ES2628847T3 - Producción de isoprenoides derivados de acetil-coenzima a - Google Patents
Producción de isoprenoides derivados de acetil-coenzima a Download PDFInfo
- Publication number
- ES2628847T3 ES2628847T3 ES12795948T ES12795948T ES2628847T3 ES 2628847 T3 ES2628847 T3 ES 2628847T3 ES 12795948 T ES12795948 T ES 12795948T ES 12795948 T ES12795948 T ES 12795948T ES 2628847 T3 ES2628847 T3 ES 2628847T3
- Authority
- ES
- Spain
- Prior art keywords
- coenzyme
- acetyl
- production
- heterologous nucleic
- isoprenoids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003505 terpenes Chemical class 0.000 title abstract 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 title 2
- 229940100228 acetyl coenzyme a Drugs 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 abstract 1
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 abstract 1
- 101710088194 Dehydrogenase Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01034—Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/08—Transferases for other substituted phosphate groups (2.7.8)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161557893P | 2011-11-09 | 2011-11-09 | |
| PCT/US2012/064532 WO2013071172A1 (en) | 2011-11-09 | 2012-11-09 | Production of acetyl-coenzyme a derived isoprenoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2628847T3 true ES2628847T3 (es) | 2017-08-04 |
Family
ID=47295179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12795948T Active ES2628847T3 (es) | 2011-11-09 | 2012-11-09 | Producción de isoprenoides derivados de acetil-coenzima a |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8415136B1 (enExample) |
| EP (1) | EP2776571B1 (enExample) |
| JP (2) | JP6073350B2 (enExample) |
| KR (1) | KR102021914B1 (enExample) |
| CN (1) | CN104039974B (enExample) |
| AU (1) | AU2012335091B2 (enExample) |
| BR (1) | BR112014010750B1 (enExample) |
| CA (1) | CA2853679C (enExample) |
| DK (1) | DK2776571T3 (enExample) |
| ES (1) | ES2628847T3 (enExample) |
| IN (1) | IN2014CN03791A (enExample) |
| MX (1) | MX346459B (enExample) |
| PT (1) | PT2776571T (enExample) |
| SG (1) | SG11201402083XA (enExample) |
| WO (1) | WO2013071172A1 (enExample) |
| ZA (1) | ZA201402989B (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PL1756292T3 (pl) | 2004-03-31 | 2015-03-31 | Cargill Inc | Sposób fermentacji cukrów zawierających oligomeryczne sacharydy |
| BR112014002745A8 (pt) * | 2011-08-05 | 2017-06-20 | Danisco Us Inc | produção de isoprenoides sob condições de ph neutro |
| SG11201401249PA (en) | 2011-10-07 | 2014-05-29 | Danisco Us Inc | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| BR112014010750B1 (pt) * | 2011-11-09 | 2021-09-21 | Amyris, Inc | Produção de isoprenoides derivados de acetil-coenzima a |
| US20150315615A1 (en) * | 2012-12-10 | 2015-11-05 | Cargill, Incorporated | Batch feed process for fermenting sugars |
| EP2971027B1 (en) | 2013-03-15 | 2019-01-30 | Amyris, Inc. | Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds |
| ES2735331T3 (es) * | 2013-04-10 | 2019-12-18 | Goodyear Tire & Rubber | Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides |
| US9617569B2 (en) | 2013-11-15 | 2017-04-11 | Samsung Electronics Co., Ltd. | Genetically engineered yeast cell producing lactate including acetaldehyde dehydrogenase, method of producing yeast cell, and method of producing lactate using the same |
| WO2015077752A1 (en) | 2013-11-25 | 2015-05-28 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
| EP4296364B1 (en) | 2013-12-03 | 2025-12-03 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| WO2015095804A1 (en) | 2013-12-19 | 2015-06-25 | Amyris, Inc. | Methods for genomic integration |
| WO2015148272A1 (en) * | 2014-03-28 | 2015-10-01 | Danisco Us Inc. | Altered host cell pathway for improved ethanol production |
| JP6034332B2 (ja) | 2014-05-30 | 2016-11-30 | トヨタ自動車株式会社 | 組換え微生物及び当該組換え微生物を用いた物質製造方法 |
| CN107002109A (zh) * | 2014-08-21 | 2017-08-01 | 马努斯生物合成股份有限公司 | 含氧萜烯的生产方法 |
| CN107075450B (zh) * | 2014-09-08 | 2021-05-07 | 淡马锡生命科学研究院有限公司 | 在红冬孢酵母属和红酵母属物种中高效产生多不饱和脂肪酸(pufa)的方法 |
| JP6470532B2 (ja) * | 2014-09-17 | 2019-02-13 | 積水化学工業株式会社 | 組換え細胞、並びに、有機化合物の生産方法 |
| CN120624582A (zh) | 2014-09-18 | 2025-09-12 | 基因组股份公司 | 具有提高的能源效率的非天然微生物 |
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| DE102015103608A1 (de) * | 2015-03-11 | 2016-09-15 | Basf Se | Verfahren zur mikrobiellen de novo Synthese von Terpenen |
| KR101782891B1 (ko) * | 2015-07-08 | 2017-09-29 | 한국과학기술연구원 | 미어신 생산용 벡터 및 균주, 및 이를 이용한 미어신의 생산방법 |
| CN108779468A (zh) * | 2015-10-29 | 2018-11-09 | 阿迈瑞斯公司 | 生成月桂烯的组合物和方法 |
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| JPWO2017094053A1 (ja) * | 2015-11-30 | 2018-09-13 | 積水化学工業株式会社 | 組換え細胞、組換え細胞の製造方法、並びに、有機化合物の生産方法 |
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| AU2019360932A1 (en) | 2018-10-15 | 2021-05-06 | Amyris, Inc. | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
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| FR745875A (fr) | 1932-11-16 | 1933-05-17 | Système d'adaptation aux brouettes, de roues à bandage pneumatique | |
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| EP2024504B2 (en) | 2006-05-26 | 2022-12-14 | Amyris, Inc. | Production of isoprenoids |
| WO2009005704A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| PL2173881T3 (pl) | 2007-07-23 | 2017-05-31 | Dsm Ip Assets B.V. | Acetylo-coa wytwarzający enzymy w drożdżach |
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| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
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| EP2277989A1 (en) * | 2009-07-24 | 2011-01-26 | Technische Universiteit Delft | Fermentative glycerol-free ethanol production |
| CN106047782A (zh) * | 2010-05-05 | 2016-10-26 | 基因组股份公司 | 用于丁二烯生物合成的微生物和方法 |
| JP5056897B2 (ja) | 2010-05-14 | 2012-10-24 | トヨタ自動車株式会社 | ２−ブタノールの製造方法及び２−ブタノール生産能を有する組換え微生物 |
| DE102010029973A1 (de) * | 2010-06-11 | 2011-12-15 | Evonik Degussa Gmbh | Mikrobiologische Herstellung von C4-Körpern aus Saccharose und Kohlendioxid |
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| BR112014010750B1 (pt) * | 2011-11-09 | 2021-09-21 | Amyris, Inc | Produção de isoprenoides derivados de acetil-coenzima a |
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- 2012-11-09 BR BR112014010750-5A patent/BR112014010750B1/pt active IP Right Grant
- 2012-11-09 ES ES12795948T patent/ES2628847T3/es active Active
- 2012-11-09 DK DK12795948.4T patent/DK2776571T3/en active
- 2012-11-09 WO PCT/US2012/064532 patent/WO2013071172A1/en not_active Ceased
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- 2012-11-09 US US13/673,819 patent/US8415136B1/en active Active
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- 2012-11-09 CA CA2853679A patent/CA2853679C/en active Active
- 2012-11-09 KR KR1020147015594A patent/KR102021914B1/ko active Active
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- 2012-11-09 JP JP2014541353A patent/JP6073350B2/ja active Active
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| Publication number | Publication date |
|---|---|
| AU2012335091B2 (en) | 2016-06-16 |
| BR112014010750A2 (pt) | 2017-06-13 |
| US20140154765A1 (en) | 2014-06-05 |
| MX2014005543A (es) | 2014-06-04 |
| DK2776571T3 (en) | 2017-06-26 |
| WO2013071172A1 (en) | 2013-05-16 |
| JP2017055777A (ja) | 2017-03-23 |
| CN104039974B (zh) | 2016-10-12 |
| JP6461208B2 (ja) | 2019-01-30 |
| EP2776571B1 (en) | 2017-04-12 |
| CA2853679C (en) | 2021-05-04 |
| CA2853679A1 (en) | 2013-05-16 |
| US8415136B1 (en) | 2013-04-09 |
| PT2776571T (pt) | 2017-07-07 |
| KR20140093981A (ko) | 2014-07-29 |
| US20150093797A1 (en) | 2015-04-02 |
| US20130236942A1 (en) | 2013-09-12 |
| JP6073350B2 (ja) | 2017-02-01 |
| ZA201402989B (en) | 2015-11-25 |
| KR102021914B1 (ko) | 2019-09-17 |
| SG11201402083XA (en) | 2014-06-27 |
| CN104039974A (zh) | 2014-09-10 |
| AU2012335091A1 (en) | 2014-06-19 |
| EP2776571A1 (en) | 2014-09-17 |
| IN2014CN03791A (enExample) | 2015-10-16 |
| US8603800B2 (en) | 2013-12-10 |
| US8859261B2 (en) | 2014-10-14 |
| JP2014532444A (ja) | 2014-12-08 |
| MX346459B (es) | 2017-03-22 |
| US9914941B2 (en) | 2018-03-13 |
| BR112014010750B1 (pt) | 2021-09-21 |
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