BR112014010750A2 - produção de isoprenoides derivados de acetil-coenzima a - Google Patents
produção de isoprenoides derivados de acetil-coenzima aInfo
- Publication number
- BR112014010750A2 BR112014010750A2 BR112014010750A BR112014010750A BR112014010750A2 BR 112014010750 A2 BR112014010750 A2 BR 112014010750A2 BR 112014010750 A BR112014010750 A BR 112014010750A BR 112014010750 A BR112014010750 A BR 112014010750A BR 112014010750 A2 BR112014010750 A2 BR 112014010750A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoprenides
- derived
- production
- acetyl coenzyme
- coenzyme
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01034—Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/08—Transferases for other substituted phosphate groups (2.7.8)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161557893P | 2011-11-09 | 2011-11-09 | |
| US61/557,893 | 2011-11-09 | ||
| PCT/US2012/064532 WO2013071172A1 (en) | 2011-11-09 | 2012-11-09 | Production of acetyl-coenzyme a derived isoprenoids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014010750A2 true BR112014010750A2 (pt) | 2017-06-13 |
| BR112014010750B1 BR112014010750B1 (pt) | 2021-09-21 |
Family
ID=47295179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014010750-5A BR112014010750B1 (pt) | 2011-11-09 | 2012-11-09 | Produção de isoprenoides derivados de acetil-coenzima a |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8415136B1 (pt) |
| EP (1) | EP2776571B1 (pt) |
| JP (2) | JP6073350B2 (pt) |
| KR (1) | KR102021914B1 (pt) |
| CN (1) | CN104039974B (pt) |
| AU (1) | AU2012335091B2 (pt) |
| BR (1) | BR112014010750B1 (pt) |
| CA (1) | CA2853679C (pt) |
| DK (1) | DK2776571T3 (pt) |
| ES (1) | ES2628847T3 (pt) |
| IN (1) | IN2014CN03791A (pt) |
| MX (1) | MX346459B (pt) |
| PT (1) | PT2776571T (pt) |
| SG (1) | SG11201402083XA (pt) |
| WO (1) | WO2013071172A1 (pt) |
| ZA (1) | ZA201402989B (pt) |
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| DK1756292T3 (da) * | 2004-03-31 | 2014-10-27 | Cargill Inc | Fremgangsmåde til at fermentere sukre indeholdende oligomeriske saccharider |
| WO2013022799A1 (en) * | 2011-08-05 | 2013-02-14 | Danisco Us Inc. | PRODUCTION OF ISOPRENOIDS UNDER NEUTRAL pH CONDITIONS |
| WO2013066568A1 (en) | 2011-10-07 | 2013-05-10 | Danisco Us Inc. | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| IN2014CN03791A (pt) * | 2011-11-09 | 2015-10-16 | Amyris Inc | |
| BR112015012946B1 (pt) * | 2012-12-10 | 2021-09-28 | Cargill, Incorporated | Processo de fermentação em lote para fermentar um hidrolisato de amido |
| EP2971027B1 (en) | 2013-03-15 | 2019-01-30 | Amyris, Inc. | Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds |
| WO2014169144A2 (en) * | 2013-04-10 | 2014-10-16 | Danisco Us Inc. | Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids |
| EP2873725B1 (en) | 2013-11-15 | 2016-09-07 | Samsung Electronics Co., Ltd | Genetically Engineered Yeast Cell Producing Lactate Including Acetaldehyde Dehydrogenase, Method of Producing Yeast Cell, and Method of Producing Lactate Using the Same |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| CN106029886B (zh) | 2013-12-19 | 2021-02-05 | 阿迈瑞斯公司 | 基因组整合的方法 |
| EP3122876B1 (en) | 2014-03-28 | 2020-11-25 | Danisco US Inc. | Altered host cell pathway for improved ethanol production |
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| JP6735750B2 (ja) | 2014-08-21 | 2020-08-05 | マナス バイオシンセシス インコーポレイテッド | 含酸素テルペンの産生方法 |
| WO2016039685A1 (en) * | 2014-09-08 | 2016-03-17 | Temasek Life Sciences Laboratory Limited | Methods for efficient production of polyunsaturated fatty acids (pufa) in rhodosporidium and rhodotorula species |
| JP6470532B2 (ja) * | 2014-09-17 | 2019-02-13 | 積水化学工業株式会社 | 組換え細胞、並びに、有機化合物の生産方法 |
| EP3741865B1 (en) | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| EP3227461A1 (en) | 2014-12-05 | 2017-10-11 | Amyris, Inc. | High-throughput sequencing of polynucleotides |
| DE102015103608A1 (de) * | 2015-03-11 | 2016-09-15 | Basf Se | Verfahren zur mikrobiellen de novo Synthese von Terpenen |
| KR101782891B1 (ko) * | 2015-07-08 | 2017-09-29 | 한국과학기술연구원 | 미어신 생산용 벡터 및 균주, 및 이를 이용한 미어신의 생산방법 |
| EP3368673B1 (en) * | 2015-10-29 | 2020-07-29 | Amyris, Inc. | Compositions and methods for production of myrcene |
| CN108473528A (zh) | 2015-10-29 | 2018-08-31 | 赛诺米克斯公司 | 高强度甜味剂 |
| EP3385378A4 (en) * | 2015-11-30 | 2019-04-24 | Sekisui Chemical Co., Ltd. | RECOMBINANT CELL, PROCESS FOR PRODUCING THE RECOMBINANT CELL, AND PROCESS FOR PRODUCING AN ORGANIC COMPOUND |
| EP3478844A4 (en) * | 2016-07-01 | 2020-04-08 | International Flavors & Fragrances Inc. | COMPOSITIONS AND METHODS FOR PRODUCING CITRUS TERPENOIDS |
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| CN106893726B (zh) * | 2017-02-20 | 2020-06-09 | 天津大学 | 一种启动子以及重组酵母菌株 |
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| MX2019012940A (es) | 2017-05-03 | 2019-12-16 | Firmenich Incorporated | Metodos para producir edulcorantes de alta intensidad. |
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| EP3665292B1 (en) | 2017-08-07 | 2024-03-06 | Total Raffinage Chimie | Process for recovering isoprenoids produced by microorganisms |
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| CN107841523A (zh) * | 2017-10-19 | 2018-03-27 | 浙江大学 | 利用群体感应分子诱导从桦褐孔菌中提取三萜类物质方法 |
| CN107937431A (zh) * | 2017-10-28 | 2018-04-20 | 国际竹藤中心 | 一种提高酿酒酵母合成芳樟醇能力的方法 |
| JP2021505154A (ja) | 2017-12-07 | 2021-02-18 | ザイマージェン インコーポレイテッド | 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路 |
| CN111868047A (zh) | 2017-12-21 | 2020-10-30 | 齐默尔根公司 | 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物 |
| SG11202103802XA (en) | 2018-10-15 | 2021-05-28 | Amyris Inc | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
| CN111378588A (zh) * | 2018-12-29 | 2020-07-07 | 中国科学院青岛生物能源与过程研究所 | 一种转化纤维素水解液合成法尼烯的基因工程菌及其应用 |
| CN111378587B (zh) * | 2018-12-29 | 2022-08-05 | 中国科学院青岛生物能源与过程研究所 | 一种合成β-法尼烯的基因工程菌及其应用 |
| JP7518838B2 (ja) | 2019-01-24 | 2024-07-18 | アミリス， インコーポレイテッド | レバウジオシドの高効率な生成のためのａｂｃトランスポーター |
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| JP2023533969A (ja) * | 2020-07-08 | 2023-08-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | イソプレノールの生産に有用な改変酵母宿主細胞 |
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| NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
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| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
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| IN2014CN03791A (pt) * | 2011-11-09 | 2015-10-16 | Amyris Inc |
-
2012
- 2012-11-09 IN IN3791CHN2014 patent/IN2014CN03791A/en unknown
- 2012-11-09 ES ES12795948T patent/ES2628847T3/es active Active
- 2012-11-09 SG SG11201402083XA patent/SG11201402083XA/en unknown
- 2012-11-09 CA CA2853679A patent/CA2853679C/en active Active
- 2012-11-09 CN CN201280066027.XA patent/CN104039974B/zh active Active
- 2012-11-09 AU AU2012335091A patent/AU2012335091B2/en active Active
- 2012-11-09 DK DK12795948.4T patent/DK2776571T3/en active
- 2012-11-09 BR BR112014010750-5A patent/BR112014010750B1/pt active IP Right Grant
- 2012-11-09 US US13/673,819 patent/US8415136B1/en active Active
- 2012-11-09 MX MX2014005543A patent/MX346459B/es active IP Right Grant
- 2012-11-09 JP JP2014541353A patent/JP6073350B2/ja active Active
- 2012-11-09 PT PT127959484T patent/PT2776571T/pt unknown
- 2012-11-09 KR KR1020147015594A patent/KR102021914B1/ko active IP Right Grant
- 2012-11-09 WO PCT/US2012/064532 patent/WO2013071172A1/en active Application Filing
- 2012-11-09 EP EP12795948.4A patent/EP2776571B1/en active Active
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2013
- 2013-01-28 US US13/752,293 patent/US8603800B2/en active Active
- 2013-10-24 US US14/062,798 patent/US8859261B2/en active Active
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2014
- 2014-04-24 ZA ZA2014/02989A patent/ZA201402989B/en unknown
- 2014-09-02 US US14/474,976 patent/US9914941B2/en active Active
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2017
- 2017-01-04 JP JP2017000210A patent/JP6461208B2/ja active Active
Also Published As
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|---|---|
| MX2014005543A (es) | 2014-06-04 |
| WO2013071172A1 (en) | 2013-05-16 |
| SG11201402083XA (en) | 2014-06-27 |
| DK2776571T3 (en) | 2017-06-26 |
| JP6461208B2 (ja) | 2019-01-30 |
| CN104039974A (zh) | 2014-09-10 |
| CA2853679C (en) | 2021-05-04 |
| US9914941B2 (en) | 2018-03-13 |
| KR20140093981A (ko) | 2014-07-29 |
| JP2014532444A (ja) | 2014-12-08 |
| IN2014CN03791A (pt) | 2015-10-16 |
| PT2776571T (pt) | 2017-07-07 |
| CA2853679A1 (en) | 2013-05-16 |
| AU2012335091B2 (en) | 2016-06-16 |
| ZA201402989B (en) | 2015-11-25 |
| AU2012335091A1 (en) | 2014-06-19 |
| US20130236942A1 (en) | 2013-09-12 |
| BR112014010750B1 (pt) | 2021-09-21 |
| MX346459B (es) | 2017-03-22 |
| ES2628847T3 (es) | 2017-08-04 |
| US8859261B2 (en) | 2014-10-14 |
| KR102021914B1 (ko) | 2019-09-17 |
| US8415136B1 (en) | 2013-04-09 |
| EP2776571A1 (en) | 2014-09-17 |
| EP2776571B1 (en) | 2017-04-12 |
| US8603800B2 (en) | 2013-12-10 |
| US20150093797A1 (en) | 2015-04-02 |
| JP2017055777A (ja) | 2017-03-23 |
| JP6073350B2 (ja) | 2017-02-01 |
| US20140154765A1 (en) | 2014-06-05 |
| CN104039974B (zh) | 2016-10-12 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/11/2012, OBSERVADAS AS CONDICOES LEGAIS. |