ada
- Prior art date
Links
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 150000003505 terpenes Chemical class 0.000 abstract 2
- 108030002854 Acetoacetyl-CoA synthases Proteins 0.000 abstract 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 abstract 1
- 230000000397 acetylating effect Effects 0.000 abstract 1
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 abstract 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
- 108010004621 phosphoketolase Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01034—Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/08—Transferases for other substituted phosphate groups (2.7.8)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161557893P | 2011-11-09 | 2011-11-09 | |
| PCT/US2012/064532 WO2013071172A1 (en) | 2011-11-09 | 2012-11-09 | Production of acetyl-coenzyme a derived isoprenoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN03791A true IN2014CN03791A (enExample) | 2015-10-16 |
Family
ID=47295179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3791CHN2014 IN2014CN03791A (enExample) | 2011-11-09 | 2012-11-09 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8415136B1 (enExample) |
| EP (1) | EP2776571B1 (enExample) |
| JP (2) | JP6073350B2 (enExample) |
| KR (1) | KR102021914B1 (enExample) |
| CN (1) | CN104039974B (enExample) |
| AU (1) | AU2012335091B2 (enExample) |
| BR (1) | BR112014010750B1 (enExample) |
| CA (1) | CA2853679C (enExample) |
| DK (1) | DK2776571T3 (enExample) |
| ES (1) | ES2628847T3 (enExample) |
| IN (1) | IN2014CN03791A (enExample) |
| MX (1) | MX346459B (enExample) |
| PT (1) | PT2776571T (enExample) |
| SG (1) | SG11201402083XA (enExample) |
| WO (1) | WO2013071172A1 (enExample) |
| ZA (1) | ZA201402989B (enExample) |
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| PL1756292T3 (pl) | 2004-03-31 | 2015-03-31 | Cargill Inc | Sposób fermentacji cukrów zawierających oligomeryczne sacharydy |
| WO2013022799A1 (en) * | 2011-08-05 | 2013-02-14 | Danisco Us Inc. | PRODUCTION OF ISOPRENOIDS UNDER NEUTRAL pH CONDITIONS |
| US8993305B2 (en) | 2011-10-07 | 2015-03-31 | Danisco Us Inc. | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| IN2014CN03791A (enExample) * | 2011-11-09 | 2015-10-16 | Amyris Inc | |
| BR112015012946B1 (pt) * | 2012-12-10 | 2021-09-28 | Cargill, Incorporated | Processo de fermentação em lote para fermentar um hidrolisato de amido |
| KR102159691B1 (ko) | 2013-03-15 | 2020-09-24 | 아미리스 인코퍼레이티드 | 아세틸-코엔자임 a 유래 화합물을 생산하기 위한 포스포케톨라제 및 포스포트랜스아세틸라제의 용도 |
| CN105555952A (zh) * | 2013-04-10 | 2016-05-04 | 丹尼斯科美国公司 | 用于乙酰辅酶a-衍生代谢物、异戊二烯、类异戊二烯前体和类异戊二烯的改善生产的磷酸解酮酶 |
| US9617569B2 (en) | 2013-11-15 | 2017-04-11 | Samsung Electronics Co., Ltd. | Genetically engineered yeast cell producing lactate including acetaldehyde dehydrogenase, method of producing yeast cell, and method of producing lactate using the same |
| WO2015077752A1 (en) | 2013-11-25 | 2015-05-28 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| AU2014368982B2 (en) | 2013-12-19 | 2021-03-25 | Amyris, Inc. | Methods for genomic integration |
| WO2015148272A1 (en) * | 2014-03-28 | 2015-10-01 | Danisco Us Inc. | Altered host cell pathway for improved ethanol production |
| JP6034332B2 (ja) * | 2014-05-30 | 2016-11-30 | トヨタ自動車株式会社 | 組換え微生物及び当該組換え微生物を用いた物質製造方法 |
| WO2016029153A1 (en) | 2014-08-21 | 2016-02-25 | Manus Biosynthesis, Inc. | Methods for production of oxygenated terpenes |
| MY182911A (en) | 2014-09-08 | 2021-02-05 | Temasek Life Sciences Laboratory Ltd | Methods for efficient production of polyunsaturated fatty acids (pufa) in rhodosporidium and rhodotorula species |
| JP6470532B2 (ja) * | 2014-09-17 | 2019-02-13 | 積水化学工業株式会社 | 組換え細胞、並びに、有機化合物の生産方法 |
| US20170298363A1 (en) | 2014-09-18 | 2017-10-19 | Genomatica, Inc | Non-natural microbial organisms with improved energetic efficiency |
| US20180127804A1 (en) | 2014-12-05 | 2018-05-10 | Amyris, Inc. | High-throughput sequencing of polynucleotides |
| DE102015103608A1 (de) * | 2015-03-11 | 2016-09-15 | Basf Se | Verfahren zur mikrobiellen de novo Synthese von Terpenen |
| KR101782891B1 (ko) * | 2015-07-08 | 2017-09-29 | 한국과학기술연구원 | 미어신 생산용 벡터 및 균주, 및 이를 이용한 미어신의 생산방법 |
| EP3368673B1 (en) | 2015-10-29 | 2020-07-29 | Amyris, Inc. | Compositions and methods for production of myrcene |
| AU2016344131A1 (en) | 2015-10-29 | 2018-05-10 | Senomyx, Inc. | High intensity sweeteners |
| JPWO2017094053A1 (ja) * | 2015-11-30 | 2018-09-13 | 積水化学工業株式会社 | 組換え細胞、組換え細胞の製造方法、並びに、有機化合物の生産方法 |
| EP3478844A4 (en) * | 2016-07-01 | 2020-04-08 | International Flavors & Fragrances Inc. | COMPOSITIONS AND METHODS FOR PRODUCING CITRUS TERPENOIDS |
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| CN106893726B (zh) * | 2017-02-20 | 2020-06-09 | 天津大学 | 一种启动子以及重组酵母菌株 |
| JP7397665B2 (ja) * | 2017-02-27 | 2023-12-13 | 積水化学工業株式会社 | 組換え細胞、組換え細胞の製造方法、並びに、イソプレン又はテルペンの生産方法 |
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| WO2019030073A1 (en) | 2017-08-07 | 2019-02-14 | Total Raffinage Chimie | PROCESS FOR RECOVERING ISOPRENOIDS PRODUCED BY MICROORGANISMS |
| WO2019030007A1 (en) | 2017-08-07 | 2019-02-14 | Total Raffinage Chimie | PROCESS FOR RECOVERING FERMENTATION PRODUCTS |
| JP2019041712A (ja) * | 2017-09-05 | 2019-03-22 | 株式会社デンソー | 組み換え体及びスクアレンの製造方法 |
| CN107841523A (zh) * | 2017-10-19 | 2018-03-27 | 浙江大学 | 利用群体感应分子诱导从桦褐孔菌中提取三萜类物质方法 |
| CN107937431A (zh) * | 2017-10-28 | 2018-04-20 | 国际竹藤中心 | 一种提高酿酒酵母合成芳樟醇能力的方法 |
| KR20200095534A (ko) | 2017-12-07 | 2020-08-10 | 지머젠 인코포레이티드 | 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로 |
| KR20200111172A (ko) | 2017-12-21 | 2020-09-28 | 지머젠 인코포레이티드 | 네페탈락톨 산화 환원 효소, 네페탈락톨 합성 효소, 및 네페탈락톤을 생산할 수 있는 미생물 |
| CA3114953A1 (en) | 2018-10-15 | 2020-04-23 | Amyris, Inc. | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
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| KR20210089717A (ko) | 2018-11-07 | 2021-07-16 | 피르메니히 인코포레이티드 | 고강도 감미료의 제조 방법 |
| CN111378587B (zh) * | 2018-12-29 | 2022-08-05 | 中国科学院青岛生物能源与过程研究所 | 一种合成β-法尼烯的基因工程菌及其应用 |
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| CN109929937B (zh) * | 2019-04-01 | 2023-04-21 | 广东省科学院动物研究所 | 龟嗜皮菌特异性鉴定引物、试剂盒及其鉴定方法 |
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| CN116376995B (zh) * | 2022-04-02 | 2024-01-26 | 元素驱动(杭州)生物科技有限公司 | 一种利用苏氨酸制备甘氨酸、乙酰辅酶a及乙酰辅酶a衍生物的方法 |
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| KR20250130385A (ko) | 2023-01-03 | 2025-09-01 | 아미리스 인코퍼레이티드 | 세스퀴테르페노이드를 생산할 수 있는 숙주 세포 및 이의 사용 방법 |
| EP4658757A1 (en) | 2023-02-03 | 2025-12-10 | Amyris, Inc. | Host cells capable of producing retinol or retinol precursors and methods of use thereof |
| CN121079426A (zh) | 2023-05-15 | 2025-12-05 | 帝斯曼知识产权资产管理有限公司 | 发酵过程中减少乳液形成的方法 |
| KR20250105748A (ko) | 2023-12-29 | 2025-07-09 | 포항공과대학교 산학협력단 | 이소프레놀 고생산 균주 및 이를 이용한 이소프레놀 생산방법 |
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| FR745875A (fr) | 1932-11-16 | 1933-05-17 | Système d'adaptation aux brouettes, de roues à bandage pneumatique | |
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| IN2014CN03791A (enExample) * | 2011-11-09 | 2015-10-16 | Amyris Inc |
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2012
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|---|---|
| US8859261B2 (en) | 2014-10-14 |
| MX346459B (es) | 2017-03-22 |
| KR20140093981A (ko) | 2014-07-29 |
| KR102021914B1 (ko) | 2019-09-17 |
| JP6461208B2 (ja) | 2019-01-30 |
| US20150093797A1 (en) | 2015-04-02 |
| ZA201402989B (en) | 2015-11-25 |
| US9914941B2 (en) | 2018-03-13 |
| BR112014010750A2 (pt) | 2017-06-13 |
| EP2776571A1 (en) | 2014-09-17 |
| BR112014010750B1 (pt) | 2021-09-21 |
| CA2853679C (en) | 2021-05-04 |
| AU2012335091B2 (en) | 2016-06-16 |
| WO2013071172A1 (en) | 2013-05-16 |
| US20140154765A1 (en) | 2014-06-05 |
| US8603800B2 (en) | 2013-12-10 |
| CA2853679A1 (en) | 2013-05-16 |
| CN104039974A (zh) | 2014-09-10 |
| JP2014532444A (ja) | 2014-12-08 |
| US8415136B1 (en) | 2013-04-09 |
| JP2017055777A (ja) | 2017-03-23 |
| DK2776571T3 (en) | 2017-06-26 |
| US20130236942A1 (en) | 2013-09-12 |
| EP2776571B1 (en) | 2017-04-12 |
| JP6073350B2 (ja) | 2017-02-01 |
| SG11201402083XA (en) | 2014-06-27 |
| ES2628847T3 (es) | 2017-08-04 |
| PT2776571T (pt) | 2017-07-07 |
| AU2012335091A1 (en) | 2014-06-19 |
| CN104039974B (zh) | 2016-10-12 |
| MX2014005543A (es) | 2014-06-04 |
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